WO2008114513A1 - 心筋梗塞の予防および／または治療薬 - Google Patents

心筋梗塞の予防および／または治療薬 Download PDF

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Publication number
WO2008114513A1
WO2008114513A1 PCT/JP2008/000652 JP2008000652W WO2008114513A1 WO 2008114513 A1 WO2008114513 A1 WO 2008114513A1 JP 2008000652 W JP2008000652 W JP 2008000652W WO 2008114513 A1 WO2008114513 A1 WO 2008114513A1
Authority
WO
WIPO (PCT)
Prior art keywords
prophylactic
therapeutic agent
cardiac infarction
disclosed
infarction
Prior art date
Application number
PCT/JP2008/000652
Other languages
English (en)
French (fr)
Inventor
Tetsuo Minamino
Masafumi Kitakaze
Masatsugu Hori
Hiroyuki Takahama
Hiroshi Kikuchi
Kouichi Hashimoto
Hideo Kobayashi
Ayako Iijima
Daigo Asano
Original Assignee
Osaka University
Japan As Represented By The President Of National Cardiovascular Center
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osaka University, Japan As Represented By The President Of National Cardiovascular Center, Daiichi Sankyo Company, Limited filed Critical Osaka University
Priority to EP08720537A priority Critical patent/EP2123284A4/en
Priority to JP2009505085A priority patent/JP5333970B2/ja
Publication of WO2008114513A1 publication Critical patent/WO2008114513A1/ja
Priority to US12/562,887 priority patent/US9095600B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　本発明は、新規な心筋梗塞の予防および／または治療薬に関する。 　アデノシンを保持する脂質膜構造体を含有する心筋梗塞もしくは心筋虚血再灌流障害の予防および／または治療薬。
PCT/JP2008/000652 2007-03-20 2008-03-19 心筋梗塞の予防および／または治療薬 WO2008114513A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08720537A EP2123284A4 (en) 2007-03-20 2008-03-19 PREVENTIVE AND / OR THERAPEUTIC ACTIVE INGREDIENTS FOR HEART INFARS
JP2009505085A JP5333970B2 (ja) 2007-03-20 2008-03-19 心筋梗塞の予防および／または治療薬
US12/562,887 US9095600B2 (en) 2007-03-20 2009-09-18 Prophylactic and/or therapeutic agent for cardiac infarction

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-073016 2007-03-20
JP2007073016 2007-03-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/562,887 Continuation US9095600B2 (en) 2007-03-20 2009-09-18 Prophylactic and/or therapeutic agent for cardiac infarction

Publications (1)

Publication Number Publication Date
WO2008114513A1 true WO2008114513A1 (ja) 2008-09-25

Family

ID=39765631

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000652 WO2008114513A1 (ja) 2007-03-20 2008-03-19 心筋梗塞の予防および／または治療薬

Country Status (5)

Country Link
US (1) US9095600B2 (ja)
EP (1) EP2123284A4 (ja)
JP (1) JP5333970B2 (ja)
TW (1) TW200843786A (ja)
WO (1) WO2008114513A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017048792A1 (en) * 2015-09-14 2017-03-23 Vivacelle Bio, Inc. Compositions and methods for treating conditions related to lack of blood supply, shock and neuronal injuries
WO2017222912A1 (en) 2016-06-20 2017-12-28 Vivacelle Bio, Inc. Compositions and methods for reducing reperfusion injury
CN108324725A (zh) * 2017-01-20 2018-07-27 柴秋 N6-（2-羟乙基）腺苷在制备预防或治疗心肌缺血再灌注损伤的药物中的应用
EP3946368A4 (en) * 2019-04-03 2022-12-28 New York University ADENOSIN-ENCAPSULATING LIPOSOMES
CN110507663A (zh) * 2019-08-07 2019-11-29 南昌大学 神经节苷脂gm3在制备治疗动脉粥样硬化药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05208993A (ja) * 1991-08-07 1993-08-20 Bioresearch Spa 虚血治療用製薬組成物
WO1995005832A1 (fr) * 1993-08-25 1995-03-02 Otsuka Pharmaceutical Factory, Inc. Analeptique des fonctions cardiaques
JP2006505365A (ja) * 2002-11-08 2006-02-16 コナー　メドシステムズ，　インコーポレイテッド 虚血障害後の組織のダメージを抑制するための方法および装置

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789734A (en) * 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
DE69018460T2 (de) * 1989-04-18 1995-11-09 Vestar Inc Markierung mit liposomen von ischämischen geweben.
US5843473A (en) * 1989-10-20 1998-12-01 Sequus Pharmaceuticals, Inc. Method of treatment of infected tissues
US6623671B2 (en) * 1990-10-05 2003-09-23 Royden M. Coe Liposome extrusion process
US5593688A (en) * 1993-06-25 1997-01-14 Nexstar Pharmaceuticals, Inc. Liposomal targeting of ischemic tissue
US5852000A (en) 1993-08-25 1998-12-22 Otsuka Pharmaceutical Factory, Inc. Cardiac rehabilitation agent
CA2305726A1 (en) * 1997-10-07 1999-04-15 Regents Of The University Of California Treating occlusive peripheral vascular disease and coronary disease with combinations of heparin and an adenoside a2 agonist, or with adenosine
US6627732B1 (en) * 1998-04-16 2003-09-30 Teijin Limited Glutathione derivatives and their dosage forms
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
US20020151508A1 (en) * 2001-02-09 2002-10-17 Schering Corporation Methods for treating proliferative diseases
US6599283B1 (en) * 2001-05-04 2003-07-29 Cv Therapeutics, Inc. Method of preventing reperfusion injury
US20040142014A1 (en) 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
CA2531062A1 (en) * 2003-07-02 2005-01-13 Emory University Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury
EP1773298A1 (en) * 2004-08-06 2007-04-18 Biospectrum, Inc. Multiple layered liposome and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05208993A (ja) * 1991-08-07 1993-08-20 Bioresearch Spa 虚血治療用製薬組成物
WO1995005832A1 (fr) * 1993-08-25 1995-03-02 Otsuka Pharmaceutical Factory, Inc. Analeptique des fonctions cardiaques
JP2006505365A (ja) * 2002-11-08 2006-02-16 コナー　メドシステムズ，　インコーポレイテッド 虚血障害後の組織のダメージを抑制するための方法および装置

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"JAPIC Iryo-yo Iyakuhin-shu", 1 September 2006, JAPAN PHARMACEUTICAL INFORMATION CENTER, pages: 88 - 90
DRUG DEVELOPMENT RESEARCH, vol. 28, 1993, pages 432 - 437
J. AM. COLL. CARDIOL., 2005, pages 1775 - 1780
See also references of EP2123284A4 *

Also Published As

Publication number Publication date
US9095600B2 (en) 2015-08-04
TW200843786A (en) 2008-11-16
EP2123284A1 (en) 2009-11-25
JPWO2008114513A1 (ja) 2010-07-01
EP2123284A4 (en) 2011-07-06
US20100098753A1 (en) 2010-04-22
JP5333970B2 (ja) 2013-11-06

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