WO2008126446A1 - 生体分子検出標識剤、その製造方法、及びそれを用いた検出方法 - Google Patents

生体分子検出標識剤、その製造方法、及びそれを用いた検出方法 Download PDF

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Publication number
WO2008126446A1
WO2008126446A1 PCT/JP2008/051173 JP2008051173W WO2008126446A1 WO 2008126446 A1 WO2008126446 A1 WO 2008126446A1 JP 2008051173 W JP2008051173 W JP 2008051173W WO 2008126446 A1 WO2008126446 A1 WO 2008126446A1
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label
same
biomolecule
detecting
radiant ray
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PCT/JP2008/051173
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English (en)
French (fr)
Inventor
Kazuya Tsukada
Naoko Furusawa
Hideki Hoshino
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Konica Minolta Medical & Graphic, Inc.
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Application filed by Konica Minolta Medical & Graphic, Inc. filed Critical Konica Minolta Medical & Graphic, Inc.
Publication of WO2008126446A1 publication Critical patent/WO2008126446A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G31/00—Compounds of vanadium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/50—Solid solutions
    • C01P2002/52—Solid solutions containing elements as dopants
    • C01P2002/54—Solid solutions containing elements as dopants one element only
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Luminescent Compositions (AREA)

Abstract

　複数の検出手段により被検体の様々な情報を獲得できる生体分子検出用の標識剤を提供する。本発明の生体分子検出標識剤は、放射源を使用した放射後に、放射線の吸収および／もしくは散乱および／もしくは回折により、かつ／または磁場中の放射線の吸収と放出により、かつ／または放射線による励起後の蛍光放出により検出することができ、かつ生体親和性の表面修飾物質が生体分子またはその他の有機基質を検出するために表面に結合することができるように表面が処理された、希土類ドープ金属を含み、粒径変動係数が10～30％である、無機のナノ粒子を含有することを特徴とする。少なくともＧｄを含むことが望ましく、さらに該ナノ粒子のホスト材料として、少なくともバナジン酸塩を含むことが望ましい。
PCT/JP2008/051173 2007-03-19 2008-01-28 生体分子検出標識剤、その製造方法、及びそれを用いた検出方法 WO2008126446A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007070896 2007-03-19
JP2007-070896 2007-03-19

Publications (1)

Publication Number Publication Date
WO2008126446A1 true WO2008126446A1 (ja) 2008-10-23

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ID=39863605

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PCT/JP2008/051173 WO2008126446A1 (ja) 2007-03-19 2008-01-28 生体分子検出標識剤、その製造方法、及びそれを用いた検出方法

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WO (1) WO2008126446A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020252871A1 (zh) * 2019-06-21 2020-12-24 博阳生物科技（上海）有限公司 一种用于均相化学发光检测的受体试剂及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004077389A (ja) * 2002-08-21 2004-03-11 Hitachi Software Eng Co Ltd 半導体ナノ粒子を含む機能性蛍光試薬
JP2004508215A (ja) * 2000-09-08 2004-03-18 ナノゾルティオンス　ゲーエムベーハー ナノ粒子の合成
WO2006009077A1 (ja) * 2004-07-16 2006-01-26 Fujifilm Corporation 蛍光検出方法
JP2006023140A (ja) * 2004-07-07 2006-01-26 Hitachi Maxell Ltd 複合化粒子
JP2006515418A (ja) * 2002-08-27 2006-05-25 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 規定された数のリガンドを有するナノ粒子の製造

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004508215A (ja) * 2000-09-08 2004-03-18 ナノゾルティオンス　ゲーエムベーハー ナノ粒子の合成
JP2004077389A (ja) * 2002-08-21 2004-03-11 Hitachi Software Eng Co Ltd 半導体ナノ粒子を含む機能性蛍光試薬
JP2006515418A (ja) * 2002-08-27 2006-05-25 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 規定された数のリガンドを有するナノ粒子の製造
JP2006023140A (ja) * 2004-07-07 2006-01-26 Hitachi Maxell Ltd 複合化粒子
WO2006009077A1 (ja) * 2004-07-16 2006-01-26 Fujifilm Corporation 蛍光検出方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020252871A1 (zh) * 2019-06-21 2020-12-24 博阳生物科技（上海）有限公司 一种用于均相化学发光检测的受体试剂及其应用

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