WO2008078362A1 - 抗腫瘍剤及びこれを含有する食品 - Google Patents

抗腫瘍剤及びこれを含有する食品 Download PDF

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Publication number
WO2008078362A1
WO2008078362A1 PCT/JP2006/325624 JP2006325624W WO2008078362A1 WO 2008078362 A1 WO2008078362 A1 WO 2008078362A1 JP 2006325624 W JP2006325624 W JP 2006325624W WO 2008078362 A1 WO2008078362 A1 WO 2008078362A1
Authority
WO
WIPO (PCT)
Prior art keywords
antitumor agent
same
food containing
nerigoside
bisdeoxynarciclasine
Prior art date
Application number
PCT/JP2006/325624
Other languages
English (en)
French (fr)
Inventor
Kuniaki Nerome
Original Assignee
The Institute Of Biological Resources
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Institute Of Biological Resources filed Critical The Institute Of Biological Resources
Priority to PCT/JP2006/325624 priority Critical patent/WO2008078362A1/ja
Publication of WO2008078362A1 publication Critical patent/WO2008078362A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

　ナリゴシド、オレアンドリゲニン　サルメントシド、オレアシドＡ、オレアンドリン、８β－ヒドロキシオドロシドＡ、ナルシクラシン、trans－ジヒドロナルシクラシン及びビスデオキシナルシクラシンからなる群から選ばれる少なくとも１種を含有する抗腫瘍剤を提供する。この抗腫瘍剤の有効成分は、キョウチクトウ及びショウキズイセンの抽出物から単離したものであり、優れた腫瘍治療効果を有し、副作用が少ないとの利点を有する。
PCT/JP2006/325624 2006-12-22 2006-12-22 抗腫瘍剤及びこれを含有する食品 WO2008078362A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2006/325624 WO2008078362A1 (ja) 2006-12-22 2006-12-22 抗腫瘍剤及びこれを含有する食品

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2006/325624 WO2008078362A1 (ja) 2006-12-22 2006-12-22 抗腫瘍剤及びこれを含有する食品

Publications (1)

Publication Number Publication Date
WO2008078362A1 true WO2008078362A1 (ja) 2008-07-03

Family

ID=39562161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2006/325624 WO2008078362A1 (ja) 2006-12-22 2006-12-22 抗腫瘍剤及びこれを含有する食品

Country Status (1)

Country Link
WO (1) WO2008078362A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102030796A (zh) * 2010-10-22 2011-04-27 贵州省中国科学院天然产物化学重点实验室 从夹竹桃中分离出的几种强心苷化合物及其应用
KR101099651B1 (ko) * 2008-10-24 2011-12-29 한국생명공학연구원 개상사화 추출물을 유효성분으로 함유하는 암 예방 및 치료용 또는 혈관신생 억제용 약학적 조성물
WO2012026641A1 (ko) 2010-08-27 2012-03-01 한국과학기술연구원 치매의 예방 또는 치료용 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6322025A (ja) * 1986-05-13 1988-01-29 フセイン・ジ−ヤ・オ−ゼル キョウチクトウ種抽出物からなる細胞増殖性疾患治療用組成物
WO2000047215A2 (en) * 1999-02-12 2000-08-17 Cellpath, Inc. Methods for anti-tumor therapy
JP2002526452A (ja) * 1998-09-24 2002-08-20 オゼル・ファーマスーティカルズ・インコーポレイテッド キョウチクトウ抽出物、その医薬組成物及びその調整方法
JP2005289963A (ja) * 2004-03-12 2005-10-20 Hokubu Norin Koto Gakko Koenkai 抗腫瘍剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6322025A (ja) * 1986-05-13 1988-01-29 フセイン・ジ−ヤ・オ−ゼル キョウチクトウ種抽出物からなる細胞増殖性疾患治療用組成物
JP2002526452A (ja) * 1998-09-24 2002-08-20 オゼル・ファーマスーティカルズ・インコーポレイテッド キョウチクトウ抽出物、その医薬組成物及びその調整方法
WO2000047215A2 (en) * 1999-02-12 2000-08-17 Cellpath, Inc. Methods for anti-tumor therapy
JP2005289963A (ja) * 2004-03-12 2005-10-20 Hokubu Norin Koto Gakko Koenkai 抗腫瘍剤

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ABE F. ET AL.: "Oleasides; Novel Cardenolides with an Unusual Framework in Nerium (Nerium 10)", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 27, no. 7, 1979, pages 1604 - 1610, XP003022700 *
ABE F. ET AL.: "Presence of Cardenolides and Ursolic acid from Oleander Leaves in Larvae and Frass of Daphnis Nerii", PHYTOCHEMISTRY, vol. 42, no. 1, 1996, pages 45 - 49, XP003023202 *
PETTIT G.R. ET AL.: "Antineoplastic Agents. 527. Synthesis of 7-Deoxynarcistatin, 7-Deoxy-trans-dihydronarcistatin, and trans-Dihydronarcistatin 1", JOURNAL OF NATURAL PRODUCTS, vol. 68, no. 2, 2005, pages 207 - 211, XP003022699 *
PETTIT G.R. ET AL.: "Antineoplastic Agents. 553. The Texas Grasshopper Brachystola magna", JOURNAL OF NATURAL PRODUCTS, vol. 68, no. 8, 2005, pages 1256 - 1258, XP003022698 *
YAMACUHI T. ET AL.: "Quantitative Variations in the Cardiac Glycosides of Oleander", PHYTOCHEMISTRY, vol. 22, no. 10, 1983, pages 2211 - 2214, XP003023201 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101099651B1 (ko) * 2008-10-24 2011-12-29 한국생명공학연구원 개상사화 추출물을 유효성분으로 함유하는 암 예방 및 치료용 또는 혈관신생 억제용 약학적 조성물
WO2012026641A1 (ko) 2010-08-27 2012-03-01 한국과학기술연구원 치매의 예방 또는 치료용 조성물
JP2013537560A (ja) * 2010-08-27 2013-10-03 コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー 認知症の予防または治療用組成物
CN102030796A (zh) * 2010-10-22 2011-04-27 贵州省中国科学院天然产物化学重点实验室 从夹竹桃中分离出的几种强心苷化合物及其应用

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