WO2008130319A3 - Nouveaux composés 805 - Google Patents

Nouveaux composés 805 Download PDF

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Publication number
WO2008130319A3
WO2008130319A3 PCT/SE2008/050458 SE2008050458W WO2008130319A3 WO 2008130319 A3 WO2008130319 A3 WO 2008130319A3 SE 2008050458 W SE2008050458 W SE 2008050458W WO 2008130319 A3 WO2008130319 A3 WO 2008130319A3
Authority
WO
WIPO (PCT)
Prior art keywords
tetrahydronaphtalene
chromane
pain
novel
treatment
Prior art date
Application number
PCT/SE2008/050458
Other languages
English (en)
Other versions
WO2008130319A2 (fr
Inventor
Yevgeni Besidski
Alf Claesson
Gabor Csjernyik
Ylva Gravenfors
Inger Kers
Karin Skogholm
Daniel Sohn
Original Assignee
Astrazeneca Ab
Yevgeni Besidski
Alf Claesson
Gabor Csjernyik
Ylva Gravenfors
Inger Kers
Karin Skogholm
Daniel Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Yevgeni Besidski, Alf Claesson, Gabor Csjernyik, Ylva Gravenfors, Inger Kers, Karin Skogholm, Daniel Sohn filed Critical Astrazeneca Ab
Publication of WO2008130319A2 publication Critical patent/WO2008130319A2/fr
Publication of WO2008130319A3 publication Critical patent/WO2008130319A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés et une composition pharmaceutique contenant ces composés et l'utilisation desdits composés en thérapie. Cette invention porte également sur des procédés de préparation de ces composés et sur de nouveaux intermédiaires utiles dans la préparation de ces derniers.
PCT/SE2008/050458 2007-04-23 2008-04-22 Nouveaux composés 805 WO2008130319A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91330907P 2007-04-23 2007-04-23
US60/913,309 2007-04-23

Publications (2)

Publication Number Publication Date
WO2008130319A2 WO2008130319A2 (fr) 2008-10-30
WO2008130319A3 true WO2008130319A3 (fr) 2008-12-18

Family

ID=39876086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2008/050458 WO2008130319A2 (fr) 2007-04-23 2008-04-22 Nouveaux composés 805

Country Status (1)

Country Link
WO (1) WO2008130319A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120122924A1 (en) * 2010-11-15 2012-05-17 Abbott Laboratories Nampt inhibitors
JP6117104B2 (ja) 2010-11-15 2017-04-19 アッヴィ・インコーポレイテッド Ｎａｍｐｔおよびｒｏｃｋ阻害薬
WO2015006280A1 (fr) * 2013-07-10 2015-01-15 Vertex Pharmaceuticals Incorporated Amides de pipéridine fusionnés utiles en tant que modulateurs de canaux ioniques
WO2020054657A1 (fr) 2018-09-10 2020-03-19 科研製薬株式会社 Dérivé d'amide hétéroaromatique et médicament le contenant
CN112062688B (zh) * 2020-09-28 2023-02-03 绍兴兴欣新材料股份有限公司 一种n,n-二乙基乙酰胺的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034883A1 (fr) * 1996-03-22 1997-09-25 Astra Aktiebolag Derives de 1,2,3,4-tetrahydronaphthalene substitues
WO1999005134A1 (fr) * 1997-07-25 1999-02-04 Astra Aktiebolag Derives de 1,2,3,4-tetrahydronaphthalene substitue
WO1999014212A1 (fr) * 1997-09-18 1999-03-25 Astrazeneca Ab Derives de chromane substitues
WO1999014213A1 (fr) * 1997-09-18 1999-03-25 Astrazeneca Ab Derives de chromane substitue
WO2005013914A2 (fr) * 2003-08-08 2005-02-17 Vertex Pharmaceuticals Incorporated Compositions utilisees comme inhibiteurs de canaux sodium voltage dependants
US20060025415A1 (en) * 2003-08-08 2006-02-02 Gonzalez Jesus E Iii Compositions useful as inhibitors of voltage-gated sodium channels

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034883A1 (fr) * 1996-03-22 1997-09-25 Astra Aktiebolag Derives de 1,2,3,4-tetrahydronaphthalene substitues
WO1999005134A1 (fr) * 1997-07-25 1999-02-04 Astra Aktiebolag Derives de 1,2,3,4-tetrahydronaphthalene substitue
WO1999014212A1 (fr) * 1997-09-18 1999-03-25 Astrazeneca Ab Derives de chromane substitues
WO1999014213A1 (fr) * 1997-09-18 1999-03-25 Astrazeneca Ab Derives de chromane substitue
WO2005013914A2 (fr) * 2003-08-08 2005-02-17 Vertex Pharmaceuticals Incorporated Compositions utilisees comme inhibiteurs de canaux sodium voltage dependants
US20050137190A1 (en) * 2003-08-08 2005-06-23 Gonzalez Jesus E.Iii Compositions useful as inhibitors of voltage-gated sodium channels
US20060025415A1 (en) * 2003-08-08 2006-02-02 Gonzalez Jesus E Iii Compositions useful as inhibitors of voltage-gated sodium channels

Also Published As

Publication number Publication date
WO2008130319A2 (fr) 2008-10-30

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