WO2008031257A1 - Dispositif de commande de percussion pour canon à gènes - Google Patents

Dispositif de commande de percussion pour canon à gènes Download PDF

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Publication number
WO2008031257A1
WO2008031257A1 PCT/CN2006/002129 CN2006002129W WO2008031257A1 WO 2008031257 A1 WO2008031257 A1 WO 2008031257A1 CN 2006002129 W CN2006002129 W CN 2006002129W WO 2008031257 A1 WO2008031257 A1 WO 2008031257A1
Authority
WO
WIPO (PCT)
Prior art keywords
firing
valve shaft
tube portion
gene gun
firing tube
Prior art date
Application number
PCT/CN2006/002129
Other languages
English (en)
Chinese (zh)
Inventor
Hai-Lung Huang
Original Assignee
Hai-Lung Huang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hai-Lung Huang filed Critical Hai-Lung Huang
Priority to PCT/CN2006/002129 priority Critical patent/WO2008031257A1/fr
Publication of WO2008031257A1 publication Critical patent/WO2008031257A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Definitions

  • the present invention relates to a gene gun, and more particularly to the structural design proposed for the firing control device in the gene gun. Background technique
  • a gene gun is a tool used for gene transfer and other purposes. It mainly uses high-pressure gas (helium, nitrogen, etc.) to attach DNA or vaccine to metal particles (such as high-density metal particles such as tungsten and gold). Pushed into the deep layers of plants and animals to overcome the biological limitations of the cell wall, it is widely used in animal and plant gene transfer, gene therapy, vaccine research and so on.
  • high-pressure gas helium, nitrogen, etc.
  • the design of the aforementioned gene gun mainly includes a gas pipeline externally connected to a high-pressure gas source, and a gene gun body.
  • the gas pipeline is provided with a control group, and the gene gun body is provided with a grip, and a starter device is connected to the control group.
  • the gene gun body is provided with a device such as a sprayer and a feeding mechanism, and a vaccine, DNA, or the like is input by the feeding mechanism, thereby controlling the input of the high-pressure gas, and the vaccine or DNA is directed to the target via the sprayer. Things.
  • the aforementioned gene gun design is an apparatus for transferring a vaccine into an animal or plant.
  • the firing control group of the gene gun rapidly injects the vaccine into the plant and animal cells at each firing. Immediately after the stop, the appropriate follow-up thrust is not provided, making the vaccine difficult to reach the intended location of the target, thus affecting the effectiveness of the vaccine. Summary of the invention
  • a primary object of the present invention is to provide a firing control device for a gene gun that further provides a subsequent thrust when the gene gun is fired, so that the vaccine can be effectively controlled to be launched at a predetermined position of the target.
  • the firing control device for a gene gun of the present invention comprises: a firing control group and a trigger unit disposed in a gene gun body, wherein the firing control group includes a valve shaft and an action a plate, a spring and an adjusting block, the valve shaft is air-tightly arranged in the firing tube portion of the gun body, the valve shaft has a valve block at the front end thereof, and the valve port of the firing tube portion is controlled to open and close, and the action plate is pivoted In the firing tube portion, the upper end is connected to the valve shaft, and the lower end extends beyond the firing tube portion to connect the firing member of the trigger unit to the torsion spring.
  • the adjusting block has a screwing portion, and the adjustable position is screwed to the firing tube portion.
  • the spring is disposed in the firing tube portion and abuts between the rear end of the valve shaft and the adjusting block; or the firing control group includes a valve shaft and a spring, and the spring is sleeved on the valve shaft and abuts
  • the firing portion is connected between the pipe portion and the valve shaft, and the rear end of the valve shaft is connected to the firing member of the trigger unit which is subjected to the torsion spring.
  • the achievable effect of the present invention is: when the firing control device is applied to the gene gun, in addition to the firing control group, the introduction of the high pressure gas can be controlled, and is introduced into the barrel of the front end of the gun body.
  • the vaccine provides power to the target object.
  • the firing control group of the present invention is further abutted against the upper end of the plate through the spring of the valve shaft, and is offset from the lower end of the action plate by a trigger unit acting on the torsion spring, or
  • the spring valve shaft directly abuts against the trigger unit that is subjected to the torsion spring, and the force part of the valve shaft is offset, delaying the valve port time of the front end of the valve shaft to close the firing tube portion, thereby prolonging the action time of the high pressure gas push vaccine.
  • the vaccine can be made deeper to the intended location of the target.
  • Figure 1 is a schematic plan view showing the first preferred embodiment of the gene gun firing control device of the present invention applied to a gene gun.
  • FIG. 2 to 6 are schematic views showing the operation of the first preferred embodiment of the firing control device shown in Fig. 1 applied to a gene gun.
  • Fig. 7 is a schematic view showing the operation of adjusting the elastic force of the first preferred embodiment of the gene gun firing control device shown in Fig. 1.
  • Fig. 8 is a schematic plan view showing the first preferred embodiment of the gene gun firing control device of the present invention applied to another type of gene gun.
  • FIG. 9 to 11 are schematic views showing the operation of the first preferred embodiment of the firing control device shown in FIG. 8 applied to another type of gene gun.
  • Figure 12 is a schematic plan view showing the application of the second preferred embodiment of the gene gun firing control device of the present invention to a gene gun.
  • FIG. 13 to 15 are views showing the operation of the second preferred embodiment of the firing control device shown in Fig. 12 applied to a gene gun.
  • a schematic diagram of a second gene gun which can be seen in the figure, includes a gun body 10, a barrel 40, and a firing control device of the present invention.
  • the firing control device includes a trigger unit 30 and a firing control group. 20, where:
  • the upper portion of the gun body 10 has a lateral firing tube portion 11 and a gun handle on the rear side of the firing tube portion 11.
  • the firing tube portion 11 is internally provided with an assembly hole 12 at the front end and an air chamber. 13 is located behind the assembly hole 12, and an action chamber 14 is located behind the air chamber 13.
  • the assembly hole 12 and the air chamber 13 are connected with a valve port 16 having a slightly smaller aperture.
  • the valve port 16 is adjacent to one end of the air chamber 13.
  • the air chamber 13 and the action chamber 14 are connected to a middle hole having a slightly smaller aperture, and a relay block 15 is disposed between the air chamber 13 and the action chamber 14.
  • the relay block 15 is connected to the air chamber 13 and the operating chamber 14, and the firing tube portion 11 is provided with an air inlet hole 18 extending from the outside into the air chamber 13 for externally connecting a high-pressure air source.
  • the firing tube portion 11 is further provided with a through hole 17 extending upward from the bottom of the firing tube portion 11 to the front portion of the operating chamber 14.
  • the rear end of the firing tube portion 11 is further provided with a screw hole 19 communicating axially from the outside to the operating chamber 14.
  • the air inlet hole 18 provided in the gun body 10 is designed as shown in FIG. 1, FIG. 8, etc., wherein, in the embodiment shown in FIG. 1, the air inlet hole 18 is taken from the side of the firing tube portion 11. Radially penetrates into the air chamber 13, as shown in the embodiment of Fig. 8, the air inlet hole 18 extends forward from the rear end of the firing tube portion 11 and penetrates downward to the air chamber 13.
  • the rear end of the barrel 40 has a connecting portion 43 for assembling into the mounting hole 12 at the front end of the gun body 10.
  • the barrel 40 has an axially extending tube hole 41, and the middle portion of the tube hole 41 is small.
  • the hole section 411, the front and the rear sections respectively form a tapered expansion section 412, 413 which gradually increases in diameter toward the outside, and forms a Venturi tubular.
  • the middle section of the barrel 40 is further provided with a small-aperture vaccine inlet 42 extending from the outside. Up to the small hole section 411, the vaccine inlet 42 can also be provided with a connecting member 44 for externally connecting the gene source.
  • the trigger unit 30 of the present invention comprises a gusset 31, a firing member 32 and two torsion springs 33, 34.
  • the gusset 31 is assembled to the bottom of the gun body 10 by a pivotal engagement torque spring 33 at its upper end.
  • the outer side of the bottom end of the gun body 10 is disposed in the gun body 10 with a lower end of the firing member 32, and the upper end portion of the firing member 32 extends below the through hole 17 of the firing portion 11.
  • the latching portion 311 and the passive portion 321 are respectively disposed at adjacent ends of the gusset 31 and the firing member 32.
  • the firing control group 20 of the present invention is mounted in the firing tube portion 11 of the gun body 10, and includes a valve shaft 21, an action plate 22, a spring 23 and an adjusting block 24, wherein - the valve shaft 21 is in the middle portion
  • the airtightly movable group is disposed in the middle hole of the firing tube portion 11, and the front and rear ends respectively extend into the air chamber 13 and the action chamber 14.
  • the front end of the valve shaft 21 has a wide block 211 which can be controlled at the valve port 16. Opening and closing, the rear end is provided with a convex driving portion 212, and the valve block 211 can be provided with a first sealing ring 213 so that the valve port 16 can be controlled to be sealed, and the middle portion of the valve shaft 21 can be installed.
  • a second sealing ring 214 is for airtightly abutting between the inner wall of the middle hole of the firing tube portion 11 and the ceramic shaft 21.
  • the action plate 22 is pivotally disposed in the through hole 17 of the firing tube portion 11 through a pivot portion thereof.
  • the upper portion of the action plate 22 extends into the action chamber 14 to abut the driving portion 212 on the valve shaft 21.
  • the lower portion of the action plate 22 protrudes out through the through hole 17 of the firing tube portion 11, and the firing member 32 of the trigger unit 30 abuts against the rear end thereof.
  • the upper portion of the action plate 22 has a fork shape with an opening facing upward for the sleeve. It is connected to both sides of the valve shaft 21 and abuts the driving portion 212 laterally.
  • the adjusting block 24 has a screwing portion 241 for screwing into the screw hole 19 at the rear end of the firing tube portion 11.
  • the spring 23 is disposed at the two ends of the operating chamber 14 of the firing tube portion 11 and abuts between the valve shaft 21 and the adjusting block 24, and the adjusting block 24 screwed to the rear end of the firing tube portion 11 can be rotated to change position and adjust the spring. 23 The amount of spring applied to the valve shaft 21.
  • FIG. 2 to FIG. 7 or FIG. 9 to FIG. 11 for externally connecting the air inlet hole 18 of the gun body 10 to nitrogen, nitrogen, and the like.
  • the high-pressure gas is used as the power source, and the vaccine inlet 42 of the barrel 40 is externally connected to the vaccine source.
  • the gusset 31 of the trigger unit 30 is pressed, so that the gusset 31 has the dialing portion 311.
  • the passive portion 321 of the firing member 32 is pushed forward, and after the firing member 32 is rotated backward by an angle, the elastic force is supplied by the torsion spring 34, and the upper end portion of the firing member 32 is rotated against the action plate 22 to rotate the action plate 22.
  • valve shaft 21 is pushed back, so that the front end valve block 211 opens the valve port 16, so that the high pressure gas enters the barrel 40 through the gas chamber 13 and the valve port 16, wherein:
  • the gene gun forms a venturi structure inside the barrel 40, so that the high pressure gas accelerates when passing through the small hole section 411 in the middle thereof, and the fluid pressure at the small hole section 411 is small, so that the vaccine naturally
  • the vaccine inlet 42 is inhaled, and the vaccine is pushed into the target by the high pressure gas through the barrel 40.
  • the spring 23 is biased by the driving portion 212 of the valve shaft 21
  • the lower end of the action plate 22 is further abutted by the firing member 32 which is acted upon by the torsion spring 34, and the valve block at the front end of the valve shaft 21 is delayed by the force of the two portions being offset. 211 closes the valve port 16 time, thereby prolonging the action time of the high-pressure gas push vaccine, so that the vaccine can be deep to the target position, so that the accuracy of the vaccine injection operation is even more remarkable.
  • the firing control group 20 of the present invention can adjust the elastic force applied to the valve shaft 21 by the adjusting block 24 screwed to the rear end of the firing tube portion 11, thereby controlling the length of time for the valve block 211 to open the valve port 16, and further Adjusting the action time of controlling the high-pressure gas source enables the vaccine to be effectively controlled to the depth of the target, so that the effectiveness of the vaccine injection can be achieved to a better extent.
  • the gene gun includes a gun body 10, a barrel 40, and the present invention.
  • the firing control device includes a trigger unit 30 and a firing control group 20, wherein the composition of the gun body 10, the barrel 40, the trigger unit 30, and the firing control group 20 is substantially the same as that shown in FIG.
  • the preferred embodiment has the same structural design, and the same portions are not described herein again.
  • the gene gun different from the first preferred embodiment is:
  • the gun body 10 is axially disposed with a mounting hole 12 at the front end and an air chamber 13 at the rear end of the mounting hole 12, and the mounting hole 12 is connected to the connecting portion 43 of the barrel 40.
  • the mounting hole 12 is connected with the air chamber 13 to be connected with a valve port 16 , and an air inlet hole 18 is defined in the firing tube portion 11 opposite to the air chamber 13 .
  • the rear end of the plenum 13 forms a cornice.
  • the trigger unit 30 also includes a gusset 31, a firing member 32 and two torsion springs 33, 34.
  • the gusset 31 and the firing member 32 are each assembled in the gun body 10 by a pivotal coupling torque spring 33, 34.
  • the shank of the gusset 31 is extended outside the bottom end of the gun body 10.
  • the upper end of the firing member 32 extends toward the rear end opening of the plenum 13 of the firing tube portion 11.
  • the firing control group 20 is also mounted in the firing tube portion 11 of the gun body 10 and includes a valve shaft 21 and a spring 23, wherein:
  • the valve shaft 21 is movably assembled in the air chamber 13 of the firing tube portion 11, the outer diameter of which is slightly smaller than the diameter of the air chamber 13, and the front end of the valve shaft 21 has a larger outer diameter including the first sealing ring 213.
  • the valve block 211 can be controlled to open and close at the valve port 16, the rear end of the valve shaft 21 has a larger outer diameter striking portion 215 including a second sealing ring 214, and is airtightly movably disposed at the rear of the air chamber 13 And extending the rear end opening, the firing member 32 of the trigger unit 30 strikes the outer end portion.
  • the spring 23 is sleeved outside the valve shaft 21, and both ends abut against the inner wall of the firing tube portion 11 and the inner end portion of the striking portion 215.
  • FIG. 13 to FIG. 15 is a schematic view showing the operation of the second preferred embodiment of the firing control device of the present invention applied to a gene gun.
  • the air inlet 18 of the gun body 10 is externally connected with a high-pressure gas.
  • the power source, and the vaccine inlet 42 of the barrel 40 is externally connected to the vaccine source.
  • the spring force is provided by the torsion spring 34, so that the upper end portion of the firing member 32 is rotated against the rear end striking portion 215 of the valve shaft 21, thereby pushing the valve shaft 21 forward, so that the front end valve block 211 opens the valve port 16, so that the front end valve block 211 opens the valve port 16
  • the high pressure gas enters the barrel 40 via the plenum 13 and the valve port 16.
  • the firing control group 20 Since the spring 23 is compressed between the firing tube portion 11 and the strike portion 215 of the valve shaft 21, the firing member 32 acts as a two-force portion with respect to the torsion spring 34.
  • the parts are offset, thereby delaying the time when the valve block 211 at the front end of the valve shaft 21 closes the valve port 16, thereby prolonging the action time of the high-pressure gas push vaccine, so that the vaccine can be deepened to a predetermined position of the target, and the accuracy of the vaccine injection operation is made.

Abstract

La présente invention concerne un dispositif de commande de percussion pour canon à gènes, qui comprend un ensemble de commande de percussion (20) monté dans une partie tube de percussion du corps du canon, et un ensemble de détente (30). Un ressort (23) est monté entre une tige de soupape (21) contenue dans la partie tube de percussion (11) et une unité de réglage (24) vissée sur l'extrémité arrière de la partie tube de percussion dans l'ensemble de commande de percussion, afin qu'il soit relié à une plaque d'actionnement (22) de la tige de soupape, et donc à un élément de percussion (32) actionné par une force de torsion à ressort dans l'ensemble de détente. Le dispositif selon l'invention permet de commander efficacement une source de gaz haute pression de façon à fournir ensuite une force de poussée, ce qui permet d'injecter de manière commandable un vaccin au niveau d'un site désiré de la cible.
PCT/CN2006/002129 2006-08-22 2006-08-22 Dispositif de commande de percussion pour canon à gènes WO2008031257A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2006/002129 WO2008031257A1 (fr) 2006-08-22 2006-08-22 Dispositif de commande de percussion pour canon à gènes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2006/002129 WO2008031257A1 (fr) 2006-08-22 2006-08-22 Dispositif de commande de percussion pour canon à gènes

Publications (1)

Publication Number Publication Date
WO2008031257A1 true WO2008031257A1 (fr) 2008-03-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2006/002129 WO2008031257A1 (fr) 2006-08-22 2006-08-22 Dispositif de commande de percussion pour canon à gènes

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1305007A (zh) * 2001-02-27 2001-07-25 周芳 一种手枪式气体基因枪
CN1305006A (zh) * 2001-02-27 2001-07-25 周芳 一种台式气体基因枪
US6436709B1 (en) * 2001-10-19 2002-08-20 Bioware Technology Co., Ltd. Low pressure-accelerated particle gene gun
CN1475277A (zh) * 2003-07-04 2004-02-18 清华大学 纱窗式整流加速基因微弹的方法及基因枪
EP1444999A1 (fr) * 2003-02-03 2004-08-11 BioWare Technology Co., Ltd Pistolet de gène accéléré par gaz de basse pression

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1305007A (zh) * 2001-02-27 2001-07-25 周芳 一种手枪式气体基因枪
CN1305006A (zh) * 2001-02-27 2001-07-25 周芳 一种台式气体基因枪
US6436709B1 (en) * 2001-10-19 2002-08-20 Bioware Technology Co., Ltd. Low pressure-accelerated particle gene gun
EP1444999A1 (fr) * 2003-02-03 2004-08-11 BioWare Technology Co., Ltd Pistolet de gène accéléré par gaz de basse pression
CN1475277A (zh) * 2003-07-04 2004-02-18 清华大学 纱窗式整流加速基因微弹的方法及基因枪

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