WO2008090857A1 - 化合物、α1アドレナリン受容体拮抗剤、及び組成物 - Google Patents

化合物、α1アドレナリン受容体拮抗剤、及び組成物 Download PDF

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Publication number
WO2008090857A1
WO2008090857A1 PCT/JP2008/050747 JP2008050747W WO2008090857A1 WO 2008090857 A1 WO2008090857 A1 WO 2008090857A1 JP 2008050747 W JP2008050747 W JP 2008050747W WO 2008090857 A1 WO2008090857 A1 WO 2008090857A1
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Prior art keywords
compound
composition
receptor antagonist
adrenaline receptor
disclosed
Prior art date
Application number
PCT/JP2008/050747
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English (en)
French (fr)
Inventor
Toshiyuki Wakimoto
Haruo Nukaya
Yoshihide Suwa
Yoshiaki Yokoo
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Suntory Holdings Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Holdings Limited filed Critical Suntory Holdings Limited
Priority to EP08703597A priority Critical patent/EP2128148A4/en
Priority to CA002676208A priority patent/CA2676208A1/en
Priority to US12/522,776 priority patent/US8110601B2/en
Priority to JP2008523056A priority patent/JP4790803B2/ja
Publication of WO2008090857A1 publication Critical patent/WO2008090857A1/ja

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/007Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/111Aromatic compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/116Heterocyclic compounds
    • A23K20/121Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/142Amino acids; Derivatives thereof
    • A23K20/147Polymeric derivatives, e.g. peptides or proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

 高血圧治療だけでなく、前立腺肥大症治療等に対しても有効な治療効果を発揮し得る新規の化合物、α1アドレナリン受容体拮抗剤、及び組成物を提供する。化合物は、以下の構造式(1)で示される。
PCT/JP2008/050747 2007-01-22 2008-01-22 化合物、α1アドレナリン受容体拮抗剤、及び組成物 WO2008090857A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08703597A EP2128148A4 (en) 2007-01-22 2008-01-22 COMPOUND, ALPHA-1-ADRENALINE-RECEPTOR ANTAGONIST AND COMPOSITION
CA002676208A CA2676208A1 (en) 2007-01-22 2008-01-22 Compound, a1 adrenergic receptor antagonist agent, and composition
US12/522,776 US8110601B2 (en) 2007-01-22 2008-01-22 Compound, α1 adrenergic receptor antagonistic agent, and composition
JP2008523056A JP4790803B2 (ja) 2007-01-22 2008-01-22 化合物、α1アドレナリン受容体拮抗剤、及び組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007012019 2007-01-22
JP2007-012019 2007-01-22

Publications (1)

Publication Number Publication Date
WO2008090857A1 true WO2008090857A1 (ja) 2008-07-31

Family

ID=39644433

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050747 WO2008090857A1 (ja) 2007-01-22 2008-01-22 化合物、α1アドレナリン受容体拮抗剤、及び組成物

Country Status (5)

Country Link
US (1) US8110601B2 (ja)
EP (1) EP2128148A4 (ja)
JP (1) JP4790803B2 (ja)
CA (1) CA2676208A1 (ja)
WO (1) WO2008090857A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010229215A (ja) * 2009-03-26 2010-10-14 Wakayama Prefecture 有機蛍光材料及び着色料

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002978A1 (ja) * 2002-06-26 2004-01-08 Suntory Limited 消化管運動促進飲食物
WO2006057406A1 (ja) * 2004-11-29 2006-06-01 Suntory Limited 口腔内刺激物質
WO2006092893A1 (ja) * 2005-03-02 2006-09-08 Suntory Limited 消化管運動促進化合物
JP2006273842A (ja) * 2005-03-02 2006-10-12 Suntory Ltd 消化管運動促進物質の合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3475459A (en) * 1966-11-23 1969-10-28 Canadian Patents Dev Hordatine compounds and synthesis
JP3864921B2 (ja) 2002-03-29 2007-01-10 住友金属工業株式会社 低合金鋼
JP2006057406A (ja) 2004-08-23 2006-03-02 Toyo Tire & Rubber Co Ltd 仮復旧用ゴムマット
JP2006092893A (ja) 2004-09-24 2006-04-06 Nec Access Technica Ltd コネクタ付き接続ケーブル

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002978A1 (ja) * 2002-06-26 2004-01-08 Suntory Limited 消化管運動促進飲食物
WO2006057406A1 (ja) * 2004-11-29 2006-06-01 Suntory Limited 口腔内刺激物質
WO2006092893A1 (ja) * 2005-03-02 2006-09-08 Suntory Limited 消化管運動促進化合物
JP2006273842A (ja) * 2005-03-02 2006-10-12 Suntory Ltd 消化管運動促進物質の合成方法

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A.GRAHAM ET AL., SYNTHESIS, vol. 1032, 1984
B.DRAKE, SYNTHESIS, vol. 579, 1994
DOCHERTY, J.R. ET AL., NAUNYN SCHEMIEDEBERG'S ARCH.PHARMACOL., vol. 317, 1981, pages 5 - 7
H.SAITO, ORG.LETT., vol. 4, 2002, pages 3887 - 3890
KUO Y.-H. ET AL.: "Synthesis of 5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furancarbaldehyde, a Novel Adenosine A1 Receptor Ligand from the Root of Salvia miltiorrhiza", JOURNAL OF NATURAL PRODUCTS, vol. 59, no. 6, 1996, pages 625 - 628, XP008108907 *
MITCHEL, A.D. ET AL., BRT.J.PHARMACOL., vol. 98, 1989, pages 883 - 889
See also references of EP2128148A4 *
SHUUJI TAKAORI; HIDEOMI FUKUDA; AKINORI AKAIKE: "Goodman & Gilman's The Pharmacological Basis of Therapeutics 10th cdition", vol. 1, HIROKAWA BOOK CO., pages: 308 - 316
W.K UROSAWA, TETRAHEDRON, vol. 60, 2004, pages 9615 - 9628

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010229215A (ja) * 2009-03-26 2010-10-14 Wakayama Prefecture 有機蛍光材料及び着色料

Also Published As

Publication number Publication date
JPWO2008090857A1 (ja) 2010-05-20
EP2128148A4 (en) 2011-06-22
CA2676208A1 (en) 2008-07-31
JP4790803B2 (ja) 2011-10-12
US20100004328A1 (en) 2010-01-07
EP2128148A1 (en) 2009-12-02
US8110601B2 (en) 2012-02-07

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