WO2008070358A3 - Inhibiteurs de la sérine protéase de l'hépatite c et utilisations de ceux-ci - Google Patents

Inhibiteurs de la sérine protéase de l'hépatite c et utilisations de ceux-ci Download PDF

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Publication number
WO2008070358A3
WO2008070358A3 PCT/US2007/083034 US2007083034W WO2008070358A3 WO 2008070358 A3 WO2008070358 A3 WO 2008070358A3 US 2007083034 W US2007083034 W US 2007083034W WO 2008070358 A3 WO2008070358 A3 WO 2008070358A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
tripeptidic
pyrrolopyrazine
pyrrolopyrimidine
pyrrolopyridine
Prior art date
Application number
PCT/US2007/083034
Other languages
English (en)
Other versions
WO2008070358A2 (fr
Inventor
David Alan Campbell
Michael E Hepperle
David T Winn
Juan Manuel Betancort
Original Assignee
Phenomix Corp
David Alan Campbell
Michael E Hepperle
David T Winn
Juan Manuel Betancort
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phenomix Corp, David Alan Campbell, Michael E Hepperle, David T Winn, Juan Manuel Betancort filed Critical Phenomix Corp
Publication of WO2008070358A2 publication Critical patent/WO2008070358A2/fr
Publication of WO2008070358A3 publication Critical patent/WO2008070358A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Abstract

La présente invention concerne de nouveaux composés qui miment des peptides avec une proline pénultième C-terminale, de tels composés étant utiles en tant qu'inhibiteurs de protéase, notamment en tant qu'inhibiteurs de sérine protéases, et plus particulièrement en tant qu'inhibiteurs de la sérine protéase NS3 du virus de l'hépatite C. Les composés trouvent une utilité en tant qu'agents antiviraux destinés à l'hépatite C. L'invention propose en outre des procédés d'utilisation de tels inhibiteurs, seuls ou en combinaison avec d'autres agents thérapeutiques, pour traiter une infection par l'hépatite C chez un sujet en besoin d'un tel traitement.
PCT/US2007/083034 2006-11-16 2007-10-30 Inhibiteurs de la sérine protéase de l'hépatite c et utilisations de ceux-ci WO2008070358A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85943306P 2006-11-16 2006-11-16
US60/859,433 2006-11-16
US88459207P 2007-01-11 2007-01-11
US60/884,592 2007-01-11

Publications (2)

Publication Number Publication Date
WO2008070358A2 WO2008070358A2 (fr) 2008-06-12
WO2008070358A3 true WO2008070358A3 (fr) 2008-11-06

Family

ID=39492946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/083034 WO2008070358A2 (fr) 2006-11-16 2007-10-30 Inhibiteurs de la sérine protéase de l'hépatite c et utilisations de ceux-ci

Country Status (1)

Country Link
WO (1) WO2008070358A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN102159245B (zh) * 2008-09-17 2013-07-24 贝林格尔.英格海姆国际有限公司 Hcv ns3蛋白酶抑制剂与干扰素和利巴韦林的组合

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* Cited by examiner, † Cited by third party
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MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
TW201040181A (en) 2009-04-08 2010-11-16 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
WO2011017389A1 (fr) 2009-08-05 2011-02-10 Idenix Pharmaceuticals, Inc. Inhibiteurs macrocycliques de la sérine protéase macrocyclique utiles contre les infections virales, en particulier le virus de l’hépatite c
KR20120106942A (ko) * 2009-10-30 2012-09-27 베링거 인겔하임 인터내셔날 게엠베하 Ｂｉ２０１３３５, 인터페론 알파 및 리바비린을 포함하는 ｈｃｖ 병용 치료요법을 위한 투여 용법
WO2012109398A1 (fr) 2011-02-10 2012-08-16 Idenix Pharmaceuticals, Inc. Inhibiteurs macrocycliques de sérine protéase, compositions pharmaceutiques les contenant et leur utilisation pour le traitement des infections par le vhc
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2725012A1 (fr) * 2011-06-21 2014-04-30 Mitsubishi Gas Chemical Company, Inc. Amide d'acide 1-amino-2-vinyl cyclopropane carboxylique, sel de celui-ci et son procédé de fabrication
PT2909205T (pt) 2012-10-19 2017-02-06 Bristol Myers Squibb Co Derivados de carbamato de hexadecahidrociclopropa(e)pirrolo(1,2- a)(1,4)diazaciclopentadecinilo substituídos com 9-metilo como inibidores da protease não estrutural 3 (ns3) para o tratamento de infeções por vírus da hepatite c
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9409943B2 (en) 2012-11-05 2016-08-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP6342922B2 (ja) 2013-03-07 2018-06-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
CN103408559B (zh) * 2013-08-08 2016-06-29 南京大学 一种喜树碱及其衍生物的快速合成方法

Citations (16)

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WO2002060926A2 (fr) * 2000-11-20 2002-08-08 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2003064416A1 (fr) * 2002-02-01 2003-08-07 Boehringer Ingelheim International Gmbh Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c
WO2003099274A1 (fr) * 2002-05-20 2003-12-04 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2004101605A1 (fr) * 2003-03-05 2004-11-25 Boehringer Ingelheim International Gmbh Composes d'inhibition de l'hepatite c
WO2004103996A1 (fr) * 2003-05-21 2004-12-02 Boehringer Ingelheim International Gmbh Composes inhibiteurs de l'hepatite c
WO2005051410A1 (fr) * 2003-11-20 2005-06-09 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2006020276A2 (fr) * 2004-07-16 2006-02-23 Gilead Sciences, Inc. Composés antiviraux
WO2006086381A2 (fr) * 2005-02-08 2006-08-17 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2006122188A2 (fr) * 2005-05-10 2006-11-16 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2007008657A2 (fr) * 2005-07-11 2007-01-18 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2007015824A2 (fr) * 2005-07-25 2007-02-08 Intermune, Inc. Nouveaux inhibiteurs macrocycliques de la multiplication du virus de l’hépatite c
WO2007014919A1 (fr) * 2005-07-29 2007-02-08 Tibotec Pharmaceuticals Ltd. Inhibiteurs macrocycliques du virus de l'hépatite c
WO2007146695A1 (fr) * 2006-06-06 2007-12-21 Enanta Pharmaceuticals, Inc. Inhibiteurs oximyle acycliques de protéase de l'hépatite c
WO2008005511A2 (fr) * 2006-07-05 2008-01-10 Intermune, Inc. Nouveaux inhibiteurs de la réplication du virus de l'hépatite c
WO2008008776A2 (fr) * 2006-07-11 2008-01-17 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
WO2008021956A2 (fr) * 2006-08-11 2008-02-21 Enanta Pharmaceuticals, Inc. Inhibiteurs d'acylamino-hétéroaryle de la protéase du virus de l'hépatite c

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060926A2 (fr) * 2000-11-20 2002-08-08 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2003064416A1 (fr) * 2002-02-01 2003-08-07 Boehringer Ingelheim International Gmbh Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c
WO2003099274A1 (fr) * 2002-05-20 2003-12-04 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2004101605A1 (fr) * 2003-03-05 2004-11-25 Boehringer Ingelheim International Gmbh Composes d'inhibition de l'hepatite c
WO2004103996A1 (fr) * 2003-05-21 2004-12-02 Boehringer Ingelheim International Gmbh Composes inhibiteurs de l'hepatite c
WO2005051410A1 (fr) * 2003-11-20 2005-06-09 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2006020276A2 (fr) * 2004-07-16 2006-02-23 Gilead Sciences, Inc. Composés antiviraux
WO2006086381A2 (fr) * 2005-02-08 2006-08-17 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2006122188A2 (fr) * 2005-05-10 2006-11-16 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2007008657A2 (fr) * 2005-07-11 2007-01-18 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2007015824A2 (fr) * 2005-07-25 2007-02-08 Intermune, Inc. Nouveaux inhibiteurs macrocycliques de la multiplication du virus de l’hépatite c
WO2007014919A1 (fr) * 2005-07-29 2007-02-08 Tibotec Pharmaceuticals Ltd. Inhibiteurs macrocycliques du virus de l'hépatite c
WO2007146695A1 (fr) * 2006-06-06 2007-12-21 Enanta Pharmaceuticals, Inc. Inhibiteurs oximyle acycliques de protéase de l'hépatite c
WO2008005511A2 (fr) * 2006-07-05 2008-01-10 Intermune, Inc. Nouveaux inhibiteurs de la réplication du virus de l'hépatite c
WO2008008776A2 (fr) * 2006-07-11 2008-01-17 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
WO2008021956A2 (fr) * 2006-08-11 2008-02-21 Enanta Pharmaceuticals, Inc. Inhibiteurs d'acylamino-hétéroaryle de la protéase du virus de l'hépatite c

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102159245B (zh) * 2008-09-17 2013-07-24 贝林格尔.英格海姆国际有限公司 Hcv ns3蛋白酶抑制剂与干扰素和利巴韦林的组合

Also Published As

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