WO2008114918A1 - Timbre transdermique d'ionophorèse et son procédé de fabrication - Google Patents

Timbre transdermique d'ionophorèse et son procédé de fabrication Download PDF

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Publication number
WO2008114918A1
WO2008114918A1 PCT/KR2007/005140 KR2007005140W WO2008114918A1 WO 2008114918 A1 WO2008114918 A1 WO 2008114918A1 KR 2007005140 W KR2007005140 W KR 2007005140W WO 2008114918 A1 WO2008114918 A1 WO 2008114918A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrode layer
positive electrode
iontophoresis patch
negative electrode
iontophoresis
Prior art date
Application number
PCT/KR2007/005140
Other languages
English (en)
Inventor
Nam In Kim
Myoung Woo Chung
Seung Gyu Lim
Original Assignee
Rocket Electric Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020070026688A external-priority patent/KR100844103B1/ko
Priority claimed from KR1020070099132A external-priority patent/KR100868350B1/ko
Application filed by Rocket Electric Co., Ltd filed Critical Rocket Electric Co., Ltd
Publication of WO2008114918A1 publication Critical patent/WO2008114918A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details

Definitions

  • FIG. 1 is a cross-sectional view schematically illustrating the structure of an iontophoresis patch according to the present invention
  • FIG. 2 is a top plan view illustrating a conductive electrode layer formed on a patch sheet
  • FIG. 3 is a top plan view illustrating a positive electrode layer and a negative electrode layer formed on the conductive electrode layer
  • FIG. 4 is a top plan view illustrating a hydrogel layer formed on the positive electrode layer and the negative electrode layer.
  • patch sheet 20 conductive electrode layer 30: current path 40: positive electrode layer 50: negative electrode layer 60: hydrogel layer 70: insulation film
  • the present invention relates to a patch system using the principle of iontophoresis as a means for penetrating the skin with a material of interest, such as a pharmaceutical or a cosmetic.
  • iontophoresis refers to a technique for allowing minute current to flow through the skin so that, an electrically charged material of interest penetrates into the skin using electrorepulsive force.
  • a patch containing the material of interest is attached to the skin, a circuit is formed, and current is generated, so that the material of interest penetrates into the skin using electrorepulsive force.
  • a conventional iontophoresis instrument is operated by attaching two electrodes to the skin of the human body and connecting each of the electrodes to an electrical device by wires.
  • the material of interest is placed on the surface of the electrode, and, when the electrical device is powered on, the penetration of the material of interest into the human body occurs.
  • the electrical device is designed so that the amount and time of current application can be adjusted.
  • such a system is disadvantageous because the patient is connected to the electrical device by wires, and thus the usual movement and activity of the patient are limited.
  • a recent patch type iontophoresis system has developed toward the incorporation of an electrical circuit and a current source into one patch. Such a system is realized in a manner such that an iontophoresis patch and a battery are electrically connected to each other in the form of one patch. This is considered to be superior to conventional systems, in which power is supplied through wires from the outside.
  • a conventional iontophoresis patch is manufactured in a manner such that a patch and a battery are separately produced, the battery is electrically connected to the body of the patch to thus be inserted into the patch, and then an assembly process is conducted.
  • the iontophoresis patch is poor in terms of storage of the mounted battery, and the assembly procedure is complicated, undesirably resulting in low productivity and in increased costs.
  • efficiency is decreased, and therefore limitations are imposed on the penetration of cosmetics or pharmaceuticals into the skin.
  • the present invention has been made keeping in mind the above problems encountered in the related art, and provides an iontophoresis patch, in which iontophoresis patch electrodes and a battery are constructed as one system so that the efficacy of penetration of a material of interest into the skin is increased, and the ease of storage of the patch is improved.
  • the iontophoresis patch according to the present invention is characterized in that it comprises a patch sheet, a conductive electrode layer disposed on the patch sheet to be in contact therewith, a positive electrode layer containing manganese dioxide and a negative electrode layer containing zinc, which are disposed on both sides of the conductive electrode layer to be in contact with the conductive electrode layer, a hydrogel layer disposed on each of the positive electrode layer and the negative electrode layer to be in contact therewith, and a current path formed between the positive electrode layer and the negative electrode layer on the conductive electrode layer in order to realize connection therebetween.
  • an iontophoresis patch is characterized in that, when the patch, comprising a patch sheet 10, a conductive electrode layer 20, a positive electrode layer 40 disposed on one portion of the conductive electrode layer to be in contact therewith, and a negative electrode layer 50 disposed on the other portion of the conductive electrode layer to be in contact therewith, is attached to the skin, it is operated by a battery.
  • the patch sheet 10 carbon ink is applied, thus forming the conductive electrode layer 20.
  • the conductive electrode thus formed is composed of carbon ink, comprising carbon powder
  • the patch may be imparted with flexibility, manufacturing processability, and electrochemical resistance. Instead of carbon powder, silver powder may be used.
  • a slurry comprising manganese dioxide powder and carbon powder, capable of generating current, and a binder solution
  • a slurry comprising manganese dioxide powder and carbon powder, capable of generating current, and a binder solution
  • a slurry comprising zinc powder and carbon powder, capable of generating current, and a binder solution
  • the positive electrode layer and the negative electrode layer are characterized in that manganese dioxide and zinc are used in the form of powder to realize high current density and facilitate the manufacturing process.
  • a current path 30 connected with the conductive electrode is provided therebetween. Furthermore, the current path is covered with a piece of insulation tape or film 70 for dielectric treatment so that current leakage is suppressed when the patch is attached to the skin of the human body to thus bring it into direct contact therewith.
  • an ion-conductive hydrogel layer 60 containing zinc chloride is formed on each of the positive electrode layer and the negative electrode layer.
  • the material of interest which is to penetrate into the human body, is included along with hydrogel.
  • the material of interest may be used in such a way that it is packaged separately and then spread on the hydrogel layer when the patch is used. As such, the type of electrode to be mounted is determined, depending on whether the material of interest is positively or negatively charged.
  • an impermeable film 60 is provided.
  • the impermeable film is completed by subjecting it to attachment to the upper surface of the hydrogel layer and then to cutting in the shape of the patch.
  • the iontophoresis patch having the impermeable film attached thereto is sealed using a metal laminate film case and is made commercially available in that state.
  • the sealing process is typically conducted in an air atmosphere. However, in the case where there is concern about an oxidation reaction between the positive electrode/negative electrode and the hydrogel, it is preferred that the sealing process be performed in an inert atmosphere or in an oxygen- free atmosphere.
  • FIG. 1 is a cross-sectional view schematically illustrating the structure of the iontophoresis patch according to the present invention.
  • the patch sheet 10 include a polyethylene terephthalate (PET) film or a polyacrylonitrile (PAN) film, which is corona-treated and has a thickness of 10 ⁇ 50 ⁇ m.
  • the conductive electrode layer 20 may be formed through silk printing, off-set printing, evaporation, or slurry coating using metal powder, such as carbon ink or silver ink, or a slurry comprising a carbon component and a polymer.
  • the conductive electrode layer 20 having a thickness of about 15 ⁇ m.
  • the positive electrode layer 40 is disposed on one portion of the conductive electrode, and the negative electrode layer 50 is disposed on the other portion thereof.
  • the current path 30 is formed between the positive electrode layer and the negative electrode layer on the conductive electrode layer, so that current flows therebetween.
  • the width of the current path is preferably set at 2-5 mm, and more preferably about 5 mm.
  • the slurry obtained by mixing manganese dioxide powder, carbon powder, and a binder solution is printed on the conductive electrode layer, thus forming the positive electrode layer 40.
  • the active material for the positive electrode of the battery various materials have been investigated. Among them, particularly useful is manganese dioxide, in consideration of electrical capacitance, voltage, electrochemical properties, and circulation conditions of products .
  • the binder solution is prepared by adding one or more polymers selected from among polyethylene oxide, polyvinyl alcohol, polyvinyl pyrrolidone, 2-hydroxyethyl cellulose, polymethyl methacrylate, and polyvinylidene fluoride with a solvent.
  • a multi-component binder system comprising two or more binders is more favorable in terms of electrical efficiency, mechanical strength, and force of adhesion to the conductive electrode, compared to when the binder is used alone.
  • the electrode binder is composed of a combination of polyethylene oxide, polymethyl methacrylate, and polyvinylidene fluoride, electrode durability and manufacturing processability are predicted to be superior.
  • the negative electrode layer 50 which is disposed on the conductive electrode layer to be in contact therewith and is provided parallel to the positive electrode layer, is formed through a printing process using the slurry comprising zinc powder, carbon powder, and a binder solution.
  • the active material for the negative electrode various materials have been investigated. Among them, particularly useful is zinc in powder form in terms of electrical capacitance, voltage, electrochemical properties, and manufacturing processability.
  • the binder solution is prepared by adding one or more polymers selected from among polyethylene oxide, polyvinyl alcohol, polyvinyl pyrrolidone, and polymethyl methacrylate with a binder solvent.
  • the negative electrode binder includes a combination of polyethylene oxide, polyvinyl pyrrolidone, and polymethyl methacrylate, electrical efficiency, manufacturing processability, and force of adhesion to the conductive electrode layer are predicted to be superior.
  • the thickness of the positive electrode layer and the negative electrode layer is determined in consideration of electrical capacitance, and is typically set to 80-100 ⁇ m.
  • FIG. 2 is a top plan view illustrating the conductive electrode layer 20 formed on the patch sheet 10, in the structure of the iontophoresis patch according to the present invention.
  • FIG. 3 is a top plan view illustrating the positive electrode layer 40 and the negative electrode layer 50, which are disposed on both sides of the conductive electrode layer 20, in the structure of the iontophoresis patch according to the present invention.
  • the distance between the positive electrode layer and the negative electrode layer is preferably l ⁇ 20 mm, and more preferably 4 ⁇ 10 mm. The optimal distance is set taking into consideration the magnitude of current flowing between the patch and the skin and contact resistance.
  • the current path 30 xs formed between the positive electrode layer and the negat ive electrode layer on the conductive electrode layer so that current flows therebetween.
  • the width of the current path is 2 ⁇ 5 mm, and 5 may be adjusted depending on the magnitude of current flowing between the positive electrode and the negat ive electrode.
  • the insulation tape is also attached to the current path, thereby suppressing current leakage upon attachment of the patch to the skin of the human body.
  • FIG. 4 is a top plan view illustrating the hydrogel layer 60 formed on each of the positive electrode layer 40 and the negative electrode layer 50 in the structure of the iontophoresis patch according to the present invention.
  • the positive electrode layer and the negative electrode are a top plan view illustrating the hydrogel layer 60 formed on each of the positive electrode layer 40 and the negative electrode layer 50 in the structure of the iontophoresis patch according to the present invention.
  • the ion-conductive hydrogel layer 60 containing dissolved zinc chloride is formed, in order to function as an electrolyte.
  • the hydrogel is generally composed of hydrophilic gel, and is mainly prepared by mixing agarose and polyvinyl alcohol with water in which an electrolyte is
  • the electrolyte preferably contains one or more selected from among zinc chloride, ammonium chloride, and sodium chloride.
  • the impermeable film is attached to the upper surface of the hydrogel layer 60, after which the patch of the invention is placed into a metal laminate case, thus packaging it.
  • the patch is removed from the case, the impermeable film is removed from the 0 hydrogel layer, and then the material of interest (cosmetic material) is spread on the electrode or is attached thereto.
  • electrodes for use in a patch and a battery for operating the electrodes are integrated, thus exhibiting superior battery storage properties and increasing the efficacy of the patch. Further, the manufacturing process is simplified, thus facilitating mass production.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

La présente invention concerne un timbre transdermique basé sur le principe d'ionophorèse et son procédé de fabrication, dans lequel une électrode du timbre comporte un matériau d'électrode positive contenant du dioxyde de manganèse lui permettant d'agir comme une électrode positive, et dont l'autre électrode comporte un matériau d'électrode négative contenant du zinc lui permettant d'agir comme une électrode négative, assurant ainsi l'intégration du timbre et de la pile.
PCT/KR2007/005140 2007-03-19 2007-10-19 Timbre transdermique d'ionophorèse et son procédé de fabrication WO2008114918A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2007-0026688 2007-03-19
KR1020070026688A KR100844103B1 (ko) 2007-03-19 2007-03-19 이온토포레시스용 패치
KR1020070099132A KR100868350B1 (ko) 2007-10-02 2007-10-02 이온토포레시스 패치 및 그 제조방법
KR10-2007-0099132 2007-10-02

Publications (1)

Publication Number Publication Date
WO2008114918A1 true WO2008114918A1 (fr) 2008-09-25

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Application Number Title Priority Date Filing Date
PCT/KR2007/005140 WO2008114918A1 (fr) 2007-03-19 2007-10-19 Timbre transdermique d'ionophorèse et son procédé de fabrication

Country Status (1)

Country Link
WO (1) WO2008114918A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2266659A2 (fr) * 2008-04-07 2010-12-29 Rocket Electric Co., Ltd Patch d'ionophorèse à pile intégrée
JP2013508069A (ja) * 2009-10-22 2013-03-07 ロケット エレクトリック カンパニー リミテッド 薄型電池を備える装置及びイオントフォレーシスパッチ
JP2014207987A (ja) * 2013-03-28 2014-11-06 株式会社 東北テクノアーチ 生体組織貼付用キット及び生体組織貼付用パッチ
WO2016047811A1 (fr) * 2014-09-26 2016-03-31 株式会社東北テクノアーチ Timbre favorisant la cicatrisation
US9643001B2 (en) 2015-04-14 2017-05-09 Taiwan Textile Research Institute Wound care dressing
JP2021112467A (ja) * 2020-01-21 2021-08-05 賢司 小蒲 生体電池治療具
EP4094801A4 (fr) * 2020-01-21 2024-02-07 Iongear Co Ltd Appareil médical à batterie biogalvanique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5897522A (en) * 1995-12-20 1999-04-27 Power Paper Ltd. Flexible thin layer open electrochemical cell and applications of same
US20030088204A1 (en) * 2001-11-02 2003-05-08 Joshi Ashok V Novel iontophoretic drug delivery systems
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5897522A (en) * 1995-12-20 1999-04-27 Power Paper Ltd. Flexible thin layer open electrochemical cell and applications of same
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US20030088204A1 (en) * 2001-11-02 2003-05-08 Joshi Ashok V Novel iontophoretic drug delivery systems

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2266659A2 (fr) * 2008-04-07 2010-12-29 Rocket Electric Co., Ltd Patch d'ionophorèse à pile intégrée
EP2266659A4 (fr) * 2008-04-07 2011-12-07 Rocket Electric Co Ltd Patch d'ionophorèse à pile intégrée
JP2013508069A (ja) * 2009-10-22 2013-03-07 ロケット エレクトリック カンパニー リミテッド 薄型電池を備える装置及びイオントフォレーシスパッチ
US8914103B2 (en) 2009-10-22 2014-12-16 Rocket Electric Co., Ltd Device and iontophoresis patch comprising thin film battery
JP2014207987A (ja) * 2013-03-28 2014-11-06 株式会社 東北テクノアーチ 生体組織貼付用キット及び生体組織貼付用パッチ
WO2016047811A1 (fr) * 2014-09-26 2016-03-31 株式会社東北テクノアーチ Timbre favorisant la cicatrisation
JP2016067401A (ja) * 2014-09-26 2016-05-09 株式会社 東北テクノアーチ 創傷治癒用パッチ
US9643001B2 (en) 2015-04-14 2017-05-09 Taiwan Textile Research Institute Wound care dressing
TWI581771B (zh) * 2015-04-14 2017-05-11 財團法人紡織產業綜合研究所 傷口護理用敷材
JP2021112467A (ja) * 2020-01-21 2021-08-05 賢司 小蒲 生体電池治療具
EP4094801A4 (fr) * 2020-01-21 2024-02-07 Iongear Co Ltd Appareil médical à batterie biogalvanique

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