WO2008078453A1 - 血小板産生促進因子及びその利用 - Google Patents

血小板産生促進因子及びその利用 Download PDF

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Publication number
WO2008078453A1
WO2008078453A1 PCT/JP2007/071220 JP2007071220W WO2008078453A1 WO 2008078453 A1 WO2008078453 A1 WO 2008078453A1 JP 2007071220 W JP2007071220 W JP 2007071220W WO 2008078453 A1 WO2008078453 A1 WO 2008078453A1
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WIPO (PCT)
Prior art keywords
extract
production promoting
promoting factor
platelet production
general formula
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PCT/JP2007/071220
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English (en)
French (fr)
Inventor
Takahiro Sato
Ikuo Morita
Masato Shimizu
Shujiro Seo
Masamichi Watanabe
Masaru Uchida
Minoru Ono
Original Assignee
National University Corporation Tokyo Medical And Dental University
Tokiwa Phytochemical Co., Ltd.
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Application filed by National University Corporation Tokyo Medical And Dental University, Tokiwa Phytochemical Co., Ltd. filed Critical National University Corporation Tokyo Medical And Dental University
Priority to JP2008550984A priority Critical patent/JP5144540B2/ja
Publication of WO2008078453A1 publication Critical patent/WO2008078453A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/203—Unsaturated compounds containing keto groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Abstract

　本発明の目的は、巨核球系細胞における胞体突起形成又は血小板形成を効果的に促進することのできる新規な血小板産生促進因子を提供し、また、前記血小板産生促進因子を利用し、有用な医薬品等の組成物や各種方法を提供することにある。即ち本発明は、下記一般式（１）で示される化合物を、精製を行なっていない植物、動物、及び微生物の少なくともいずれかの抽出物における濃度よりも高濃度で含むことを特徴とする植物、動物、及び微生物の少なくともいずれかの抽出物乃至その処理物；下記一般式（１）で示される化合物；前記抽出物乃至その処理物、或いは前記化合物を含む医薬品等の組成物；前記抽出物乃至その処理物、或いは前記化合物を利用した各種方法である。
PCT/JP2007/071220 2006-12-27 2007-10-31 血小板産生促進因子及びその利用 WO2008078453A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008550984A JP5144540B2 (ja) 2006-12-27 2007-10-31 血小板産生促進因子及びその利用

Applications Claiming Priority (2)

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JP2006351681 2006-12-27
JP2006-351681 2006-12-27

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WO2008078453A1 true WO2008078453A1 (ja) 2008-07-03

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WO (1) WO2008078453A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015514129A (ja) * 2012-04-11 2015-05-18 バギ リサーチ リミテッド カワラタケ抽出物、生物学的に活性な化合物を単離する方法、およびその使用
WO2017131228A1 (ja) * 2016-01-29 2017-08-03 国立大学法人京都大学 血小板産生促進剤のスクリーニング方法
CN107353219A (zh) * 2017-07-25 2017-11-17 四川省农业科学院农产品加工研究所 一种玛咖酰胺化合物及其合成方法、应用
CN110461155A (zh) * 2017-03-14 2019-11-15 揖斐电株式会社 植物活化剂

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003073329A (ja) * 2001-09-04 2003-03-12 Kagome Co Ltd アルデヒドデヒドロゲナーゼ阻害剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003073329A (ja) * 2001-09-04 2003-03-12 Kagome Co Ltd アルデヒドデヒドロゲナーゼ阻害剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VOLLENWEIDER S. ET AL.: "Fatty acid ketodienes and fatty acid ketotrienes: Michael addition acceptors that accumulate in wounded and diseased Arabidopsis leaves", THE PLANT JOURNAL, vol. 24, no. 4, 2000, pages 467 - 476, XP003022687 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9861604B2 (en) 2012-04-11 2018-01-09 Bagi Research Limited Coriolus versicolor extracts, methods of isolating biologically-active compounds, and uses thereof
JP2015514129A (ja) * 2012-04-11 2015-05-18 バギ リサーチ リミテッド カワラタケ抽出物、生物学的に活性な化合物を単離する方法、およびその使用
JP7350246B2 (ja) 2016-01-29 2023-09-26 国立大学法人京都大学 血小板産生促進剤のスクリーニング方法
WO2017131228A1 (ja) * 2016-01-29 2017-08-03 国立大学法人京都大学 血小板産生促進剤のスクリーニング方法
US11977071B2 (en) 2016-01-29 2024-05-07 Kyoto University Method for screening for platelet production promoters
JPWO2017131228A1 (ja) * 2016-01-29 2018-11-22 国立大学法人京都大学 血小板産生促進剤のスクリーニング方法
EP3409774A4 (en) * 2016-01-29 2019-10-23 Kyoto University SCREENING PROCESS FOR PROMOTER OF THROMBOZYTE PRODUCTION
US11016083B2 (en) 2016-01-29 2021-05-25 Kyoto University Method for screening for platelet production promoters
CN110461155A (zh) * 2017-03-14 2019-11-15 揖斐电株式会社 植物活化剂
US11457627B2 (en) 2017-03-14 2022-10-04 Ibiden Co., Ltd. Plant activator
CN110461155B (zh) * 2017-03-14 2021-11-16 揖斐电株式会社 植物活化剂
EP3597039B1 (en) * 2017-03-14 2024-05-01 Ibiden Co., Ltd. Plant activator
CN107353219A (zh) * 2017-07-25 2017-11-17 四川省农业科学院农产品加工研究所 一种玛咖酰胺化合物及其合成方法、应用

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JP5144540B2 (ja) 2013-02-13

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