WO2008081116A3 - Préparations cellulaires pour une utilisation comme agent stimulant la revascularisation - Google Patents

Préparations cellulaires pour une utilisation comme agent stimulant la revascularisation Download PDF

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Publication number
WO2008081116A3
WO2008081116A3 PCT/FR2007/002003 FR2007002003W WO2008081116A3 WO 2008081116 A3 WO2008081116 A3 WO 2008081116A3 FR 2007002003 W FR2007002003 W FR 2007002003W WO 2008081116 A3 WO2008081116 A3 WO 2008081116A3
Authority
WO
WIPO (PCT)
Prior art keywords
revascularisation
stimulating agent
cellular preparations
relates
cell precursors
Prior art date
Application number
PCT/FR2007/002003
Other languages
English (en)
Other versions
WO2008081116A2 (fr
Inventor
Gerard Tobelem
Ricousse-Roussanne Sophie Le
Philippe Foubert
Jean-Sebastien Silvestre
Original Assignee
Inst Vaisseaux Et Du Sang
Assist Publ Hopitaux De Paris
Univ Paris 7 Denis Diderot
Gerard Tobelem
Ricousse-Roussanne Sophie Le
Philippe Foubert
Jean-Sebastien Silvestre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Vaisseaux Et Du Sang, Assist Publ Hopitaux De Paris, Univ Paris 7 Denis Diderot, Gerard Tobelem, Ricousse-Roussanne Sophie Le, Philippe Foubert, Jean-Sebastien Silvestre filed Critical Inst Vaisseaux Et Du Sang
Priority to CN2007800509221A priority Critical patent/CN101600446B/zh
Priority to US12/517,281 priority patent/US20100086524A1/en
Priority to BRPI0719910-4A2A priority patent/BRPI0719910A2/pt
Priority to AU2007341179A priority patent/AU2007341179B2/en
Priority to JP2009539782A priority patent/JP5390394B2/ja
Priority to CA002670654A priority patent/CA2670654A1/fr
Priority to EP07871799A priority patent/EP2101795A2/fr
Publication of WO2008081116A2 publication Critical patent/WO2008081116A2/fr
Publication of WO2008081116A3 publication Critical patent/WO2008081116A3/fr
Priority to IL199148A priority patent/IL199148A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une préparation cellulaire comprenant des précurseurs de cellules endothéliales (EPCs) et des précurseurs de cellules musculaires lisses (SMCs), comme produit de combinaison pour une administration simultanée, séparée ou étalée dans le temps, pour une utilisation comme agent stimulant la revascularisation. L'invention concerne également l'utilisation d'une telle préparation cellulaire.
PCT/FR2007/002003 2006-12-06 2007-12-06 Préparations cellulaires pour une utilisation comme agent stimulant la revascularisation WO2008081116A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN2007800509221A CN101600446B (zh) 2006-12-06 2007-12-06 用作血管再形成刺激剂的细胞制备物
US12/517,281 US20100086524A1 (en) 2006-12-06 2007-12-06 Cellular preparations for use as a revascularization stimulating agent
BRPI0719910-4A2A BRPI0719910A2 (pt) 2006-12-06 2007-12-06 Preparação celular e utilização da mesma
AU2007341179A AU2007341179B2 (en) 2006-12-06 2007-12-06 Cellular preparations for use as a revascularisation stimulating agent
JP2009539782A JP5390394B2 (ja) 2006-12-06 2007-12-06 血管再生促進薬剤
CA002670654A CA2670654A1 (fr) 2006-12-06 2007-12-06 Preparations cellulaires pour une utilisation comme agent stimulant la revascularisation
EP07871799A EP2101795A2 (fr) 2006-12-06 2007-12-06 Préparations cellulaires pour une utilisation comme agent stimulant la revascularisation
IL199148A IL199148A (en) 2006-12-06 2009-06-04 Intracellular preparation for use as a stimulant for blood vessel development

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0610638A FR2909559B1 (fr) 2006-12-06 2006-12-06 Preparations cellulaires pour une utilisation comme agent stimulant la revascularisation
FR0610638 2006-12-06

Publications (2)

Publication Number Publication Date
WO2008081116A2 WO2008081116A2 (fr) 2008-07-10
WO2008081116A3 true WO2008081116A3 (fr) 2008-09-12

Family

ID=38171140

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/002003 WO2008081116A2 (fr) 2006-12-06 2007-12-06 Préparations cellulaires pour une utilisation comme agent stimulant la revascularisation

Country Status (10)

Country Link
US (1) US20100086524A1 (fr)
EP (1) EP2101795A2 (fr)
JP (2) JP5390394B2 (fr)
CN (1) CN101600446B (fr)
AU (1) AU2007341179B2 (fr)
BR (1) BRPI0719910A2 (fr)
CA (1) CA2670654A1 (fr)
FR (1) FR2909559B1 (fr)
IL (1) IL199148A (fr)
WO (1) WO2008081116A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2909559B1 (fr) * 2006-12-06 2012-09-07 Inst Vaisseaux Et Du Sang Preparations cellulaires pour une utilisation comme agent stimulant la revascularisation
FR2957799B1 (fr) * 2010-03-26 2012-08-17 Inst Des Vaisseaux Et Du Sang Compositions proangiogeniques, leur procede de preparation et leurs utilisations
JPWO2012096257A1 (ja) * 2011-01-12 2014-06-09 株式会社ライフアートビレッジ 育毛剤

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998019712A1 (fr) * 1996-11-08 1998-05-14 St. Elizabeth's Medical Center Of Boston, Inc. Procede de regulation de l'angiogenese
WO2001094555A1 (fr) * 2000-06-07 2001-12-13 Assistance Publique - Hopitaux De Paris Procede d'obtention de populations cellulaires caracterisees d'origine musculaire et utilisations
FR2889200A1 (fr) * 2005-07-27 2007-02-02 Inst Vaisseaux Et Du Sang Ass Systeme marqueur cellulaire/ligand, ou le marqueur est du type eph, materiau cellulaire comprenant ce systeme, procede de preparation et utilisation proangiogenique
FR2890977A1 (fr) * 2005-09-19 2007-03-23 Assist Publ Hopitaux De Paris Procede d'obtention de cellules musculaires lisses humaines et leurs applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003901668A0 (en) * 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
WO2003027281A2 (fr) * 2001-09-20 2003-04-03 Kyowa Hakko Kogyo Kk Cellules souches totipotentes provenant des tissus intestinaux de muscle squelettique
US7247477B2 (en) * 2002-04-16 2007-07-24 Technion Research & Development Foundation Ltd. Methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells
US7354763B2 (en) * 2002-04-16 2008-04-08 Technion Research & Development Foundation Ltd. Generating vascular smooth muscle cells in vitro from ES cells
FR2909559B1 (fr) * 2006-12-06 2012-09-07 Inst Vaisseaux Et Du Sang Preparations cellulaires pour une utilisation comme agent stimulant la revascularisation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998019712A1 (fr) * 1996-11-08 1998-05-14 St. Elizabeth's Medical Center Of Boston, Inc. Procede de regulation de l'angiogenese
WO2001094555A1 (fr) * 2000-06-07 2001-12-13 Assistance Publique - Hopitaux De Paris Procede d'obtention de populations cellulaires caracterisees d'origine musculaire et utilisations
FR2889200A1 (fr) * 2005-07-27 2007-02-02 Inst Vaisseaux Et Du Sang Ass Systeme marqueur cellulaire/ligand, ou le marqueur est du type eph, materiau cellulaire comprenant ce systeme, procede de preparation et utilisation proangiogenique
FR2890977A1 (fr) * 2005-09-19 2007-03-23 Assist Publ Hopitaux De Paris Procede d'obtention de cellules musculaires lisses humaines et leurs applications

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CIRCULATION, vol. 114, no. 18, Suppl. S, October 2006 (2006-10-01), 79TH ANNUAL SCIENTIFIC SESSION OF THE AMERICAN-HEART-ASSOCIATION; CHICAGO, IL, USA; NOVEMBER 12 -15, 2006, pages 103, ISSN: 0009-7322 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; October 2006 (2006-10-01), FOUBERT PHILIPPE ET AL: "EphB4 activation increases pro-angiogenic potential of endothelial progenitor cells. Role of p-selectin glycoprotein ligand-1", XP002439910, Database accession no. PREV200700121137 *
FOUBERT, P. ET AL: "PSGL-1?mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells", JOURNAL OF CLINICAL INVESTIGATION, vol. 117, no. 6, June 2007 (2007-06-01), pages 1527 - 1537, XP002439684 *
LE RICOUSSE-ROUSSANNE S ET AL: "Ex vivo differentiated endothelial and smooth muscle cells from human cord blood progenitors home to the angiogenic tumor vasculature", CARDIOVASCULAR RESEARCH 01 APR 2004 NETHERLANDS, vol. 62, no. 1, 1 April 2004 (2004-04-01), pages 176 - 184, XP002385798, ISSN: 0008-6363 *
NOREN N K ET AL: "Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 101, no. 15, 13 April 2004 (2004-04-13), pages 5583 - 5588, XP002992943, ISSN: 0027-8424 *
RAFII SHAHIN ET AL: "Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 9, no. 6, June 2003 (2003-06-01), pages 702 - 712, XP002351665, ISSN: 1078-8956 *
WANG H U ET AL: "Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin - B2 and its receptor Eph - B4 [see comments]", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 93, no. 5, 29 May 1998 (1998-05-29), pages 741 - 753, XP002120944, ISSN: 0092-8674 *
WANG Z ET AL: "Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 103, no. 1, 4 September 2003 (2003-09-04), pages 100 - 109, XP002385074, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
WO2008081116A2 (fr) 2008-07-10
JP5390394B2 (ja) 2014-01-15
FR2909559A1 (fr) 2008-06-13
CN101600446B (zh) 2013-04-24
BRPI0719910A2 (pt) 2014-03-04
EP2101795A2 (fr) 2009-09-23
AU2007341179A1 (en) 2008-07-10
CA2670654A1 (fr) 2008-07-10
AU2007341179B2 (en) 2013-07-18
CN101600446A (zh) 2009-12-09
JP2014039560A (ja) 2014-03-06
JP2010511399A (ja) 2010-04-15
FR2909559B1 (fr) 2012-09-07
US20100086524A1 (en) 2010-04-08
IL199148A (en) 2014-07-31

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