WO2008055709A1 - Dérivés indoles et indazoles en tant qu'agents anti-inflammatoires - Google Patents

Dérivés indoles et indazoles en tant qu'agents anti-inflammatoires Download PDF

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Publication number
WO2008055709A1
WO2008055709A1 PCT/EP2007/009912 EP2007009912W WO2008055709A1 WO 2008055709 A1 WO2008055709 A1 WO 2008055709A1 EP 2007009912 W EP2007009912 W EP 2007009912W WO 2008055709 A1 WO2008055709 A1 WO 2008055709A1
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WO
WIPO (PCT)
Prior art keywords
group
alkyl
fluoropyridin
chloro
phenyl
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PCT/EP2007/009912
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English (en)
Inventor
Markus Berger
Hartmut Rehwinkel
Heike Schaecke
Matti Lepisto
Karl Edmann
Original Assignee
Bayer Schering Pharma Aktiengesellschaft
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06090204A external-priority patent/EP1921068A1/fr
Application filed by Bayer Schering Pharma Aktiengesellschaft, Astrazeneca Ab filed Critical Bayer Schering Pharma Aktiengesellschaft
Publication of WO2008055709A1 publication Critical patent/WO2008055709A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Definitions

  • the present invention relates to compounds of formula I, a process for their production and their use as anti-inflammatory agents.
  • anti-inflammatory agents of the following general formula
  • the Ar radical comprises phthalides, thiophthalides, benzoxazinones or phthalazinones.
  • these compounds show dissociations of action between anti-inflammatory and undesirable metabolic actions and are superior to the previously described nonsteroidal glucocorticoids or exhibit at least just as good an action.
  • This invention therefore relates to stereoisomers of general formula I
  • B is selected from the group consisting of CH 2 and CO
  • Y is selected from the group consisting of CH and N
  • Ar is selected from the group consisting of a phenyl, a pyridinyl or a pyrimidinyl rest
  • Ar is not 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl,
  • R 1 , R 2 are independently selected from the group consisting of a hydrogen atom or a (d-C-O-alkyl group,
  • R 1 , R 2 together form a C 3 -C 6 cycloalkyl-ring
  • R 3 is selected from the group consisting of a phenyl, a pyrimidinyl and a pyridinyl rest
  • R 6 means hydrogen or CrC 4 -alkyl
  • R 4 is selected from the group consisting of hydrogen, halogen, cyano, nitro, hydroxy, or (Ci-C 5 )-alkyl, (CrC 5 )-halo-alkyl, (C r C 5 )alkoxy, (Ci-C 5 )halo- alkoxy and COOR 6 , in which R 6 has the above identified meaning.
  • alkyl refers to straight or branched derivatives.
  • propyl comprises "-propyl and /so -propyl
  • butyl comprises "-butyl, /so -butyl and tert -butyl.
  • haloalkyl refers to straight or branched alkyl derivatives in which at least one hydrogen is substituted by a halogen atom, preferably by a fluoro atom.
  • halopropyl comprises perfluoro- "-propyl and perfluoro' so -propyl, as well as 1-chloro propyl
  • haloethyl comprises 1-fluoroethyl, 2,2,2- trifluoroethyl, 1-chloroethyl and 2-chloroethyl.
  • alkoxy refers to straight or branched derivatives.
  • propoxy comprises "- propoxy and /so - propoxy
  • butoxy comrises "-butoxy, /so -butoxy and tert -butoxy.
  • halo alkoxy refers to straight or branched alkoxy derivatives in which at least one hydrogen is substituted by a halogen atom, preferably by a fluoro atom.
  • halopropoxy comprises perfluoro- "-propoxy and perfluoro' so -propoxy, as well as 1-chloropropoxy
  • haloethoxy comprises 1 -fluoroethoxy, 2,2,2- trifluoroethoxy, 1-chloroethoxy and 2-chloroethoxy.
  • halogen atom or halogen means a fluorine, chlorine, bromine or iodine atom. Preferred is a fluorine, chlorine or bromine atom. More preferred is a fluorine or chlorine atom. Most preferred is a fluorine atom.
  • the invention provides compounds of general formula I, in which Ar is selected from the group comprising:
  • the invention provides compounds of general formula I 1 in which one of R 1 and R 2 is methyl and the other is hydrogen. In another embodiment the invention provides compounds of general formula I, in which R 1 and R 2 together form a cyclopropyl, a cyclobutyl, a cyclopentyl or a cyclohexyl ring. Compounds of general formula I, in which R 1 and R 2 are both methyl are, however, a preferred subject of the invention.
  • the invention provides compounds of general formula I, in which B is a -CH 2 - group (amines) or o in which B is a — c — group (amides).
  • the invention provides compounds of general formula I, in which Y is a nitrogen atom (indazoles) or in which Y is a CH group (indoles).
  • Y is a N atom.
  • the link between the amine or amide and the indazole or indole can be formed via the 4-, 5- or 6-position of the indazole or indole. Preferred are the 4- and the 5- position. Most preferred is the 4-position.
  • the invention provides compounds of general formula I, in which R 3 is selected from the group comprising:
  • preferred groups R 4 are hydrogen, methyl and fluoro.
  • Z is selected from the group consisting of CH 2 and CO
  • Y is selected from the group consisting of CH and N
  • Ar is selected from the group consisting of a phenyl, a pyridinyl or a pyrimidinyl rest
  • R 5 means hydrogen or C r C 4 -alkyl
  • R 1 , R 2 are independently selected from the group consisting of a hydrogen atom or a (CrC 4 )-alkyl group
  • R 1 , R 2 together form a C 3 -C 6 cycloalkyl-ring
  • R 3 is selected from the group consisting of a phenyl, a pyrimidinyl and a pyridinyl rest
  • R 6 means hydrogen or CrC 4 -alkyl
  • R 4 is selected from the group consisting of halogen, cyano, nitro,
  • Preferred groups R 4 in the embodiment according to formula Ia are F, Cl or a CF 3 - group.
  • Benzo[1 ,3]dioxol-4-yl 4-Fluoro-Benzo[1 ,3]dioxol-4-yl, 5-Fluoro-Benzo[1 ,3]dioxol-4-yl, 4-Chloro-Benzo[1 ,3]dioxol-4-yl, 5-Chloro-Benzo[1 ,3]dioxol-4-yl, 2,4-Difluorophenyl, 2,5-Difluorophenyl 2-Chloro-5-fluorophenyl, 5-Chloro-2-fluorophenyl.
  • Preferred groups R 3 in the embodiment according to formula Ia is the group consisting of:
  • 6-chloropyridin-3-yl 5-chloropyridin-3-yl, 4-chloropyridin-3-yl, 2-fluoropyhdin-4-yl, 3-fluoropyridin-4-yl, 2-chloropyridin-4-yl,
  • the invention relates to the use of the compounds of general formula I or Ia for the production of pharmaceutical agents as well as their use for the production of pharmaceutical agents for treating inflammatory diseases.
  • the compounds of general formula I or Ia according to the invention may have several stereoisomers.
  • Subjects of this invention are all possible enantiomers or diastereomers, both as racemates and in enantiomer-pure form.
  • the compounds according to the invention can also be present in the form of salts with physiologically compatible anions, for example in the form of hydrochlorides, sulfates, nitrates, phosphates, pivalates, maleates, fumarates, tartrates, benzoates, mesylates, citrates or succinates.
  • the compounds can be produced by the various processes that are generally described in WO98/54159, WO00/32584, WO02/10143 and WO05/003098).
  • the expert in the field does know from these sources together with the information provided below and his general knowledge how to synthesize the compounds according to the present invention.
  • Title compound (I) can also be synthesized with by reductive amination of an aldehyde of general formula (IV), in which Ar, R 1 and R 2 have the meanings that are indicated for formula (I), and an amino-1 -arylindazole or indole of general formula (V), in which Y and R 3 are defined as described above, according to the methods that are known to one skilled in the art, whereby, e.g., sodium cyanoborohydride, sodium triacetoxy borohydride, sodium borohydride or hydrogen is considered as a reducing agent under palladium catalysis and e.g. acetic acid or titanium tetra alcoholates are considered as acidic catalysts for the imine formation.
  • an aldehyde of general formula (IV) in which Ar, R 1 and R 2 have the meanings that are indicated for formula (I), and an amino-1 -arylindazole or indole of general formula (V), in which Y and R 3 are defined as described above, according to the methods
  • An epoxide of general formula (Vl) in which Ar, R 1 and R 2 have the above- indicated meaning, can be opened by an amino-1 -arylindazole or indole of general formula (V), in which Y and R 3 are defined as described above, according to the methods that are known to one skilled in the art, whereby, e.g., DABCO or boron trifluorid are present during the reaction (WO 2005/003098), to give the amine (Ia).
  • amide (Ib) is obtained with use of dehydrating coupling reagents, as they are known from peptide chemistry, e.g., dicyclohexylcarbodiimide or 1-(3-dimethylaminopropyl)-3- ethylcarbodiimides, or by upstream conversion of the acid into an acid chloride, e.g., with thionyl chloride or POCI 3 and subsequent reaction with the amino-1 -arylindazole or indole.
  • dehydrating coupling reagents as they are known from peptide chemistry, e.g., dicyclohexylcarbodiimide or 1-(3-dimethylaminopropyl)-3- ethylcarbodiimides, or by upstream conversion of the acid into an acid chloride, e.g., with thionyl chloride or POCI 3 and subsequent reaction with the amino-1 -arylindazole or indole.
  • the compounds according to the invention are present as racemic mixtures, they can be separated into pure, optically active forms according to the methods of racemate separation that are familiar to one skilled in the art.
  • the racemic mixtures can be separated by chromatography on an even optically active carrier material (CHIRALPAK AD®) into the pure isomers.
  • CHIRALPAK AD® optically active carrier material
  • an optically active acid for example, mandelic acid, camphorsulfonic acid or tartaric acid can be used.
  • glucocorticoid receptor glucocorticoid receptor
  • MR mineral corticoid receptor
  • PR progesterone receptor
  • AR androgen receptor
  • the GR-mediated inhibition of the transcription of cytokines, adhesion molecules, enzymes and other pro-inflammatory factors is considered. This inhibition is produced by an interaction of the GR with other transcription factors, e.g., AP-1 and NF-kappa-B (for a survey, see Cato, A. C. B., and Wade, E., BioEssays 18, 371- 378, 1996).
  • the compounds of general formula I or Ia according to the invention inhibit the secretion of cytokine IL-8 into the human monocyte cell line THP-1 that is triggered by lipopolysaccharide (LPS).
  • LPS lipopolysaccharide
  • the concentration of the cytokines was determined in the supernatant by means of commercially available ELISA kits.
  • the anti-inflammatory action of the compounds of general formula I or Ia was tested in the animal experiment by tests in the croton oil-induced inflammation in rats and mice (J. Exp. Med. (1995), 182, 99-108). To this end, croton oil in ethanolic solution was applied topically to the animals' ears. The test substances were also applied topically or systemically at the same time or two hours before the croton oil. After 16-24 hours, the ear weight was measured as a yardstick for inflammatory edema, the peroxidase activity as a yardstick for the invasions of granulocytes, and the elastase activity as a yardstick for the invasion of neutrophilic granulocytes. In this test, the compounds of general formula I or Ia inhibit the three above-mentioned inflammation parameters both after topical administration and after systemic administration.
  • glucocorticoid therapy One of the most frequent undesirable actions of a glucocorticoid therapy is the so-called "steroid diabetes" [cf., Hatz, H. J., Glucocorticoide: lmmunsammlunguben, Pharmakologie und Therapierichtlinien [Glucocorticoids: Immunological Bases, Pharmacology and Therapy Guidelines],ticianliche Verlagsgesellschaft mbH, Stuttgart, 1998].
  • the reason for this is the stimulation of gluconeogenesis in the liver by induction of the enzymes responsible in this respect and by free amino acids, which are produced from the degradation of proteins (catabolic action of glucocorticoids).
  • a key enzyme of the catabolic metabolism in the liver is tyrosinamino transferase (TAT).
  • the activity of this enzyme can be determined from liver homogenates by photometry and represents a good measurement of the undesirable metabolic actions of glucocorticoids.
  • To measure the TAT induction the animals are sacrificed 8 hours after the test substances are administered, the livers are removed, and the TAT activity is measured in the homogenate. In this test, at doses in which they have an anti-inflammatory action, the compounds of general formula I induce little or no tyrosinamino transferase.
  • the compounds of general formula I or Ia according to the invention can be used as medications for treatment or prophylaxis of the following pathologic conditions in mammals and humans:
  • DISEASE stands for the following indications:
  • ARDS - Adult respiratory distress syndrome
  • Rheumatic diseases/autoimmune diseases/joint diseases which coincide with inflammatory, allergic and/or proliferative processes: - All forms of rheumatic diseases, especially rheumatoid arthritis, acute rheumatic fever, polymyalgia rheumatica, Behcet's disease
  • Vascular inflammations (vasculitides) - Panarteritis nodosa, temporal arteritis, erythema nodosum
  • eczema All forms of eczema, such as, e.g., atopic eczema (primarily in children)
  • Bullous dermatoses such as, e.g., autoimmune pemphigus vulgaris, bullous pemphigoid
  • Kidney diseases which coincide with inflammatory, allergic and/or proliferative processes: - Nephrotic syndrome
  • Gastrointestinal diseases which coincide with inflammatory, allergic and/or proliferative processes:
  • Otitis externa e.g., caused by contact dermatitis, infection, etc.
  • Tumor diseases which coincide with inflammatory, allergic and/or proliferative processes, such as, e.g.:
  • Severe shock conditions e.g., anaphylactic shock, systemic inflammatory response syndrome (SIRS)
  • SIRS systemic inflammatory response syndrome
  • - Acquired primary suprarenal insufficiency e.g., Addison's disease, autoimmune adrenalitis, meta-infective tumors, metastases, etc.
  • diabetes type I insulin-dependent diabetes
  • osteoarthritis a progressive hypertension
  • Guillain-Barre syndrome a progressive hypertension
  • restenoses after percutaneous transluminal angioplasty Alzheimer's disease, acute and chronic pain
  • arteriosclerosis a progressive hypertension
  • reperfusion injury a progressive hypertension
  • myocardial infarction a progressive hypertension
  • thermal injury multiple organ injury secondary to trauma
  • acute purulent meningitis necrotizing enterocolitis and syndromes associated with hemodialysis
  • leukopheresis granulocyte transfusion.
  • the compounds of general formula I according to the invention can be used for treatment and prophylaxis of additional pathologic conditions that are not mentioned above, for which synthetic glucocorticoids are now used (see in this respect Hatz, H. J., Glucocorticoide: lmmunologische Grundlagen, Pharmakologie und Therapierichtlinien, Academicliche Verlagsgesellschaft mbH, Stuttgart, 1998).
  • the suitable dose varies and depends on, for example, the active strength of the compound of general formula I, the host, the type of administration, and the type and severity of the conditions that are to be treated, as well as the use as a prophylactic agent or therapeutic agent.
  • the invention provides:
  • a process for treating a DISE ⁇ ASE comprises an administration of an amount of the compound according to the invention, in which the amount suppresses the disease and in which the amount of compound is given to a patient who requires such a medication;
  • a pharmaceutical composition for treating a DISEASE comprises one of the compounds according to the invention or mixture thereof and at least one pharmaceutical adjuvant and/or vehicle.
  • the daily doses comprise a range of 1 ⁇ g to 100,000 ⁇ g of the compound according to the invention per kg of body weight.
  • a recommended daily dose lies in the range of 1 ⁇ g to 100,000 ⁇ g per kg of body weight.
  • a dose of 10 to 30,000 ⁇ g per kg of body weight and more preferred is a dose of 10 to 10,000 ⁇ g per kg of body weight.
  • this dose is suitably administered several times daily.
  • individual doses can be given that are significantly above the above-mentioned doses.
  • the formulation of the pharmaceutical preparations based on the new compounds is carried out in a way that is known in the art by the active ingredient being processed with the vehicles that are commonly used in galenicals, fillers, substances that influence decomposition, binding agents, moisturizers, lubricants, absorbents, diluents, flavoring correctives, coloring agents, etc., and converted into the desired form of administration.
  • the vehicles that are commonly used in galenicals, fillers, substances that influence decomposition, binding agents, moisturizers, lubricants, absorbents, diluents, flavoring correctives, coloring agents, etc.
  • correspondingly prepared crystal suspensions can be used.
  • aqueous and oily injection solutions or suspensions and corresponding depot preparations can be used.
  • the new compounds can be used in the form of suppositories, capsules, solutions (e.g., in the form of enemas) and ointments both for systemic and for local treatment.
  • the latter can be used in the form of aerosols and inhalants.
  • the new compounds can be used as drops, ointments and tinctures in corresponding pharmaceutical preparations.
  • formulations in gels, ointments, fatty ointments, creams, pastes, powders, milk and tinctures are possible.
  • the dosage of the compounds of general formula I or Ia should be 0.01%-20% in these preparations to achieve a sufficient pharmacological action.
  • the invention also comprises the compounds of general formula I or Ia according to the invention as therapeutic active ingredients.
  • the compounds of general formula I or Ia according to the invention are part of the invention as therapeutic active ingredients together with pharmaceutically compatible and acceptable adjuvants and vehicles.
  • the invention also comprises a pharmaceutical composition that contains one of the pharmaceutically active compounds according to the invention or mixtures thereof or a pharmaceutically compatible salt thereof and a pharmaceutically compatible salt or pharmaceutically compatible adjuvants and vehicles.
  • the compounds according to the invention can optionally also be formulated and/or administered in combination with other active ingredients.
  • the invention therefore also relates to combination therapies or combined compositions, in which a compound of general formula (I) or (Ia) or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition that contains a compound of general formula (I) or (Ia) or a pharmaceutically acceptable salt thereof, is administered either simultaneously (optionally in the same composition) or in succession together with one or more pharmaceutical agents for treating one of the above-mentioned pathologic conditions.
  • a compound of general formula (I) of this invention can be combined with one or more pharmaceutical agents for treating such a condition.
  • the pharmaceutical agent that is to be combined can be selected from the following list:
  • a PDE4 inhibitor including an inhibitor of the PDE4D isoform
  • a selective ⁇ .sub2.adrenoceptor agonist such as, for example, metaproterenol, isoproterenol, isoprenaline, albuterol, salbutamol, formoterol, salmeterol, terbutaline, orcipresnaline, bitolterol mesylate, pirbuterol or indacaterol;
  • a muscarine receptor antagonist for example, an M1 , M2 or M3 antagonist, such as, for example, a more selective M3 antagonist, such as, for example, ipratropium bromide, tiotropium bromide, oxitropium bromide, pirenzepine ortelenzepine;
  • a modulator of the chemokine receptor function (such as, for example, a CCR1 receptor antagonist); or
  • such a combination with a compound of general formula (I) or (Ia) or a pharmaceutically acceptable salt thereof is used for treatment of COPD, asthma or allergic rhinitis and can be administered by inhalation or orally in combination with xanthine (such as, for example, aminophylline or thyeophylline), which also can be administered by inhalation or orally.
  • xanthine such as, for example, aminophylline or thyeophylline
  • Example A11 4-(4-Chloro-2-hydroxyoxyphenyl)-1 -(1 H-indol-4- ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-ol (WO 2005/003098) can be reacted with (6-fluoropyridin-3-yl)boronic acid under copper acetate catalysis.
  • Example A11 4-(4-Chloro-2-hydroxyoxyphenyl)-1 -(1 H-indol-4- ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-ol (WO 2005/003098) can be reacted with (6-fluoropyridin-3-yl)boronic acid under copper acetate catalysis.
  • Example A19 4-(benzo[1 ,3]dioxol-4-yl)-1 -(1 H-indol-4-ylamino)- 4-methyl-2-(trifluoromethyl)pentan-2-ol can be reacted with 4-fluorophenyl boronic acid under copper acetate catalysis.
  • Example A19 4-(benzo[1 ,3]dioxol-4-yl)-1 -(1 H-indol-4-ylamino)- 4-methyl-2-(trifluoromethyl)pentan-2-ol can be reacted with 4-fluorophenyl boronic acid under copper acetate catalysis.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (I), leurs méthodes de production et leur utilisation en tant qu'agents anti-inflammatoires.
PCT/EP2007/009912 2006-11-08 2007-11-08 Dérivés indoles et indazoles en tant qu'agents anti-inflammatoires WO2008055709A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85748406P 2006-11-08 2006-11-08
US60/857,484 2006-11-08
EPEP06090204.6 2006-11-08
EP06090204A EP1921068A1 (fr) 2006-11-08 2006-11-08 Dérivés d'indazole et d'indole comme agents anti-inflammatoires

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WO2008055709A1 true WO2008055709A1 (fr) 2008-05-15

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017162747A1 (fr) 2016-03-23 2017-09-28 Astrazeneca Ab Forme physique d'un modulateur sélectif du récepteur des glucocorticoïdes
US9963462B2 (en) 2015-09-30 2018-05-08 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Sepiapterin reductase inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082280A1 (fr) * 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Mimetiques de glucocorticoiques, procedes de fabrication, compositions pharmaceutiques, et utilisations correspondants
WO2005003098A1 (fr) * 2003-07-01 2005-01-13 Schering Aktiengesellschaft Derives de pentanol substitues par un heterocycle, procede de production de ces composes et leur utilisation comme agents anti-inflammatoires
WO2006108699A1 (fr) * 2005-04-14 2006-10-19 Glaxo Group Limited Indazoles en tant que ligands de recepteur glucocorticoide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082280A1 (fr) * 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Mimetiques de glucocorticoiques, procedes de fabrication, compositions pharmaceutiques, et utilisations correspondants
WO2005003098A1 (fr) * 2003-07-01 2005-01-13 Schering Aktiengesellschaft Derives de pentanol substitues par un heterocycle, procede de production de ces composes et leur utilisation comme agents anti-inflammatoires
WO2006108699A1 (fr) * 2005-04-14 2006-10-19 Glaxo Group Limited Indazoles en tant que ligands de recepteur glucocorticoide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963462B2 (en) 2015-09-30 2018-05-08 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Sepiapterin reductase inhibitors
WO2017162747A1 (fr) 2016-03-23 2017-09-28 Astrazeneca Ab Forme physique d'un modulateur sélectif du récepteur des glucocorticoïdes

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