WO2008081927A1 - 抗癌剤の併用による癌治療方法 - Google Patents

抗癌剤の併用による癌治療方法 Download PDF

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Publication number
WO2008081927A1
WO2008081927A1 PCT/JP2007/075277 JP2007075277W WO2008081927A1 WO 2008081927 A1 WO2008081927 A1 WO 2008081927A1 JP 2007075277 W JP2007075277 W JP 2007075277W WO 2008081927 A1 WO2008081927 A1 WO 2008081927A1
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Prior art keywords
cancer
combination
rituximab
anticancer agents
treating cancer
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PCT/JP2007/075277
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English (en)
French (fr)
Inventor
Takahito Nakahara
Kentaro Yamanaka
Aya Kita
Hiroshi Koutoku
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Astellas Pharma Inc.
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Priority to JP2008552180A priority Critical patent/JP4788774B2/ja
Priority to ES07860480T priority patent/ES2409755T3/es
Priority to EP07860480.8A priority patent/EP2127652B1/en
Priority to PL07860480T priority patent/PL2127652T3/pl
Priority to CA002672933A priority patent/CA2672933A1/en
Priority to DK07860480.8T priority patent/DK2127652T3/da
Publication of WO2008081927A1 publication Critical patent/WO2008081927A1/ja

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    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K33/243—Platinum; Compounds thereof
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Abstract

　本発明は、医薬、殊に、臭化　1-(2-メトキシエチル)-2-メチル-4,9-ジオキソ-3-(ピラジン-2-イルメチル)-4,9-ジヒドロ-1H-ナフト[2,3-d]イミダゾール-3-イウムを有効成分として含み、カルボプラチン、シスプラチン、パクリタキセル、ビノレルビン、ゲムシタビン、イリノテカン、ドセタキセル、ドキソルビシン、ダカルバジン及びリツキシマブからなる群から選択される１以上の抗癌剤、若しくは、リツキシマブ含有併用療法であるR-ICE及びR-DHAPと併用して適用する治療用組成物に関する。本発明組成物は、全ての固形癌及びリンパ腫、好ましくは、皮膚癌、膀胱癌、乳癌、子宮癌、卵巣癌、前立腺癌、肺癌、大腸癌、膵癌、腎癌、胃癌などの治療に有用である。特に、他の抗癌剤に対して抵抗性の癌に対する治療剤として期待される。
PCT/JP2007/075277 2006-12-29 2007-12-28 抗癌剤の併用による癌治療方法 WO2008081927A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008552180A JP4788774B2 (ja) 2006-12-29 2007-12-28 抗癌剤の併用による癌治療方法
ES07860480T ES2409755T3 (es) 2006-12-29 2007-12-28 Método para Tratar el Cáncer Utilizando un Agente Anticanceroso Combinado
EP07860480.8A EP2127652B1 (en) 2006-12-29 2007-12-28 Method for treating cancer using anticancer agent in combination
PL07860480T PL2127652T3 (pl) 2006-12-29 2007-12-28 Sposób leczenia choroby nowotworowej wykorzystujący czynnik przeciwnowotworowy w kombinacji
CA002672933A CA2672933A1 (en) 2006-12-29 2007-12-28 Method of treating cancer by a combined therapy of anticancer agents
DK07860480.8T DK2127652T3 (da) 2006-12-29 2007-12-28 Fremgangsmåde til behandling af cancer under anvendelse af anticancermiddel i kombination

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88280906P 2006-12-29 2006-12-29
US60/882809 2006-12-29
US95077107P 2007-07-19 2007-07-19
US60/950771 2007-07-19

Publications (1)

Publication Number Publication Date
WO2008081927A1 true WO2008081927A1 (ja) 2008-07-10

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PCT/JP2007/075277 WO2008081927A1 (ja) 2006-12-29 2007-12-28 抗癌剤の併用による癌治療方法

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US (3) US7618992B2 (ja)
EP (2) EP2609920A1 (ja)
JP (2) JP4788774B2 (ja)
CA (1) CA2672933A1 (ja)
DK (1) DK2127652T3 (ja)
ES (1) ES2409755T3 (ja)
PL (1) PL2127652T3 (ja)
PT (1) PT2127652E (ja)
WO (1) WO2008081927A1 (ja)

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WO2010146634A1 (ja) * 2009-06-19 2010-12-23 株式会社セレックス 膵臓癌の免疫療法剤及び免疫療法
WO2011029415A1 (en) 2009-09-10 2011-03-17 Univerzita Palackeho Cyclobutan-1,1 -dicarboxylato complexes of platinum with n6-benzyladenine derivatives, method of their preparation and application of these complexes as drugs in antitumour therapy
WO2014142220A1 (ja) * 2013-03-13 2014-09-18 アステラス製薬株式会社 抗腫瘍剤
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010146634A1 (ja) * 2009-06-19 2010-12-23 株式会社セレックス 膵臓癌の免疫療法剤及び免疫療法
JP2011001315A (ja) * 2009-06-19 2011-01-06 Cellex Corp 膵臓癌の免疫療法剤
US8613916B2 (en) 2009-06-19 2013-12-24 Cellex Corporation Immunotherapy for pancreatic cancer
WO2011029415A1 (en) 2009-09-10 2011-03-17 Univerzita Palackeho Cyclobutan-1,1 -dicarboxylato complexes of platinum with n6-benzyladenine derivatives, method of their preparation and application of these complexes as drugs in antitumour therapy
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JP2011168619A (ja) 2011-09-01
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USRE45105E1 (en) 2014-09-02
JP4788774B2 (ja) 2011-10-05
JPWO2008081927A1 (ja) 2010-04-30
PL2127652T3 (pl) 2013-10-31
EP2127652A1 (en) 2009-12-02
PT2127652E (pt) 2013-07-08
DK2127652T3 (da) 2013-06-10
EP2609920A1 (en) 2013-07-03
US20080166344A1 (en) 2008-07-10
US20090263390A1 (en) 2009-10-22
EP2127652B1 (en) 2013-05-15
CA2672933A1 (en) 2008-07-10
US7618992B2 (en) 2009-11-17
US8003105B2 (en) 2011-08-23

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