WO2008084869A1 - 一分子型生物発光可視化プローブ - Google Patents
一分子型生物発光可視化プローブ Download PDFInfo
- Publication number
- WO2008084869A1 WO2008084869A1 PCT/JP2008/050370 JP2008050370W WO2008084869A1 WO 2008084869 A1 WO2008084869 A1 WO 2008084869A1 JP 2008050370 W JP2008050370 W JP 2008050370W WO 2008084869 A1 WO2008084869 A1 WO 2008084869A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ligand
- molecule
- lbd
- domain
- binding molecule
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/448,881 US8124424B2 (en) | 2007-01-12 | 2008-01-15 | Single molecule-format bioluminescent probe |
JP2008553132A JP5099560B2 (ja) | 2007-01-12 | 2008-01-15 | 一分子型生物発光可視化プローブ |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007005144 | 2007-01-12 | ||
JP2007-005144 | 2007-01-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008084869A1 true WO2008084869A1 (ja) | 2008-07-17 |
Family
ID=39608756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/050370 WO2008084869A1 (ja) | 2007-01-12 | 2008-01-15 | 一分子型生物発光可視化プローブ |
Country Status (3)
Country | Link |
---|---|
US (1) | US8124424B2 (ja) |
JP (1) | JP5099560B2 (ja) |
WO (1) | WO2008084869A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010119721A1 (ja) | 2009-04-17 | 2010-10-21 | 独立行政法人産業技術総合研究所 | 超高輝度で安定な人工生物発光酵素 |
WO2014065047A1 (ja) | 2012-10-26 | 2014-05-01 | 独立行政法人産業技術総合研究所 | 人工生物発光酵素 |
WO2016127302A1 (zh) * | 2015-02-10 | 2016-08-18 | 深圳市第二人民医院 | 检测细胞外基质mmp13的bret探针、基因、表达载体和构建方法 |
JP2016163559A (ja) * | 2015-02-26 | 2016-09-08 | 富山県 | Vdrビタミンd結合ドメインを含む融合タンパク質及びその使用 |
US10214766B2 (en) | 2013-10-18 | 2019-02-26 | National Institute Of Advanced Industrial Science And Technology | Luminescent substrate for use in artificial bioluminescent enzyme |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009153399A (ja) * | 2007-12-25 | 2009-07-16 | National Institute Of Advanced Industrial & Technology | 一分子型リアルタイム生物発光イメージングプローブ |
WO2016139643A2 (en) * | 2015-03-04 | 2016-09-09 | University College Dublin, National University Of Ireland, Dublin | Molecular sensors |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004104222A1 (ja) * | 2003-05-22 | 2004-12-02 | Japan Science And Technology Agency | 蛋白質相互作用解析用プローブ及びそれを用いた蛋白質相互作用の解析方法 |
WO2005078119A1 (ja) * | 2004-02-12 | 2005-08-25 | Japan Science And Technology Agency | 核内レセプターのアゴニスト・アンタゴニスト検出用プローブとそれを用いた核内レセプターに対するアゴニストおよびアンタゴニストのスクリーニング方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7834148B2 (en) * | 2006-05-23 | 2010-11-16 | Stanford University | Protein phosphorylation imaging systems, methods of making phosphorylation imaging systems, and methods of use thereof |
-
2008
- 2008-01-15 JP JP2008553132A patent/JP5099560B2/ja not_active Expired - Fee Related
- 2008-01-15 US US12/448,881 patent/US8124424B2/en not_active Expired - Fee Related
- 2008-01-15 WO PCT/JP2008/050370 patent/WO2008084869A1/ja active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004104222A1 (ja) * | 2003-05-22 | 2004-12-02 | Japan Science And Technology Agency | 蛋白質相互作用解析用プローブ及びそれを用いた蛋白質相互作用の解析方法 |
WO2005078119A1 (ja) * | 2004-02-12 | 2005-08-25 | Japan Science And Technology Agency | 核内レセプターのアゴニスト・アンタゴニスト検出用プローブとそれを用いた核内レセプターに対するアゴニストおよびアンタゴニストのスクリーニング方法 |
Non-Patent Citations (5)
Title |
---|
AWAIS M. ET AL.: "A fluorescent indicator to visualize activities of the androgen receptor ligands in single living cells", ANGEW. CHEM. INT. ED. ENGL., vol. 45, no. 17, 2006, pages 2707 - 2712 * |
KIM S.B. ET AL.: "A method for determining the activities of cytokines based on the nuclear transport of nuclear factor-kappaB", ANAL. BIOCHEM., vol. 359, no. 1, 2006, pages 147 - 149, XP024942282, DOI: doi:10.1016/j.ab.2006.07.013 * |
KIM S.B. ET AL.: "Bioluminescent indicator for determining protein-protein interactions using intramolecular complementation of split click beetle luciferase", ANAL. CHEM., vol. 79, no. 13, 1 July 2007 (2007-07-01), pages 4820 - 4826 * |
KIM S.B. ET AL.: "Integrated molecule-format bioluminescent probe for visualizing androgenicity of ligands based on the intramolecular association of androgen receptor with its recognition Peptide", ANAL. CHEM., vol. 79, no. 5, 1 March 2007 (2007-03-01), pages 1874 - 1880, XP008123064, DOI: doi:10.1021/AC061934U * |
PAULMURUGAN R. ET AL.: "Firefly luciferase enzyme fragment complementation for imaging in cells and living animals", ANAL. CHEM., vol. 77, no. 5, 2005, pages 1295 - 1302, XP002506343, DOI: doi:10.1021/AC0484777 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010119721A1 (ja) | 2009-04-17 | 2010-10-21 | 独立行政法人産業技術総合研究所 | 超高輝度で安定な人工生物発光酵素 |
WO2014065047A1 (ja) | 2012-10-26 | 2014-05-01 | 独立行政法人産業技術総合研究所 | 人工生物発光酵素 |
US10533231B2 (en) | 2012-10-26 | 2020-01-14 | National Institute Of Advanced Industrial Science And Technology | Artificial bioluminescent enzyme |
US10214766B2 (en) | 2013-10-18 | 2019-02-26 | National Institute Of Advanced Industrial Science And Technology | Luminescent substrate for use in artificial bioluminescent enzyme |
WO2016127302A1 (zh) * | 2015-02-10 | 2016-08-18 | 深圳市第二人民医院 | 检测细胞外基质mmp13的bret探针、基因、表达载体和构建方法 |
JP2016163559A (ja) * | 2015-02-26 | 2016-09-08 | 富山県 | Vdrビタミンd結合ドメインを含む融合タンパク質及びその使用 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2008084869A1 (ja) | 2010-05-06 |
JP5099560B2 (ja) | 2012-12-19 |
US8124424B2 (en) | 2012-02-28 |
US20100273150A1 (en) | 2010-10-28 |
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