WO2008111295A1 - 全身性エリテマトーデスの予防及び／又は治療剤 - Google Patents

全身性エリテマトーデスの予防及び／又は治療剤 Download PDF

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Publication number
WO2008111295A1
WO2008111295A1 PCT/JP2008/000478 JP2008000478W WO2008111295A1 WO 2008111295 A1 WO2008111295 A1 WO 2008111295A1 JP 2008000478 W JP2008000478 W JP 2008000478W WO 2008111295 A1 WO2008111295 A1 WO 2008111295A1
Authority
WO
WIPO (PCT)
Prior art keywords
prevention
treatment
agent
lupus erythematosus
systemic lupus
Prior art date
Application number
PCT/JP2008/000478
Other languages
English (en)
French (fr)
Inventor
Yuichiro Tabunoki
Original Assignee
Kowa Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co., Ltd. filed Critical Kowa Co., Ltd.
Priority to US12/529,610 priority Critical patent/US20100120732A1/en
Priority to JP2009503901A priority patent/JPWO2008111295A1/ja
Priority to EP08720364A priority patent/EP2123280A1/en
Publication of WO2008111295A1 publication Critical patent/WO2008111295A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

　本発明は、２－ベンジル－５－（４－クロロフェニル）－６－［４－（メチルチオ）フェニル］－２Ｈ－ピリダジン－３－オン又はその溶媒和物と副腎皮質ステロイド剤とを組み合わせてなる全身性エリテマトーデスの予防及び／又は治療剤に関する。本発明の医薬は、経口投与が可能で、副作用が少なくＳＬＥに伴う症状に対して優れた抑制作用を示し、ＳＬＥの予防及び治療に有用である。
PCT/JP2008/000478 2007-03-09 2008-03-07 全身性エリテマトーデスの予防及び／又は治療剤 WO2008111295A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/529,610 US20100120732A1 (en) 2007-03-09 2008-03-07 Agent for prevention and/or treatment of systemic lupus erythematosus
JP2009503901A JPWO2008111295A1 (ja) 2007-03-09 2008-03-07 全身性エリテマトーデスの予防及び／又は治療剤
EP08720364A EP2123280A1 (en) 2007-03-09 2008-03-07 Agent for prevention and/or treatment of systemic lupus erythematosus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007060090 2007-03-09
JP2007-060090 2007-03-09

Publications (1)

Publication Number Publication Date
WO2008111295A1 true WO2008111295A1 (ja) 2008-09-18

Family

ID=39759239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000478 WO2008111295A1 (ja) 2007-03-09 2008-03-07 全身性エリテマトーデスの予防及び／又は治療剤

Country Status (6)

Country Link
US (1) US20100120732A1 (ja)
EP (1) EP2123280A1 (ja)
JP (1) JPWO2008111295A1 (ja)
KR (1) KR20090125246A (ja)
CN (1) CN101631551A (ja)
WO (1) WO2008111295A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014199364A1 (en) 2013-06-13 2014-12-18 Bnai Zion Medical Center Semaphorin 3a for treatment and prognosis of systemic lupus erythematosus
WO2018102552A1 (en) * 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
WO2018145080A1 (en) 2017-02-06 2018-08-09 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025697A1 (fr) 1997-11-19 1999-05-27 Kowa Co., Ltd. Nouveaux derives de pyridazine et medicaments contenant ces composes comme principe actif
JP2000198776A (ja) * 1997-11-19 2000-07-18 Kowa Co 新規ピリダジン誘導体及びこれを有効成分とする医薬
JP2004131393A (ja) * 2002-10-08 2004-04-30 Kowa Co 易溶出性製剤
WO2004096280A1 (ja) * 2003-04-29 2004-11-11 Kowa Co., Ltd. 超難水溶性薬物含有組成物及びその製造法
WO2004096281A1 (ja) * 2003-04-29 2004-11-11 Kowa Co., Ltd. 溶出性に優れた超難水溶性薬物含有組成物及びその製造法
WO2006080312A1 (ja) * 2005-01-25 2006-08-03 Kowa Co., Ltd. 吸着多孔体の製造法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025697A1 (fr) 1997-11-19 1999-05-27 Kowa Co., Ltd. Nouveaux derives de pyridazine et medicaments contenant ces composes comme principe actif
JP2000198776A (ja) * 1997-11-19 2000-07-18 Kowa Co 新規ピリダジン誘導体及びこれを有効成分とする医薬
JP2004131393A (ja) * 2002-10-08 2004-04-30 Kowa Co 易溶出性製剤
WO2004096280A1 (ja) * 2003-04-29 2004-11-11 Kowa Co., Ltd. 超難水溶性薬物含有組成物及びその製造法
WO2004096281A1 (ja) * 2003-04-29 2004-11-11 Kowa Co., Ltd. 溶出性に優れた超難水溶性薬物含有組成物及びその製造法
WO2006080312A1 (ja) * 2005-01-25 2006-08-03 Kowa Co., Ltd. 吸着多孔体の製造法

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
ANN. RHEUM. DIS., vol. 59, no. I, 2000, pages 103 - 108
ANN. RHEUM. DIS., vol. 64, 2005, pages 630 - 633
ARTHRITIS & RHEUMATISM, vol. 50, 2004, pages 3161 - 3169
ARTHRITIS & RHEUMATISM, vol. 50, 2004, pages 3958 - 3967
EXPERT OPIN. THER. TARGETS, vol. 10, 2006, pages 803 - 815
HASHIMOTO H.: "SLE no Byogata Bunrui to Soreni Taio suru Chiryoho", IGAKU NO ARUMI, vol. 158, no. 1, 6 July 1991 (1991-07-06), pages 69 - 73, XP008119085 *
J. EXP. MED., vol. 166, 1987, pages 798 - 803
J. PHARMACOBIO-DYN, vol. 15, 1992, pages 649 - 655
JAPAN INTRACTABLE DISEASES INFORMATION CENTER, 28 February 2007 (2007-02-28), Retrieved from the Internet <URL:http://www.nanbyou.or.jp/sikkan/063_i.htm>
LUPUS, vol. 13, 2004, pages 344 - 347
MOOSIG F. ET AL.: "IL-1RA in refractory systemic lupus erythematosus", LUPUS, vol. 13, no. 8, 2004, pages 605 - 606, XP008119083 *
NIPPON RINSHO, vol. 63, no. 5, 2005, pages 247 - 252
NIPPON RINSHO, vol. 63, no. 5, 2005, pages 253 - 259
PEDIATR. INT., vol. 44, 2002, pages 199 - 204

Also Published As

Publication number Publication date
KR20090125246A (ko) 2009-12-04
JPWO2008111295A1 (ja) 2010-06-24
US20100120732A1 (en) 2010-05-13
CN101631551A (zh) 2010-01-20
EP2123280A1 (en) 2009-11-25

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