WO2008119353A1 - Bispecific antibodies and methods for production thereof - Google Patents
Bispecific antibodies and methods for production thereof Download PDFInfo
- Publication number
- WO2008119353A1 WO2008119353A1 PCT/DK2008/000124 DK2008000124W WO2008119353A1 WO 2008119353 A1 WO2008119353 A1 WO 2008119353A1 DK 2008000124 W DK2008000124 W DK 2008000124W WO 2008119353 A1 WO2008119353 A1 WO 2008119353A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibody
- replaced
- igg4
- region
- vivo method
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08715601.4A EP2139924B1 (en) | 2007-03-29 | 2008-03-28 | Bispecific antibodies and methods for production thereof |
JP2010500070A JP5681482B2 (en) | 2007-03-29 | 2008-03-28 | Bispecific antibody and method for producing the same |
CN200880018280.1A CN101802015B (en) | 2007-03-29 | 2008-03-28 | Bispecific antibodies and methods for production thereof |
US12/593,759 US9212230B2 (en) | 2007-03-29 | 2008-03-28 | Bispecific antibodies and methods for production thereof |
MX2009010282A MX2009010282A (en) | 2007-03-29 | 2008-03-28 | Bispecific antibodies and methods for production thereof. |
AU2008234248A AU2008234248C1 (en) | 2007-03-29 | 2008-03-28 | Bispecific antibodies and methods for production thereof |
CA2681974A CA2681974C (en) | 2007-03-29 | 2008-03-28 | Bispecific antibodies and methods for production thereof |
ES08715601.4T ES2593484T3 (en) | 2007-03-29 | 2008-03-28 | Bispecific antibodies and their production methods |
IL201082A IL201082A (en) | 2007-03-29 | 2009-09-21 | Bispecific antibodies and methods for production thereof |
US14/934,956 US10906991B2 (en) | 2007-03-29 | 2015-11-06 | Bispecific antibodies and methods for production thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92084007P | 2007-03-29 | 2007-03-29 | |
US60/920,840 | 2007-03-29 | ||
DKPA200700491 | 2007-03-29 | ||
DKPA200700491 | 2007-03-29 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/593,759 A-371-Of-International US9212230B2 (en) | 2007-03-29 | 2008-03-28 | Bispecific antibodies and methods for production thereof |
US14/934,956 Division US10906991B2 (en) | 2007-03-29 | 2015-11-06 | Bispecific antibodies and methods for production thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008119353A1 true WO2008119353A1 (en) | 2008-10-09 |
WO2008119353A8 WO2008119353A8 (en) | 2009-07-30 |
Family
ID=39672666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2008/000124 WO2008119353A1 (en) | 2007-03-29 | 2008-03-28 | Bispecific antibodies and methods for production thereof |
Country Status (11)
Country | Link |
---|---|
US (2) | US9212230B2 (en) |
EP (2) | EP2626372B1 (en) |
JP (2) | JP5681482B2 (en) |
CN (2) | CN101802015B (en) |
AU (1) | AU2008234248C1 (en) |
CA (1) | CA2681974C (en) |
ES (2) | ES2593484T3 (en) |
IL (1) | IL201082A (en) |
MX (1) | MX2009010282A (en) |
NZ (1) | NZ614857A (en) |
WO (1) | WO2008119353A1 (en) |
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WO2012143523A1 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecifc antibodies against her2 |
WO2012143524A2 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
WO2013004842A2 (en) | 2011-07-06 | 2013-01-10 | Genmab A/S | Antibody variants and uses thereof |
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WO2013166236A1 (en) * | 2012-05-03 | 2013-11-07 | Regeneron Pharmaceuticals, Inc. | Human antibodies to fel d1 and methods of use thereof |
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WO2014009474A1 (en) | 2012-07-13 | 2014-01-16 | F. Hoffmann-La Roche Ag | Method for the detection of a multispecific binder |
WO2014030728A1 (en) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | Fcγriib-specific fc region variant |
WO2014108198A1 (en) | 2013-01-10 | 2014-07-17 | Genmab B.V. | Human igg1 fc region variants and uses thereof |
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EP2626372A1 (en) | 2013-08-14 |
CA2681974C (en) | 2019-12-31 |
US20160159930A1 (en) | 2016-06-09 |
JP2014239689A (en) | 2014-12-25 |
NZ614857A (en) | 2015-04-24 |
EP2139924A1 (en) | 2010-01-06 |
US20100105874A1 (en) | 2010-04-29 |
EP2139924B1 (en) | 2016-07-06 |
AU2008234248B2 (en) | 2014-07-10 |
WO2008119353A8 (en) | 2009-07-30 |
CA2681974A1 (en) | 2008-10-09 |
ES2667863T3 (en) | 2018-05-14 |
AU2008234248A1 (en) | 2008-10-09 |
ES2593484T3 (en) | 2016-12-09 |
CN101802015A (en) | 2010-08-11 |
MX2009010282A (en) | 2009-10-12 |
JP2010522701A (en) | 2010-07-08 |
CN101802015B (en) | 2015-05-06 |
AU2008234248C1 (en) | 2015-01-22 |
EP2626372B1 (en) | 2018-03-21 |
US10906991B2 (en) | 2021-02-02 |
CN104497143B (en) | 2020-08-25 |
IL201082A0 (en) | 2010-05-17 |
US9212230B2 (en) | 2015-12-15 |
CN104497143A (en) | 2015-04-08 |
JP5681482B2 (en) | 2015-03-11 |
IL201082A (en) | 2017-04-30 |
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