WO2008142706A3 - Novel process for the synthesis of pioglitazone and its salts thereof - Google Patents

Novel process for the synthesis of pioglitazone and its salts thereof Download PDF

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Publication number
WO2008142706A3
WO2008142706A3 PCT/IN2008/000315 IN2008000315W WO2008142706A3 WO 2008142706 A3 WO2008142706 A3 WO 2008142706A3 IN 2008000315 W IN2008000315 W IN 2008000315W WO 2008142706 A3 WO2008142706 A3 WO 2008142706A3
Authority
WO
WIPO (PCT)
Prior art keywords
pioglitazone
synthesis
salts
novel process
thiazolidinedione derivatives
Prior art date
Application number
PCT/IN2008/000315
Other languages
French (fr)
Other versions
WO2008142706A2 (en
Inventor
Om Dutt Tyagi
Purna Chandra Ray
Konudula Babu Rao
Yogendra Kumar Chauhan
Raja Mahendar Reddy Nalla
Gadamsetty Prasad
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2008142706A2 publication Critical patent/WO2008142706A2/en
Publication of WO2008142706A3 publication Critical patent/WO2008142706A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Present invention relates to an improved process for the preparation of thiazolidinedione derivatives. Further the invention provides the hydrogenation of acid addition salt of benzylidene compound with less reducing agent under low Hydrogen gas pressure to get substantially pure thiazolidinedione derivatives with improved yields.
PCT/IN2008/000315 2007-05-18 2008-05-19 Novel process for the synthesis of pioglitazone and its salts thereof WO2008142706A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1050CH2007 2007-05-18
IN1050/CHE/2008 2007-05-18

Publications (2)

Publication Number Publication Date
WO2008142706A2 WO2008142706A2 (en) 2008-11-27
WO2008142706A3 true WO2008142706A3 (en) 2009-12-03

Family

ID=40032272

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000315 WO2008142706A2 (en) 2007-05-18 2008-05-19 Novel process for the synthesis of pioglitazone and its salts thereof

Country Status (1)

Country Link
WO (1) WO2008142706A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101824032B (en) * 2010-04-23 2015-09-09 浙江华海药业股份有限公司 A kind of process modification method preparing U-72107A
WO2012153312A1 (en) 2011-05-11 2012-11-15 Ranbaxy Laboratories Limited Process for the purification of pioglitazone
EP3816155A1 (en) * 2013-08-23 2021-05-05 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0257781A1 (en) * 1986-07-24 1988-03-02 Takeda Chemical Industries, Ltd. A method for producing thiazolidinedione derivatives
US20060252803A1 (en) * 2001-12-20 2006-11-09 Ben-Zion Dolitzky Hydrogenation of precursors to thiazolidinedione antihyperglycemics

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0257781A1 (en) * 1986-07-24 1988-03-02 Takeda Chemical Industries, Ltd. A method for producing thiazolidinedione derivatives
US20060252803A1 (en) * 2001-12-20 2006-11-09 Ben-Zion Dolitzky Hydrogenation of precursors to thiazolidinedione antihyperglycemics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
OKAMOTO, K. ET AL.: "Recoverable, Reusable, Highly Active, and Sulfur-Tolerant Polymer Incarcerated Palladium for Hydrogenation", JOURNAL OF ORGANIC CHEMISTRY, vol. 69, no. 8, 2004, pages 2871 - 2873 *

Also Published As

Publication number Publication date
WO2008142706A2 (en) 2008-11-27

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