WO2008096846A1 - 安定同位体標識タンパク質合成用組成物及び安定同位体標識タンパク質の製造方法 - Google Patents

安定同位体標識タンパク質合成用組成物及び安定同位体標識タンパク質の製造方法 Download PDF

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Publication number
WO2008096846A1
WO2008096846A1 PCT/JP2008/052116 JP2008052116W WO2008096846A1 WO 2008096846 A1 WO2008096846 A1 WO 2008096846A1 JP 2008052116 W JP2008052116 W JP 2008052116W WO 2008096846 A1 WO2008096846 A1 WO 2008096846A1
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WO
WIPO (PCT)
Prior art keywords
stable isotope
protein labeled
synthesis
composition
labeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/JP2008/052116
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English (en)
French (fr)
Inventor
Shigeyuki Yokoyama
Takanori Kigawa
Jun Yokoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Sanso Holdings Corp
RIKEN
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Nippon Sanso Holdings Corp
RIKEN
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Application filed by Nippon Sanso Holdings Corp, RIKEN filed Critical Nippon Sanso Holdings Corp
Priority to JP2008557162A priority Critical patent/JPWO2008096846A1/ja
Publication of WO2008096846A1 publication Critical patent/WO2008096846A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　本発明は、核磁気共鳴分光（NMR）法ならびに質量分析分野において有用な安定同位体標識タンパク質を安価に合成する手段を提供することを課題とする。 　本発明によれば、(A) L-アラニン、L-アルギニン、L-アスパラギン酸、L-グルタミン酸、グリシン、L-ヒスチジン、L-イソロイシン、L-ロイシン、L-リジン、L-メチオニン、L-フェニルアラニン、L-プロリン、L-セリン、L-スレオニン、L-チロシン、L-バリンの16種類のアミノ酸からなるアミノ酸混合物、(B) インドール、(C) 硫化水素または硫化ナトリウム、および(D) アンモニウム塩を含み、かつ前記アミノ酸混合物中のアミノ酸の少なくとも１種、および/または、インドール、硫化水素または硫化物塩、アンモニウム塩のいずれかまたは全部が安定同位体で標識されていることを特徴とする、安定同位体標識タンパク質合成用組成物、ならびに該組成物を用いる安定同位体標識タンパク質の合成方法が提供される。
PCT/JP2008/052116 2007-02-09 2008-02-08 安定同位体標識タンパク質合成用組成物及び安定同位体標識タンパク質の製造方法 Ceased WO2008096846A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008557162A JPWO2008096846A1 (ja) 2007-02-09 2008-02-08 安定同位体標識タンパク質合成用組成物及び安定同位体標識タンパク質の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007030650 2007-02-09
JP2007-030650 2007-11-06

Publications (1)

Publication Number Publication Date
WO2008096846A1 true WO2008096846A1 (ja) 2008-08-14

Family

ID=39681747

Family Applications (1)

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PCT/JP2008/052116 Ceased WO2008096846A1 (ja) 2007-02-09 2008-02-08 安定同位体標識タンパク質合成用組成物及び安定同位体標識タンパク質の製造方法

Country Status (2)

Country Link
JP (1) JPWO2008096846A1 (ja)
WO (1) WO2008096846A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019024326A (ja) * 2017-07-25 2019-02-21 大陽日酸株式会社 標識代謝物の製造方法、代謝物の定量方法、及び標識代謝物製造キット
JP2020064051A (ja) * 2018-08-29 2020-04-23 国立大学法人 岡山大学 神経変性疾患の診断用ペプチドマーカー

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113125594B (zh) * 2021-04-02 2022-06-24 安徽国肽生物科技有限公司 一种肽链水解试剂及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01101892A (ja) * 1987-10-16 1989-04-19 Res Assoc Util Of Light Oil Ｌ―トリプトファンの製造法
JPH02222692A (ja) * 1989-02-23 1990-09-05 Kyowa Hakko Kogyo Co Ltd Ｌ―含硫アミノ酸の製造法
JPH08103283A (ja) * 1994-10-06 1996-04-23 Mitsubishi Chem Corp トリプトファンの製造法
WO2004104210A1 (ja) * 2003-05-22 2004-12-02 Riken 無細胞タンパク質合成系によるタンパク質の製造方法及びタンパク質合成用試薬キット

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62143690A (ja) * 1985-12-18 1987-06-26 Mitsui Toatsu Chem Inc 酵素法によるｌ−含硫アミノ酸の製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01101892A (ja) * 1987-10-16 1989-04-19 Res Assoc Util Of Light Oil Ｌ―トリプトファンの製造法
JPH02222692A (ja) * 1989-02-23 1990-09-05 Kyowa Hakko Kogyo Co Ltd Ｌ―含硫アミノ酸の製造法
JPH08103283A (ja) * 1994-10-06 1996-04-23 Mitsubishi Chem Corp トリプトファンの製造法
WO2004104210A1 (ja) * 2003-05-22 2004-12-02 Riken 無細胞タンパク質合成系によるタンパク質の製造方法及びタンパク質合成用試薬キット

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019024326A (ja) * 2017-07-25 2019-02-21 大陽日酸株式会社 標識代謝物の製造方法、代謝物の定量方法、及び標識代謝物製造キット
JP2020064051A (ja) * 2018-08-29 2020-04-23 国立大学法人 岡山大学 神経変性疾患の診断用ペプチドマーカー
JP7457300B2 (ja) 2018-08-29 2024-03-28 国立大学法人 岡山大学 神経変性疾患の診断用ペプチドマーカー

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JPWO2008096846A1 (ja) 2010-05-27

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