WO2008100130A2 - Composition contenant de l'extrait de piper sarmentosum (kadok) et du collagène - Google Patents

Composition contenant de l'extrait de piper sarmentosum (kadok) et du collagène

Info

Publication number
WO2008100130A2
WO2008100130A2 PCT/MY2008/000010 MY2008000010W WO2008100130A2 WO 2008100130 A2 WO2008100130 A2 WO 2008100130A2 MY 2008000010 W MY2008000010 W MY 2008000010W WO 2008100130 A2 WO2008100130 A2 WO 2008100130A2
Authority
WO
WIPO (PCT)
Prior art keywords
juice concentrate
functional food
food preparation
composition
collagen
Prior art date
Application number
PCT/MY2008/000010
Other languages
English (en)
Other versions
WO2008100130A3 (fr
Inventor
Tuck Pooi Soo
Original Assignee
Tuck Pooi Soo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tuck Pooi Soo filed Critical Tuck Pooi Soo
Publication of WO2008100130A2 publication Critical patent/WO2008100130A2/fr
Publication of WO2008100130A3 publication Critical patent/WO2008100130A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A23L2/395—Dry compositions in a particular shape or form
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a composition containing an extract obtained from the leaves of Piper sarmentosum (otherwise known as the kadok plant in
  • composition of the present invention can be consumed orally in a daily serving and is effective in accelerating the regeneration of cartilage in joints and is useful for relieving joint pain in people with osteoarthritis.
  • antioxidants are needed by the human body for optimal well being, especially for maintaining a healthy body system and defense mechanism against cell damage (Rohana et al., 2002).
  • the term, antioxidant is used to describe a dietary component that can function to decrease tissue damage by reactive oxygen (Vimala & Ilham, 1999).
  • Fruits and vegetables are rich source of many food factors including vitamins, minerals and phytochemicals which may act as antioxidants (Lampe, 1999).
  • the antioxidant activity of fruits and vegetables is often assumed to be of greatest importance in combating a number of degenerative diseases, as free radical-related damage has been implicated in causing many of these conditions (Ames, 1998).
  • a daily consumption of five or more servings of antioxidant-rich food (Baghurst et al., 1992) will provide the body with the essential antioxidants needed to prevent degenerative diseases, premature aging symptoms, chronic fatigue and general disability.
  • naringenin a naturally occurring antioxidant superoxide scavenger was found in the methanolic leave extracts of Piper sarmentosum, otherwise known as the kadok plant in Malaysia (Vimala et al, 2003). Kadok is a medicinal plant and has been used extensively in traditional medicine in Malaysia. This plant could be considered as antioxidant food and if consumed daily, the naringenin present in the food could scavenge access free-radicals in the human biological system and could prevent oxidative related diseases. Furthermore, the antioxidant food supplies the body with the essential antioxidant nutrients needed to enhance the body's immune system, eliminate excess free radicals and keep the oxidative stress state in balance. Hence consuming the leaves of P. sarmentosum can provide the necessary amount of naringenin.
  • Degenerative joint diseases commonly known as orthroses
  • bradytrophic tissue tendon, cartilage
  • tendon cartilage
  • peptides soluble in cold water and specifically those from a group of hydrolyzed collagens, are suitable for the treatment of orthroses.
  • Particularly suitable is an enzymatically hydrolyzed collagen having an average molecular weight of from 10,000 to 80,000 daltons.
  • Such enzymatically hydrolyzed collagen is almost flavourless or neutral in flavour, is soluble in cold water, and, unlike denatured collagen (i.e.gelatin) is incapable of binding significant amounts of water.
  • Collagen is a fiber protein forming the main constituent of the supporting tissue and connective tissue in animals (including humans) and, more particularly, is found in the skin, tendons and bones. Therefore hydrolyzed collagen, and specifically enzymatically hydrolyzed collagen, may be produced from animal skin, animal bones, and other sufficiently purified connective tissue.
  • Such enzymatically hydrolyzed collagens have previously been used in the pharmaceutical industry as tabletting aids, encasing agents and fillers.
  • Glucosamine sulfate is a substance found naturally in the human body and in particular it is found in high concentrations in joint structures. Glucosamine sulfate is a stable, tasteless and water-soluble nutrient and can be extracted from animal tissue such as crab, lobster or shrimp shells. It is readily absorbed from the intestines, stays in the blood for several hours, and very little is excreted. Glucosamine is a form of amino sugar that is believed to play a role in cartilage formation and repair. However, the body's production of glucosamine decreases as a person ages, thereby inhibiting the new growth of cartilage destroyed through wear and tear.
  • OA glucosamine sulfate
  • NSAIDS nonsteroidal anti-inflammatory drugs
  • Glucosamine sulfate taken as a dietary supplement, has been shown to exert a protective effect against joint destruction and is selectively used by joint tissues, exerting a dramatic positive effect in reducing arthritic symptoms and promoting healthy joint function.
  • a composition comprising an extract obtained from the leaves of Piper sarmentosum as a first component and collagen as a second component can help prevent oxidative related diseases in the humans and also exert a protective effect against joint destruction and slow cartilage damage in people with osteoarthritis.
  • the composition of the present invention is effective in relieving joint pain and swollen joint in people with osteoarthritis. Because the extract has an anti-inflammatory function and the collagen functions to regenerate the cartilage, the combined effect of the composition is that it will accelerate the regeneration of the cartilage in joints and helps to reduce pain and swollen in joints in people with osteoarthritis.
  • compositions comprising the leave extract of Piper sarmentosum, collagen and glucosamine sulfate also has the same combined effect of accelerating the regeneration of cartilage in joints and helps to reduce pain and swollen in joints in people with osteoarthritis.
  • the composition comprising the leave extract of Piper sarmentosum and collagen and the composition comprising the leave extract of Piper sarmentosum, collagen and glucosamine sulfate can be blended together in the form of a powder.
  • compositions in powder form are suitable for use as functional food preparation and can be consumed orally as a daily serving.
  • composition comprising the leave extract of Piper sarmentosum and collagen and the composition comprising the leave extract of Piper sarmentosum, collagen and glucosamine sulfate can also be formulated into a beverage.
  • the composition in the form of a powder is mixed with one or more fruit juice concentrates and the beverage thus constituted can be consumed as a functional food preparation.
  • the functional food preparation in the form of a beverage is recommended as a dietary serving and can be consumed orally once each day.
  • composition comprising an extract obtained from the leaves of Piper sarmentosum as the first component and collagen as the second component.
  • composition comprising an extract obtained from the leaves of Piper sarmentosum as the first component, collagen as the second component and glucosamine sulfate as the third component.
  • composition thus formulated can be used as a functional food preparation and accordingly, this is a third aspect of the present invention.
  • the functional food preparation can be consumed orally in daily serving and is effective in accelerating the regeneration of cartilage and thereby reducing pain in joints.
  • the fourth aspect of the present invention is that there is provided a composition for use as a functional food preparation and is effective in accelerating the regeneration of cartilage and thereby reducing pain in joints.
  • the extract obtained from the leaves of Piper sarmentosum as the first component and collagen as the second component can be blended and mixed to form a powder.
  • the fifth aspect of the present invention is that there is provided a process for making a composition for use as a functional food preparation comprising an extract obtained from the leaves of Piper sarmentosum as the first component and collagen as the second component characterized in that the extract from the leaves of Piper sarmentosum is mixed with the collagen and then blended to form a powder.
  • a sixth aspect of the present invention is that the process of making a composition for use as a functional food preparation comprising an extract obtained from the leaves of Piper sarmentosum as the first component, collagen as the second component and glucosamine sulfate as the third component characterized in that the extract from the leaves of Piper sarmentosum, the collagen and glucosamine sulfate are mixed and then blended to form a powder.
  • the composition of the present invention in the form of a powder can also be formulated into a beverage by the addition of one or more fruit juice concentrates. Therefore a final aspect of the present invention is that there is provided a composition which can be formulated into a beverage by the addition of one or more fruit juice concentrates.
  • compositions comprising the leave extract of Piper sarmentosum (kadok) as the first component and collagen as the second component and a composition comprising the leave extract of Piper sarmentosum (kadok) as the first component, collagen as the second component and glucosamine sulfate as the third component yields surprising health benefits.
  • the compositions of the present invention deliver therapeutic amount of naringenin and collagen and/or glucosamine sulfate for nutritionally promoting a healthy body system and defense mechanism against cell damage and for promoting healthy joint function in humans.
  • the amount of leave extract used is at least 20mg of the total weight of the composition while the amount of collagen used is at least 8g of the total weight of the composition.
  • the amount of glucosamine sulfate used is between Ig to 1.5g of the total weight of the composition.
  • the leave extract used in formulating these compositions is obtained using standard extraction methods known in the art while the collagen and glucosamine sulfate are known and available commercially.
  • compositions of the present invention are obtained by blending the leave extract of Piper sarmentosum with the collagen or by blending the leave extract of Piper sarmentosum, the collagen and glucosamine sulfate to form a powder.
  • the powder can be consumed orally in a daily serving as a functional food preparation and is effective in accelerating the regeneration of cartilage and in relieving joint pain and swollen joint in people with osteoarthritis.
  • the composition of the present invention can also be formulated into a beverage by mixing the powder with one or more fruit juice concentrates selected from the group consisting of apple juice concentrate, banana juice concentrate, orange juice concentrate, guava juice concentrate, dragon fruit juice concentrate, papaya juice concentrate, pineapple juice concentrate, tomato juice concentrate, prune juice concentrate, carrot juice concentrate and grape juice concentrate.
  • a liquid beverage is a convenient delivery form, but other delivery forms are equally efficacious.
  • Tablets or capsule forms of the present composition and complemented with fruit juice concentrates can be prepared and coated by methods known to those of ordinary skill in the art.
  • the beverages thus constituted can be consumed as functional food preparation and is effective in accelerating the regeneration of cartilage and in relieving joint pain and swollen joint in people with osteoarthritis.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Cette invention concerne une composition contenant un extrait obtenu à partir de feuilles de Piper sarmentosum et du collagène. Cette composition peut être absorbée par voie orale de manière quotidienne et elle est efficace pour accélérer la régénération des cartilages dans les articulations, elle est également utile pour soulager la douleur articulaire chez des personnes atteintes d'arthrose.
PCT/MY2008/000010 2007-02-16 2008-02-14 Composition contenant de l'extrait de piper sarmentosum (kadok) et du collagène WO2008100130A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI20070230 2007-02-16
MYPI20070230 2007-02-16

Publications (2)

Publication Number Publication Date
WO2008100130A2 true WO2008100130A2 (fr) 2008-08-21
WO2008100130A3 WO2008100130A3 (fr) 2008-10-09

Family

ID=39588055

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MY2008/000010 WO2008100130A2 (fr) 2007-02-16 2008-02-14 Composition contenant de l'extrait de piper sarmentosum (kadok) et du collagène

Country Status (1)

Country Link
WO (1) WO2008100130A2 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102038007A (zh) * 2009-10-09 2011-05-04 中国热带农业科学院环境与植物保护研究所 假蒟提取物及其在制备杀虫抑菌剂中的应用
WO2011112067A1 (fr) * 2010-03-11 2011-09-15 Universiti Sains Malaysia Composition à base de plantes ayant une propriété anti-obésité
EP2384724A2 (fr) 2010-05-04 2011-11-09 Heraeus Medical GmbH Dispositif de sortie pour masses pâteuses
US8596499B2 (en) 2010-05-04 2013-12-03 Heraeus Medical Gmbh Cartridge system with rotatable closure and dispensing tube
US8608030B2 (en) 2010-05-04 2013-12-17 Heraeus Medical Gmbh Cartridge system with compressed gas cartridge
US8944296B2 (en) 2010-05-04 2015-02-03 Heraeus Medical Gmbh Dispensing device for cartridges
US9095871B2 (en) 2010-05-04 2015-08-04 Heraeus Medical Gmbh Cartridge system and dispensing tube for said cartridge system
JP2019126330A (ja) * 2018-01-26 2019-08-01 正治 長尾 抗ガン機能を持つ清涼飲料水と製造方法

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EP0719554A1 (fr) * 1993-07-09 1996-07-03 Kureha Chemical Industry Co., Ltd. Flavonoides comme agents chondroprotectives
US6224871B1 (en) * 1998-03-11 2001-05-01 Reliv International, Inc. Dietary supplement for nutritionally promoting healthy joint function

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CN1813922A (zh) * 2005-11-28 2006-08-09 蓝子花 一种红黑二丸祛湿镇痛药酒

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Publication number Priority date Publication date Assignee Title
EP0719554A1 (fr) * 1993-07-09 1996-07-03 Kureha Chemical Industry Co., Ltd. Flavonoides comme agents chondroprotectives
US6224871B1 (en) * 1998-03-11 2001-05-01 Reliv International, Inc. Dietary supplement for nutritionally promoting healthy joint function

Non-Patent Citations (4)

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Title
DATABASE WPI Week 200682 Thomson Scientific, London, GB; AN 2006-801132 XP002488983 & CN 1 813 922 A (LAN Z) 9 August 2006 (2006-08-09) *
DEAL C L ET AL: "NUTRACEUTICALS AS THERAPEUTIC AGENTS IN OSTEOARTHRITIS THE ROLE OF GLUCOSAMINE, CHONDROITIN SULFATE, AND COLLAGEN HYDROLYSATE" RHEUMATIC DISEASES CLINICS OF NORTH AMERICA, W.B. SAUNDERS, PHILADELPHIA, PA, US, vol. 25, no. 2, 1 May 1999 (1999-05-01), pages 379-395, XP009050485 ISSN: 0889-857X *
STOEHR J R ET AL: "Isobutylamides and a new methylbutylamide from Piper sarmentosum" PLANTA MEDICA, vol. 65, no. 2, March 1999 (1999-03), pages 175-177, XP009103434 ISSN: 0032-0943 *
SUBRAMANIAM V. ET AL: "Natural Antioxidants: Piper samentosum (Kadok) and Morinda elliptica (Mengkudu)" MAL J NUTR, vol. 9, no. 1, 2003, pages 41-51, XP002488982 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102038007A (zh) * 2009-10-09 2011-05-04 中国热带农业科学院环境与植物保护研究所 假蒟提取物及其在制备杀虫抑菌剂中的应用
WO2011112067A1 (fr) * 2010-03-11 2011-09-15 Universiti Sains Malaysia Composition à base de plantes ayant une propriété anti-obésité
EP2384724A2 (fr) 2010-05-04 2011-11-09 Heraeus Medical GmbH Dispositif de sortie pour masses pâteuses
AU2011202037B2 (en) * 2010-05-04 2013-01-17 Heraeus Medical Gmbh Dispensing device for pasty materials
US8596499B2 (en) 2010-05-04 2013-12-03 Heraeus Medical Gmbh Cartridge system with rotatable closure and dispensing tube
US8608030B2 (en) 2010-05-04 2013-12-17 Heraeus Medical Gmbh Cartridge system with compressed gas cartridge
US8944296B2 (en) 2010-05-04 2015-02-03 Heraeus Medical Gmbh Dispensing device for cartridges
US9073081B2 (en) 2010-05-04 2015-07-07 Heraeus Medical Gmbh Dispensing device for pasty materials
US9095871B2 (en) 2010-05-04 2015-08-04 Heraeus Medical Gmbh Cartridge system and dispensing tube for said cartridge system
JP2019126330A (ja) * 2018-01-26 2019-08-01 正治 長尾 抗ガン機能を持つ清涼飲料水と製造方法

Also Published As

Publication number Publication date
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