WO2008142147A1 - Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis - Google Patents
Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis Download PDFInfo
- Publication number
- WO2008142147A1 WO2008142147A1 PCT/EP2008/056333 EP2008056333W WO2008142147A1 WO 2008142147 A1 WO2008142147 A1 WO 2008142147A1 EP 2008056333 W EP2008056333 W EP 2008056333W WO 2008142147 A1 WO2008142147 A1 WO 2008142147A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carboxylic acid
- pyrrolidone
- arginine
- salts
- citrulline
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES08759934.6T ES2554776T3 (en) | 2007-05-22 | 2008-05-22 | Combination consisting of pyrrolidono-5-carboxylic acid and at least one citrulline, arginine and asparagine compound and its use in the treatment of atopic dermatitis |
MX2009012472A MX2009012472A (en) | 2007-05-22 | 2008-05-22 | Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis. |
JP2010508859A JP2010527970A (en) | 2007-05-22 | 2008-05-22 | A combination comprising pyrrolidone-5-carboxylic acid and at least one compound selected from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis |
CA002687324A CA2687324A1 (en) | 2007-05-22 | 2008-05-22 | Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis |
CN200880016754A CN101686957A (en) | 2007-05-22 | 2008-05-22 | Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis |
US12/601,113 US8795705B2 (en) | 2007-05-22 | 2008-05-22 | Dermatologic compositions comprising pyrrolidone-5-carboxylic acid and at least one entity chosen from citrulline, arginine and asparagine, and uses thereof in the treatment of atopic dermatitis |
EP08759934.6A EP2164482B1 (en) | 2007-05-22 | 2008-05-22 | Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis |
BRPI0810323-2A2A BRPI0810323A2 (en) | 2007-05-22 | 2008-05-22 | "COMBINATION OF 5-CARBOXYLIC PYROLIDONE ACID, USE OF 5-CARBOXYLIC PYROLIDONE ACID, COMPOSITION AND USE" |
RU2009147465/15A RU2476214C2 (en) | 2007-05-22 | 2008-05-22 | Combination containing pyrrolidone-5-carboxylic acid and at least one compound of citrulline, arginine and asparagine, and using them for treating atopic dermatitis |
AU2008252925A AU2008252925B2 (en) | 2007-05-22 | 2008-05-22 | Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis |
PL08759934T PL2164482T3 (en) | 2007-05-22 | 2008-05-22 | Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis |
US12/790,194 US20100324111A1 (en) | 2007-05-22 | 2010-05-28 | Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and aspragine, and use thereof in the tratment of atopic dermatitis |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0755186A FR2916351B1 (en) | 2007-05-22 | 2007-05-22 | PHARMACEUTICAL COMPOSITION COMPRISING AT LEAST TWO COMPOUNDS SELECTED BY PYRROLIDONE-5-CARBOXYLIC ACID, CITRULLINE, ARGININE AND ASPARAGINE AND THEIR USE IN THE TREATMENT OF ATOPIC DERMATITIS |
FR0755186 | 2007-05-22 | ||
US92471207P | 2007-05-29 | 2007-05-29 | |
US60/924,712 | 2007-05-29 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/790,194 Continuation-In-Part US20100324111A1 (en) | 2007-05-22 | 2010-05-28 | Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and aspragine, and use thereof in the tratment of atopic dermatitis |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008142147A1 true WO2008142147A1 (en) | 2008-11-27 |
Family
ID=38606551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/056333 WO2008142147A1 (en) | 2007-05-22 | 2008-05-22 | Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis |
Country Status (15)
Country | Link |
---|---|
US (1) | US8795705B2 (en) |
EP (2) | EP2164482B1 (en) |
JP (2) | JP2010527970A (en) |
KR (1) | KR20100017202A (en) |
CN (1) | CN101686957A (en) |
BR (1) | BRPI0810323A2 (en) |
CA (1) | CA2687324A1 (en) |
ES (2) | ES2554834T3 (en) |
FR (1) | FR2916351B1 (en) |
HU (2) | HUE025824T2 (en) |
MX (1) | MX2009012472A (en) |
PL (2) | PL2218452T3 (en) |
PT (2) | PT2164482E (en) |
RU (1) | RU2476214C2 (en) |
WO (1) | WO2008142147A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130109949A (en) * | 2010-06-17 | 2013-10-08 | 가부시키가이샤 시세이도 | Oil-in-water type emulsion skin cosmetic |
KR20170033101A (en) | 2015-09-16 | 2017-03-24 | 원광대학교산학협력단 | Composition for improving liver function comprising citrulline as an active ingredient |
KR101732428B1 (en) | 2015-06-25 | 2017-05-24 | 이정재 | Elastic liposome composition and cosmetic composition comprising the same |
EP3756642A1 (en) | 2019-06-28 | 2020-12-30 | Merck Patent GmbH | Method to increase cellular availability of calcium in skin cells and mixtures |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101066859B1 (en) * | 2010-12-10 | 2011-09-26 | 전명자 | Pad and insole containing the same |
JP6009147B2 (en) * | 2011-03-15 | 2016-10-19 | 株式会社 資生堂 | Bleomycin hydrolase production promoter |
RU2538084C1 (en) * | 2013-07-25 | 2015-01-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации" (ГБОУ ВПО УГМА Минздрава России) | Agent for treating and preventing atopic dermatitis |
US9909427B2 (en) | 2015-12-22 | 2018-03-06 | General Electric Company | Turbine airfoil with trailing edge cooling circuit |
JP7019684B2 (en) * | 2016-06-17 | 2022-02-15 | ドラッグ デリバリー ソリューションズ アーペーエス | Formulation for use in the treatment of uremic pruritus |
CN112569162B (en) * | 2019-09-27 | 2024-04-12 | 默克专利股份有限公司 | Synergistic effect of radix Ophiopogonis extract, amino acid derivative and calcium lactate hydrate |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4837019A (en) * | 1986-08-11 | 1989-06-06 | Charles Of The Ritz Group Ltd. | Skin treatment composition and method for treating burned skin |
DE4341000A1 (en) * | 1993-12-02 | 1995-06-08 | Beiersdorf Ag | Use of L-arginine, L-ornithine or L-citrulline and topical preparations with these substances |
JPH0987126A (en) * | 1995-09-20 | 1997-03-31 | Ajinomoto Co Inc | Cosmetic |
EP1226822A2 (en) * | 2001-01-29 | 2002-07-31 | Ajinomoto Co., Inc. | Promoter for production of nitric oxide or nitric oxide synthase, and cosmetic or pharmaceutical composition comprising the same |
DE10393402T5 (en) * | 2002-06-19 | 2005-09-29 | Ajinomoto Co., Inc. | Agent and toiletry or pharmaceutical composition for accelerating uptake of basic amino acids into cells |
US20060063827A1 (en) * | 2004-09-23 | 2006-03-23 | Yu Ruey J | Systemic administration of therapeutic amino acids and N-acetylamino acids |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS61215307A (en) | 1985-03-20 | 1986-09-25 | Shiseido Co Ltd | External agent for skin |
JPS61215308A (en) | 1985-03-20 | 1986-09-25 | Shiseido Co Ltd | External agent for skin |
JPH0729911B2 (en) | 1986-05-15 | 1995-04-05 | 株式会社資生堂 | External skin preparation |
JPH0820525A (en) | 1994-07-06 | 1996-01-23 | Nendo Kagaku Kenkyusho:Kk | Body shampoo |
RU2188029C2 (en) * | 1995-09-07 | 2002-08-27 | Л'Ореаль | Application of extract out of nonphotosynthetic bacterium and extract-containing composition |
RU2169000C2 (en) | 1995-09-07 | 2001-06-20 | Л'Ореаль | Use of iridaceae extract, composition containing thereof and method of cosmetic treatment |
FR2768622B1 (en) | 1997-09-22 | 1999-11-26 | Oreal | Rosacea extract as antagonist of bradykinin |
FR2778562B1 (en) * | 1998-05-14 | 2000-08-04 | Sephra | PHARMACEUTICAL, HYGIENIC AND / OR COSMETIC COMPOSITION CONTAINING SEAWATER AND ARGININE |
DE19831798A1 (en) * | 1998-07-15 | 2000-01-27 | Mandorlo Investment Gmbh Luxem | Microcirculation improving skin and tissue care or treatment composition, containing salts, aminoacids and peroxide, used as cosmetic, medicament or nutrient supplement |
JP2002053428A (en) | 2000-08-12 | 2002-02-19 | Tadashi Fukiya | Skin care preparation |
DE10111049A1 (en) * | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Cosmetic or dermatological preparations for combating inflammatory disorders or dryness of the skin, containing agents inhibiting the onset of nitrogen monoxide synthase activity |
JP2004168763A (en) * | 2002-10-30 | 2004-06-17 | Dsr Corp | Skin cosmetic |
WO2005077349A1 (en) | 2004-02-17 | 2005-08-25 | Otsuka Pharmaceutical Co., Ltd. | HUMAN β-DEFENSIN PRODUCTION ACCELERATOR |
-
2007
- 2007-05-22 FR FR0755186A patent/FR2916351B1/en not_active Expired - Fee Related
-
2008
- 2008-05-22 PL PL10165250T patent/PL2218452T3/en unknown
- 2008-05-22 PL PL08759934T patent/PL2164482T3/en unknown
- 2008-05-22 JP JP2010508859A patent/JP2010527970A/en active Pending
- 2008-05-22 EP EP08759934.6A patent/EP2164482B1/en active Active
- 2008-05-22 MX MX2009012472A patent/MX2009012472A/en active IP Right Grant
- 2008-05-22 ES ES10165250.1T patent/ES2554834T3/en active Active
- 2008-05-22 BR BRPI0810323-2A2A patent/BRPI0810323A2/en not_active Application Discontinuation
- 2008-05-22 EP EP10165250.1A patent/EP2218452B1/en active Active
- 2008-05-22 US US12/601,113 patent/US8795705B2/en active Active
- 2008-05-22 KR KR1020097024242A patent/KR20100017202A/en not_active Application Discontinuation
- 2008-05-22 CN CN200880016754A patent/CN101686957A/en active Pending
- 2008-05-22 PT PT87599346T patent/PT2164482E/en unknown
- 2008-05-22 HU HUE08759934A patent/HUE025824T2/en unknown
- 2008-05-22 RU RU2009147465/15A patent/RU2476214C2/en active
- 2008-05-22 ES ES08759934.6T patent/ES2554776T3/en active Active
- 2008-05-22 WO PCT/EP2008/056333 patent/WO2008142147A1/en active Application Filing
- 2008-05-22 CA CA002687324A patent/CA2687324A1/en not_active Abandoned
- 2008-05-22 HU HUE10165250A patent/HUE026388T2/en unknown
- 2008-05-22 PT PT101652501T patent/PT2218452E/en unknown
-
2014
- 2014-01-10 JP JP2014003184A patent/JP2014065742A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4837019A (en) * | 1986-08-11 | 1989-06-06 | Charles Of The Ritz Group Ltd. | Skin treatment composition and method for treating burned skin |
DE4341000A1 (en) * | 1993-12-02 | 1995-06-08 | Beiersdorf Ag | Use of L-arginine, L-ornithine or L-citrulline and topical preparations with these substances |
JPH0987126A (en) * | 1995-09-20 | 1997-03-31 | Ajinomoto Co Inc | Cosmetic |
EP1226822A2 (en) * | 2001-01-29 | 2002-07-31 | Ajinomoto Co., Inc. | Promoter for production of nitric oxide or nitric oxide synthase, and cosmetic or pharmaceutical composition comprising the same |
DE10393402T5 (en) * | 2002-06-19 | 2005-09-29 | Ajinomoto Co., Inc. | Agent and toiletry or pharmaceutical composition for accelerating uptake of basic amino acids into cells |
US20060063827A1 (en) * | 2004-09-23 | 2006-03-23 | Yu Ruey J | Systemic administration of therapeutic amino acids and N-acetylamino acids |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130109949A (en) * | 2010-06-17 | 2013-10-08 | 가부시키가이샤 시세이도 | Oil-in-water type emulsion skin cosmetic |
EP2583663A4 (en) * | 2010-06-17 | 2015-08-19 | Shiseido Co Ltd | Oil-in-water type emulsion skin cosmetic |
KR101692801B1 (en) * | 2010-06-17 | 2017-01-05 | 가부시키가이샤 시세이도 | Oil-in-water type emulsion skin cosmetic |
KR101732428B1 (en) | 2015-06-25 | 2017-05-24 | 이정재 | Elastic liposome composition and cosmetic composition comprising the same |
KR20170033101A (en) | 2015-09-16 | 2017-03-24 | 원광대학교산학협력단 | Composition for improving liver function comprising citrulline as an active ingredient |
EP3756642A1 (en) | 2019-06-28 | 2020-12-30 | Merck Patent GmbH | Method to increase cellular availability of calcium in skin cells and mixtures |
US11737997B2 (en) | 2019-06-28 | 2023-08-29 | Merck Patent Gmbh | Method to increase cellular availability of calcium in skin cells and mixtures |
Also Published As
Publication number | Publication date |
---|---|
US20100291002A1 (en) | 2010-11-18 |
JP2014065742A (en) | 2014-04-17 |
CN101686957A (en) | 2010-03-31 |
PT2164482E (en) | 2016-02-03 |
HUE026388T2 (en) | 2016-06-28 |
PT2218452E (en) | 2016-01-27 |
FR2916351A1 (en) | 2008-11-28 |
PL2164482T3 (en) | 2016-05-31 |
US8795705B2 (en) | 2014-08-05 |
CA2687324A1 (en) | 2008-11-27 |
AU2008252925A1 (en) | 2008-11-27 |
RU2476214C2 (en) | 2013-02-27 |
HUE025824T2 (en) | 2016-05-30 |
KR20100017202A (en) | 2010-02-16 |
ES2554834T3 (en) | 2015-12-23 |
EP2218452A1 (en) | 2010-08-18 |
EP2164482A1 (en) | 2010-03-24 |
PL2218452T3 (en) | 2016-04-29 |
RU2009147465A (en) | 2011-06-27 |
EP2218452B1 (en) | 2015-09-30 |
EP2164482B1 (en) | 2015-10-07 |
MX2009012472A (en) | 2009-12-01 |
FR2916351B1 (en) | 2012-12-07 |
JP2010527970A (en) | 2010-08-19 |
BRPI0810323A2 (en) | 2014-10-14 |
ES2554776T3 (en) | 2015-12-23 |
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