WO2008067711A1 - Composés à structure du cycle à 4 éléments substitués et leurs utilisations en tant que médicament - Google Patents

Composés à structure du cycle à 4 éléments substitués et leurs utilisations en tant que médicament Download PDF

Info

Publication number
WO2008067711A1
WO2008067711A1 PCT/CN2007/002959 CN2007002959W WO2008067711A1 WO 2008067711 A1 WO2008067711 A1 WO 2008067711A1 CN 2007002959 W CN2007002959 W CN 2007002959W WO 2008067711 A1 WO2008067711 A1 WO 2008067711A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
substituted
halogen atom
alkoxy
amide
Prior art date
Application number
PCT/CN2007/002959
Other languages
English (en)
Chinese (zh)
Inventor
Mingwei Wang
Desu Chen
Na Li
Qing Liu
Jiayu Liao
Original Assignee
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences filed Critical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
Publication of WO2008067711A1 publication Critical patent/WO2008067711A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés à structure de cycle à 4 éléments substitués représentés par la formule générale I ou la formule générale II, ou des sels, des esters, des solvates, des complexes métalliques de ceux-ci acceptables sur le plan pharmaceutique, ou des promédicaments possédant la même action pharmacologique. Elle concerne également leur utilisation en tant que type de régulateurs d'accepteurs de glucagons-1 dans la prévention et/ou le traitement de troubles métaboliques (notamment, mais sans s'y limiter, le diabète, la résistance à l'insuline et l'adipose), de l'angiocardiopathie, de maladies neurodégénératives (telles que la maladie d'Alzheimer).
PCT/CN2007/002959 2006-12-05 2007-10-16 Composés à structure du cycle à 4 éléments substitués et leurs utilisations en tant que médicament WO2008067711A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200610119109.2 2006-12-05
CN2006101191092A CN101195613B (zh) 2006-12-05 2006-12-05 一类具有取代四元环结构的化合物及其医学用途

Publications (1)

Publication Number Publication Date
WO2008067711A1 true WO2008067711A1 (fr) 2008-06-12

Family

ID=39491650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2007/002959 WO2008067711A1 (fr) 2006-12-05 2007-10-16 Composés à structure du cycle à 4 éléments substitués et leurs utilisations en tant que médicament

Country Status (2)

Country Link
CN (1) CN101195613B (fr)
WO (1) WO2008067711A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101195612B (zh) * 2006-12-05 2012-08-08 中国科学院上海药物研究所 一类具有取代环丁烷结构的化合物、及其制备方法和医学用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1626521A (zh) * 2003-12-12 2005-06-15 中国科学院上海药物研究所 一类胰高血糖样肽－1 受体激动剂及其制备方法和用途
CN1884278A (zh) * 2005-06-24 2006-12-27 中国科学院上海药物研究所 一类胰高血糖样肽－1受体调节剂、制备方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101195612B (zh) * 2006-12-05 2012-08-08 中国科学院上海药物研究所 一类具有取代环丁烷结构的化合物、及其制备方法和医学用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1626521A (zh) * 2003-12-12 2005-06-15 中国科学院上海药物研究所 一类胰高血糖样肽－1 受体激动剂及其制备方法和用途
CN1884278A (zh) * 2005-06-24 2006-12-27 中国科学院上海药物研究所 一类胰高血糖样肽－1受体调节剂、制备方法和用途

Also Published As

Publication number Publication date
CN101195613A (zh) 2008-06-11
CN101195613B (zh) 2012-08-08

Similar Documents

Publication Publication Date Title
WO2008119238A1 (fr) Composés hétérocycliques substitués à cinq éléments, leur méthode de préparation et leur utilisation en médecine
US9458118B2 (en) Sodium channel modulators for the treatment of pain and diabetes
WO2009129696A1 (fr) Type de modulateurs positifs de transduction de signalisation de récepteur, procédés de préparation et utilisations de ceux-ci
Liu et al. Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor
JP2018510866A (ja) 腸受容体を活性化させるための、ファルネソイドｘ受容体アゴニストでの、成体の潜在性自己免疫性糖尿病の治療
JPWO2008139879A1 (ja) Ｇ蛋白質共役型レセプター抑制剤および医薬
JP2007537434A (ja) 機能的ｇｈｓ−ｒアンタゴニスト
CA2613155C (fr) Regulateurs de recepteurs de peptide-1 de type glucagon, procedes de preparation et d'utilisation de ceux-ci
US9504675B2 (en) Alpha-ketoheterocycles and methods of making and using
WO2008067711A1 (fr) Composés à structure du cycle à 4 éléments substitués et leurs utilisations en tant que médicament
Tang et al. Structure–activity relationship and hypoglycemic activity of tricyclic matrines with advantage of treating diabetic nephropathy
EP2668951B1 (fr) Dérivés de 1,2,4-oxadiazol utilisés en tant que médicaments modulateurs du récepteur pour le peptide glp-1
WO2008067709A1 (fr) Composés de cyclobutane substitués, procédés de préparation et leurs utilisations pharmaceutiques
WO2008067712A1 (fr) Composés à structure de cyclopentane, procédé de préparation et utilisations médicales de ceux-ci
WO2008067713A1 (fr) Composés à structure de cyclopentane, leurs procédés de préparation et leurs utilisations médicales
JP2000500490A (ja) 糖尿病治療用の４−ヒドロキシクマリン−３−カルボキシアミド
CN112745319B (zh) 一类取代三环结构的化合物、其制备方法及用途
CN115304604B (zh) 一种双靶点西格列汀衍生物
WO2008067710A1 (fr) Composés de cyclohexane substitués, procédés de préparation et utilisations médicales correspondants
CN115246816B (zh) 一种双靶点阿格列汀衍生物
TW202342014A (zh) １，３－苯并二氧戊環衍生物
WO2008119248A1 (fr) Méthode de préparation d'une réaction photochimique de composés cycliques à quatre éléments
WO2007009353A1 (fr) Composes thiazol-4-one substitues, leurs procedes de fabrication et leur utilisation

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07816573

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07816573

Country of ref document: EP

Kind code of ref document: A1