WO2008099071A3 - Anticorps monoclonal dirigé contre le récepteur humain des ldl - Google Patents

Anticorps monoclonal dirigé contre le récepteur humain des ldl Download PDF

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Publication number
WO2008099071A3
WO2008099071A3 PCT/FR2007/002187 FR2007002187W WO2008099071A3 WO 2008099071 A3 WO2008099071 A3 WO 2008099071A3 FR 2007002187 W FR2007002187 W FR 2007002187W WO 2008099071 A3 WO2008099071 A3 WO 2008099071A3
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WO
WIPO (PCT)
Prior art keywords
monoclonal antibody
directed against
antibody directed
nucleic acid
human ldl
Prior art date
Application number
PCT/FR2007/002187
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English (en)
Other versions
WO2008099071A2 (fr
WO2008099071A8 (fr
Inventor
Romeuf Christophe De
Christian Behrens
Original Assignee
Lfb Biotechnologies Soc Par Ac
Romeuf Christophe De
Christian Behrens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lfb Biotechnologies Soc Par Ac, Romeuf Christophe De, Christian Behrens filed Critical Lfb Biotechnologies Soc Par Ac
Priority to AU2007346741A priority Critical patent/AU2007346741A1/en
Priority to CN200780048492A priority patent/CN101679524A/zh
Priority to JP2009543504A priority patent/JP2010514434A/ja
Priority to CA002661853A priority patent/CA2661853A1/fr
Priority to US12/519,275 priority patent/US20100098706A1/en
Priority to EP07872460A priority patent/EP2167544A2/fr
Publication of WO2008099071A2 publication Critical patent/WO2008099071A2/fr
Publication of WO2008099071A3 publication Critical patent/WO2008099071A3/fr
Publication of WO2008099071A8 publication Critical patent/WO2008099071A8/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un anticorps monoclonal dirigé contre le récepteur humain des LDL (Low Density Lipoprotein), dans lequel la région variable de chacune de ses chaînes légères est codée par la séquence d'acide nucléique murine SEQ ID NO : 5, la région variable de chacune de ses chaînes lourdes est codée par la séquence d'acide nucléique murine SEQ ID NO : 7, ou par des séquences d'acide nucléique présentant une homologie suffisante avec les séquences SEQ ID NO : 5 et SEQ ID NO : 7 pour que la nature et l'affinité de la liaison dudit anticorps à son antigène ne soient pas modifiées, et les régions constantes de ses chaînes légères et de ses chaînes lourdes sont des régions constantes provenant d'une espèce non-murine.
PCT/FR2007/002187 2006-12-29 2007-12-28 Anticorps monoclonal dirigé contre le récepteur humain des ldl WO2008099071A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2007346741A AU2007346741A1 (en) 2006-12-29 2007-12-28 Monoclonal antibody directed against the human LDL receptor
CN200780048492A CN101679524A (zh) 2006-12-29 2007-12-28 针对人类ldl受体的单克隆抗体
JP2009543504A JP2010514434A (ja) 2006-12-29 2007-12-28 ヒトｌｄｌ受容体に対するモノクローナル抗体
CA002661853A CA2661853A1 (fr) 2006-12-29 2007-12-28 Anticorps monoclonal dirige contre le recepteur humain des ldl
US12/519,275 US20100098706A1 (en) 2006-12-29 2007-12-28 Monoclonal antibody directed against the human ldl receptor
EP07872460A EP2167544A2 (fr) 2006-12-29 2007-12-28 Antocorps monoclonal dirige contre le recepteur humain des ldl

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0611546 2006-12-29
FR0611546A FR2910896B1 (fr) 2006-12-29 2006-12-29 Anticorps monoclonal dirige contre le recepteur humain des ldl

Publications (3)

Publication Number Publication Date
WO2008099071A2 WO2008099071A2 (fr) 2008-08-21
WO2008099071A3 true WO2008099071A3 (fr) 2008-12-18
WO2008099071A8 WO2008099071A8 (fr) 2009-10-22

Family

ID=38229736

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/002187 WO2008099071A2 (fr) 2006-12-29 2007-12-28 Anticorps monoclonal dirigé contre le récepteur humain des ldl

Country Status (9)

Country Link
US (1) US20100098706A1 (fr)
EP (1) EP2167544A2 (fr)
JP (1) JP2010514434A (fr)
KR (1) KR20100014279A (fr)
CN (1) CN101679524A (fr)
AU (1) AU2007346741A1 (fr)
CA (1) CA2661853A1 (fr)
FR (1) FR2910896B1 (fr)
WO (1) WO2008099071A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9623117B2 (en) * 2011-04-04 2017-04-18 Wisconsin Alumni Research Foundation Method for selective targeting and entry of bacterial toxins to cells
SG10201811017QA (en) * 2013-06-26 2019-01-30 Numab Innovation Ag Novel antibody frameworks

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068710A1 (fr) * 2000-03-13 2001-09-20 Applied Research Systems Ars Holding N.V. Anticorps monoclonaux anti-recepteur de ldl humain, leur preparation et utilisation
WO2007014991A1 (fr) * 2005-08-03 2007-02-08 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Groupement D'interet Public Anticorps diriges contre le recepteur du ldl

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2879204B1 (fr) * 2004-12-15 2007-02-16 Lab Francais Du Fractionnement Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068710A1 (fr) * 2000-03-13 2001-09-20 Applied Research Systems Ars Holding N.V. Anticorps monoclonaux anti-recepteur de ldl humain, leur preparation et utilisation
WO2007014991A1 (fr) * 2005-08-03 2007-02-08 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Groupement D'interet Public Anticorps diriges contre le recepteur du ldl

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEISIEGEL U ET AL: "MONOCLONAL ANTIBODIES TO THE LOW DENSITY LIPOPROTEIN RECEPTOR AS PROBES FOR STUDY OF RECEPTOR-MEDIATED ENDOCYTOSIS AND THE GENETICS OF FAMILIAL HYPERCHOLESTEROLEMIA", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,, US, vol. 256, no. 22, 25 November 1981 (1981-11-25), pages 11923 - 11931, XP001188226, ISSN: 0021-9258 *
FAVRE G: "TARGETTING OF CYTOTOXIC DRUGS VIA THE LOW DENSITY LIPOPROTEINS LDL RECEPTOR PATHWAY PRINCIPLE AND APPLICATION WITH LIPOPHILIC DERIVATIVES OF ELLIPTICINE", COMPTES RENDUS DES SEANCES DE LA SOCIETE DE BIOLOGIE ET DE SES FILIALES, vol. 186, no. 1-2, 1992, pages 73 - 87, XP009086850, ISSN: 0037-9026 *
SAMADI-BABOLI M ET AL: "Low density lipoprotein for cytotoxic drug targeting: Improved activity of elliptinium derivative against B16 melanoma in mice", BRITISH JOURNAL OF CANCER, vol. 68, no. 2, 1993, pages 319 - 326, XP009086872, ISSN: 0007-0920 *

Also Published As

Publication number Publication date
FR2910896B1 (fr) 2012-11-16
WO2008099071A2 (fr) 2008-08-21
CA2661853A1 (fr) 2008-08-21
US20100098706A1 (en) 2010-04-22
EP2167544A2 (fr) 2010-03-31
KR20100014279A (ko) 2010-02-10
WO2008099071A8 (fr) 2009-10-22
JP2010514434A (ja) 2010-05-06
FR2910896A1 (fr) 2008-07-04
AU2007346741A1 (en) 2008-08-21
CN101679524A (zh) 2010-03-24

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