WO2008128526A3 - Verwendung von egfl7 zur modulation von stammzellen - Google Patents

Verwendung von egfl7 zur modulation von stammzellen Download PDF

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Publication number
WO2008128526A3
WO2008128526A3 PCT/DE2008/000678 DE2008000678W WO2008128526A3 WO 2008128526 A3 WO2008128526 A3 WO 2008128526A3 DE 2008000678 W DE2008000678 W DE 2008000678W WO 2008128526 A3 WO2008128526 A3 WO 2008128526A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
egfl7
stem cell
cell modulation
modulation
Prior art date
Application number
PCT/DE2008/000678
Other languages
English (en)
French (fr)
Other versions
WO2008128526A2 (de
WO2008128526A9 (de
Inventor
Mirko Schmidt
Ivan Dikic
Karl H Plate
Frank Bicker
Original Assignee
Univ Jw Goethe Frankfurt Main
Mirko Schmidt
Ivan Dikic
Karl H Plate
Frank Bicker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jw Goethe Frankfurt Main, Mirko Schmidt, Ivan Dikic, Karl H Plate, Frank Bicker filed Critical Univ Jw Goethe Frankfurt Main
Publication of WO2008128526A2 publication Critical patent/WO2008128526A2/de
Publication of WO2008128526A9 publication Critical patent/WO2008128526A9/de
Publication of WO2008128526A3 publication Critical patent/WO2008128526A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF] (urogastrone)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate

Abstract

Die Erfindung betrifft die Verwendung eines Polynukleotids zur Modulation von Stammzellen. Erfindungsgemäß kodiert das Polynukleotid für a) ein EGFL7 Polypeptid oder für dessen gleichwirkende Polypeptidfragmente, oder b) ein Polypeptid, das mindestens 80 % Sequenzidentität zu den unter a) genannten Polypeptid oder Polypeptidfragmenten aufweist und welches zu dem EGFL7 Polypeptid gleichwirkend ist, oder c) ein Polypeptid, das mit einem unter a) und b) genannten Polypeptid oder Polypeptidfragment inhibierend in Wechselwirkung tritt.
PCT/DE2008/000678 2007-04-20 2008-04-21 Verwendung von egfl7 zur modulation von stammzellen WO2008128526A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007019162.8 2007-04-20
DE200710019162 DE102007019162A1 (de) 2007-04-20 2007-04-20 Verwendung von EGFL7 zur Modulation von Zellen

Publications (3)

Publication Number Publication Date
WO2008128526A2 WO2008128526A2 (de) 2008-10-30
WO2008128526A9 WO2008128526A9 (de) 2009-02-19
WO2008128526A3 true WO2008128526A3 (de) 2009-06-11

Family

ID=39768010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2008/000678 WO2008128526A2 (de) 2007-04-20 2008-04-21 Verwendung von egfl7 zur modulation von stammzellen

Country Status (2)

Country Link
DE (1) DE102007019162A1 (de)
WO (1) WO2008128526A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013061112A1 (en) * 2011-10-24 2013-05-02 Centre National De La Recherche Scientifique Use of egfl7 modulators for promoting or inhibiting migration of immune cells across vascular endothelium
WO2019049939A1 (en) * 2017-09-06 2019-03-14 The University Of Tokyo METHODS AND COMPOSITIONS FOR PROPAGATION OF CELLS

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057983A2 (en) * 1997-06-18 1998-12-23 Zymogenetics, Inc. Mammalian neuro-growth factor like protein
WO2001057191A1 (en) * 2000-02-01 2001-08-09 Neurogeneration, Inc. Generation of dopaminergic neurons from human nervous system stem cells
WO2003024478A1 (en) * 2001-09-19 2003-03-27 Neuronova Ab Treatment of central nervous system disorders by use of pdgf or vegf
WO2006095175A1 (en) * 2005-03-09 2006-09-14 The University Court of the University of Edingburgh Directed neural differentiation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166907A1 (en) 1997-06-18 2003-09-04 Zymogenetics, Inc. Mammalian neuro-growth factor like protein

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057983A2 (en) * 1997-06-18 1998-12-23 Zymogenetics, Inc. Mammalian neuro-growth factor like protein
WO2001057191A1 (en) * 2000-02-01 2001-08-09 Neurogeneration, Inc. Generation of dopaminergic neurons from human nervous system stem cells
WO2003024478A1 (en) * 2001-09-19 2003-03-27 Neuronova Ab Treatment of central nervous system disorders by use of pdgf or vegf
WO2006095175A1 (en) * 2005-03-09 2006-09-14 The University Court of the University of Edingburgh Directed neural differentiation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
STUHLMANN H ET AL: "Molecular regulation of vascular system development in mammals", SCIENTIFIC REPORT 2006, THE SCRIPPS RESEARCH INSTITUTE, 2006, XP002504301, Retrieved from the Internet <URL:http://www.scripps.edu/news/sr/sr2006/cb06stuhlmann.html> [retrieved on 20081117] *
TANIGAKI K ET AL: "Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate", NEURON, vol. 29, no. 1, January 2001 (2001-01-01), pages 45 - 55, XP002504302, ISSN: 0896-6273 *

Also Published As

Publication number Publication date
WO2008128526A2 (de) 2008-10-30
WO2008128526A9 (de) 2009-02-19
DE102007019162A1 (de) 2008-10-23

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