WO2008024986A3 - Apparatus and methods for determining optical tissue properties - Google Patents

Apparatus and methods for determining optical tissue properties Download PDF

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Publication number
WO2008024986A3
WO2008024986A3 PCT/US2007/076781 US2007076781W WO2008024986A3 WO 2008024986 A3 WO2008024986 A3 WO 2008024986A3 US 2007076781 W US2007076781 W US 2007076781W WO 2008024986 A3 WO2008024986 A3 WO 2008024986A3
Authority
WO
WIPO (PCT)
Prior art keywords
light source
specimen
specific illumination
specific
methods
Prior art date
Application number
PCT/US2007/076781
Other languages
French (fr)
Other versions
WO2008024986A2 (en
Inventor
Daniel G Stearns
Bradley W Rice
Original Assignee
Xenogen Corp
Daniel G Stearns
Bradley W Rice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenogen Corp, Daniel G Stearns, Bradley W Rice filed Critical Xenogen Corp
Publication of WO2008024986A2 publication Critical patent/WO2008024986A2/en
Publication of WO2008024986A3 publication Critical patent/WO2008024986A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0064—Body surface scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium

Abstract

Disclosed are apparatus and methods for determining accurate optical property values of turbid media. In one embodiment, the method includes (a) providing a light source, having a first wavelength and a known illumination power, sequentially at a plurality of specific illumination positions on a first surface of the specimen; (b) for each specific position of the light source, obtaining light emission measurements from a second surface of the specimen that is opposite the first surface, wherein the light emission measurements are obtained for a plurality of surface positions of the second surface; and (c) for each specific illumination position of the light source at the first surface of the specimen, determining one or more optical properties for the specimen based on the specific illumination position of the light source, the first wavelength of the light source, the known illumination power of the light source, and the obtained light emission measurements for such each specific illumination position. The optical properties for the plurality of specific illumination positions of the light source are individually determined for each specific illumination position of the light source.
PCT/US2007/076781 2006-08-24 2007-08-24 Apparatus and methods for determining optical tissue properties WO2008024986A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84024706P 2006-08-24 2006-08-24
US60/840,247 2006-08-24

Publications (2)

Publication Number Publication Date
WO2008024986A2 WO2008024986A2 (en) 2008-02-28
WO2008024986A3 true WO2008024986A3 (en) 2008-04-10

Family

ID=39107725

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/076781 WO2008024986A2 (en) 2006-08-24 2007-08-24 Apparatus and methods for determining optical tissue properties
PCT/US2007/076813 WO2008025006A2 (en) 2006-08-24 2007-08-24 Spectral unmixing for in-vivo imaging

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2007/076813 WO2008025006A2 (en) 2006-08-24 2007-08-24 Spectral unmixing for in-vivo imaging

Country Status (2)

Country Link
EP (1) EP2068714A2 (en)
WO (2) WO2008024986A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2920874B1 (en) 2007-09-10 2010-08-20 Biospace Lab LUMINESCENCE IMAGING INSTALLATION AND METHOD
FR2969497B1 (en) 2010-12-27 2013-06-28 Ceva Sante Animale LUMINESCENT COMPOSITION AS A BIOMARKER IN AN AVIAN EGG, CORRESPONDING DEVICE AND METHOD.
EP2518474A1 (en) 2011-04-27 2012-10-31 Well Dynamics Applications S.r.l. WDA Method for the determination of analytes in the hair
US9314218B2 (en) * 2011-06-20 2016-04-19 Caliper Life Sciences, Inc. Integrated microtomography and optical imaging systems
CN107184181A (en) * 2017-05-15 2017-09-22 清华大学 The processing method and system of Dynamic Fluorescence molecular tomographic
EP3517934A1 (en) 2018-01-24 2019-07-31 I Love My Body Research S.r.l. Method for the determination of analytes in the hair

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030002028A1 (en) * 2001-05-17 2003-01-02 Rice Bradley W. Method and apparatus for determining target depth, brightness and size within a body region

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8103331B2 (en) * 2004-12-06 2012-01-24 Cambridge Research & Instrumentation, Inc. Systems and methods for in-vivo optical imaging and measurement

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030002028A1 (en) * 2001-05-17 2003-01-02 Rice Bradley W. Method and apparatus for determining target depth, brightness and size within a body region

Also Published As

Publication number Publication date
EP2068714A2 (en) 2009-06-17
WO2008025006A3 (en) 2008-10-23
WO2008024986A2 (en) 2008-02-28
WO2008025006A2 (en) 2008-02-28

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