WO2008120085A3 - Composition angiogenique comprenant un complexe entre un polymere amphiphile et un pdgf - Google Patents

Composition angiogenique comprenant un complexe entre un polymere amphiphile et un pdgf Download PDF

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Publication number
WO2008120085A3
WO2008120085A3 PCT/IB2008/000762 IB2008000762W WO2008120085A3 WO 2008120085 A3 WO2008120085 A3 WO 2008120085A3 IB 2008000762 W IB2008000762 W IB 2008000762W WO 2008120085 A3 WO2008120085 A3 WO 2008120085A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
amphiphilic
pdgf
therapeutic composition
group
Prior art date
Application number
PCT/IB2008/000762
Other languages
English (en)
Other versions
WO2008120085A2 (fr
Inventor
Olivier Soula
Gérard Soula
Rémi SOULA
Rosy Eloy
Original Assignee
Adocia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adocia filed Critical Adocia
Priority to EP08737361A priority Critical patent/EP2131864A2/fr
Publication of WO2008120085A2 publication Critical patent/WO2008120085A2/fr
Publication of WO2008120085A3 publication Critical patent/WO2008120085A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne l'utilisation d'un polymère amphiphile pour la préparation d'une composition thérapeutique destinée à favoriser l'angiogénèse sur son site d'administration comprenant un complexe entre un polymère et un PDGF caractérisée en ce que le polymère est amphiphile. Dans un mode de réalisation le PDGF est choisi dans le groupe des PDGFs (Platelet-Derivated Growth Factors) et le polymère amphiphile est choisi dans le groupe : des polymères amphiphiles constitués d'un squelette polymérique hydrophile fonctionnalisé par des substituants hydrophobes et des groupements hydrophiles de formule générale (I). L'invention concerne également l'utilisation selon l'une quelconque des revendications précédentes, caractérisée en ce que la composition thérapeutique est sous forme d'un gel, d'une crème, d'une solution, d'un spray, d'une pâte ou d'un patch ou d'un pansement.
PCT/IB2008/000762 2007-03-29 2008-03-31 Composition angiogenique comprenant un complexe entre un polymere amphiphile et un pdgf WO2008120085A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08737361A EP2131864A2 (fr) 2007-03-29 2008-03-31 Composition angiogénique comprenant un complexe entre un polymère amphiphile et un pdgf

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90736807P 2007-03-29 2007-03-29
US60/907,368 2007-03-29
FR0702314A FR2914191A1 (fr) 2007-03-29 2007-03-29 Composition angiogenique.
FR0702314 2007-03-29

Publications (2)

Publication Number Publication Date
WO2008120085A2 WO2008120085A2 (fr) 2008-10-09
WO2008120085A3 true WO2008120085A3 (fr) 2009-09-11

Family

ID=38567015

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/000762 WO2008120085A2 (fr) 2007-03-29 2008-03-31 Composition angiogenique comprenant un complexe entre un polymere amphiphile et un pdgf

Country Status (4)

Country Link
US (2) US20080293635A1 (fr)
EP (1) EP2131864A2 (fr)
FR (1) FR2914191A1 (fr)
WO (1) WO2008120085A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2738274A1 (fr) * 2008-09-26 2010-04-01 Adocia Complexe constitue d'un polysaccharide et d'une hpb

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457093A (en) * 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
WO1995026736A1 (fr) * 1994-03-30 1995-10-12 Universite Paris Val De Marne Utilisation de biopolymeres pour le traitement des muscles
WO2002058718A2 (fr) * 2001-01-26 2002-08-01 Genetix Pharmaceuticals, Inc. Methodes et compositions permettant de stimuler l'angiogenese
US20040131583A1 (en) * 1998-07-21 2004-07-08 Denis Barritault Biocompatible polymers, process for their preparation and compositions containing them
WO2007013100A1 (fr) * 2005-07-26 2007-02-01 Virchow Biotech Private Limited Formulation de gel comprenant le facteur de croissance dérivé des plaquettes
WO2007034320A2 (fr) * 2005-09-26 2007-03-29 Adocia Complexe polymere amphiphile-pdgf
WO2007116143A1 (fr) * 2006-04-07 2007-10-18 Adocia Polysaccharides bifonctionnalises

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2772382B1 (fr) * 1997-12-11 2000-03-03 Solutions Derives de dextrane, leur procede de preparation et leurs applications comme medicaments a action biologique specifique
US7368125B2 (en) * 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457093A (en) * 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
WO1995026736A1 (fr) * 1994-03-30 1995-10-12 Universite Paris Val De Marne Utilisation de biopolymeres pour le traitement des muscles
US20040131583A1 (en) * 1998-07-21 2004-07-08 Denis Barritault Biocompatible polymers, process for their preparation and compositions containing them
WO2002058718A2 (fr) * 2001-01-26 2002-08-01 Genetix Pharmaceuticals, Inc. Methodes et compositions permettant de stimuler l'angiogenese
WO2007013100A1 (fr) * 2005-07-26 2007-02-01 Virchow Biotech Private Limited Formulation de gel comprenant le facteur de croissance dérivé des plaquettes
WO2007034320A2 (fr) * 2005-09-26 2007-03-29 Adocia Complexe polymere amphiphile-pdgf
WO2007034321A2 (fr) * 2005-09-26 2007-03-29 Biodex Compositions pharmaceutiques a activite cicatrisante comprenant au moins un derive de dextrane soluble et au moins un facteur de croissance derive des plaquettes
WO2007116143A1 (fr) * 2006-04-07 2007-10-18 Adocia Polysaccharides bifonctionnalises

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CARION O ET AL: "Polysaccharide microarray for polysaccharide-PDGF interaction studies", CHEMBIOCHEM, WILEY, WEINHEIM, DE, vol. 7, 7 May 2006 (2006-05-07), pages 817 - 826, XP002441279, ISSN: 1439-4227 *
PARK J S ET AL: "N-acetyl histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: Endocytosis, exocytosis and drug release", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 115, no. 1, 28 September 2006 (2006-09-28), pages 37 - 45, XP024957637, ISSN: 0168-3659, [retrieved on 20060928] *

Also Published As

Publication number Publication date
US20080293635A1 (en) 2008-11-27
FR2914191A1 (fr) 2008-10-03
EP2131864A2 (fr) 2009-12-16
WO2008120085A2 (fr) 2008-10-09
US20100190709A1 (en) 2010-07-29

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