WO2008102037A8 - Uso de compuestos como inhibidores de la flavodoxina de helicobacter - Google Patents
Uso de compuestos como inhibidores de la flavodoxina de helicobacter Download PDFInfo
- Publication number
- WO2008102037A8 WO2008102037A8 PCT/ES2008/000093 ES2008000093W WO2008102037A8 WO 2008102037 A8 WO2008102037 A8 WO 2008102037A8 ES 2008000093 W ES2008000093 W ES 2008000093W WO 2008102037 A8 WO2008102037 A8 WO 2008102037A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- helicobacter
- flavodoxin
- inhibitors
- compounds
- equals
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 241000589989 Helicobacter Species 0.000 title abstract 2
- 108010057366 Flavodoxin Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Uso del compuesto de fórmula general (I), o cualquiera de sus sales, para Ia elaboración de una composición farmacéutica para el tratamiento de enfermedades infecciosas, más particularmente para el tratamiento de helicobacter. Y es NO2, COOH ó SO3H; Z es O, N ó S; X1 y X2 son halógenos y pueden ser iguales o diferentes; y m y n toma valores de entre O a 3 y pueden ser iguales o diferentes.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/528,278 US8080664B2 (en) | 2007-02-23 | 2008-02-20 | Use of compounds as inhibitors for Helicobacter flavodoxin |
EP08736697A EP2113251A4 (en) | 2007-02-23 | 2008-02-20 | USE OF COMPOUNDS AS INHIBITORS OF HELICOBACTER FLAVODOXIN |
JP2009550299A JP5324475B2 (ja) | 2007-02-23 | 2008-02-20 | ヘリコバクターフラボドキシン阻害剤としての化合物の利用 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200700566A ES2304112B1 (es) | 2007-02-23 | 2007-02-23 | Uso de compuestos como inhibidores de la flavodoxina de helicobacter. |
ESP200700566 | 2007-02-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008102037A1 WO2008102037A1 (es) | 2008-08-28 |
WO2008102037A8 true WO2008102037A8 (es) | 2009-07-23 |
Family
ID=39708046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2008/000093 WO2008102037A1 (es) | 2007-02-23 | 2008-02-20 | Uso de compuestos como inhibidores de la flavodoxina de helicobacter |
Country Status (5)
Country | Link |
---|---|
US (1) | US8080664B2 (es) |
EP (1) | EP2113251A4 (es) |
JP (1) | JP5324475B2 (es) |
ES (1) | ES2304112B1 (es) |
WO (1) | WO2008102037A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2853530A1 (en) * | 2013-09-25 | 2015-04-01 | Université de Rennes 1 | New PI3K/AKT/mTOR inhibitors and pharmaceutical uses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3394191A (en) * | 1966-02-09 | 1968-07-23 | Monsanto Co | Phenyl beta-nitrostyryl sulfides |
US3629465A (en) * | 1966-08-22 | 1971-12-21 | Givaudan Corp | Preservatives for aqueous systems |
US3985761A (en) * | 1974-10-24 | 1976-10-12 | Sarabhai Research Centre | Nitrothiazolyl derivatives of nitrostyrene |
WO1988003147A1 (en) | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
US5763470A (en) * | 1995-06-07 | 1998-06-09 | Sugen Inc. | Benzopyran compounds and methods for their use |
GB9526407D0 (en) | 1995-12-22 | 1996-02-21 | Glaxo Group Ltd | Substances and their uses |
ATE260242T1 (de) | 1998-12-17 | 2004-03-15 | Hoffmann La Roche | 7-aryl-6(z)heptatriensäure retinamide als apoptose induzierende verbindungen und deren verwendung als antikrebsmittel |
DE10045599B4 (de) * | 2000-09-15 | 2004-06-03 | Wella Ag | Haarfärbemittel auf der Basis von 4-Nitro-2,1,3-benzoxadiazol-Derivaten und dessen Verwendung als Farbstoff zum Färben von Haaren |
US20040167189A1 (en) * | 2002-03-22 | 2004-08-26 | The Government Of The U.S.A., As Represented By The Secretary, Dept. Of Health And Human Services | Materials and methods for inhibiting Wip1 |
US7638554B2 (en) * | 2002-04-18 | 2009-12-29 | Sri International | Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents |
ITRM20030194A1 (it) * | 2003-04-24 | 2004-10-25 | Univ Roma | Uso di derivati del 7-nitro-2, 1, 3-benzossadiazolo per |
CA2557144A1 (en) * | 2004-02-23 | 2005-09-09 | Prolexys Pharmaceuticals Inc. | Non-peptidyl agents with phsp20-like activity, and uses thereof |
JP2008503591A (ja) * | 2004-06-22 | 2008-02-07 | ライジェル ファーマシューティカルズ, インコーポレイテッド | ユビキチンリガーゼ阻害剤 |
-
2007
- 2007-02-23 ES ES200700566A patent/ES2304112B1/es active Active
-
2008
- 2008-02-20 US US12/528,278 patent/US8080664B2/en not_active Expired - Fee Related
- 2008-02-20 JP JP2009550299A patent/JP5324475B2/ja not_active Expired - Fee Related
- 2008-02-20 WO PCT/ES2008/000093 patent/WO2008102037A1/es active Application Filing
- 2008-02-20 EP EP08736697A patent/EP2113251A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP2113251A4 (en) | 2010-07-21 |
EP2113251A1 (en) | 2009-11-04 |
WO2008102037A1 (es) | 2008-08-28 |
ES2304112B1 (es) | 2009-08-13 |
US8080664B2 (en) | 2011-12-20 |
JP5324475B2 (ja) | 2013-10-23 |
ES2304112A1 (es) | 2008-09-01 |
US20100317862A1 (en) | 2010-12-16 |
JP2010519245A (ja) | 2010-06-03 |
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