WO2008059068A3 - Carbonyl-substituierte titanocene - Google Patents

Carbonyl-substituierte titanocene Download PDF

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Publication number
WO2008059068A3
WO2008059068A3 PCT/EP2007/062511 EP2007062511W WO2008059068A3 WO 2008059068 A3 WO2008059068 A3 WO 2008059068A3 EP 2007062511 W EP2007062511 W EP 2007062511W WO 2008059068 A3 WO2008059068 A3 WO 2008059068A3
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WIPO (PCT)
Prior art keywords
substituted
unsaturated
cyclic
branched
saturated
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Application number
PCT/EP2007/062511
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English (en)
French (fr)
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WO2008059068A2 (de
Inventor
Aram Prokop
Anja Selig
Andreas Gansaeuer
Dieter Franke
Original Assignee
Charite Universitaetsmedizin
Univ Bonn
Aram Prokop
Anja Selig
Andreas Gansaeuer
Dieter Franke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Charite Universitaetsmedizin, Univ Bonn, Aram Prokop, Anja Selig, Andreas Gansaeuer, Dieter Franke filed Critical Charite Universitaetsmedizin
Publication of WO2008059068A2 publication Critical patent/WO2008059068A2/de
Publication of WO2008059068A3 publication Critical patent/WO2008059068A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Arzneimittel enthaltend eine Verbindung der folgenden Formel (Ia) oder (Ib) wobei Z ausgewählt ist aus der Gruppe bestehend aus einer kovalenten Bindung, mindestens einem mindestens zweiwertigen Heteroatom, einer gesättigten, ungesättigten, verzweigten, unverzweigten und/oder cyclischen, substituierten oder unsubstituierten Kohlenwasserstoffkette, einer mit Heteroatomen in der Kette versehenen gesättigten oder ungesättigten, verzweigten, unverzweigten und/oder cyclischen, substituierten oder unsubstituierten Kohlenwasserstoffkette oder Kombinationen davon, R`1 bis R`4 sowie R``1 bis R``5 jeweils unabhängig voneinander H, mindestens ein Heteroatom, eine gesättigte, ungesättigte, verzweigte, unverzweigte und/oder cyclische, substituierte oder unsubstituierte Kohlenwasserstoffkette, eine mit Heteroatomen in der Kette versehene gesättigte oder ungesättigte, verzweigte, unverzweigte und/oder cyclische, substituierte oder unsubstituierte Kohlenwasserstoffkette oder Kombinationen davon bedeuten, die beiden Cyclopentadienylringe gegebenenfalls über irgendeinen der Reste R``1 bis R``5 verknüpft sind, R1 und R2 jeweils unabhängig voneinander H, ein Heteroatom, eine gesättigte, ungesättigte, verzweigte, unverzweigte und/oder cyclische, substituierte oder unsubstituierte Kohlenwasserstoffkette, eine mit Heteroatomen in der Kette versehene gesättigte oder ungesättigte, verzweigte, unverzweigte und/oder cyclische, substituierte oder unsubstituierte Kohlenwasserstoffkette oder Kombinationen davon bedeuten, A`, A`` jeweils unabhängig voneinander, F, Cl, Br, I, und/oder ein physiologisch verträglicher Säurerest einer organischen oder anorganischen Säure ist, n eine positive ganze Zahl, insbesondere 1, 2, 3 ist, X = O, S, NH, NR3, NR4R5 ist, wobei R3, R4 und R5 jeweils unabhängig voneinander die für R`1 bis R`4 genannten Bedeutungen haben, Y = eine kovalente Bindung, O, S, oder NR6 ist, wobei R6 die für R`1 bis R`4 genannte Bedeutung hat.
PCT/EP2007/062511 2006-11-17 2007-11-19 Carbonyl-substituierte titanocene WO2008059068A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006054690.3 2006-11-17
DE102006054690A DE102006054690A1 (de) 2006-11-17 2006-11-17 Carbonyl-substituierte Titanocene

Publications (2)

Publication Number Publication Date
WO2008059068A2 WO2008059068A2 (de) 2008-05-22
WO2008059068A3 true WO2008059068A3 (de) 2008-07-31

Family

ID=39145202

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PCT/EP2007/062511 WO2008059068A2 (de) 2006-11-17 2007-11-19 Carbonyl-substituierte titanocene

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US (1) US20090005338A1 (de)
DE (1) DE102006054690A1 (de)
WO (1) WO2008059068A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010007097A1 (de) * 2010-02-06 2011-08-11 Matteo Scabini Konjugate aus [F-18]-Traegern mit bioaktiven, organischen Verbindungen und deren Darstellung
EP2774930A1 (de) 2013-03-07 2014-09-10 Aptenia S.R.L. Metallocenverbindungen und markierte Moleküle damit für In-vivo-Bildgebung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0202673A2 (de) * 1985-05-22 1986-11-26 Petra Prof. Dr. Köpf-Maier Cytostatisch wirksame Titanocen-Komplexe
JPS62246939A (ja) * 1986-04-21 1987-10-28 Toray Ind Inc 二軸延伸ポリエステルフイルム

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL102866A (en) * 1992-08-19 1998-08-16 Technion Res & Dev Foundation Metallocenes as anti-tumor drugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0202673A2 (de) * 1985-05-22 1986-11-26 Petra Prof. Dr. Köpf-Maier Cytostatisch wirksame Titanocen-Komplexe
JPS62246939A (ja) * 1986-04-21 1987-10-28 Toray Ind Inc 二軸延伸ポリエステルフイルム

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OKAZAKI, IWAO ET AL: "Biaxially stretched polyester films for magnetic tapes", XP007904671, retrieved from STN Database accession no. 1988:113844 *
STROOT J ET AL: "Reactions of pentafulvene complexes of titanium with nitriles and iso-nitriles - Synthesis and isomerizations of .sigma.,.pi.-chelate complexes with Cp.apprx.N-ligands", ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, VERLAG JOHANN AMBROSIUS BARTH. LEIPZIG, DD, vol. 628, no. 4, 1 January 2002 (2002-01-01), pages 755 - 761, XP008089084, ISSN: 0044-2313 *

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WO2008059068A2 (de) 2008-05-22
US20090005338A1 (en) 2009-01-01
DE102006054690A1 (de) 2008-05-21

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