WO2008024026A3 - Use of 9-oxoacridine-10-acetic acid, its salts and esters for the treatment, prophylaxis or relapse prevention of prostate cancer - Google Patents

Use of 9-oxoacridine-10-acetic acid, its salts and esters for the treatment, prophylaxis or relapse prevention of prostate cancer Download PDF

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Publication number
WO2008024026A3
WO2008024026A3 PCT/RU2007/000423 RU2007000423W WO2008024026A3 WO 2008024026 A3 WO2008024026 A3 WO 2008024026A3 RU 2007000423 W RU2007000423 W RU 2007000423W WO 2008024026 A3 WO2008024026 A3 WO 2008024026A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxoacridine
acetic acid
prostate cancer
prophylaxis
treatment
Prior art date
Application number
PCT/RU2007/000423
Other languages
French (fr)
Other versions
WO2008024026A2 (en
Inventor
Kirill Gennadievich Surkov
Original Assignee
Kirill Gennadievich Surkov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirill Gennadievich Surkov filed Critical Kirill Gennadievich Surkov
Publication of WO2008024026A2 publication Critical patent/WO2008024026A2/en
Publication of WO2008024026A3 publication Critical patent/WO2008024026A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

The present invention provides the use of 9-oxoacridine-10-acetic acid, its pharmaceutically acceptable salts and esters, in combination with antiandrogenic hormonotherapy, for the treatment, prophylaxis and relapse prevention of prostate cancer. A method of treatment or prophylaxis of prostate cancer comprises the steps of (a) administration of an effective amount of 9-oxoacridine-10-acetic acid, its pharmaceutically acceptable salt or ester to a patient in need thereof and (b) hormonotherapy aimed at decreasing androgen action. Further, a method of inducing or increasing the sensitivity of prostate cancer to hormone therapy aimed at decreasing androgen action is provided, wherein the method comprises administration of 9-oxoacridine-10-acetic acid, its pharmaceutically acceptable salt or ester.
PCT/RU2007/000423 2006-07-31 2007-07-31 Use of 9-oxoacridine-10-acetic acid, its salts and esters for the treatment, prophylaxis or relapse prevention of prostate cancer WO2008024026A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2006127809/15A RU2325160C1 (en) 2006-07-31 2006-07-31 Means of treatment and relapse prevention of prostate cancer
RU2006127809 2006-07-31

Publications (2)

Publication Number Publication Date
WO2008024026A2 WO2008024026A2 (en) 2008-02-28
WO2008024026A3 true WO2008024026A3 (en) 2008-05-29

Family

ID=39107233

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2007/000423 WO2008024026A2 (en) 2006-07-31 2007-07-31 Use of 9-oxoacridine-10-acetic acid, its salts and esters for the treatment, prophylaxis or relapse prevention of prostate cancer

Country Status (2)

Country Link
RU (1) RU2325160C1 (en)
WO (1) WO2008024026A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2460544C2 (en) * 2010-11-19 2012-09-10 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ РНИОН Минздравсоцразвития России) Method for assessing clinical effectiveness in prostate cancer
RU2524309C1 (en) * 2013-04-18 2014-07-27 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Method for selecting therapeutic approach to locally advanced prostate cancer
ES2925946T3 (en) * 2017-09-27 2022-10-20 Novel Pharma Inc Derivative of GnRH conjugated with long-acting palmitic acid and pharmaceutical composition containing the same
RU2730530C1 (en) * 2019-10-29 2020-08-24 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" New chemical compound of l-lysine 9-oxoacridinyl-10-acetate, stimulating production of interleukin-24 and tumour necrosis factor - beta

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681360A (en) * 1971-04-09 1972-08-01 Hoffmann La Roche Antiviral substituted acridanones
RU2126253C1 (en) * 1996-06-06 1999-02-20 Сурков Кирилл Геннадьевич Agent inducing estrogen and progestine receptors
RU2162843C2 (en) * 1998-05-19 2001-02-10 Закрытое Акционерное Общество "Асгл - Исследовательские Лаборатории" Method of preparing sodium 10-methylene carboxylate-9-acridone or 10- methylenecarboxy-9-acridone from acridone
UA11926U (en) * 2005-07-11 2006-01-16 Volodymyr Volodymyrovy Kilessa Method for immune correction

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681360A (en) * 1971-04-09 1972-08-01 Hoffmann La Roche Antiviral substituted acridanones
RU2126253C1 (en) * 1996-06-06 1999-02-20 Сурков Кирилл Геннадьевич Agent inducing estrogen and progestine receptors
RU2162843C2 (en) * 1998-05-19 2001-02-10 Закрытое Акционерное Общество "Асгл - Исследовательские Лаборатории" Method of preparing sodium 10-methylene carboxylate-9-acridone or 10- methylenecarboxy-9-acridone from acridone
UA11926U (en) * 2005-07-11 2006-01-16 Volodymyr Volodymyrovy Kilessa Method for immune correction

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1996, SURKOV K G ET AL: "[Neovir, an interferon inductor, modifies expression of steroid hormone receptors in hormone-dependent tissues and restores sensitivity to tamoxifen in patients with inoperable breast cancer]", XP002474585, Database accession no. NLM9123898 *
SZULC B ET AL: "COMPETITION OF SODIUM SALT OF 9-OXO-10-ACRIDINEACETIC ACID WITH ANALOGS DURING INDUCTION OF INTERFERON IN THE MOUSE BONE MARROW-DERIVED MACROPHAGES", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, POLISH ACADEMY OF SCIENCES, WROCLAW, PL, vol. 33, no. 219, 1985, pages 287 - 297, XP009015170, ISSN: 0004-069X *
SZULC Z ET AL: "SYNTHESIS OF CHOLINE ESTER OF 9-OXO-10-ACRIDINEACETIC ACID AND OF CONGENERS AS POTENTIAL INTERFERON INDUCERS", POLISH JOURNAL OF CHEMISTRY, POLISH CHEMICAL SOCIETY, vol. 60, no. 4-6, 1986, pages 615 - 619, XP009015180 *
TSYRLINA YE V ET AL: "Effect of neoadjuvant therapy with neovir on steroid hormone receptor level in endometrial carcinoma", VOPROSY ONKOLOGII (ST. PETERSBURG), vol. 47, no. 2, 2001, pages 214 - 217, XP009097909, ISSN: 0507-3758 *
VOPROSY ONKOLOGII 1996, vol. 42, no. 6, 1996, pages 28 - 32, ISSN: 0507-3758 *

Also Published As

Publication number Publication date
WO2008024026A2 (en) 2008-02-28
RU2006127809A (en) 2008-02-10
RU2325160C1 (en) 2008-05-27

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