WO2008114709A1 - 血球系に特異的あるいは破骨細胞分化に特異的なバイオマーカー - Google Patents

血球系に特異的あるいは破骨細胞分化に特異的なバイオマーカー Download PDF

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Publication number
WO2008114709A1
WO2008114709A1 PCT/JP2008/054706 JP2008054706W WO2008114709A1 WO 2008114709 A1 WO2008114709 A1 WO 2008114709A1 JP 2008054706 W JP2008054706 W JP 2008054706W WO 2008114709 A1 WO2008114709 A1 WO 2008114709A1
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WIPO (PCT)
Prior art keywords
specific
biomarker
blood cell
aptamer
antibody
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PCT/JP2008/054706
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English (en)
French (fr)
Inventor
Ai Wakamatsu
Junichi Yamamoto
Takao Isogai
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Reverse Proteomics Research Institute Co., Ltd.
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Application filed by Reverse Proteomics Research Institute Co., Ltd. filed Critical Reverse Proteomics Research Institute Co., Ltd.
Priority to JP2009505187A priority Critical patent/JP5451376B2/ja
Publication of WO2008114709A1 publication Critical patent/WO2008114709A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　本発明は、血球系又は破骨細胞の障害に基づく疾患に対する診断用試薬、及び新たな作用機序を有する、このような疾患に対する医薬等の開発に有用な手段を提供する。 　より詳細には、本発明は、血球系に特異的あるいは破骨細胞分化に特異的なバイオマーカーとして使用し得る、新規ポリペプチド及びその特異的な部分ペプチド、並びに新規ポリヌクレオチド及びその特異的な部分ヌクレオチド；このようなポリヌクレオチド及びその特異的な部分ペプチドの発現ベクター；このような発現ベクターが導入された形質転換体；このようなバイオマーカーに対するアンチセンス分子、ＲＮＡｉ誘導性核酸（例、ｓｉＲＮＡ）、アプタマー、抗体、及びそれらを含む組成物；このようなバイオマーカーの発現又は機能が調節された、哺乳動物細胞又は非ヒト哺乳動物；このようなバイオマーカーの測定用手段（例、プライマーセット、核酸プローブ、抗体、アプタマー）、及びそれらを含む試薬などを提供する。
PCT/JP2008/054706 2007-03-15 2008-03-14 血球系に特異的あるいは破骨細胞分化に特異的なバイオマーカー WO2008114709A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009505187A JP5451376B2 (ja) 2007-03-15 2008-03-14 血球系に特異的あるいは破骨細胞分化に特異的なバイオマーカー

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007066434 2007-03-15
JP2007-066434 2007-03-15

Publications (1)

Publication Number Publication Date
WO2008114709A1 true WO2008114709A1 (ja) 2008-09-25

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PCT/JP2008/054706 WO2008114709A1 (ja) 2007-03-15 2008-03-14 血球系に特異的あるいは破骨細胞分化に特異的なバイオマーカー

Country Status (2)

Country Link
JP (1) JP5451376B2 (ja)
WO (1) WO2008114709A1 (ja)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005039635A2 (en) * 2003-10-22 2005-05-06 Novartis Ag Genes involved in neurodegenerative disorders

Family Cites Families (5)

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ATE310100T1 (de) * 2000-06-09 2005-12-15 Boehringer Ingelheim Int Screeningverfahren für modulatoren von methyltransferase abhängiger chromosomenstabilität
AU2001288743A1 (en) * 2000-09-05 2002-03-22 The Rockefeller University Osteoclast-associated receptor
JP2004298093A (ja) * 2003-03-31 2004-10-28 Amusaito:Kk トランスジェニックメダカ
WO2006063462A1 (en) * 2004-12-13 2006-06-22 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
DK1874331T3 (en) * 2005-04-19 2014-12-01 King S College London APPLICATION OF BIP against bone loss and osteoporosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005039635A2 (en) * 2003-10-22 2005-05-06 Novartis Ag Genes involved in neurodegenerative disorders

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
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Publication number Publication date
JPWO2008114709A1 (ja) 2010-07-01
JP5451376B2 (ja) 2014-03-26

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