WO2008146005A3 - Lyophilisation de substances cibles - Google Patents

Lyophilisation de substances cibles Download PDF

Info

Publication number
WO2008146005A3
WO2008146005A3 PCT/GB2008/001835 GB2008001835W WO2008146005A3 WO 2008146005 A3 WO2008146005 A3 WO 2008146005A3 GB 2008001835 W GB2008001835 W GB 2008001835W WO 2008146005 A3 WO2008146005 A3 WO 2008146005A3
Authority
WO
WIPO (PCT)
Prior art keywords
target substance
freeze
chamber
carrier
freeze drying
Prior art date
Application number
PCT/GB2008/001835
Other languages
English (en)
Other versions
WO2008146005A2 (fr
Inventor
John Morton Broughall
Charles Richard Wedge
Charles Munro
Original Assignee
Oxford Biosensors Ltd
John Morton Broughall
Charles Richard Wedge
Charles Munro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Biosensors Ltd, John Morton Broughall, Charles Richard Wedge, Charles Munro filed Critical Oxford Biosensors Ltd
Publication of WO2008146005A2 publication Critical patent/WO2008146005A2/fr
Publication of WO2008146005A3 publication Critical patent/WO2008146005A3/fr

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)

Abstract

Dans un procédé de lyophilisation d'une substance cible, la substance cible est supportée par un support que l'on fait passer dans une chambre de congélation en vue d'une réduction de température de la substance cible, puis dans une chambre de séchage. Un vide ou une pression réduite est appliqué(e) pendant le procédé, pendant une partie finale de l'opération de congélation lorsque la substance cible et le support sont présents dans la chambre de congélation, et/ou lorsque la substance cible et le support sont transférés de la chambre de congélation à la chambre de séchage. Le vide ou la pression réduite est également appliqué(e) lorsque la substance cible et le support sont présents dans la chambre de séchage. Ce procédé permet de commencer la congélation à une température voisine de la température d'affaissement de la substance cible et de maintenir cette température tout en compensant le refroidissement par évaporation, ce qui permet d'obtenir un cycle de lyophilisation extrêmement rapide et efficace, d'où une vitesse de refroidissement plus lente produisant des structures optimales à utiliser.
PCT/GB2008/001835 2007-05-31 2008-05-30 Lyophilisation de substances cibles WO2008146005A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0710379A GB0710379D0 (en) 2007-05-31 2007-05-31 Freeze drying of target substances
GB0710379.9 2007-05-31

Publications (2)

Publication Number Publication Date
WO2008146005A2 WO2008146005A2 (fr) 2008-12-04
WO2008146005A3 true WO2008146005A3 (fr) 2009-05-07

Family

ID=38289592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/001835 WO2008146005A2 (fr) 2007-05-31 2008-05-30 Lyophilisation de substances cibles

Country Status (2)

Country Link
GB (1) GB0710379D0 (fr)
WO (1) WO2008146005A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104677057B (zh) 2015-03-03 2017-02-01 华南理工大学 变频交流电场辅助冻干药物脂质体粉的方法和设备
GB202212257D0 (en) * 2022-08-23 2022-10-05 Stow Roger Valentine Drying apparatus and associated drying process

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192645A (en) * 1959-10-07 1965-07-06 Leybold Aulagen Holding A G Apparatus and method for vacuum freeze drying substances in a tunnel dryer having sealing locks
US3242575A (en) * 1960-11-05 1966-03-29 Manaresi Alessandra Lyophilization apparatus
US4104807A (en) * 1976-04-10 1978-08-08 Boehringer Mannheim Gmbh Machine for the continuous preparation and packaging of freeze-dried materials
US4501719A (en) * 1981-05-04 1985-02-26 Marquest Medical Products, Inc. Tray apparatus for freeze-drying biologicals having a predetermined unit dosage
US4597188A (en) * 1985-03-04 1986-07-01 Trappler Edward H Freeze dry process and structure
US5964043A (en) * 1995-03-18 1999-10-12 Glaxo Wellcome Inc. Freeze-drying process and apparatus
WO2003056319A2 (fr) * 2001-12-21 2003-07-10 Oxford Biosensors Limited Electrode sous forme de microbande
US20040043042A1 (en) * 2001-12-03 2004-03-04 Johnson Audrey M. Microscale lyophilization and drying methods for the stabilization of molecules
WO2006000823A2 (fr) * 2004-06-29 2006-01-05 Oxford Biosensors Limited Capteur electrochimique
US20070000145A1 (en) * 2004-08-27 2007-01-04 Dynax Corporation Method for drying and storing activated aluminum fine particles
WO2007066132A1 (fr) * 2005-12-09 2007-06-14 Oxford Biosensors Limited Lyophilisation de substances cibles

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192645A (en) * 1959-10-07 1965-07-06 Leybold Aulagen Holding A G Apparatus and method for vacuum freeze drying substances in a tunnel dryer having sealing locks
US3242575A (en) * 1960-11-05 1966-03-29 Manaresi Alessandra Lyophilization apparatus
US4104807A (en) * 1976-04-10 1978-08-08 Boehringer Mannheim Gmbh Machine for the continuous preparation and packaging of freeze-dried materials
US4501719A (en) * 1981-05-04 1985-02-26 Marquest Medical Products, Inc. Tray apparatus for freeze-drying biologicals having a predetermined unit dosage
US4597188A (en) * 1985-03-04 1986-07-01 Trappler Edward H Freeze dry process and structure
US5964043A (en) * 1995-03-18 1999-10-12 Glaxo Wellcome Inc. Freeze-drying process and apparatus
US20040043042A1 (en) * 2001-12-03 2004-03-04 Johnson Audrey M. Microscale lyophilization and drying methods for the stabilization of molecules
WO2003056319A2 (fr) * 2001-12-21 2003-07-10 Oxford Biosensors Limited Electrode sous forme de microbande
WO2006000823A2 (fr) * 2004-06-29 2006-01-05 Oxford Biosensors Limited Capteur electrochimique
US20070000145A1 (en) * 2004-08-27 2007-01-04 Dynax Corporation Method for drying and storing activated aluminum fine particles
WO2007066132A1 (fr) * 2005-12-09 2007-06-14 Oxford Biosensors Limited Lyophilisation de substances cibles

Also Published As

Publication number Publication date
GB0710379D0 (en) 2007-07-11
WO2008146005A2 (fr) 2008-12-04

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