WO2008096564A1 - Microchip inspection system, microchip inspection equipment and program - Google Patents

Microchip inspection system, microchip inspection equipment and program Download PDF

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Publication number
WO2008096564A1
WO2008096564A1 PCT/JP2008/050119 JP2008050119W WO2008096564A1 WO 2008096564 A1 WO2008096564 A1 WO 2008096564A1 JP 2008050119 W JP2008050119 W JP 2008050119W WO 2008096564 A1 WO2008096564 A1 WO 2008096564A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluorescence
microchip
intensity
target substance
light
Prior art date
Application number
PCT/JP2008/050119
Other languages
French (fr)
Japanese (ja)
Inventor
Tsuneo Sawazumi
Original Assignee
Konica Minolta Medical & Graphic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konica Minolta Medical & Graphic, Inc. filed Critical Konica Minolta Medical & Graphic, Inc.
Priority to JP2008557037A priority Critical patent/JPWO2008096564A1/en
Publication of WO2008096564A1 publication Critical patent/WO2008096564A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

A microchip inspection system which can perform inspection of a target substance with high precision. The microchip inspection system comprises a microchip including at least a target substance and a fluorescence-labeled reagent bonding specifically to the target substance and having a part to be detected where measurement of the intensity of fluorescence for detecting reaction of the target substance and the reagent is performed; a photodetecting section provided in correspondence with the microchip part to be detected and irradiating the part with excitation light and receiving fluorescence from the part; and a control section for detecting reaction based on the measurement of the intensity of fluorescence at the photodetecting section. The photodetecting section has a first light receiving means for receiving light of first fluorescence wavelength band, and a second light receiving means for receiving light of second fluorescence wavelength band, and the control section detects reaction based on the relative relation of a first intensity of fluorescence received by the first light receiving means and a second intensity of fluorescence received by the second light receiving means.
PCT/JP2008/050119 2007-02-07 2008-01-09 Microchip inspection system, microchip inspection equipment and program WO2008096564A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008557037A JPWO2008096564A1 (en) 2007-02-07 2008-01-09 Microchip inspection system, microchip inspection apparatus and program

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007027825 2007-02-07
JP2007-027825 2007-02-07

Publications (1)

Publication Number Publication Date
WO2008096564A1 true WO2008096564A1 (en) 2008-08-14

Family

ID=39681475

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050119 WO2008096564A1 (en) 2007-02-07 2008-01-09 Microchip inspection system, microchip inspection equipment and program

Country Status (2)

Country Link
JP (1) JPWO2008096564A1 (en)
WO (1) WO2008096564A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001228148A (en) * 1999-12-06 2001-08-24 Mitsubishi Rayon Co Ltd Organism-associated substance microarray and detecting method using it
US20050227275A1 (en) * 2004-04-07 2005-10-13 Access Bio, Inc. Nucleic acid detection system
JP2005300292A (en) * 2004-04-09 2005-10-27 Hitachi High-Technologies Corp Biosample component detection method and its device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001228148A (en) * 1999-12-06 2001-08-24 Mitsubishi Rayon Co Ltd Organism-associated substance microarray and detecting method using it
US20050227275A1 (en) * 2004-04-07 2005-10-13 Access Bio, Inc. Nucleic acid detection system
JP2005300292A (en) * 2004-04-09 2005-10-27 Hitachi High-Technologies Corp Biosample component detection method and its device

Also Published As

Publication number Publication date
JPWO2008096564A1 (en) 2010-05-20

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