WO2008018309A1

WO2008018309A1 - Wire, and medical device, for removing intravascular foreign matter

Info

Publication number: WO2008018309A1
Application number: PCT/JP2007/064849
Authority: WO
Inventors: Aya Sekido; Takeshi Kanamaru
Original assignee: Terumo Kabushiki Kaisha
Priority date: 2006-08-07
Filing date: 2007-07-30
Publication date: 2008-02-14

Abstract

A wire for removing intravascular foreign matter, comprising a flexible lengthy wire main body; a first loop wire part of loop form disposed at the distal end of the wire main body; at least one second loop wire part of loop form provided so as to cross two different points of the first loop wire part, thereby retaining the loop size of the first loop wire part; and at least one hanging wire part provided so as to hang between the first loop wire part and the second loop wire part on at least either the distal end side or the proximal end side of the second loop wire part.

Description

Specification

Intravascular foreign matter removal wire and medical device

Technical field

[0001] The present invention relates to an intravascular foreign matter removing wire for removing foreign matter in a blood vessel and a medical instrument including the same.

Background art

[0002] According to the demographic statistics of the Ministry of Health, Labor and Welfare, the first cause of death in Japan is cancer, second is heart disease, third is stroke, especially death due to stroke and sequelae increase, and establishment of treatment methods Is an urgent need.

[0003] In recent years, thrombolytic therapies using thrombolytic agents have been developed for the treatment of strokes! And for the treatment of acute cerebral infarction, and their therapeutic effects have been pointed out, but their limitations have also been pointed out. In other words, doctors experience that thrombolytic agents require a long time for thrombolysis, small thrombi further fly to form new emboli sites, and there are thrombi that do not dissolve with thrombolytic agents. It is recognized from.

[0004] In the case of cerebral infarction, if the blood flow can be resumed within 3 hours after the onset of the infarction, not only will the survival rate increase, but it has been proven in the US and Europe that it can be inserted into the cerebral blood vessels. There is a strong demand for the development of medical devices that can directly remove blood clots (wires for removing foreign substances in blood vessels).

[0005] A conventional intravascular foreign matter removing wire has a long wire body and a capturing part that is provided on the distal end side of the wire body and captures a thrombus (see, for example, Patent Document 1). . The trapping part is composed of two branch wire parts that branch from the tip of the wire body and three filament parts that are installed between these branch wire parts, and a foreign matter trapping space is formed inside. Yes.

[0006] However, this intravascular foreign matter removing wire is used depending on the state of the blood vessel into which the wire is inserted (for example, the size of the inner diameter), the state of the thrombus (for example, the size and shape), and the degree of bending of the blood vessel. There has been a problem that each branch wire part and each filament part (capturing part) are pressed against the thrombus and the inner wall of the blood vessel, and the foreign substance capturing space may be crushed. In this case, thrombus Is stored in the foreign matter capturing space, that is, it is difficult to capture the thrombus.

[0007] Patent Document 1: Japanese Patent Application Laid-Open No. 2003-10193

Disclosure of the invention

[0008] An object of the present invention is to remove a foreign substance in a blood vessel that reliably secures a space for catching a foreign substance in a blood vessel and can reliably catch the foreign substance in the blood vessel even when an external force is applied. To provide chairs and medical devices.

In order to achieve the above object, the present invention provides:

A long wire body having flexibility;

A first loop wire portion that is provided at the tip of the wire body and forms a loop shape, and intersects with two different locations of the first loop wire portion, and the size of the loop of the first loop wire portion Maintaining at least one second loop wire portion having a loop shape, and at least one of a distal end side and a proximal end side with respect to the second loop wire portion,

An intravascular foreign matter removing wire comprising: one loop wire portion and at least one construction wire portion constructed between the second loop wire portion and the second loop wire portion.

[0010] Thereby, even when an external force is applied, a space for capturing a foreign substance in the blood vessel (hereinafter simply referred to as “foreign substance”) (hereinafter, this space is referred to as “foreign substance capturing space”) is ensured. This ensures that foreign objects can be captured.

[0011] Further, in the intravascular foreign matter removing wire of the present invention, the first loop wire portion and the first loop wire portion

It is preferable that the force S in the vicinity of the intersection with the two loop wire portions is substantially orthogonal.

[0012] Thereby, for example, the first loop wire portion, the second loop wire portion, and the erected wire portion are defined as compared with a case where the vicinity of the intersection portion intersects at an acute angle or an obtuse angle). space

That is, the foreign matter capturing space is increased, and therefore, the foreign matter can be easily captured in the foreign matter capturing space.

[0013] Further, in the intravascular foreign matter removing wire of the present invention, the second loop wire portion is disposed in the vicinity of the central portion of the wire body in the axial direction of the first loop wire portion. preferable.

[0014] Thereby, even if an external force acts on the first loop wire portion, for example, from the outside to the axis of the wire main body and in the opposite direction (even when an external force is applied), the first loop wire portion Hard to crush Thus, the foreign substance in the blood vessel can be captured (stored) easily and reliably in the foreign substance capturing space.

[0015] Further, in the intravascular foreign matter removing wire of the present invention, the first loop wire portion has an elliptical shape or an oval shape, and a length in a major axis direction thereof is the second loop wire. Larger than the maximum diameter of the loop of the part! /, Preferably a thing! /.

[0016] Thereby, it is possible to capture a relatively long foreign substance in the blood vessel.

In the intravascular foreign matter removing wire of the present invention, the first loop wire portion has an elliptical shape or an oval shape, and the length in the major axis direction is the second loop wire. It is preferable to be about the same as or smaller than the maximum diameter of the loop of the part! /.

[0018] Accordingly, it is possible to collect not only a vertically long foreign object in a posture oriented parallel to the longitudinal direction of the wire but also a horizontally oriented foreign material oriented in a direction perpendicular to the longitudinal direction of the wire.

[0019] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that a plurality of the second loop wire portions are provided! /.

[0020] Thereby, even when an external force is applied to the first loop wire portion, the size of the loop of the first loop wire portion can be more reliably maintained, and thus the foreign matter capturing space can be surely secured. It is ensured and foreign matter can be reliably caught in the foreign matter catching space.

[0021] Further, in the intravascular foreign matter removing wire of the present invention, the plurality of second loop wire portions are more unevenly distributed on the distal end side than the central portion in the axial direction of the wire body of the first loop wire portion. It is preferable.

[0022] Thereby, when the intravascular foreign matter removing wire is pulled in the proximal direction, the trapped foreign matter can be prevented from unintentionally leaving the distal end side.

[0023] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that the plurality of second loop wire portions are arranged almost in parallel with each other! /.

[0024] Thereby, even when an external force is applied to the first loop wire portion, the size of the loop of the first loop wire portion can be more reliably maintained, and thus the foreign matter capturing space can be reliably established. It is ensured and foreign matter can be reliably caught in the foreign matter catching space.

[0025] In the intravascular foreign matter removing wire of the present invention, the plurality of second loop wire portions In this case, it is preferable that the interval between them is gradually increased in the direction of the tip.

[0026] Thereby, the size of the loop of the first loop wire portion, in particular, the curvature (size of the string) of the tip side of the center portion of the first loop wire portion is not excessively or deficient. It can be maintained almost constant (uniform) regardless of the magnitude of the external force.

In the intravascular foreign matter removing wire of the present invention, it is preferable that the erection wire portion is provided on the distal end side and the proximal end side with respect to the second loop wire portion, respectively. Better!/,

[0028] With this, when a foreign object is captured in the foreign object capturing space, the foreign object is reliably prevented from detaching to the distal end side by the distal-side erection arm part, and the proximal-side erected wire part As a result, separation to the proximal end side is surely prevented. As a result, the force S can be used to more reliably capture foreign matter.

[0029] Further, in the intravascular foreign matter removing wire of the present invention, the erection wire portion on the distal end side with respect to the second loop wire portion and the erection portion on the proximal end side with respect to the second loop wire portion The shear portion is preferably unevenly distributed on the opposite side of each other via the first loop wire portion.

[0030] Thus, when a foreign object is captured in the foreign object capturing space, the foreign object is reliably prevented from detaching to the distal end side by the distal-side erection gear part, and the proximal-side erected wire part As a result, separation to the proximal end side is surely prevented. As a result, the force S can be used to more reliably capture foreign matter.

[0031] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that a plurality of the erected wire portions on the distal end side are provided with respect to the second loop wire portion! / .

[0032] Thereby, even if an external force is applied to the first loop wire portion or the second loop wire portion, these loop wire portions are more reliably prevented from being deformed, and thus the foreign matter capturing space. Is reliably secured, and foreign matter can be reliably caught in the foreign matter catching space.

[0033] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that the plurality of erected wire portions are arranged around an axis of the wire main body.

[0034] Thereby, the arrangement density of the plurality of erection wire portions in the vicinity of the distal end portion of the first loop wire portion becomes relatively high, and thus it is more reliable that the captured foreign matter is detached to the distal end side. To prevent Stop with force S

[0035] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that the plurality of erected wire portions are arranged substantially parallel to each other!

[0036] Thereby, a relatively large foreign object can be suitably captured.

[0037] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that a plurality of the construction wire portions on the proximal end side with respect to the second loop wire portion are provided! /. ,.

[0038] Thereby, even when an external force is applied to the first loop wire portion or the second loop wire portion, these loop wire portions are more reliably prevented from being deformed. Is reliably secured, and foreign matter can be reliably caught in the foreign matter catching space.

[0039] In the intravascular foreign matter removing wire of the present invention, it is preferable that the plurality of erected wire portions are arranged around the axis of the wire body.

[0040] Thereby, the arrangement density of the plurality of erected wire portions in the vicinity of the proximal end portion of the first loop wire portion becomes relatively high, and therefore, the captured foreign matter is prevented from separating toward the proximal end side. Use force S to prevent it more reliably.

[0041] In the intravascular foreign matter removing wire of the present invention, it is preferable that the plurality of erected wire portions are arranged substantially parallel to each other!

[0042] Thereby, a relatively large foreign object can be suitably captured.

[0043] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that the erected wire portion be bent outwardly!

[0044] Thereby, even when an external force is applied to the erection wire portion from the outside, the erection wire portion is prevented from being deformed, so that a foreign matter catching space is surely secured, and the foreign matter catching space is secured in the foreign matter catching space. Can be reliably captured.

[0045] Further, in the intravascular foreign matter removing wire of the present invention, a plate-shaped member is installed at the tip of the first loop wire portion,

The erection wire portion is preferably provided on the distal end side with respect to the second loop wire portion, and is connected to the first loop wire portion via the member.

[0046] Thus, when the intravascular foreign matter removing wire is placed in the blood vessel, blood flow is suppressed in the vicinity of the plate-shaped member, and thus an operation (capturing operation) when capturing the foreign matter is facilitated. Do That's the power S.

[0047] In the intravascular foreign matter removing wire of the present invention, the opening between the first loop wire portion and the second loop wire not provided with the erection wire portion is a foreign matter in the blood vessel. It is preferred to be used as a mouthpiece.

[0048] Thereby, the foreign matter can be reliably stored (taken in) the foreign matter capturing space.

[0049] In order to achieve the above object, the present invention provides:

The intravascular foreign matter removal wire;

A medical device comprising a catheter having a lumen capable of accommodating the wire for removing foreign matter in a blood vessel.

[0050] Thereby, even when an external force is applied, it is possible to reliably secure a foreign matter capturing space for capturing the foreign matter and reliably capture the foreign matter.

Brief Description of Drawings

FIG. 1 is a perspective view showing a first embodiment of the intravascular foreign matter removing wire of the present invention.

[FIG. 2] FIG. 2 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in FIG.

[Fig. 3] Fig. 3 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in Fig. 1.

[Fig. 4] Fig. 4 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in Fig. 1.

FIG. 5 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in FIG. 1.

[Fig. 6] Fig. 6 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in Fig. 1.

FIG. 7 is a perspective view showing a second embodiment of the intravascular foreign matter removing wire of the present invention.

FIG. 8 is a perspective view showing a third embodiment of the intravascular foreign matter removing wire of the present invention. FIG. 9 is a perspective view showing a fourth embodiment of the intravascular foreign matter removing wire of the present invention.

FIG. 10 is a perspective view showing a fifth embodiment of the intravascular foreign matter removing wire of the present invention.

FIG. 11 is a perspective view showing a sixth embodiment of the intravascular foreign matter removing wire of the present invention.

FIG. 12 is a perspective view showing a seventh embodiment of the intravascular foreign matter removing wire of the present invention.

BEST MODE FOR CARRYING OUT THE INVENTION

[0052] Hereinafter, the intravascular foreign matter removing wire and medical device of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

FIG. 1 is a perspective view showing a first embodiment of the intravascular foreign matter removing wire of the present invention, and FIGS. 2 to 6 show how to use the intravascular foreign matter removing wire shown in FIG. 1, respectively. It is a figure for explaining in order. In the following, for convenience of explanation, the upper side in FIG. 1 (the same applies to FIGS. 7 to 12) is referred to as the “front end”, and the lower side is referred to as the “base end”. The left side is called “tip” and the right side is called “base”. The left side in Fig. 1 (similarly in Figs. 7 to 12) is called "left", and the right side is called "right".

[0054] The intravascular foreign matter removing wire 1A shown in Fig. 1 (similarly in Fig. 4 to Fig. 6) is a foreign matter that causes embolization of blood clots and blood clots in the blood vessel 100 (hereinafter referred to as "emboli"). Is captured and removed).

This intravascular foreign matter removing wire 1A has a long wire body 2 and a capturing portion 3 provided at the tip of the wire body 2 and capable of capturing the embolus 200 in the blood vessel 100. . The configuration of each part will be described below.

[0056] The wire body 2 has moderate rigidity and elasticity (flexibility) over the entire length! The structure of the wire body 2 is not particularly limited. For example, the structure of the single wire, a bundle of a plurality of wires, a hollow shape, a tubular structure, a multilayer structure, a core material and its outer periphery It may be one having a coil wound around or a combination of these. [0057] The constituent material of the wire body 2 is not particularly limited, and various metal materials, various plastics, and the like can be used alone or in combination.

[0058] Further, the wire body 2 is located on the proximal end side and is relatively hard! /, The first part, the third part located relatively on the distal end side, and the first part. And the second part which is located between the third part and the third part, and the flexibility changes. In other words, the wire body 2 is preferably such that the rigidity (bending rigidity, torsional rigidity, etc.) gradually decreases from the proximal end toward the distal end. As a result, the operation at hand is reliably transmitted to the distal end, and the traveling performance within the blood vessel 100 and the operability at the bent portion are improved, and the flexibility of the distal end is improved and the blood vessel 100 is prevented from being damaged. be able to. In other words, it is possible to maintain a higher safety lifetime while maintaining the torque transmission performance, pushability (pushability), and kink resistance (bending resistance S resistance) of the wire body 2.

[0059] The outer surface (surface) of the wire body 2 may be provided with a coating layer that reduces frictional resistance with the inner surface of the catheter 8 described later. As a result, insertion and removal of the catheter 8 can be performed more smoothly. Examples of the coating layer include a coating layer of a fluorine resin such as polytetrafluoroethylene, and a hydrophilic polymer coat having lubricity when wet.

[0060] At the distal end side of the wire body 2 as described above, a capturing part 3 coaxial with the shaft 22 of the wire body 2 is provided. In the natural state, the capturing unit 3 is in the state shown in FIG. 1 (the same applies to FIGS. 4 to 6) (this state is hereinafter referred to as “the expanded diameter state”). In this expanded state, a foreign substance capturing space 31 capable of capturing the embolus 200 in the blood vessel 100 is formed inside the capturing unit 3.

[0061] The capturing part 3 can be deformed from the expanded state to a state where it is folded and reduced to a size that can be accommodated in the catheter 8 (this state is hereinafter referred to as a "reduced diameter state"). ing

[0062] Such a capturing portion 3 can be deformed (restored) from the reduced diameter state to the expanded diameter state by its own elasticity.

[0063] The capturing part 3 is provided at the tip of the wire body 2, and intersects with a first loop wire part 4 forming a loop shape and two different locations inside the first loop wire part 4 to form a loop shape. Between the second loop wire portion 5a and the first loop wire portion 4 and the second loop wire portion 5a. It has installed wire portions 7a and 7b.

[0064] In the present embodiment, the first loop wire portion 4 has an elliptical shape or an oval shape (in the configuration shown in Fig. 1, an elliptical shape).

[0065] The first loop wire portion 4 has a proximal end portion 44 of the first loop wire portion 4 that is a wire so that its long axis substantially coincides with the axis 22 of the wire body 2 (becomes parallel). It is fixed to the tip of the body 2 (see Fig. 1). The fixing method is not particularly limited. For example, the base end portion 44 of the first loop wire portion 4 is knitted (wrapped) to the distal end portion of the wire body 2, brazed, welded, bonded by IJ, etc. It can be fixed by applying. In addition, a coil 21 is provided at the tip of the wire body 2 to cover a fixing portion (brazing portion) of the first loop wire portion 4 with respect to the wire body 2. The outer surface of the coil 21 is smooth, which provides higher safety.

Note that the first loop wire portion 4 is composed of two branch wire portions branched from the tip of the wire body 2, and it can also be said that these tips are connected to each other.

[0067] The second loop wire portion 5a maintains the size of the loop of the first loop wire portion 4.

[0068] The second loop wire portion 5a has a substantially circular shape. In the capturing part 3, the length in the major axis direction of the first loop wire part 4 is set to be larger than the diameter (maximum diameter) of the loop of the second loop wire part. As a result, there is an advantage that a possibility that a relatively long thrombus (emboli 200) can be captured is increased.

As shown in FIG. 1, the second loop wire portion 5a is fixed near the central portion 42 in the direction of the axis 22 of the wire body 2 of the first loop wire portion 4. The fixing method is not particularly limited. For example, a part (intersection portion 32) of the second loop wire portion 5a is knitted (wrapped) around the central portion 42 of the first loop wire portion ₄ and brazed. Fix with force S by welding, bonding with adhesive, etc.

Note that the second loop wire portion 5a may be simply contacted without being fixed to the wire body 2 of the first loop wire portion 4. In this case, when trying to capture a relatively large thrombus (emboli 200), the second loop wire portion 5a moves in the distal direction with respect to the first loop wire portion 4, and the opening 34 expands. Thrombus easily enters. [0071] By the second loop wire portion 5a fixed in the vicinity of the central portion 42 of the first loop wire portion 4, the first loop wire portion 4 is directed, for example, from the outside toward the shaft 22 of the wire body 2. Even if an external force is applied in the force direction (the short axis direction of the first loop wire portion 4) (even when an external force is applied), the first loop wire portion 4 (capturing portion 3) is not easily crushed. Therefore, the embolus 200 can be easily captured (stored) in the foreign material capturing space 31 (see FIG. 6).

[0072] In addition, the second loop wire portion 5a is provided in the vicinity of the intersection portion 32 between the first loop wire portion 4 and the second loop wire portion 5a substantially orthogonally. As a result, the foreign matter capturing space 31 becomes larger than the case where, for example, the vicinity of the intersecting portion 32 intersects at an acute angle or an obtuse angle, and thus the embolus 200 is easily captured in the foreign matter capturing space 31. can do

Yes

[0073] By such a second loop wire portion 5a, the capturing portion 3 is inserted into the blood vessel 100 having a relatively small inner diameter (for example, near the branching portion of the blood vessel), and is pressed against the inner wall of the blood vessel, so that the capturing portion 3 ( For example, even when an external force is applied to the first loop wire portion 4), it is reliably prevented that the first loop wire portion 4 is bent toward the inside (foreign matter capturing space 31 side) by the external force. That is, the size of the loop of the first loop wire portion 4 is reliably maintained (see FIG. 4).

[0074] Thus, even when the capturing part 3 is inserted into the blood vessel 100 and the capturing part 3 is pressed against the inner wall of the blood vessel 100 (a state in which an external force is applied), the foreign matter capturing space 31 is formed. Crushing is surely prevented, that is, the foreign matter capturing space 31 is ensured to the maximum extent. Therefore, the embolus 200 can be accommodated in the foreign substance capture space 31 (capture part 3), that is, the embolus 200 can be reliably captured (see FIG. 6).

It should be noted that the first loop wire portion 4 is different from the second loop wire portion 5a in the configuration shown in FIG. 1 in that each intersection 32 is on the central axis 51 of the second loop wire portion 5a. The force that is positioned is not limited to this, and it may be located on the right side or the left side in FIG. When the first loop wire portion 4 is displaced (positioned) V on the right or left side in FIG. 1 with respect to the central axis 51, the amount of deviation of the intersection 32 with respect to the central axis 51 is not particularly limited. For example, 35 to 70% of the diameter of the second loop wire portion 5a is preferable, and 45 to 55% is more preferable. [0076] In the capturing part 3, an erected wire part 7a is provided on the distal end side with respect to the second loop wire part 5a, and an erected wire part 7b on the proximal end side with respect to the second loop wire part 5a. Is provided.

The construction wire portion 7 a has a distal end portion (one end portion) 71 connected to a distal end portion (top portion) 41 of the first loop wire portion 4. Further, the base end portion (the other end portion) 72 of the construction wire portion 7a is connected to a part of the second loop wire portion 5a on the left side in FIG. 1 with respect to the first loop wire portion 4. .

[0078] The erected wire portion 7b has a tip 71 connected to a part of the second loop wire portion 5a on the right side in FIG. 1 with respect to the first loop wire portion 4. Further, the base end portion 72 of the erection wire portion 7a is connected to the base end portion 44 of the first loop wire portion 4.

As described above, in the capturing part 3, the installation wire part 7a, the installation wire part 7b, and the force first loop filler part 4 are unevenly distributed on the opposite sides. The embolus 200 captured in the capturing part 3 (in the foreign matter capturing space 31) is reliably prevented from detaching to the tip side and the left side in FIG. 1 by the erection wire part 7a. Detachment to the proximal side and the right side in Fig. 1 is reliably prevented. As a result, the embolus 200 can be captured more reliably.

[0080] Further, the erected wire portions 7a and 7b contribute to maintaining the shape of the capturing portion 3, that is, the capturing portion 3 is prevented from being crushed by an external force.

[0081] Further, since the erection wire portion 7a and the erection wire portion 7b are provided unevenly as described above, the capture portion 3 is not provided with the erection wire portion. Between 4 and the second loop wire portion 5a. Between them, the opening 33 located on the distal end side (right side in FIG. 1) with respect to the second loop wire portion 5a and the proximal end side (see FIG. 1) with respect to the second loop wire portion 5a. An opening 34 located in the middle left) is formed!

[0082] As shown in Figs. 1 and 5, in the capturing unit 3 (intravascular foreign matter removing wire 1A), when the opening 34 force embolus 200 is captured, the embolus 200 is captured in the capturing unit 3. Used as an intake port for importing. As described above, the opening 34 functions as an intake port for the embolus 200, so that the embolus 200 can be reliably stored (taken in) the foreign matter capturing space 31. [0083] Further, since the foreign matter capturing space 31 is formed so that the embolus 200 can move in a straight line from the opening 34 to the opening 33, when the embolus 200 is captured, the embolus 200 is installed in the erected wire portion. It is prevented that the embolus 200 enters the capturing part 3 by being hit by 7a, 7b, etc., and the embolus 200 can be captured (stored) smoothly (smoothly).

[0084] Further, the maximum separation distance between the first loop wire portion 4 and the second loop wire portion 5a in the opening 34 is not particularly limited. For example, the diameter of the second loop wire portion 5 is 1 to 3 It is preferable that the ratio is 2 to 2.5 times. Thereby, the force depending on the size of the embolus 200 can be reliably taken into the foreign matter capturing space 31 through the opening 34. In addition, unintentional detachment of the embolus 200 taken in is prevented, so that the embolus 200 can be reliably captured.

[0085] The circumferential length of the second loop wire portion 5a between the intersecting portions 32 on the side where the erected wire portion 7b is erected! /, Na! /, (Not present), ensures the opening 33 sufficiently large. In consideration of this, about 35 to 70% of the entire circumference of the second loop wire portion 5a is preferable, and about 45 to 55% is more preferable.

[0086] Further, each of the erected wire portions 7a and 7b has an arch shape curved outward. As a result, even if an external force is applied to the erection wire portion 7a (same as the erection wire portion 7b) from outside, the erection wire portion 7a is prevented from being deformed, that is, the capturing portion 3 is relatively difficult to be crushed. . Thereby, the foreign substance capturing space 31 (the expanded diameter state of the capturing part 3) is reliably ensured, and thus the embolus 200 can be reliably captured in the foreign substance capturing space 31.

[0087] Further, the installation method of the erection wire portion 7a (the same applies to the erection wire portion 7b) is not particularly limited. For example, one linear body (wire) is connected to the first end portion (tip portion) thereof. There may be mentioned a method in which the first loop wire portion 4 is brought into contact with the other end portion (base end portion) in accordance with the second loop wire portion 5a.

[0088] The first loop wire portion 4, the second loop wire portion 5a, and the erection wire portions 7a and 7b can all be formed of a single linear body (wire).

[0089] Also, the first loop wire portion 4, the second loop wire portion 5a, the erection wire portions 7a and 7b

The constituent material of (capturing section 3) is not particularly limited, but for example, an alloy that exhibits superelasticity in vivo is preferable. As a result, the deformation (displacement) of the capturing part 3 from the reduced diameter state to the enlarged diameter state can be caused more reliably, and more accurate restoration can be achieved in the expanded diameter state. The shape is obtained. Further, since the second loop wire portion 5a is made of the alloy, the force S can be maintained more reliably to maintain the size of the loop of the first loop wire portion 4 even when an external force is applied. Therefore, the foreign substance capturing space 31 can be ensured more reliably.

[0090] Here, an alloy exhibiting superelasticity in a living body is almost at least at a living body temperature (around 37 ° C), even if it is deformed (bent, pulled, compressed) to a region where a normal metal undergoes composition deformation. It has the property of recovering to its original shape, and is also called a shape memory alloy, superelastic alloy, or the like.

[0091] The shape memory alloy and the superelastic alloy are not particularly limited. For example, titanium (Ti—Ni, Ti—Pd, Ti—Nb—Sn) and copper alloys are preferable.

Note that the medical device 9 of the present invention has such an intravascular foreign matter removing wire 1A and a force taper 8.

[0093] Next, an example of a method of using the intravascular foreign matter removing wire 1A of the present invention will be described in detail.

[1] FIG. 2 shows a state where an embolus 200 such as a thrombus is clogged in the blood vessel 100 to block the blood flow. The embolus 200 is pressed against the inner wall of the blood vessel 100 by blood pressure and does not move easily!

A catheter (microcatheter) 8 and a guide wire 10 passed through the lumen of the catheter 8 are inserted into the blood vessel 100 and protruded from the distal end opening 81 of the catheter 8. Insert 101 from the embolus 200 to the back (peripheral side). In other words, the distal end portion 101 of the guide wire 10 passes through the gap between the embolus 200 and the inner wall of the blood vessel 100 and exceeds the embolus 200. This operation can be performed more easily by using, for example, a micro guide wire having excellent lubricity as the guide wire 10.

[0096] [2] When the distal end portion 101 of the guide wire 10 exceeds the embolus 200, the catheter 8 is advanced relative to the guide wire 10, and the distal end portion of the catheter 8 is connected to the embolus 200 as shown in FIG. Enter the gap with the inner wall of the blood vessel 100. At this time, since the distal end portion of the catheter 8 smoothly enters the gap along the guide wire 10, this operation can be easily performed.

[0097] It should be noted that as a conventional treatment, there is a thrombus that does not dissolve with a thrombolytic agent, in which the thrombolytic agent is flowed retrogradely through the catheter 8 in this state to accelerate the thrombolysis. It is often experienced by doctors to work and dissolve for a long time. The present invention is also useful in such a case.

[3] From the state shown in FIG. 3, the guide wire 10 is removed, and the intravascular foreign matter removing wire 1 A of the present invention is inserted into the lumen of the catheter 8. As shown in FIG. 4, the capturing part 3 protrudes from the distal end opening 81 of the catheter 8 and the catheter 8 is dragged in the proximal direction.

[0099] The capturing part 3 in the catheter 8 in the reduced diameter state is automatically deployed due to its own elasticity, and becomes in the expanded diameter state. When the trapping portion 3 is in the expanded state, a foreign matter trapping space 31 that traps the embolus 200 is formed. At this time, as described above, even when the capturing part 3 is pressed against the inner wall of the blood vessel 100, the foreign substance capturing space 31 is reliably ensured.

[0100] [4] After the foreign matter capturing space 31 is formed (secured), the intravascular foreign matter removing wire 1A is moved in the proximal direction, that is, the intravascular foreign matter removing wire 1A is embolized 200. Pull back to the front. At this time, the embolus 200 starts to enter from the opening 34 toward the opening 33 (see FIG. 5). When the intravascular foreign matter removing wire 1A is further pulled in the proximal direction, the embolus 200 is scooped into the foreign matter catching space 31 of the catching portion 3 as shown in FIG. (Stored).

[5] While maintaining the state shown in FIG. 6, the intravascular foreign matter removing wire 1A is removed together with the catheter 8. As a result, the embolus 200 is collected (removed) in the parent guiding catheter or sheath introducer (not shown).

[0102] In the operation [4], the force that the embolus 200 is taken in from the opening 34 is not limited to this. Depending on the operation method (usage method) of the medical device 9, the opening 33 is directed to the opening 34. The embolus 200 may be taken up.

[0103] <Second Embodiment>

[0104] Hereinafter, the second embodiment of the intravascular foreign matter removing wire of the present invention will be described with reference to this figure. However, the difference from the above-described embodiment will be mainly described, and similar matters will be described. The explanation is omitted. [0105] This embodiment is the same as the first embodiment except that the number of installation wire portions is different.

[0106] In the intravascular foreign matter removing wire 1B shown in Fig. 7, the erected wire portion located on the proximal side with respect to the second loop wire portion 5a (corresponding to the erected wire portion 7b of the first embodiment) Is omitted. Thereby, an opening 35 is further formed between the first loop wire portion 4 and the second loop wire portion 5a. Therefore, the embolus 200 can be taken in from the base end side of the capturing part 3 through one of the openings 34 and 35. Therefore, when the embolus 200 is captured, depending on the case (for example, the state of the embolus 200 in the blood vessel 100), the erection wire portion 7a is installed! /, On the side (left side in FIG. 7). The opening 34 or the opening 35 on the opposite side (right side in FIG. 7) can be used. That is, the operability when capturing the embolus 200 is improved.

FIG. 8 is a perspective view showing a third embodiment of the intravascular foreign matter removing wire of the present invention.

Yes

Hereinafter, the third embodiment of the intravascular foreign matter removing wire of the present invention will be described with reference to this figure. However, the difference from the above-described embodiment will be mainly described, and similar matters will be described. The explanation is omitted.

The present embodiment is the same as the first embodiment except that the shape (size) of the second loop wire portion is different.

[0110] The second loop wire portion 5a 'of the intravascular foreign matter removing wire 1C shown in Fig. 8 has sharply curved curved portions 52 on opposite sides of each other via the first loop wire portion 4. Each is formed. The degree of steepness is not particularly limited. For example, the curvature radius of each curved portion 52 is 1/4 to 3/4 times the diameter of the second loop wire portion 5a ′ (2/8 to 6/8). It is more preferable to be 1/2 to 5/8 times (4/8 to 5/8 times).

[0111] When the embolus 200 is captured by each bending portion 52, the bending portion 52 can reliably engage with the embolus 200, and the operation (capturing operation) can be performed more reliably.

[0112] Further, in the capturing part 3, the longitudinal force of the first loop wire part 4 in the major axis direction is the maximum loop diameter of the second loop filler part 5a ', that is, the distance between the curved parts 52 Almost the same as Or smaller. As a result, not only vertically elongated thrombus (thrombus in the posture in which the longitudinal direction is oriented in the vertical direction in FIG. 8) but also laterally thrombus (thrombus in the posture in which the longitudinal direction is directed in the lateral direction in FIG. 8) is also collected There is an advantage that it may be possible.

[0113] <Fourth embodiment>

FIG. 9 is a perspective view showing a fourth embodiment of the intravascular foreign matter removing wire of the present invention.

[0114] Hereinafter, the fourth embodiment of the intravascular foreign matter removing wire of the present invention will be described with reference to this figure. The difference from the above-described embodiment will be mainly described, and similar matters will be described. The explanation is omitted.

This embodiment is the same as the first embodiment except that the configuration of the first loop wire portion is different.

In the intravascular foreign matter removing wire 1D shown in FIG. 9, a plate-like member (plate-like member) 6 is installed at the distal end portion 41 of the first loop wire portion 4. An erected wire portion 7 a is connected to the first loop wire portion 4 through the plate-like member 6.

Further, the plate-like member 6 is installed so that its surface 61 is substantially perpendicular to the axis 22 of the wire body 2. That is, the plate-like member 6 is installed so that one surface (surface 61) faces the front end direction. As a result, when the capturing unit 3 is placed (protruded) in the blood vessel 100 (for example, in the state shown in FIG. 4), the plate-like member 6 assumes a posture substantially perpendicular to the blood flow. In this state, blood flow is suppressed in the vicinity of the capturing part 3 (plate-like member 6), and therefore an operation (capturing operation) for capturing the embolus 200 can be easily performed.

[0118] Further, the plate-like member 6 has a disk shape. Thereby, the capturing part 3 (plate-like member 6) can move smoothly with respect to the blood vessel 100, so that the intravascular foreign matter removing wire 1D can be operated easily and smoothly.

[0119] The plate-like member 6 is not limited to a plate-like member, and may be, for example, a plate member curved into a spherical shape.

[0120] Further, the constituent material of the plate-like member 6 is not particularly limited, and various metal materials, various plastics, and the like can be used alone or in combination.

[0121] <Fifth Embodiment> FIG. 10 is a perspective view showing a fifth embodiment of the intravascular foreign matter removing wire of the present invention.

[0122] Hereinafter, the fifth embodiment of the intravascular foreign matter removing wire of the present invention will be described with reference to this figure. However, the difference from the above-described embodiment will be mainly described, and similar matters will be described. The explanation is omitted.

This embodiment is the same as the first embodiment, except that the number of second loop wire portions is different.

[0124] There are a plurality (four in this embodiment) of the intravascular foreign matter removing wire 1E shown in FIG.

Two loop wire portions 5a, 5b, 5c and 5d are provided. These second loop filler portions 5a to 5d are arranged substantially parallel to each other along the major axis direction.

[0125] With such second noreop wire portions 5a to 5d, even when an external force is applied to the first loop wire portion 4, the size of the loop of the first loop wire portion 4 is more reliably maintained. be able to. As a result, the foreign substance capturing space 31 is reliably secured, and thus the embolus 200 can be reliably captured in the foreign substance capturing space 31. In addition, when the embolus 200 is stored in the foreign substance capturing space 31, the contact area between the capturing unit 3 and the embolus 200 is larger than the contact area between the capturing unit 3 and the embolus 200 in the first embodiment. Thereby, the captured embolus 200 can be held more reliably.

[0126] Further, the second norepe wire portions 5a to 5d are arranged so as to be unevenly distributed on the front end side with respect to the central portion 42 of the first loop wire portion 4. Thereby, the embolus 200 captured by the capturing part 3 can be prevented from unintentionally separating to the distal end side when the intravascular foreign matter removing wire 1E is pulled in the proximal direction.

[0127] Further, the second loop wire portions 5a to 5d have their installation intervals, that is, adjacent first

The interval between the two loop wire portions gradually increases toward the tip. As a result, the size of the loop of the first loop wire portion 4, particularly the portion on the tip side of the central portion 42 of the first loop wire portion 4 (the second loop wire portions 5 a to 5 d are installed). The curvature (the size of the strings) can be kept in excess or deficiency, that is, it can be kept almost constant (uniform) regardless of the magnitude of the external force.

[0128] Note that the number of second loop wire portions installed is not limited to four, for example, two 3 or 5 or more.

[0130] Hereinafter, the sixth embodiment of the intravascular foreign matter removing wire of the present invention will be described with reference to this figure. However, the difference from the above-described embodiment will be mainly described, and similar matters will be described. The explanation is omitted.

[0131] This embodiment is the same as the first embodiment except that the number of installation wire portions is different.

[0132] In the intravascular foreign matter removing wire 1F shown in Fig. 11, a plurality (three in this embodiment) of erected wire portions 7c, 7d and 7e are provided on the distal end side with respect to the second loop wire portion 5a. A plurality (three in this embodiment) of erected wire portions 7f, 7g, and 7h are provided on the base end side with respect to the second loop wire portion 5a.

Thus, when the embolus 200 is stored in the foreign substance capturing space 31, the contact area between the capturing part 3 and the embolus 200 is equal to the contact area between the capturing part 3 and the embolic object 200 of the first embodiment. Become bigger. Therefore, the captured embolus 200 can be held more reliably. Further, even when an external force is applied to the capturing part 3, the capturing part 3 is more reliably prevented from being deformed. As a result, the foreign substance capturing space 31 (the expanded diameter state of the capturing unit 3) is ensured, and thus the embolus 200 can be reliably captured in the foreign object capturing space 31.

Further, the erected wire portions 7c to 7e are arranged around the shaft 22 of the wire body 2. As a result, the arrangement density of the erected wire portions 7c to 7e in the vicinity of the distal end portion 41 of the first loop wire portion 4 is relatively high (as compared with the vicinity of the second loop wire portion 5a), and thus the trap It is possible to more reliably prevent the embolus 200 that has been removed from separating toward the distal end side.

[0135] The erected wire portions 7f to 7h are also arranged around the axis 22 of the wire body 2 in the same manner as the erected wire portions 7c to 7e. As a result, the installation density of the erected wire portions 7f to 7h in the vicinity of the base end portion 44 of the first loop wire portion 4 is relatively higher (than in the vicinity of the second loop wire portion 5a). , It is possible to more reliably prevent the captured embolus 200 from detaching to the proximal end side.

Yes [0136] Although the number of installation wire portions arranged on the distal end side with respect to the second loop wire portion 5a is the same as the number of installation wire portions arranged on the proximal end side, they are the same. It is not limited and may be different.

[0137] When these installation numbers are different from each other, for example, the number of installation wire sections arranged on the distal end side is set to be larger than the installation wire section arranged on the proximal end side. Sliding power S In this case, the plurality of erection wire portions on the distal end side may be unevenly arranged on the left side in FIG. 11 with respect to the first loop wire portion 4. 11 on the left and right sides (both sides) in FIG. 11, that is, along the circumferential direction of the second loop wire portion 5a (around the axis 22 of the wire body 2) at equal angular intervals. Also good.

[0139] Hereinafter, the seventh embodiment of the intravascular foreign matter removing wire of the present invention will be described with reference to this figure. However, the difference from the above-described embodiment will be mainly described, and similar matters will be described. The explanation is omitted.

[0140] This embodiment is the same as the above except that the installation form (installation state) of each erection wire portion is different.

The same as in the sixth embodiment.

[0141] In the intravascular foreign matter removing wire 1G shown in Fig. 12, the erected wire portions 7c to 7e are arranged substantially parallel to each other. Further, the erected wire portions 7f to 7h are also arranged substantially parallel to each other, like the erected wire portions 7c to 7e.

Thereby, the relatively large embolus 200 can be captured appropriately.

As described above, the intravascular foreign matter removing wire and the medical instrument of the present invention have been described with respect to the illustrated embodiment. However, the present invention is not limited thereto, and the intravascular foreign matter removing wire and the medical device are not limited thereto. Each component of the instrument can be replaced with any component that can perform the same function. Moreover, arbitrary components may be added.

[0143] Further, the intravascular foreign matter removing wire and medical device of the present invention may be a combination of any two or more configurations (features) of the above embodiments! /.

[0144] For example, in the capturing unit of the third embodiment, like the capturing unit of the second embodiment, The erected wire portion on the base end side with respect to the two loop wire portions may be omitted.

Further, in the capturing sections of the second to fourth embodiments, the sixth embodiment, and the seventh embodiment, a plurality of second loop wire sections are provided as in the capturing section of the fifth embodiment. May be.

In addition, the first loop wire portion of the second embodiment, the third embodiment, and the fifth to seventh embodiments is similar to the first loop wire portion of the fourth embodiment. A plate-shaped member may be installed.

[0146] Further, the first loop wire portion of the fourth to seventh embodiments may be formed with a curved portion like the first loop wire portion of the third embodiment. .

[0147] In addition, in the capturing part of the sixth embodiment, the plurality of construction wire parts on the distal end side and the base end side with respect to the second loop wire part are like the plurality of construction wire parts of the seventh embodiment. Alternatively, they may be arranged parallel to each other.

[0148] Further, the capturing unit may be provided with a detachment preventing means for preventing the captured embolus from detaching. The separation preventing means is not particularly limited. For example, a material having a relatively high static friction coefficient (elastic material) coated on the capturing part, minute irregularities generated by roughing the capturing part, and capturing foreign matter. There are many minute linear objects protruding into the space.

Industrial applicability

[0149] The intravascular foreign matter removing wire of the present invention includes a flexible long wire body, a first loop wire portion that is provided at the tip of the wire body and forms a loop shape, and the first wire body. At least one second loop wire portion in the form of a loop that intersects two different portions of the loop wire portion and maintains the size of the loop of the first loop wire portion, and the second loop wire portion On the other hand, at least one of the distal end side and the proximal end side has at least one erection wire portion constructed between the first loop wire portion and the second loop wire portion. As a result, a foreign body removal wire was inserted into a blood vessel having a relatively small inner diameter, and the first loop wire portion and the second loop wire portion were pushed into the blood vessel inner wall, and an external force was applied to these portions. Even when the external force is applied, the loop size of the first loop wire portion is reliably prevented from changing, that is, the size of the loop is reliably determined. Really maintained. As a result, even when an external force is applied, a space for capturing the foreign matter in the blood vessel is reliably secured, so that the foreign matter can be reliably captured (stored) in the space. . Further, the trapped foreign matter is reliably prevented from unintentionally leaving the space by the erection wire portion. As a result, the force S can be removed to reliably remove foreign matter. Therefore, the intravascular foreign matter removing wire of the present invention has industrial applicability.

Claims

The scope of the claims

[1] a flexible long wire body;

A first loop wire portion that is provided at the tip of the wire body and forms a loop shape, and intersects with two different locations of the first loop wire portion, and the size of the loop of the first loop wire portion Maintaining at least one second loop wire portion in the form of a loop, and at least one of a distal end side and a proximal end side with respect to the second loop wire portion, the first loop wire portion and the second loop wire portion An intravascular foreign matter removing wire comprising: at least one erected wire portion erected between the loop wire portion.

2. The intravascular foreign matter removing wire according to claim 1, wherein the force near the intersection S between the first loop wire portion and the second loop wire portion is substantially orthogonal.

[3] The blood vessel according to claim 1 or 2, wherein the second loop wire portion is installed near a central portion of the first loop wire portion in the axial direction of the wire body. Inside Foreign matter removal wire.

[4] The first loop wire portion has an elliptical or oval shape, and a length in a major axis direction thereof is larger than a maximum diameter of the loop of the second loop wire portion. The wire for removing a foreign substance in a blood vessel according to item 1 or 2 of the range.

[5] The first loop wire portion has an elliptical shape or an oval shape, and a length in a major axis direction thereof is substantially equal to or smaller than a maximum diameter of the loop of the second loop wire portion. The intravascular foreign matter removing wire according to claim 1 or 2, wherein

[6] The intravascular foreign matter removing wire according to [1] or [2], wherein a plurality of the second loop wire portions are provided.

[7] The blood vessel according to claim 6, wherein the plurality of second loop wire portions are unevenly distributed on the distal end side with respect to the central portion in the axial direction of the wire main body of the first loop wire portion. Wire for removing foreign substances.

8. The intravascular foreign matter removing wire according to claim 6, wherein the plurality of second loop wire portions are disposed substantially parallel to each other.

[9] In the plurality of second loop wire portions, the installation interval thereof is gradually increased in the distal direction. The wire for removing a foreign substance in a blood vessel according to claim 6, wherein the wire is removed.

[10] The intravascular foreign matter according to [1] or [2], wherein the erection wire portion is provided on the distal end side and the proximal end side with respect to the second loop wire portion, respectively. Remover.

[11] The erected wire portion on the distal end side with respect to the second loop wire portion, and the erected wire portion on the proximal end side with respect to the second loop wire portion include the first loop wire portion. 11. The intravascular foreign matter removing wire according to claim 10, wherein the wire is unevenly distributed on opposite sides of each other

12. The intravascular foreign matter removing wire according to claim 10, wherein a plurality of the erected wire portions on the distal end side with respect to the second loop wire portion are provided.

13. The intravascular foreign matter removing wire according to claim 12, wherein the plurality of erected wire portions are arranged around an axis of the wire body.

14. The intravascular foreign matter removing wire according to claim 12, wherein the plurality of erected wire portions are arranged substantially parallel to each other.

15. The intravascular foreign matter removing wire according to claim 10, wherein a plurality of the erected wire portions on the proximal end side with respect to the second loop wire portion are provided.

16. The intravascular foreign matter removing wire according to claim 15, wherein the plurality of erected wire portions are arranged around an axis of the wire body.

17. The intravascular foreign matter removing wire according to claim 15, wherein the plurality of erected wire portions are arranged substantially parallel to each other.

18. The intravascular foreign matter removing wire according to claim 1 or 2, wherein the erected wire portion is curved outward.

[19] A plate-shaped member is installed at the tip of the first loop wire portion,

The range of claim 1 or 2, wherein the erection wire portion is provided on a distal end side with respect to the second loop wire portion, and is connected to the first loop wire portion via the member. The intravascular foreign matter removing wire as described.

[20] The opening force between the first loop wire portion not provided with the erection wire portion and the second loop wire is used as a foreign substance intake port in a blood vessel. The wire for removing a foreign substance in a blood vessel according to item 1 or 2.

21. The intravascular foreign matter removing wire according to any one of claims 1 to 20, and a catheter having a lumen capable of storing the intravascular foreign matter removing wire. Medical instrument.