WO2008077201A1 - Composition à base d'huile naphtalénique - Google Patents

Composition à base d'huile naphtalénique Download PDF

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Publication number
WO2008077201A1
WO2008077201A1 PCT/AZ2006/000009 AZ2006000009W WO2008077201A1 WO 2008077201 A1 WO2008077201 A1 WO 2008077201A1 AZ 2006000009 W AZ2006000009 W AZ 2006000009W WO 2008077201 A1 WO2008077201 A1 WO 2008077201A1
Authority
WO
WIPO (PCT)
Prior art keywords
naphthalan
oil
white
extracts
mass
Prior art date
Application number
PCT/AZ2006/000009
Other languages
English (en)
Russian (ru)
Inventor
Mushvig Hasan Oglu Mirzoyev
Adil Mustafa Oglu Agaev
Ashraf Aliabbas Oglu Jafarov
Original Assignee
Mushvig Hasan Oglu Mirzoyev
Adil Mustafa Oglu Agaev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mushvig Hasan Oglu Mirzoyev, Adil Mustafa Oglu Agaev filed Critical Mushvig Hasan Oglu Mirzoyev
Priority to PCT/AZ2006/000009 priority Critical patent/WO2008077201A1/fr
Publication of WO2008077201A1 publication Critical patent/WO2008077201A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Definitions

  • the invention relates to the creation of tools for the treatment and prevention of skin diseases and inflammatory diseases of the musculoskeletal system, namely, medicinal compositions based on naphthalan oil.
  • Preparations based on naphthalan oil are divided into emulsions (liniment), suppositories, pastes and ointments.
  • Ointment is known on the basis of refined naphthalan oil, to which 1 part of boric acid, zinc oxide and wheat starch are added, the rest is naphthalan oil (9 parts). (one)
  • a known composition based on naphthalan oil and water (4) A known composition based on naphthalan oil and water (4).
  • a disadvantage of the known formulations is that with prolonged use, burning begins at the site of application of the drug, dry skin, folliculitis and a persistent oil smell.
  • the prototype of the claimed emulsion composition is liniment based on black refined Naftalan oil and emulsion base.
  • the prototype for the composition of the ointment is a composition based on refined naphthalan oil containing paraffin and petrolatum.
  • the objective of the invention is the creation of soft, without a specific oil smell, non-irritating skin compositions for the prevention and local treatment of inflammatory diseases, both skin and joints and muscles.
  • the problem is solved in that the composition based on naphthalan oil containing an emulsion base, according to the invention, contains dearomatized white naphthalan as naphthalan oil, and contains Ti, or T 2 emulsifier as an emulsion base, and additionally, aqueous extracts of medicinal plants in the following ratio of components mass%: dearomatized white naphthalan - 12.5-30; emulsifier - 3-7; water extracts of medicinal plants - the rest;
  • a composition based on naphthalan oil containing paraffin according to the invention contains dearomatized white naphthalan as naphthalan oil, and additionally, white medical vaseline, oil extracts of medicinal plants, in the following ratio of components, mass.
  • % dearomatized white naphthalan-15-45; oil extracts-2-6; paraffin-15-20, medical white petrolatum, the rest, while the medicinal plants for the water or oil extracts of the composition contain chamomile and / or geranium, and / or eucalyptus, and / or clove, and / or lavender, and / or a rose, and / or diphazium, and / or myrtle, and / or primrose.
  • the essence of the invention lies in the fact that medicinal compositions for the local treatment of inflammatory diseases of both joints and muscles and the epidermis, by introducing new ingredients within the claimed limits, their quantitative ratio ensures the activation of metabolic processes in the skin, normalizes blood circulation, and eliminates stagnation in areas of inflammation, accelerate the penetration of active therapeutic substances into the affected areas, while not causing an allergic background.
  • compositions have bactericidal properties.
  • Medicinal plants selected as ingredients of the proposed compositions were subjected to extraction in oil and in water.
  • Water extracts were prepared by four decantation with distilled water at a temperature not exceeding 60 0 C with constant stirring for 4 hours. If the total amount of plant extracts was introduced into the composition, then they were taken in equal amounts with constant stirring for 2 hours until a homogeneous mass was obtained. Oil extracts were prepared as follows: Dried medicinal plants were crushed and mixed in equal amounts, then the resulting mixture was poured with refined vegetable oil taken in a ratio of 1:10 and heated to 60 0 C with constant stirring for 2 hours. Then this mixture is insisted for 3 to 5 days in a dark, cool place. After that, the resulting oil extract is subjected filtering to remove suspended particles.
  • Dearomatized white naphthalan is a non-tarred, colorless oily fraction of naphthalan oil, consisting mainly of polycyclic naphthenic hydrocarbons. This oil fraction is used as a basis in compositions for the treatment and prevention of inflammatory processes of skin diseases and diseases of joints and muscles.
  • Emulsifier brand Ti (FS 42-1596-81), or T 2 (according to TU 18-17 / 05-67) which are introduced into the composition to create a strong and stable emulsion.
  • This product does not cause side effects on human skin, with T 1 HT 2 ,
  • the proposed composition can be used for a long time.
  • the lower limit When the lower limit is introduced into the composition of the emulsifier composition, it results in a heterogeneous and unstable emulsion, and above the claimed limit it is not advisable, since this ingredient is overused.
  • the below-mentioned limit is introduced into the composition of the oil extract, the consistency of the ointment deteriorates due to an increase in the paraffin content (the ointment becomes not elastic and hardens quickly), and when its content increases, it also leads to a deterioration in the overall composition, since the ointment becomes more fluid.
  • Medical Vaseline (GOST 3582-84) is introduced into the composition as a filler.
  • the positive effect is that in addition to the fact that the proposed composition can be used for massage, it can also be used for cosmetic purposes.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Selon l'invention, une composition à base d'huile naphtalénique comprend du 'naphtalane blanc' (du décahydronaphtalène) désaromatisé et comprend en tant que base d'émulsion un émulsifiant T1 ou T2, et de plus des extraits aqueux de plantes médicinales, avec un rapport de composants suivant, en % en poids : décahydronaphtalène désaromatisé 12,5 à 30, émulsifiant 3 à 7, extraits de plantes médicinales pour le reste. La composition à base d'huile naphtalénique contenant de la paraffine comprend du décahydronaphtalène désaromatisé et en outre de la vaseline blanche médicale, des extraits huileux de plantes médicinales, avec un rapport de composants suivant, en % en poids : décahydronaphtalène désaromatisé 15 à 45, extraits huileux 2 à 6, paraffine 15 à 20, la vaseline blanche médicale constituant le reste. En tant que plantes médicinales pour les extraits aqueux ou huileux on utilise la camomille et/ou le géranium et/ou l'eucalyptus et/ou la lavande et/ou la rose et/ou le diphasium et/ou le myrte et/ou la primevère.
PCT/AZ2006/000009 2006-12-27 2006-12-27 Composition à base d'huile naphtalénique WO2008077201A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/AZ2006/000009 WO2008077201A1 (fr) 2006-12-27 2006-12-27 Composition à base d'huile naphtalénique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/AZ2006/000009 WO2008077201A1 (fr) 2006-12-27 2006-12-27 Composition à base d'huile naphtalénique

Publications (1)

Publication Number Publication Date
WO2008077201A1 true WO2008077201A1 (fr) 2008-07-03

Family

ID=39562042

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AZ2006/000009 WO2008077201A1 (fr) 2006-12-27 2006-12-27 Composition à base d'huile naphtalénique

Country Status (1)

Country Link
WO (1) WO2008077201A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2460901A (en) * 2008-06-20 2009-12-23 Guy Richard Simon Preston Balm for use in the treatment of percussive injuries, grazes, cuts and burns

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2074730C1 (ru) * 1993-05-24 1997-03-10 Николай Яковлевич Костеша Мазь для лечения кожных заболеваний: экземы, псориаза, нейродермита
RU2135189C1 (ru) * 1999-01-19 1999-08-27 Фармацевтическое научно-производственное предприятие "Ретиноиды" (акционерное общество закрытого типа) Мягкая лекарственная форма, содержащая нафталанскую рафинированную нефть, и способ ее получения
RU2236860C2 (ru) * 2002-11-06 2004-09-27 Саидкадам Мубораккадамович Давляткадамов Мазь "ориен" болеутоляющего и противовоспалительного действия
RU2004115454A (ru) * 2004-05-21 2005-11-10 Дмитрий Васильевич Николенко (RU) Композиция (варианты) и способ лечения псориаза, экземы, нейродермита

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2074730C1 (ru) * 1993-05-24 1997-03-10 Николай Яковлевич Костеша Мазь для лечения кожных заболеваний: экземы, псориаза, нейродермита
RU2135189C1 (ru) * 1999-01-19 1999-08-27 Фармацевтическое научно-производственное предприятие "Ретиноиды" (акционерное общество закрытого типа) Мягкая лекарственная форма, содержащая нафталанскую рафинированную нефть, и способ ее получения
RU2236860C2 (ru) * 2002-11-06 2004-09-27 Саидкадам Мубораккадамович Давляткадамов Мазь "ориен" болеутоляющего и противовоспалительного действия
RU2004115454A (ru) * 2004-05-21 2005-11-10 Дмитрий Васильевич Николенко (RU) Композиция (варианты) и способ лечения псориаза, экземы, нейродермита

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2460901A (en) * 2008-06-20 2009-12-23 Guy Richard Simon Preston Balm for use in the treatment of percussive injuries, grazes, cuts and burns
GB2460901B (en) * 2008-06-20 2012-03-21 Guy Richard Simon Preston Balm

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