WO2008098056A3 - Chélate à haute relaxation high relaxivity chelates - Google Patents

Chélate à haute relaxation high relaxivity chelates Download PDF

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Publication number
WO2008098056A3
WO2008098056A3 PCT/US2008/053186 US2008053186W WO2008098056A3 WO 2008098056 A3 WO2008098056 A3 WO 2008098056A3 US 2008053186 W US2008053186 W US 2008053186W WO 2008098056 A3 WO2008098056 A3 WO 2008098056A3
Authority
WO
WIPO (PCT)
Prior art keywords
chelates
high relaxivity
relaxivity
chelating ligands
metal
Prior art date
Application number
PCT/US2008/053186
Other languages
English (en)
Other versions
WO2008098056A2 (fr
Inventor
Peter D Caravan
Vincent Jacques
Stephane Dumas
Wei-Chuan Sun
Kevin L Zhou
Heribert Schmitt-Willich
Original Assignee
Epix Pharm Inc
Bayer Schering Pharma Ag
Peter D Caravan
Vincent Jacques
Stephane Dumas
Wei-Chuan Sun
Kevin L Zhou
Heribert Schmitt-Willich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Pharm Inc, Bayer Schering Pharma Ag, Peter D Caravan, Vincent Jacques, Stephane Dumas, Wei-Chuan Sun, Kevin L Zhou, Heribert Schmitt-Willich filed Critical Epix Pharm Inc
Publication of WO2008098056A2 publication Critical patent/WO2008098056A2/fr
Publication of WO2008098056A3 publication Critical patent/WO2008098056A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/242—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des ligands chélateurs de métal, et plus particulièrement des ligands chélateurs de métal ayant une haute relaxation lorsqu'ils se trouvent sous une forme de chélate de métal.
PCT/US2008/053186 2007-02-06 2008-02-06 Chélate à haute relaxation high relaxivity chelates WO2008098056A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67190507A 2007-02-06 2007-02-06
US11/671,905 2007-02-06

Publications (2)

Publication Number Publication Date
WO2008098056A2 WO2008098056A2 (fr) 2008-08-14
WO2008098056A3 true WO2008098056A3 (fr) 2008-10-30

Family

ID=39592734

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/053186 WO2008098056A2 (fr) 2007-02-06 2008-02-06 Chélate à haute relaxation high relaxivity chelates

Country Status (1)

Country Link
WO (1) WO2008098056A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008134289A2 (fr) * 2007-04-26 2008-11-06 Mallinckrodt Inc. Complexes de lanthanide insaturés de manière coordonnée à relaxivité élevée
DE102008045937B4 (de) * 2008-04-11 2017-01-26 Johannes-Gutenberg-Universität Mainz Radiopharmakon aus einem Metallion und einem Markierungsvorläufer und Verwendung des Radiopharmakons
RU2539565C2 (ru) * 2008-12-05 2015-01-20 Моликьюлар Инсайт Фармасьютикалз, Инк. Са-ix специфические радиофармпрепараты для лечения и визуалазиции злокачественных опухолей
RU2510938C1 (ru) * 2010-02-25 2014-04-10 Колгейт-Палмолив Компани Синтез магнолола и его аналогов
US8722020B2 (en) * 2010-03-31 2014-05-13 General Electric Company Hydroxylated contrast enhancement agents
JP2015007054A (ja) * 2014-07-24 2015-01-15 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ マグノロールおよびその類似体化合物の合成
CN106316745A (zh) * 2016-08-24 2017-01-11 苏州氟拓化工科技有限公司 一种联苯化合物的制备方法
WO2019087626A1 (fr) * 2017-10-31 2019-05-09 東洋合成工業株式会社 Générateur de photo-acide, composition de résine et procédé de production d'un dispositif à l'aide de ladite composition de résine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CARAVAN P ET AL: "Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications", CHEMICAL REVIEWS, vol. 99, 20 August 1999 (1999-08-20), pages 2293 - 2352, XP002375825, ISSN: 0009-2665 *
ZECH S G ET AL: "Probing the water coordination of protein-targeted MRI contrast agents by pulsed ENDOR spectroscopy.", CHEMPHYSCHEM : A EUROPEAN JOURNAL OF CHEMICAL PHYSICS AND PHYSICAL CHEMISTRY, vol. 6, no. 12, 9 December 2005 (2005-12-09), pages 2570 - 2577, XP009105424, ISSN: 1439-4235 *

Also Published As

Publication number Publication date
WO2008098056A2 (fr) 2008-08-14

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