WO2008120741A1 - 塩基性線維芽細胞増殖因子の徐放性製剤 - Google Patents

塩基性線維芽細胞増殖因子の徐放性製剤 Download PDF

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Publication number
WO2008120741A1
WO2008120741A1 PCT/JP2008/056162 JP2008056162W WO2008120741A1 WO 2008120741 A1 WO2008120741 A1 WO 2008120741A1 JP 2008056162 W JP2008056162 W JP 2008056162W WO 2008120741 A1 WO2008120741 A1 WO 2008120741A1
Authority
WO
WIPO (PCT)
Prior art keywords
sustained release
release preparation
growth factor
fibroblast growth
basic fibroblast
Prior art date
Application number
PCT/JP2008/056162
Other languages
English (en)
French (fr)
Inventor
Kunikazu Moribe
Atsushi Ishida
Keiji Yamamoto
Original Assignee
National University Corporation Chiba University
Kaken Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Chiba University, Kaken Pharmaceutical Co., Ltd. filed Critical National University Corporation Chiba University
Priority to JP2009507531A priority Critical patent/JPWO2008120741A1/ja
Publication of WO2008120741A1 publication Critical patent/WO2008120741A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

　本発明は、塩基性線維芽細胞増殖因子及び／又はその同族体を担持させたアガロースハイドロゲルを含有してなる徐放性製剤を提供する。好ましい徐放性製剤は、アガロースハイドロゲルがアガロースのみから調製されるもの、又は粒子状である。本発明はまた、前記徐放性製剤を製造するための、塩基性線維芽細胞増殖因子及び／又はその同族体とアガロースハイドロゲルの使用、並びに前記徐放性製剤及び当該徐放性製剤を血管新生促進又は組織再生に使用することができること又は使用すべきであることを記載した当該徐放性製剤に関する記載物を含む商業パッケージを提供する。
PCT/JP2008/056162 2007-03-30 2008-03-28 塩基性線維芽細胞増殖因子の徐放性製剤 WO2008120741A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009507531A JPWO2008120741A1 (ja) 2007-03-30 2008-03-28 塩基性線維芽細胞増殖因子の徐放性製剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007094703 2007-03-30
JP2007-094703 2007-03-30

Publications (1)

Publication Number Publication Date
WO2008120741A1 true WO2008120741A1 (ja) 2008-10-09

Family

ID=39808321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056162 WO2008120741A1 (ja) 2007-03-30 2008-03-28 塩基性線維芽細胞増殖因子の徐放性製剤

Country Status (2)

Country Link
JP (1) JPWO2008120741A1 (ja)
WO (1) WO2008120741A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012050184A1 (ja) * 2010-10-15 2012-04-19 国立大学法人京都大学 徐放性医薬組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000178180A (ja) * 1998-12-14 2000-06-27 Univ Kyoto 生体内に毛細血管が豊富な組織を作成するのに用いる新生血管床形成用用具

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000178180A (ja) * 1998-12-14 2000-06-27 Univ Kyoto 生体内に毛細血管が豊富な組織を作成するのに用いる新生血管床形成用用具

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HAGLUND B.O. ET AL.: "Dissolution Controlled Drug Release from Agarose Beads", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 20, no. 6, 1994, pages 947 - 959 *
KURANE A. ET AL.: "In vivo cellular repopulation of tubular elastin scaffolds mediated by basic fibroblast growth factor", BIOMATERIALS, vol. 28, 25 February 2007 (2007-02-25), pages 2830 - 2838, XP022004004 *
LIU J. ET AL.: "SDS-aided immobilization and controlled release of camptothecin from agarose hydrogel", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 25, no. 2-3, 2005, pages 237 - 244, XP004903821 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012050184A1 (ja) * 2010-10-15 2012-04-19 国立大学法人京都大学 徐放性医薬組成物
JP5860406B2 (ja) * 2010-10-15 2016-02-16 国立大学法人京都大学 徐放性医薬組成物
US9301917B2 (en) 2010-10-15 2016-04-05 Kyoto University Sustained-release pharmaceutical composition

Also Published As

Publication number Publication date
JPWO2008120741A1 (ja) 2010-07-15

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