WO2008079326A3 - Procédés d'utilisation et d'identification de modulateurs de dll4 - Google Patents

Procédés d'utilisation et d'identification de modulateurs de dll4 Download PDF

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Publication number
WO2008079326A3
WO2008079326A3 PCT/US2007/026149 US2007026149W WO2008079326A3 WO 2008079326 A3 WO2008079326 A3 WO 2008079326A3 US 2007026149 W US2007026149 W US 2007026149W WO 2008079326 A3 WO2008079326 A3 WO 2008079326A3
Authority
WO
WIPO (PCT)
Prior art keywords
delta
methods
identifying modulators
identifying
modulators
Prior art date
Application number
PCT/US2007/026149
Other languages
English (en)
Other versions
WO2008079326A2 (fr
Inventor
Parkash Gill
Ren Liu
Valery Krasnoperov
Original Assignee
Vasgene Therapeutics Inc
Parkash Gill
Ren Liu
Valery Krasnoperov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vasgene Therapeutics Inc, Parkash Gill, Ren Liu, Valery Krasnoperov filed Critical Vasgene Therapeutics Inc
Priority to AU2007338734A priority Critical patent/AU2007338734A1/en
Priority to EP07853456A priority patent/EP2120996A2/fr
Publication of WO2008079326A2 publication Critical patent/WO2008079326A2/fr
Publication of WO2008079326A3 publication Critical patent/WO2008079326A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne pour certains modes de réalisation des procédés d'identification et d'utilisation d'agonistes et d'antagonistes de la signalisation Dll4 (Delta-like 4).
PCT/US2007/026149 2006-12-20 2007-12-20 Procédés d'utilisation et d'identification de modulateurs de dll4 WO2008079326A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2007338734A AU2007338734A1 (en) 2006-12-20 2007-12-20 Methods for using and identifying modulators of delta-like 4
EP07853456A EP2120996A2 (fr) 2006-12-20 2007-12-20 Procédés d'utilisation et d'identification de modulateurs de dll4

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87644406P 2006-12-20 2006-12-20
US60/876,444 2006-12-20
US90175407P 2007-02-16 2007-02-16
US60/901,754 2007-02-16

Publications (2)

Publication Number Publication Date
WO2008079326A2 WO2008079326A2 (fr) 2008-07-03
WO2008079326A3 true WO2008079326A3 (fr) 2008-10-30

Family

ID=39311083

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/026149 WO2008079326A2 (fr) 2006-12-20 2007-12-20 Procédés d'utilisation et d'identification de modulateurs de dll4

Country Status (3)

Country Link
EP (1) EP2120996A2 (fr)
AU (1) AU2007338734A1 (fr)
WO (1) WO2008079326A2 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906116B2 (en) 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
EP3357932A1 (fr) 2006-09-29 2018-08-08 OncoMed Pharmaceuticals, Inc. Compositions et procédés de diagnostic et de traitement de cancer
KR20110014607A (ko) 2008-04-29 2011-02-11 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
NZ589434A (en) 2008-06-03 2012-11-30 Abbott Lab Dual variable domain immunoglobulins and uses thereof
EP2297208A4 (fr) 2008-06-03 2012-07-11 Abbott Lab Immunoglobulines à double domaine variable et leurs utilisations
PL2307459T3 (pl) 2008-07-08 2015-05-29 Oncomed Pharm Inc Czynniki wiążące receptor Notch1 i sposoby ich stosowania
CA2729949A1 (fr) 2008-07-08 2010-01-14 Abbott Laboratories Immunoglobulines a double domaine variable de prostaglandine e2 et leurs utilisations
BR112012004710A2 (pt) 2009-09-01 2016-08-16 Abbott Lab imunoglobulinas de domínio variável duplo e uso das mesmas
MX2012004415A (es) 2009-10-15 2012-05-08 Abbott Lab Inmunoglobulinas de dominio variable doble y usos de las mismas.
HUE029661T2 (en) 2009-10-16 2017-03-28 Oncomed Pharm Inc A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
ES2561102T3 (es) 2010-01-13 2016-02-24 Oncomed Pharmaceuticals, Inc. Agentes de unión a Notch1 y procedimientos de uso de los mismos
AU2011285852B2 (en) 2010-08-03 2014-12-11 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
PE20140229A1 (es) 2010-08-26 2014-03-27 Abbvie Inc Inmunoglobulinas con dominio variable dual y usos de las mismas
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
ES2707580T3 (es) 2011-09-23 2019-04-04 Oncomed Pharm Inc Agentes de unión a VEGF/DLL4 y usos de los mismos
AU2012362326A1 (en) 2011-12-30 2014-07-24 Abbvie Inc. Dual variable domain immunoglobulins against IL-13 and/or IL-17
SG11201503412RA (en) 2012-11-01 2015-05-28 Abbvie Inc Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof
JP2016522793A (ja) 2013-03-15 2016-08-04 アッヴィ・インコーポレイテッド ＩＬ−１βおよび／またはＩＬ−１７に対して指向された二重特異的結合タンパク質
JP6827415B2 (ja) 2014-10-31 2021-02-10 メレオ バイオファーマ ５ インコーポレイテッド 疾患の処置のための併用療法
WO2016094881A2 (fr) 2014-12-11 2016-06-16 Abbvie Inc. Protéines de liaison à lrp-8
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
EP3353204B1 (fr) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Anticorps anti-vegf/dll4 bi-spécifique pour le traitement du cancer de l'ovaire résistant au platine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1004669A1 (fr) * 1997-05-14 2000-05-31 Asahi Kasei Kogyo Kabushiki Kaisha Nouvel inhibiteur de differentiation
WO2007070671A2 (fr) * 2005-12-16 2007-06-21 Regeneron Pharmaceuticals, Inc. Procedes therapeutiques pour l'inhibition de croissance tumorale avec des antagonistes dll4

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1004669A1 (fr) * 1997-05-14 2000-05-31 Asahi Kasei Kogyo Kabushiki Kaisha Nouvel inhibiteur de differentiation
WO2007070671A2 (fr) * 2005-12-16 2007-06-21 Regeneron Pharmaceuticals, Inc. Procedes therapeutiques pour l'inhibition de croissance tumorale avec des antagonistes dll4

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NOGUERA-TROISE IRENE ET AL: "Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.", NATURE 21 DEC 2006, vol. 444, no. 7122, 21 December 2006 (2006-12-21), pages 1032 - 1037, XP002489427, ISSN: 1476-4687 *
RIDGWAY JOHN ET AL: "Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.", NATURE 21 DEC 2006, vol. 444, no. 7122, 21 December 2006 (2006-12-21), pages 1083 - 1087, XP002489428, ISSN: 1476-4687 *

Also Published As

Publication number Publication date
WO2008079326A2 (fr) 2008-07-03
AU2007338734A1 (en) 2008-07-03
EP2120996A2 (fr) 2009-11-25

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