WO2008124646A3 - Utilisation de protéines amyloïdes en tant qu'échafaudages pour des vaccins - Google Patents

Utilisation de protéines amyloïdes en tant qu'échafaudages pour des vaccins Download PDF

Info

Publication number
WO2008124646A3
WO2008124646A3 PCT/US2008/059499 US2008059499W WO2008124646A3 WO 2008124646 A3 WO2008124646 A3 WO 2008124646A3 US 2008059499 W US2008059499 W US 2008059499W WO 2008124646 A3 WO2008124646 A3 WO 2008124646A3
Authority
WO
WIPO (PCT)
Prior art keywords
amyloid proteins
scaffolds
epitope
compositions
target peptide
Prior art date
Application number
PCT/US2008/059499
Other languages
English (en)
Other versions
WO2008124646A2 (fr
Inventor
Amy Rosenberg
Erich James Keller
Robert Tycko
Original Assignee
Government Of The U S A As Rep
Amy Rosenberg
Erich James Keller
Robert Tycko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government Of The U S A As Rep, Amy Rosenberg, Erich James Keller, Robert Tycko filed Critical Government Of The U S A As Rep
Publication of WO2008124646A2 publication Critical patent/WO2008124646A2/fr
Publication of WO2008124646A3 publication Critical patent/WO2008124646A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0003—Invertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/005—Trypanosoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0208—Specific bacteria not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/07—Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A61K39/1045—Moraxella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/107—Vibrio
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Les modes de réalisation de la présente invention se rapportent à l'utilisation de protéines amyloïdes en tant qu'échafaudages destinés à porter des peptides hétérologues. Plus précisément, certains modes de réalisation portent sur des protéines amyloïdes qui présentent au moins un peptide cible hétérologue contenant une séquence antigénique ou au moins un épitope, et sur l'utilisation de ces compositions pour induire une réponse immunitaire audit peptide cible hétérologue, à la séquence antigénique ou à l'épitope. L'invention concerne également des procédés de fabrication et d'utilisation de ces compositions pour prévenir et/ou traiter une maladie chez l'être humain.
PCT/US2008/059499 2007-04-06 2008-04-04 Utilisation de protéines amyloïdes en tant qu'échafaudages pour des vaccins WO2008124646A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92213107P 2007-04-06 2007-04-06
US60/922,131 2007-04-06

Publications (2)

Publication Number Publication Date
WO2008124646A2 WO2008124646A2 (fr) 2008-10-16
WO2008124646A3 true WO2008124646A3 (fr) 2009-04-02

Family

ID=39831552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/059499 WO2008124646A2 (fr) 2007-04-06 2008-04-04 Utilisation de protéines amyloïdes en tant qu'échafaudages pour des vaccins

Country Status (1)

Country Link
WO (1) WO2008124646A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO652897A0 (en) 1997-04-30 1997-05-29 University Of Melbourne, The Synthetic peptide constructs for the diagnosis and treatment of periodontitis
US8129500B2 (en) 1997-12-10 2012-03-06 Csl Limited Porphyromonas gingivalis polypeptides and nucleotides
CA2652957A1 (fr) 2006-06-27 2008-01-03 Oral Health Australia Pty Ltd. Polypeptides de porphyromonas gingivalis utiles dans la prevention de la parodontolyse
CN101842486A (zh) 2007-07-12 2010-09-22 口腔健康澳洲私人有限公司 生物膜的免疫治疗
AU2008274906B2 (en) 2007-07-12 2013-11-07 Oral Health Australia Pty Ltd Biofilm treatment
RU2535898C2 (ru) * 2008-08-29 2014-12-20 Орал Хэлс Аустралиа Пти Лтд Профилактика, лечение и диагностика инфекции, вызванной бактериями p.gingivalis
US20110287047A1 (en) * 2008-11-18 2011-11-24 Crossbeta Biosciences B.V. Cross-beta structures as carrier in vaccines
US8753623B2 (en) 2009-04-29 2014-06-17 Runtao He Influenza vaccine
US9241987B2 (en) 2009-11-20 2016-01-26 The University Of Chicago Methods and compositions related to immunogenic fibrils
US10703784B2 (en) * 2011-09-30 2020-07-07 La Jolla Institute For Allergy And Immunology Antigens and epitopes derived from Mycobacterium tuberculosis
US9200082B2 (en) 2013-03-14 2015-12-01 The University Of Chicago Methods and compositions involving fibrillizing polypeptides for nanofibers
US20160326220A1 (en) 2013-12-24 2016-11-10 Vib Vzw Secretion and functional display of chimeric polypeptides
US9926352B2 (en) * 2014-03-03 2018-03-27 Serendipity Biotech Inc. Chimeric dystrophin-VSV-G protein to treat dystrophinopathies
CN112533959A (zh) * 2018-05-22 2021-03-19 阿尔伯塔大学理事会 用于基于结构的淀粉样蛋白疾病疫苗和抗原的无害的、结构化的支架

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034777A1 (fr) * 2000-10-24 2002-05-02 Chiesi Farmaceutici S.P.A. Proteines de fusion utilisees comme traitements d'immunisation contre la maladie d'alzheimer
WO2005058941A2 (fr) * 2003-12-17 2005-06-30 Elan Pharmaceuticals, Inc. Conjugues porteurs de peptide immunogene a? les techniques de production de ces conjugues
EP1685847A1 (fr) * 2001-08-20 2006-08-02 Pharmexa A/S Vaccin à base des épitopes de cellules T d'un analogue de l'amyloide béta

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034777A1 (fr) * 2000-10-24 2002-05-02 Chiesi Farmaceutici S.P.A. Proteines de fusion utilisees comme traitements d'immunisation contre la maladie d'alzheimer
EP1685847A1 (fr) * 2001-08-20 2006-08-02 Pharmexa A/S Vaccin à base des épitopes de cellules T d'un analogue de l'amyloide béta
WO2005058941A2 (fr) * 2003-12-17 2005-06-30 Elan Pharmaceuticals, Inc. Conjugues porteurs de peptide immunogene a? les techniques de production de ces conjugues

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHACKERIAN BRYCE ET AL: "Determinants of autoantibody induction by conjugated papillomavirus virus-like particles", JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 169, no. 11, 1 December 2002 (2002-12-01), pages 6120 - 6126, XP002378464, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2008124646A2 (fr) 2008-10-16

Similar Documents

Publication Publication Date Title
WO2008124646A3 (fr) Utilisation de protéines amyloïdes en tant qu'échafaudages pour des vaccins
AR125326A2 (es) Composiciones de neisseria meningitidis y métodos de las mismas
WO2012058393A3 (fr) Anticorps anti-dkk1 et leurs procédés d'utilisation
WO2011032161A3 (fr) Vaccins dirigés contre les cellules de langerhans
EP3412304A3 (fr) Épitopes agonistes hla-a24 de l'oncoprotéine muc1-c et compositions et procédés d'utilisation
EP3266464A3 (fr) Thérapeutique à base de levure pour infection chronique par l'hépatite b
MX2017014908A (es) Proteinas de union triespecificas y metodos de uso.
CO6491045A2 (es) Composiciones de proteina f de virus sincitial respiratorio (rsv) y metodos para producir las mismas
WO2016176624A3 (fr) Pestivirus porcin, vaccins et dosages
WO2010149752A3 (fr) Nouvelles compositions
WO2008118017A3 (fr) Peptides dérivés de prame et compositions immunogènes comprenant ceux-ci
DK2707393T3 (da) Fusionsproteiner og kombinationsvacciner omfattende haemoph-ilus influenzae-protein e og pilin a
MX2010004482A (es) Anticuerpos anti-proteina g vsr.
WO2009026465A3 (fr) Composition et procédés de fabrication et d'utilisation de protéines de la grippe
AR100768A1 (es) Método para disminuir la inmunogenicidad de proteínas y péptidos
BRPI1007721B1 (pt) composição de vacina para uso na indução de uma resposta imunológica contra um rotavírus em um indivíduo, cepa de rotavírus isolado de cdc-9 e cepa de rotavírus isolado de cdc-66
EA201391200A1 (ru) Способы и композиции для вакцинации от staphylococcus aureus
WO2016116905A9 (fr) Antigènes de cmv et leurs utilisations
WO2012047267A3 (fr) Immunogène polyvalent
WO2013040478A3 (fr) Compositions dérivées de hyr1 et méthodes de traitement les utilisant
NZ594268A (en) Grass peptides for vaccine
CL2011002994A1 (es) Construccion de proteina que comprende polipeptido casb7439; composicion inmunogenica que comprende dicha construccion; uso de la composicion porque sirve para inducir respuesta inmunitaria al casb7439 en un animal.
GB2429711A (en) Heart and skeletal muscle inflammation (HSMI) virus
WO2011067758A3 (fr) Fragments immunogènes et multimères pour protéines de streptococcus pneumoniae
WO2014140166A3 (fr) Vaccin

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08745177

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08745177

Country of ref document: EP

Kind code of ref document: A2