WO2008051244A3 - Dérivés de l'acide anthranilique utilisables pour le traitement d'une infection par le virus de l'hépatite c - Google Patents

Dérivés de l'acide anthranilique utilisables pour le traitement d'une infection par le virus de l'hépatite c Download PDF

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Publication number
WO2008051244A3
WO2008051244A3 PCT/US2006/045950 US2006045950W WO2008051244A3 WO 2008051244 A3 WO2008051244 A3 WO 2008051244A3 US 2006045950 W US2006045950 W US 2006045950W WO 2008051244 A3 WO2008051244 A3 WO 2008051244A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
virus
acid derivatives
anthranilic acid
derivatives useful
Prior art date
Application number
PCT/US2006/045950
Other languages
English (en)
Other versions
WO2008051244A2 (fr
Inventor
Jonathan David Bloom
Shabana Insaf
Thomas Nittoli
Alan Gordon Sutherland
Kevin J Curran
Karen Wheless
Original Assignee
Wyeth Corp
Jonathan David Bloom
Shabana Insaf
Thomas Nittoli
Alan Gordon Sutherland
Kevin J Curran
Karen Wheless
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Jonathan David Bloom, Shabana Insaf, Thomas Nittoli, Alan Gordon Sutherland, Kevin J Curran, Karen Wheless filed Critical Wyeth Corp
Priority to CA002631024A priority Critical patent/CA2631024A1/fr
Priority to EP06851777A priority patent/EP1966181A2/fr
Priority to JP2008543479A priority patent/JP2009519240A/ja
Priority to AU2006349612A priority patent/AU2006349612A1/en
Priority to BRPI0619132-0A priority patent/BRPI0619132A2/pt
Publication of WO2008051244A2 publication Critical patent/WO2008051244A2/fr
Publication of WO2008051244A3 publication Critical patent/WO2008051244A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des composés de formule (I) : dans laquelle R1 est choisi dans le groupe composé de -C(O)R et (a), dans laquelle R6 et R7 sont choisis indépendamment parmi H, un alkyle, un cycloalkyle, un hétérocycloalkyle, un hétéroaryle ou un aryle, l'un d'eux pouvant être facultativement substitué, G est choisi parmi H ou un hydroxyle, Y est O, NH ou S, X est choisi dans le groupe composé de H, un halo, un alkyle, un cycloalkyle, un perfluoroalkyle, un alcoxy, un alkylthio, un amino, un alkylamino, un dialkylamino et CN, et n est 0, 1, 2 ou 3, ou un promédicament, un sel pharmaceutiquement acceptable ou un métabolite pharmaceutiquement actif de ceux-ci. L'invention concerne également des compositions contenant les composés de l'invention et des procédés d'utilisation à la fois des composés de l'invention et des compositions de ceux-ci pour traiter ou prévenir une infection par le virus de l'hépatite C ou pour inhiber la réplication du virus de l'hépatite C.
PCT/US2006/045950 2005-12-01 2006-12-01 Dérivés de l'acide anthranilique utilisables pour le traitement d'une infection par le virus de l'hépatite c WO2008051244A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002631024A CA2631024A1 (fr) 2005-12-01 2006-12-01 Derives de l'acide anthranilique utilisables pour le traitement d'une infection par le virus de l'hepatite c
EP06851777A EP1966181A2 (fr) 2005-12-01 2006-12-01 Dérivés de l'acide anthranilique utilisables pour le traitement d'une infection par le virus de l'hépatite c
JP2008543479A JP2009519240A (ja) 2005-12-01 2006-12-01 Ｃ型肝炎ウイルスの感染の治療に有用なアントラニル酸誘導体
AU2006349612A AU2006349612A1 (en) 2005-12-01 2006-12-01 Anthranilic acid derivatives useful in treating infection with Hepatitis C virus
BRPI0619132-0A BRPI0619132A2 (pt) 2005-12-01 2006-12-01 composto métodos para inibir a replicação de um vìrus de hepatite c, para tratar ou prevenir uma infecção viral de hepatite c em um mamìfero e para inibir rna polimerase dependente do rna de hepatite c, e, composição farmacêutica

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74177205P 2005-12-01 2005-12-01
US60/741,772 2005-12-01

Publications (2)

Publication Number Publication Date
WO2008051244A2 WO2008051244A2 (fr) 2008-05-02
WO2008051244A3 true WO2008051244A3 (fr) 2008-07-17

Family

ID=39273567

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/045950 WO2008051244A2 (fr) 2005-12-01 2006-12-01 Dérivés de l'acide anthranilique utilisables pour le traitement d'une infection par le virus de l'hépatite c

Country Status (7)

Country Link
EP (1) EP1966181A2 (fr)
JP (1) JP2009519240A (fr)
CN (1) CN101336236A (fr)
AU (1) AU2006349612A1 (fr)
BR (1) BRPI0619132A2 (fr)
CA (1) CA2631024A1 (fr)
WO (1) WO2008051244A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6367712B2 (ja) 2011-08-19 2018-08-01 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｃ型肝炎ウイルス感染の治療のためのベンゾフラン化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004091724A1 (fr) * 2002-10-08 2004-10-28 Wyeth Derives d'acide anthranilique utiles dans le traitement d'infection par le virus de l'hepatite c

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004091724A1 (fr) * 2002-10-08 2004-10-28 Wyeth Derives d'acide anthranilique utiles dans le traitement d'infection par le virus de l'hepatite c

Also Published As

Publication number Publication date
CA2631024A1 (fr) 2008-05-02
WO2008051244A2 (fr) 2008-05-02
CN101336236A (zh) 2008-12-31
JP2009519240A (ja) 2009-05-14
EP1966181A2 (fr) 2008-09-10
BRPI0619132A2 (pt) 2011-09-13
AU2006349612A1 (en) 2008-05-02

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