WO2008024141A8 - Nanofiber structures on asperities for sequestering, carrying and transferring substances - Google Patents

Nanofiber structures on asperities for sequestering, carrying and transferring substances Download PDF

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Publication number
WO2008024141A8
WO2008024141A8 PCT/US2007/011228 US2007011228W WO2008024141A8 WO 2008024141 A8 WO2008024141 A8 WO 2008024141A8 US 2007011228 W US2007011228 W US 2007011228W WO 2008024141 A8 WO2008024141 A8 WO 2008024141A8
Authority
WO
WIPO (PCT)
Prior art keywords
asperities
sequestering
carrying
nanofiber structures
transferring substances
Prior art date
Application number
PCT/US2007/011228
Other languages
French (fr)
Other versions
WO2008024141A3 (en
WO2008024141A2 (en
Inventor
Darrell H Reneker
Daniel J Smith
David Barrett Meyers
Nevenka Golubovic-Liakopoulos
Alexander Marin
Alexander K Andrianov
Peter G Carroll
Sanford R Simon
Tao Han
Original Assignee
Apogee Technology Inc
Univ Akron
Darrell H Reneker
Daniel J Smith
David Barrett Meyers
Nevenka Golubovic-Liakopoulos
Alexander Marin
Alexander K Andrianov
Peter G Carroll
Sanford R Simon
Tao Han
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apogee Technology Inc, Univ Akron, Darrell H Reneker, Daniel J Smith, David Barrett Meyers, Nevenka Golubovic-Liakopoulos, Alexander Marin, Alexander K Andrianov, Peter G Carroll, Sanford R Simon, Tao Han filed Critical Apogee Technology Inc
Priority to CA002650197A priority Critical patent/CA2650197A1/en
Priority to EP07835752A priority patent/EP2015803A4/en
Priority to AU2007288442A priority patent/AU2007288442A1/en
Publication of WO2008024141A2 publication Critical patent/WO2008024141A2/en
Publication of WO2008024141A3 publication Critical patent/WO2008024141A3/en
Publication of WO2008024141A8 publication Critical patent/WO2008024141A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/07—Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)

Abstract

A device which comprises a substrate which includes a plurality of asperities, such as microneedles, extending from the surface of the substrate, and an electrospun material in contact with the substrate. The electrospun material may comprise a plurality of nanofibers which carry at least one biologically active agent. Such devices are useful as transdermal delivery devices for delivering pharmaceuticals and other biologically active agents.
PCT/US2007/011228 2006-05-09 2007-05-09 Nanofiber structures on asperities for sequestering, carrying and transferring substances WO2008024141A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002650197A CA2650197A1 (en) 2006-05-09 2007-05-09 Nanofiber structures on asperities for sequestering, carrying and transferring substances
EP07835752A EP2015803A4 (en) 2006-05-09 2007-05-09 Nanofiber structures on asperities for sequestering, carrying and transferring substances
AU2007288442A AU2007288442A1 (en) 2006-05-09 2007-05-09 Nanofiber structures on asperities for sequestering, carrying and transferring substances

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US79892806P 2006-05-09 2006-05-09
US60/798,928 2006-05-09
US84850706P 2006-09-29 2006-09-29
US84821306P 2006-09-29 2006-09-29
US84850506P 2006-09-29 2006-09-29
US84850606P 2006-09-29 2006-09-29
US84850406P 2006-09-29 2006-09-29
US60/848,506 2006-09-29
US60/848,505 2006-09-29
US60/848,507 2006-09-29
US60/848,213 2006-09-29
US60/848,504 2006-09-29

Publications (3)

Publication Number Publication Date
WO2008024141A2 WO2008024141A2 (en) 2008-02-28
WO2008024141A3 WO2008024141A3 (en) 2008-04-24
WO2008024141A8 true WO2008024141A8 (en) 2009-07-09

Family

ID=39107260

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/011228 WO2008024141A2 (en) 2006-05-09 2007-05-09 Nanofiber structures on asperities for sequestering, carrying and transferring substances

Country Status (4)

Country Link
EP (1) EP2015803A4 (en)
AU (1) AU2007288442A1 (en)
CA (1) CA2650197A1 (en)
WO (1) WO2008024141A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2820335T3 (en) 2007-04-16 2021-04-20 Corium Inc Solvent Cast Microneedle Arrays Containing Active Agent
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP2012509106A (en) * 2008-11-18 2012-04-19 スリーエム イノベイティブ プロパティズ カンパニー Hollow microneedle array and method
MX336139B (en) * 2010-04-28 2016-01-08 Kimberly Clark Co MEDICAL DEVICES FOR DELIVERY OF siRNA.
AU2015271878B2 (en) * 2010-04-28 2017-05-11 Sorrento Therapeutics, Inc. Device for delivery of rheumatoid arthritis medication
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
US9526883B2 (en) 2010-04-28 2016-12-27 Kimberly-Clark Worldwide, Inc. Composite microneedle array including nanostructures thereon
ES2636673T3 (en) 2010-04-28 2017-10-06 Kimberly-Clark Worldwide, Inc. Device for the administration of rheumatoid arthritis medications
EP2566501B1 (en) * 2010-05-04 2019-03-13 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
WO2012130193A1 (en) * 2011-03-31 2012-10-04 Zentiva, K.S. Non-covalent soluble complexes of teriparatide with polysaccharides and a dosage form of teriparatide for oral administration
KR102265775B1 (en) 2011-10-27 2021-06-16 소렌토 쎄라퓨틱스, 인코포레이티드 Transdermal delivery of high viscosity bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
CN103906549A (en) 2011-10-27 2014-07-02 金伯利-克拉克环球有限公司 Implantable devices for delivery of bioactive agents
WO2013086731A1 (en) * 2011-12-16 2013-06-20 London Metropolitan University (Lmu) Delivery apparatus
BR102012031954A2 (en) * 2012-12-14 2015-01-20 Instituto De Pesquisas Tecnológicas Do Est S. Paulo S/A Ipt ACTIVE SUBSTANCE NANOFIBERS FOR COSMETIC APPLICATION OF CONTROLLED RELEASE OBTAINED BY ELECTROPHIATION AND PROCESS
BR102012031955A2 (en) * 2012-12-14 2014-10-07 Instituto De Pesquisas Tecnológicas Do Est S. Paulo S/A Ipt NANOFIBRAS CONTAINING ACTIVE SUBSTANCE WITH CONTROLLED RELEASE FOR DONTOLOGICAL APPLICATION AND PROCESS
MX2015008157A (en) 2012-12-21 2016-02-22 Corium Int Inc Microarray for delivery of therapeutic agent and methods of use.
CN105142711B (en) 2013-03-12 2019-01-22 考里安国际公司 Micro-protuberance applicator
ES2761580T3 (en) 2013-03-15 2020-05-20 Corium Inc Microarrays for therapeutic agent delivery, methods of use and manufacturing methods
ES2908339T3 (en) 2013-03-15 2022-04-28 Corium Inc Microarray for delivery of a therapeutic agent and methods of use
EP4194028A1 (en) 2013-03-15 2023-06-14 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators
JP2016514133A (en) 2013-03-15 2016-05-19 コリウム インターナショナル， インコーポレイテッド MICROARRAY CONTAINING FINE STRUCTURE CONTAINING NO POLYMER, MANUFACTURING METHOD AND USE METHOD
KR101527469B1 (en) * 2013-11-04 2015-06-11 연세대학교 산학협력단 A Method for Fabrication of Porous fiber microstructure with various 3-dimensional Structures
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
DK3570821T3 (en) 2017-01-23 2021-10-11 Afyx Therapeutics As PROCEDURE FOR MANUFACTURING A TWO-LAYER PRODUCT BASED ON ELECTROSPUND FIBERS
DE102017112573A1 (en) * 2017-06-07 2018-12-13 Lts Lohmann Therapie-Systeme Ag Microneedle system for the application of glucagon-like peptide analogues
JP2022552832A (en) * 2019-10-08 2022-12-20 アフリックス セラピューティクス アー／エス Compositions for protein delivery
US11642288B2 (en) * 2020-02-07 2023-05-09 Kao Corporation Skin external composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
WO2005086773A2 (en) * 2004-03-08 2005-09-22 Becton Dickinson And Company A method for delivering therapeutic proteins to the intradermal compartment
US7786086B2 (en) * 2004-09-08 2010-08-31 Ramot At Tel-Aviv University Ltd. Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
CA2518650A1 (en) * 2004-09-10 2006-03-10 Dimitrios Dimitrakoudis Clostridium botulinum toxin formulation and method for reducing weight
WO2006044904A2 (en) * 2004-10-15 2006-04-27 Vanderbilt University Nano- and micro-scale engineering of polymeric scaffolds for vascular tissue engineering

Also Published As

Publication number Publication date
WO2008024141A3 (en) 2008-04-24
CA2650197A1 (en) 2008-02-28
AU2007288442A1 (en) 2008-02-28
WO2008024141A2 (en) 2008-02-28
EP2015803A4 (en) 2009-05-06
EP2015803A2 (en) 2009-01-21

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