WO2008065544A3 - Prédicteurs génétiques d'un risque de diabète sucré de type 2 - Google Patents
Prédicteurs génétiques d'un risque de diabète sucré de type 2 Download PDFInfo
- Publication number
- WO2008065544A3 WO2008065544A3 PCT/IB2007/004361 IB2007004361W WO2008065544A3 WO 2008065544 A3 WO2008065544 A3 WO 2008065544A3 IB 2007004361 W IB2007004361 W IB 2007004361W WO 2008065544 A3 WO2008065544 A3 WO 2008065544A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- risk
- type
- diabetes mellitus
- t2dm
- genetic predictors
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention concerne des procédés d'analyse d'individus étant à risque pour le développement d'un diabète sucré de Type 2 (T2DM). Des acides nucléiques obtenus à partir d'échantillons biologiques d'individus souffrant de T2DM ont été analysés et des SNP associés aux gènes de T2DM ont été découverts. De plus, des SNP en déséquilibre de liaison avec des gènes de T2DM sont décrits.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84358606P | 2006-09-11 | 2006-09-11 | |
US60/843,586 | 2006-09-11 |
Publications (2)
Publication Number | Publication Date |
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WO2008065544A2 WO2008065544A2 (fr) | 2008-06-05 |
WO2008065544A3 true WO2008065544A3 (fr) | 2009-03-19 |
Family
ID=39468332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2007/004361 WO2008065544A2 (fr) | 2006-09-11 | 2007-09-11 | Prédicteurs génétiques d'un risque de diabète sucré de type 2 |
Country Status (1)
Country | Link |
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WO (1) | WO2008065544A2 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2493916B1 (fr) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Marqueurs associés avec des tumeurs pulmonaires et leur utilisation |
EP2494351B1 (fr) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Marqueurs de tumeurs du rectum et du côlon, et leurs méthodes d'utilisation |
EP2494361B2 (fr) | 2009-10-26 | 2019-01-09 | Externautics S.p.A. | Marqueurs de tumeurs des ovaires et leurs méthodes d'utilisation |
CN104395479B (zh) * | 2012-01-27 | 2019-03-15 | 香港中文大学 | 糖尿病的生物标志物 |
BR112022017770A2 (pt) * | 2020-03-06 | 2022-11-29 | Denovo Biopharma Llc | Polinucleotídeo isolado; painel de polinucleotídeos isolados; kit que compreende o polinucleotídeo isolado ou painel; microarranjo; reagente; kit que compreende o reagente; kit que compreende o polinucleotídeo isolado ou painel; método de diagnóstico complementar; método para classificar um indivíduo para elegibilidade para um tratamento; método para rastrear um indivíduo ou uma população de indivíduos para um tratamento; método para monitorar um indivíduo durante um tratamento; método para identificar um alvo de fármaco; método para o tratamento de doença ou transtorno do sistema nervoso central (snc) em um indivíduo; uso |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004042358A2 (fr) * | 2002-11-01 | 2004-05-21 | Decode Genetics Ehf. | Gene slit-3 du diabete de type ii humain situe sur le chromosome 5q35 |
FR2847263A1 (fr) * | 2002-11-18 | 2004-05-21 | Commissariat Energie Atomique | Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans |
US20050147987A1 (en) * | 2000-09-08 | 2005-07-07 | Applera Corporation (Ny) | Polymorphisms in known genes associated with type II diabetes and obesity, methods of detection and uses thereof |
WO2006022634A1 (fr) * | 2004-07-22 | 2006-03-02 | Sequenom, Inc. | Méthodes d’identification du risque d’apparition de diabètes de type ii et traitements associés |
WO2008065682A2 (fr) * | 2006-11-30 | 2008-06-05 | Decode Genetics Ehf. | Variantes génétiques de susceptibilité au diabète mellitus de type 2 |
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2007
- 2007-09-11 WO PCT/IB2007/004361 patent/WO2008065544A2/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050147987A1 (en) * | 2000-09-08 | 2005-07-07 | Applera Corporation (Ny) | Polymorphisms in known genes associated with type II diabetes and obesity, methods of detection and uses thereof |
WO2004042358A2 (fr) * | 2002-11-01 | 2004-05-21 | Decode Genetics Ehf. | Gene slit-3 du diabete de type ii humain situe sur le chromosome 5q35 |
FR2847263A1 (fr) * | 2002-11-18 | 2004-05-21 | Commissariat Energie Atomique | Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans |
WO2006022634A1 (fr) * | 2004-07-22 | 2006-03-02 | Sequenom, Inc. | Méthodes d’identification du risque d’apparition de diabètes de type ii et traitements associés |
WO2008065682A2 (fr) * | 2006-11-30 | 2008-06-05 | Decode Genetics Ehf. | Variantes génétiques de susceptibilité au diabète mellitus de type 2 |
Non-Patent Citations (10)
Title |
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DATABASE ENTREZ PROTEIN [online] NCBI; 18 May 2005 (2005-05-18), "CAH72347. Reports calmodulin bindin...[gi:55665770]", XP002497998, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ENTREZ/VIEWER.FCGI?DB=PROTEIN Database accession no. 55665770 * |
DATABASE ENTREZ PROTEIN [online] NCBI; 7 May 2008 (2008-05-07), "CAH72347. Reports calmodulin bindin...[gi:55665770]", XP002497997, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ENTREZ/VIEWER.FCGI?DB=PROTEIN Database accession no. 55665770 * |
DATABASE PROBE [online] ncbi; 22 February 2006 (2006-02-22), "rs13266634", XP002509338, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. Pr003758580.1 * |
DATABASE SNP [online] NCBI; 10 October 2003 (2003-10-10), "rs1193179", XP002497772, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. rs1193179 * |
DATABASE SNP [online] NCBI; 13 September 2004 (2004-09-13), "rs3266634", XP002509337, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. rs13266634 * |
DIABETES GENETICS INITIATIVE OF BROAD INSTITUTE OF HARVARD AND MIT, LUND UNIVERSITY, AND NOVARTIS INSTITUTES OF BIOMEDICAL RESEARC: "Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.", SCIENCE (NEW YORK, N.Y.) 1 JUN 2007, vol. 316, no. 5829, 1 June 2007 (2007-06-01), pages 1331 - 1336, XP002509336, ISSN: 1095-9203 * |
GRANT STRUAN F A ET AL: "Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, vol. 38, no. 3, 1 March 2006 (2006-03-01), pages 320 - 323, XP009096714, ISSN: 1061-4036 * |
KANG EUN SEOK ET AL: "The influence of adiponectin gene polymorphism on the rosiglitazone response in patients with type 2 diabetes.", May 2005, DIABETES CARE MAY 2005, VOL. 28, NR. 5, PAGE(S) 1139 - 1144, ISSN: 0149-5992, XP002496473 * |
SLADEK ROBERT ET AL: "A genome-wide association study identifies novel risk loci for type 2 diabetes", NATURE, NATURE PUBLISHING GROUP, LONDON, UK, vol. 445, no. 7130, 22 February 2007 (2007-02-22), pages 881 - 885, XP002465137, ISSN: 0028-0836 * |
STEPHANE CAUCHI ET AL: "Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study", 22 January 2008, JOURNAL OF MOLECULAR MEDICINE, SPRINGER, BERLIN, DE, PAGE(S) 341 - 348, ISSN: 1432-1440, XP019576423 * |
Also Published As
Publication number | Publication date |
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WO2008065544A2 (fr) | 2008-06-05 |
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