WO2008108673A3 - Utilisation d'un peptide et d'un agent pharmaceutique analgésique - Google Patents

Utilisation d'un peptide et d'un agent pharmaceutique analgésique Download PDF

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Publication number
WO2008108673A3
WO2008108673A3 PCT/PL2008/000020 PL2008000020W WO2008108673A3 WO 2008108673 A3 WO2008108673 A3 WO 2008108673A3 PL 2008000020 W PL2008000020 W PL 2008000020W WO 2008108673 A3 WO2008108673 A3 WO 2008108673A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
pharmaceutical agent
neurodegeneration
rheumatism
gout
Prior art date
Application number
PCT/PL2008/000020
Other languages
English (en)
Other versions
WO2008108673A2 (fr
Inventor
Andrzej W Lipkowski
Daniel Carr
Aleksandra Misicka-Kesik
Piotr Kosson
Anna Klinowiecka
Original Assignee
Andrzej W Lipkowski
Daniel Carr
Aleksandra Misicka-Kesik
Piotr Kosson
Anna Klinowiecka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andrzej W Lipkowski, Daniel Carr, Aleksandra Misicka-Kesik, Piotr Kosson, Anna Klinowiecka filed Critical Andrzej W Lipkowski
Priority to EP08724030.5A priority Critical patent/EP2195006B1/fr
Priority to US12/449,944 priority patent/US9486493B2/en
Priority to DK08724030.5T priority patent/DK2195006T3/en
Priority to ES08724030.5T priority patent/ES2564825T3/es
Publication of WO2008108673A2 publication Critical patent/WO2008108673A2/fr
Publication of WO2008108673A3 publication Critical patent/WO2008108673A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne le fait que l'inflammation provoquée par des états maladifs tels que le rhumatisme, la goutte, la neurodégénérescence et les tumeurs entraîne une meilleure efficacité de la biphaline de peptide opioïde ou de ses analogues, vraisemblablement en raison de l'augmentation de la perméabilité de la 'barrière hématoencéphalique'. Il est alors possible d'utiliser ledit peptide d'opioïde pour produire un nouvel analgésique pouvant être utilisé en cas d'inflammation provoquée par les rhumatismes, la goutte, la neurodégénérescence, les traumatismes post-chirurgicaux ou post-accidentels, ou les tumeurs.
PCT/PL2008/000020 2007-03-07 2008-03-07 Utilisation d'un peptide et d'un agent pharmaceutique analgésique WO2008108673A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08724030.5A EP2195006B1 (fr) 2007-03-07 2008-03-07 Utilisation d'un analogue de la biphaline comme agent pharmaceutique analgésique
US12/449,944 US9486493B2 (en) 2007-03-07 2008-03-07 Use of a peptide and an analgesic pharmaceutical agent
DK08724030.5T DK2195006T3 (en) 2007-03-07 2008-03-07 USING A BIPHALIN-ANALOG as an analgesic
ES08724030.5T ES2564825T3 (es) 2007-03-07 2008-03-07 Uso de un análogo de bifalina como un agente farmacéutico analgésico

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PLP.381925 2007-03-07
PL381925A PL381925A1 (pl) 2007-03-07 2007-03-07 Zastosowanie peptydu i przeciwbólowy środek farmaceutyczny

Publications (2)

Publication Number Publication Date
WO2008108673A2 WO2008108673A2 (fr) 2008-09-12
WO2008108673A3 true WO2008108673A3 (fr) 2008-11-20

Family

ID=39691054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2008/000020 WO2008108673A2 (fr) 2007-03-07 2008-03-07 Utilisation d'un peptide et d'un agent pharmaceutique analgésique

Country Status (6)

Country Link
US (1) US9486493B2 (fr)
EP (1) EP2195006B1 (fr)
DK (1) DK2195006T3 (fr)
ES (1) ES2564825T3 (fr)
PL (2) PL381925A1 (fr)
WO (1) WO2008108673A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL381925A1 (pl) 2007-03-07 2008-09-15 Andrzej W. Lipkowski Zastosowanie peptydu i przeciwbólowy środek farmaceutyczny
WO2010077154A1 (fr) * 2008-12-31 2010-07-08 Action For Development Of Resarch Sp.Z.O.O. Procédé de production d'un nouveau peptide opioïde

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024831A2 (fr) * 1999-10-04 2001-04-12 Shearwater Corporation Neuropeptides stabilises par des polymeres
US20030170288A1 (en) * 2001-08-06 2003-09-11 Carr Daniel B. Drug delivery composition
WO2004014943A2 (fr) * 2002-08-13 2004-02-19 Lipkowski Andrzej W Composes, et leurs applications analgesiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919473A (en) * 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
PL381925A1 (pl) 2007-03-07 2008-09-15 Andrzej W. Lipkowski Zastosowanie peptydu i przeciwbólowy środek farmaceutyczny

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024831A2 (fr) * 1999-10-04 2001-04-12 Shearwater Corporation Neuropeptides stabilises par des polymeres
US20030170288A1 (en) * 2001-08-06 2003-09-11 Carr Daniel B. Drug delivery composition
WO2004014943A2 (fr) * 2002-08-13 2004-02-19 Lipkowski Andrzej W Composes, et leurs applications analgesiques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ABBRUSCATO THOMAS J ET AL: "Brain and spinal cord distribution of biphalin: Correlation with opioid receptor density and mechanism of CNS entry", JOURNAL OF NEUROCHEMISTRY, vol. 69, no. 3, 1997, pages 1236 - 1245, XP002495086, ISSN: 0022-3042 *
LIPKOWSKI A W ET AL: "Biological properties of a new fluorescent biphalin fragment analogue", LIFE SCIENCES, PERGAMON PRESS, OXFORD, GB, vol. 70, no. 8, 1 February 2002 (2002-02-01), pages 893 - 897, XP002267427, ISSN: 0024-3205 *

Also Published As

Publication number Publication date
PL381925A1 (pl) 2008-09-15
WO2008108673A2 (fr) 2008-09-12
DK2195006T3 (en) 2016-03-14
PL2195006T3 (pl) 2016-11-30
EP2195006A2 (fr) 2010-06-16
US20100273715A1 (en) 2010-10-28
EP2195006B1 (fr) 2015-12-09
ES2564825T3 (es) 2016-03-29
US9486493B2 (en) 2016-11-08

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