WO2008013155A1

WO2008013155A1 - Wire, and medical device, for removing intravascular foreign matter

Info

Publication number: WO2008013155A1
Application number: PCT/JP2007/064475
Authority: WO
Inventors: Aya Sekido; Takeshi Kanamaru
Original assignee: Terumo Kabushiki Kaisha
Priority date: 2006-07-27
Filing date: 2007-07-24
Publication date: 2008-01-31

Abstract

A wire for removing intravascular foreign matter that is used to trap and remove any intravascular foreign matter. This wire for removing intravascular foreign matter comprises a flexible lengthy wire main body; at least three separate wire parts branched from the distal end of the wire main body, which separate wire parts at distal ends thereof are coupled together; and at least one hanging wire part provided so as to hang between, excluding at least one set of neighboring separate wire parts, the remaining sets of neighboring separate wire parts, thereby retaining the spacing between the separate wire parts.

Description

Specification

Intravascular foreign matter removal wire and medical device

Technical field

[0001] The present invention relates to an intravascular foreign matter removing wire for removing foreign matter in a blood vessel and a medical instrument including the same.

Background art

[0002] According to the demographic statistics of the Ministry of Health, Labor and Welfare, the first cause of death in Japan is cancer, second is heart disease, third is stroke, especially death due to stroke and sequelae increase, and establishment of treatment methods Is an urgent need.

[0003] In recent years, thrombolytic therapies using thrombolytic agents have been developed for the treatment of strokes! And for the treatment of acute cerebral infarction, and their therapeutic effects have been pointed out, but their limitations have also been pointed out. In other words, doctors experience that thrombolytic agents require a long time for thrombolysis, small thrombi further fly to form new emboli sites, and there are thrombi that do not dissolve with thrombolytic agents. It is recognized from.

[0004] In the case of cerebral infarction, if the blood flow can be resumed within 3 hours after the onset of the infarction, not only will the survival rate increase, but it has been proven in the US and Europe that it can be inserted into the cerebral blood vessels. There is a strong demand for the development of medical devices that can directly remove blood clots (wires for removing foreign substances in blood vessels).

[0005] A conventional intravascular foreign matter removing wire has a long wire body and a capturing part that is provided on the distal end side of the wire body and captures a thrombus (see, for example, Patent Document 1). . The trapping part is composed of two branch wire parts that branch from the tip of the wire body and three filament parts that are installed between these branch wire parts, and a foreign matter trapping space is formed inside. Yes.

[0006] However, this intravascular foreign matter removing wire is used depending on the state of the blood vessel into which the wire is inserted (for example, the size of the inner diameter), the state of the thrombus (for example, the size and shape), and the degree of bending of the blood vessel. There has been a problem that each branch wire part and each filament part (capturing part) are pressed against the thrombus and the inner wall of the blood vessel, and the foreign substance capturing space may be crushed. In this case, thrombus Is stored in the foreign matter capturing space, that is, it is difficult to capture the thrombus.

[0007] Patent Document 1: Japanese Patent Application Laid-Open No. 2003-10193

Disclosure of the invention

[0008] An object of the present invention is to remove a foreign substance in a blood vessel that reliably secures a space for catching a foreign substance in a blood vessel and can reliably catch the foreign substance in the blood vessel even when an external force is applied. To provide chairs and medical devices.

In order to achieve the above object, the present invention provides:

A long wire body having flexibility;

Branching from the tip of the wire body, and at least three branching wire portions connected to each other; and

Except at least one pair of the adjacent branch wire portions, at least one installation wire portion that is installed between the remaining adjacent branch wire portions and maintains the distance between the branch wire portions. A wire for removing foreign matter in blood vessels, characterized by comprising:

[0010] Thereby, even when an external force is applied, it is possible to reliably secure a space for capturing the foreign matter in the blood vessel and reliably capture the foreign matter in the blood vessel.

[0011] In order to achieve the above object, the present invention provides:

A long wire body having flexibility;

At least three branch wire portions branched from the tip of the wire body;

A connecting member having a plate shape that connects the ends of each branch wire portion and the remaining adjacent branch wire portions excluding at least one pair of adjacent branch wire portions. An intravascular foreign matter removing wire having at least one erected wire portion that maintains the distance between the branch wire portions.

[0012] Thereby, even when an external force is applied, it is possible to reliably secure a space for capturing the foreign matter in the blood vessel and reliably capture the foreign matter in the blood vessel.

[0013] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that the connecting member is installed so that a surface thereof is substantially perpendicular to an axis of the sheath body.

[0014] Thereby, when the intravascular foreign matter removing wire is placed (projected) in the blood vessel, the connecting member is in a posture substantially perpendicular to the blood flow. In this state, blood flow near the connecting member Therefore, it is possible to easily perform an operation (capturing operation) when capturing a foreign substance in a blood vessel.

[0015] In the intravascular foreign matter removing wire of the present invention, it is preferable that the connecting member has a disc shape.

[0016] Thereby, the connecting member can move smoothly with respect to the blood vessel, and thus the force S for easily and smoothly operating the foreign matter removing wire can be obtained.

[0017] Further, in the intravascular foreign matter removing wire of the present invention, the three branch wire portions are provided, and the erected wire portion is interposed between one set of adjacent branch wire portions. It ’s a good idea!

[0018] Thereby, even when an external force is applied, it is possible to reliably secure a space for capturing the foreign matter in the blood vessel and reliably capture the foreign matter in the blood vessel.

[0019] In the intravascular foreign matter removing wire of the present invention, it is preferable that the erected wire portion connects the central portions in the longitudinal direction of the branch wire portion.

[0020] Thereby, the intravascular foreign matter removal wire is inserted into a blood vessel having a relatively small inner diameter (for example, near the branching portion of the blood vessel), and is pushed against the inner wall of the blood vessel, for example, the installation wire portion is installed 2 Even when an external force is applied to the branch wire portion of the book, the external force reliably prevents the branch wire portions from bending inward, that is, the distance between the branch wire portions is reduced. It is reliably maintained.

[0021] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that the erected wire portion is disposed substantially perpendicular to the axis of the wire body.

[0022] As a result, a force that efficiently draws the foreign matter toward the proximal side (hand side) is generated with respect to the foreign matter in the blood vessel that has begun to contact the erection wire portion, thereby reliably capturing the foreign matter. be able to.

[0023] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that the erected wire portion is arranged to be inclined with respect to the axis of the wire body! /.

[0024] Thereby, the contact area force between the erected wire portion and the trapped foreign matter in the blood vessel becomes relatively large, so that the trapped foreign matter can be more reliably held.

[0025] In the intravascular foreign matter removing wire of the present invention, the erected wire portion faces outward. I prefer to bend it!

[0026] Thereby, even when an external force is applied to the installation wire portion from the outside, the installation wire portion is prevented from being deformed, and thus foreign substances in the blood vessel are reliably captured inside the installation wire portion. And force S.

[0027] In the intravascular foreign matter removing wire of the present invention, it is preferable that a plurality of the erected wire portions are provided between a pair of adjacent branch wire portions.

[0028] With this, it is possible to prevent the trapped foreign matter in the blood vessel from unintentionally leaving the distal end when the intravascular foreign matter removing wire is dragged in the proximal direction.

[0029] In the intravascular foreign matter removing wire of the present invention, it is preferable that the plurality of erected wire portions are unevenly distributed on the distal end side with respect to the central portion in the longitudinal direction of the branch wire portion.

[0030] Thereby, the trapped foreign matter in the blood vessel can be prevented from unintentionally leaving the distal end side when the intravascular foreign matter removing wire is dragged in the proximal direction.

[0031] Further, in the intravascular foreign matter removing wire of the present invention, it is preferable that the plurality of erected wire portions have an arrangement density that gradually becomes sparse in the distal direction.

[0032] Thereby, the interval between the branch wire portions on which the plurality of erection wire portions are erected, in particular, the distance between the branch wire portions on the tip side (the portion where the plurality of erection wire portions are installed) is not excessive. In short, that is, it can be maintained almost constant (uniform) regardless of the magnitude of the external force.

[0033] In the intravascular foreign matter removing wire of the present invention, it is preferable that the erected wire portion is made of an alloy exhibiting superelasticity in a living body! /.

[0034] Thereby, even when an external force is applied, the interval between the branch wire portions on which the erection wire portion is erected can be reliably maintained, and therefore, each branch wire portion and the erection wire portion are defined. More secure space.

[0035] Further, in the intravascular foreign matter removing wire of the present invention, the branch wire portions are arranged at substantially equal angular intervals around the axis of the wire body when viewed from the front end side. Is preferred.

[0036] Thereby, the space defined by the branch wire portions becomes relatively large, and thus foreign substances in the blood vessel can be easily captured in the space.

[0037] In the intravascular foreign matter removing wire of the present invention, each branch wire portion faces outward. It ’s a force, it ’s curved!

[0038] Thereby, for example, even if an external force is applied to each branch wire portion from the outside to the axis of the wire body and in the opposite direction (even when an external force is applied), each branch wire portion is relatively crushed. hard. Therefore, the foreign substance in the blood vessel can be captured (accommodated) easily and reliably inside each branch wire portion.

[0039] In addition, in the intravascular foreign matter removing wire of the present invention, the opening force between a pair of adjacent branch wire portions not provided with the erected wire portion is used as a foreign matter intake port in the blood vessel. Is preferred.

[0040] Thereby, the foreign substance in the blood vessel can be reliably stored (taken in) in the space defined by each branch wire portion and the erection wire portion.

[0041] In order to achieve the above object, the present invention provides:

A long wire body having flexibility;

An intravascular foreign matter removing wire characterized by having at least one erected wire portion that is laid between two adjacent branch wire portions and that maintains the distance between the branch wire portions. is there.

[0042] Thereby, even when an external force is applied, it is possible to reliably secure a space for capturing the foreign matter in the blood vessel and reliably capture the foreign matter in the blood vessel.

[0043] In the intravascular foreign matter removing wire of the present invention, it is preferable that the at least three branch wire portions include at least one branch wire on which the erection wire portion is not erected. .

[0044] Thereby, the foreign matter in the blood vessel can be reliably stored (taken in) in the space defined by each branch wire portion and the erection wire portion.

[0045] In order to achieve the above object, the present invention provides:

The intravascular foreign matter removal wire;

A medical device comprising a catheter having a lumen capable of accommodating the wire for removing foreign matter in a blood vessel. [0046] Thereby, even when an external force is applied, it is possible to reliably secure a space for capturing the foreign matter in the blood vessel and reliably capture the foreign matter in the blood vessel.

Brief Description of Drawings

FIG. 1 is a perspective view showing a first embodiment of the intravascular foreign matter removing wire of the present invention.

FIG. 2 is a view of the intravascular foreign matter removing wire in FIG. 1 as viewed from the arrow A side.

[Fig. 3] Fig. 3 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in Fig. 1.

[Fig. 4] Fig. 4 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in Fig. 1.

FIG. 5 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in FIG. 1.

[Fig. 6] Fig. 6 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in Fig. 1.

FIG. 7 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in FIG. 1.

FIG. 8 is a perspective view showing a second embodiment of the intravascular foreign matter removing wire of the present invention.

FIG. 9 is a perspective view showing a third embodiment of the intravascular foreign matter removing wire of the present invention.

FIG. 10 is a perspective view showing a fourth embodiment of the intravascular foreign matter removing wire of the present invention.

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the intravascular foreign matter removing wire and medical device of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

FIG. 1 is a perspective view showing a first embodiment of an intravascular foreign matter removing wire according to the present invention, and FIG. 2 is a view of the intravascular foreign matter removing wire in FIG. 3 to 7 FIG. 3 is a diagram for explaining step by step how to use the intravascular foreign matter removing wire shown in FIG. 1; In the following, for convenience of explanation, the upper side in FIG. 1 (the same applies to FIGS. 8 to 10) is referred to as the “front end side”, and the lower side is referred to as the “base end side”. The left side in the figure is referred to as “tip side”, and the right side is referred to as “base side”.

[0050] The intravascular foreign matter removing wire 1A shown in Fig. 1 and Fig. 2 (similarly in Fig. 5 to Fig. 7) is a foreign matter that causes embolization of blood clots, blood clots, etc. in blood vessel 100 (hereinafter referred to as the foreign matter). This is called “emboli”.

[0051] This intravascular foreign matter removing wire 1A has a long wire body 2 and a capturing part 3 provided at the tip of the wire body 2 and capable of capturing the embolus 200 in the blood vessel 100. . The configuration of each part will be described below.

[0052] The wire body 2 has moderate rigidity and elasticity (flexibility) over the entire length. The structure of the wire body 2 is not particularly limited. For example, the structure of the single wire, a bundle of a plurality of wires, a hollow shape, a tubular structure, a multilayer structure, a core material and its outer periphery It may be one having a coil wound around or a combination of these.

[0053] The constituent material of the wire body 2 is not particularly limited, and various metal materials, various plastics, and the like can be used alone or in combination.

[0054] Further, the wire body 2 is located on the proximal end side and is relatively hard! /, The first part, the third part located on the distal end side and relatively flexible, and the first part. And the second part which is located between the third part and the third part, and the flexibility changes. In other words, the wire body 2 is preferably such that the rigidity (bending rigidity, torsional rigidity, etc.) gradually decreases from the proximal end toward the distal end. As a result, the operation at hand is reliably transmitted to the distal end, and the traveling performance within the blood vessel 100 and the operability at the bent portion are improved, and the flexibility of the distal end is improved and the blood vessel 100 is prevented from being damaged. be able to. In other words, it is possible to maintain a higher safety lifetime while maintaining the torque transmission performance, pushability (pushability), and kink resistance (bending resistance S resistance) of the wire body 2.

[0055] The outer surface (surface) of the wire body 2 may be provided with a coating layer that reduces frictional resistance with the inner surface of the catheter 8 described later. As a result, insertion and removal of the catheter 8 can be performed more smoothly. As this coating layer, for example, polytetrafluoroethylene Examples thereof include a coating layer of a fluorine resin such as len and a hydrophilic polymer coat having lubricity when wet.

[0056] At the distal end side of the wire body 2 as described above, a capturing part 3 coaxial with the axis of the wire body 2 is provided. In the natural state, the capturing part 3 is in the state shown in FIG. 1 (the same applies to FIGS. 2 and 5 to 7) (this state is hereinafter referred to as “the expanded diameter state”). In this expanded state, a foreign substance capturing space 31 capable of capturing the embolus 200 in the blood vessel 100 is formed inside the capturing part 3.

[0057] The capturing part 3 can be deformed from the expanded state to a state where it is folded and reduced to a size that can be accommodated in the catheter 8 (this state is hereinafter referred to as a "reduced diameter state"). ing

Yes

[0058] Such a capturing part 3 can be deformed (restored) from the reduced diameter state to the expanded diameter state by its own elasticity.

[0059] As shown in FIGS. 1 and 2, the capturing section 3 is composed of three wires that branch from the tip of the wire body 2 and extend (extend) toward the tip. Branch wire portions 4a, 4b and 4c, and one installation wire portion provided between a pair of adjacent branch wire portions (in this embodiment, between the branch wire portions 4a and 4b). 5a. One set of branch wire portions means “two adjacent branch wire portions”. The branch wire portion adjacent to the branch wire portion 4a is the branch wire portion 4b or 4c.

[0060] The branch wire portions 4a, 4b, and 4c have substantially the same length, and their front ends 41 are connected to each other. Further, each of the branch wire portions 4a, 4b and 4c has an arch shape in which the shape is curved outward (direction force, outward direction from the shaft 22 of the wire body 2). As a result, even if an external force acts on the branch wire portions 4a, 4b, and 4c, for example, from the outside to the shaft 22 of the wire body 2 in the opposite direction (even when an external force is applied), Portions 4a, 4b and 4c (capturing portion 3) are relatively difficult to collapse. Therefore, the embolus 200 can be captured (stored) easily and reliably in the foreign substance capturing space 31 (see FIG. 7).

Further, as shown in FIG. 2, each of the branch wire portions 4a, 4b and 4c is arranged around the axis 22 of the wire body 2 when viewed from the distal end side (arrow A side in FIG. 1). They are arranged at almost equal angular intervals. As a result, the foreign matter capturing space 31 becomes relatively large, and accordingly The embolus 200 can be easily captured in the space 31.

In the present embodiment, the proximal end portions of the branch wire portions 4a, 4b and 4c are fixed (fixed) to the distal end portion of the wire body 2, respectively. This fixing method is not particularly limited. 1S For example, the base ends of the branch wire portions 4a, 4b and 4c are knitted (wrapped) around the tip of the wire body 2, brazing, welding, bonding with an adhesive, etc. Fix with application force S.

[0063] Further, a coil 21 is provided at the distal end of the wire body 2 to cover a fixing portion (brazing portion) of the branch wire portions 4a, 4b and 4c with respect to the wire body 2. The outer surface of the coil 21 is smooth, which provides higher safety.

[0064] As shown in Fig. 1, in the capturing part 3, one installation wire part 5a is installed between the branch wire parts 4a and 4b. That is, in the capturing part 3, between the branch wire parts 4a and 4b on which one installation wire part 5a is installed, between the branch wire parts 4b and 4c on which the installation wire part 5a is not installed, and the like There is a space between the branch wire portions 4a and 4c where the erected wire portion 5a is not erected. Among the branch wire parts 4a to 4c, there is an installation wire part such as the installation wire part 5a! /, NA! /, (Free) at least one branch wire part (branch wire part 4c) exists. .

[0065] The erection wire portion 5a maintains the distance between the branch wire portions 4a and 4b. Further, the erected wire portion 5a connects the respective center portions 42 (the top portions of the arch-shaped portions) in the longitudinal direction of the branch wire portions 4a and 4b.

[0066] By this erection wire portion 5a, the capture portion 3 is inserted into the blood vessel 100 having a relatively small inner diameter (for example, near the branch portion of the blood vessel) and pushed against the inner wall of the blood vessel, for example, the branch wire portion 4a (capture portion 3). ), Even when an external force is applied, the external wire reliably prevents the branch wire portion 4a from bending toward the inside (foreign material capturing space 31 side), that is, the distance between the branch wire portions 4a and 4b. Is reliably maintained (see Fig. 5).

[0067] Thereby, even when the trapping part 3 is inserted into the blood vessel 100 and the trapping part 3 is pressed against the inner wall of the blood vessel 100 (a state in which an external force is applied), the foreign matter trapping space 31 is not generated. Crushing is surely prevented, that is, the foreign matter capturing space 31 is ensured to the maximum extent. Therefore, the embolus 200 can be accommodated in the foreign substance capture space 31 (capture part 3), that is, the embolus 200 can be reliably captured (see FIG. 7). In addition, the erection wire portion 5 a is disposed substantially perpendicular to the axis 22 of the wire body 2 in the erection direction (extension direction). As a result, a force that efficiently draws the embolus 200 toward the proximal end (hand side) is generated against the embolus 200 (thrombus) that has begun to contact the erected wire portion 5a. Can be captured. In addition, there is also an advantage that an embolus 200 having a flat tip shape such as a tray that penetrates to the tip side of the wire body 2 can be recovered!

[0069] As shown in Fig. 2 (also in Fig. 1), the erected wire portion 5a has an arch shape whose shape is curved outward. Thereby, even when an external force is applied to the erected wire portion 5a from the outside, the erected wire portion 5a is prevented from being deformed, that is, the capturing portion 3 is relatively difficult to be crushed. As a result, the foreign substance capturing space 31 (the expanded diameter state of the capturing part 3) is ensured, and thus the embolus 200 can be reliably captured in the foreign substance capturing space 31.

In addition, the erected wire portion 5a can be bent in a direction in which the branch wire portions 4a and 4b approach each other, that is, in a direction in which the curvature of the erected wire portion 5a increases. Thereby, when the capture part 3 is accommodated in the catheter 8, the capture part 3 is easily reduced in diameter.

[0071] The installation position of the erection wire portion 5a, that is, the distance m from the tip of the capturing portion 3 is not particularly limited, and is, for example, 0.;! To 0 · 7L (L is the total length of the capturing portion 3) It is more preferable that it is 0.2 to 0.5 L (see FIG. 1). In this embodiment, the installation position of the erection wire portion 5a is the central portion 42 of each of the branch wire portions 4a and 4b, that is, 0.5L.

[0072] Further, the installation method of the erection wire portion 5 is not particularly limited, and for example, one linear body

One end (tip) of the (wire) is brought into contact with the portion (tip portion) on the tip side from the center portion 42 of the branch wire portion 4b, and the other end portion (base end portion) is the center portion of the branch wire portion 4a. For example, a method based on a part (base end part) closer to the base end than 42 can be mentioned.

[0073] In addition, the bending rigidity of erection wire portion 5a is not particularly limited, for example, 0.5;! Is preferably Ru ~ 2N 'm ² der, 0.;! More that a ~ lN.m ² preferable.

[0074] In the capture unit 3 having such a configuration, a pair of adjacent branch wire portions not provided with the erection wire portion 5a (between the branch wire portions 4b and 4c in the configuration shown in Fig. 2). When the opening 43 captures the embolus 200, it takes in the embolus 200 into the foreign substance capturing space 31. Used as a mouth. As described above, the opening 43 functions as an intake port for the embolus 200, so that the embolus 200 can be reliably stored (taken in) the foreign matter capturing space 31.

[0075] The constituent materials of the branch wire portions 4a to 4c and the erection wire portion 5a (capturing portion 3) are not particularly limited. For example, an alloy exhibiting superelasticity in vivo is preferable. As a result, the deformation (displacement) of the capturing portion 3 from the reduced diameter state to the expanded diameter state can be caused more reliably, and a more accurate restored shape can be obtained in the expanded diameter state. Further, since the erected wire portion 5a is made of the above-mentioned alloy, the distance between the branch wire portions 4a and 4b can be reliably maintained even when an external force is applied. It is necessary to secure power S.

[0076] Here, an alloy exhibiting superelasticity in a living body is almost at least at a living body temperature (around 37 ° C), even if it is deformed (bent, pulled, compressed) to a region where a normal metal undergoes composition deformation. It has the property of recovering to its original shape, and is also called a shape memory alloy, superelastic alloy, or the like.

[0077] The shape memory alloy and the superelastic alloy are not particularly limited. For example, titanium-based alloys (Ti—Ni, Ti—Pd, Ti—Nb—Sn, etc.) and copper alloys are preferable.

Note that the medical device 9 of the present invention has such an intravascular foreign matter removing wire 1 A and a force taper 8.

[0079] Next, an example of a method of using the intravascular foreign matter removing wire 1A (medical device 9) of the present invention will be described in detail.

[1] FIG. 3 shows a state where an embolus 200 such as a thrombus is clogged in the blood vessel 100 and the blood flow is inhibited. The embolus 200 is pressed against the inner wall of the blood vessel 100 by blood pressure and does not move easily!

A distal end portion of the guide wire 10 in which a catheter (microcatheter) 8 and a guide wire 10 passed through the lumen are inserted into the blood vessel 100 and protruded from the distal end opening 81 of the catheter 8. Insert 101 from the embolus 200 to the back (peripheral side). In other words, the distal end portion 101 of the guide wire 10 passes through the gap between the embolus 200 and the inner wall of the blood vessel 100 and exceeds the embolus 200. This operation can be performed more easily by using, for example, a micro guide wire having excellent lubricity as the guide wire 10. [2] When the distal end portion 101 of the guide wire 10 exceeds the embolus 200, the catheter 8 is advanced relative to the guide wire 10, and the distal end portion of the catheter 8 is connected to the embolus 200 as shown in FIG. Enter the gap with the inner wall of the blood vessel 100. At this time, since the distal end portion of the catheter 8 smoothly enters the gap along the guide wire 10, this operation can be easily performed.

[0083] It should be noted that as a conventional treatment, there is a thrombus that does not dissolve with the thrombolytic agent, which has been performed in such a state that the thrombolytic agent is flowed retrogradely through the catheter 8 to accelerate the thrombolysis. It is often experienced by doctors that it takes a long time to dissolve. The present invention is also useful in such a case.

[3] From the state shown in FIG. 4, the guide wire 10 is removed, and the intravascular foreign matter removing wire 1 A of the present invention is inserted into the lumen of the catheter 8. As shown in FIG. 5, the capturing part 3 is projected from the distal end opening 81 of the catheter 8 and the catheter 8 is dragged in the proximal direction.

[0085] The capturing part 3 in the catheter 8 in the reduced diameter state is automatically expanded due to its own elasticity, and becomes in the expanded diameter state. When the trapping portion 3 is in the expanded state, a foreign matter trapping space 31 that traps the embolus 200 is formed. At this time, as described above, even when the branch wire portions 4a to 4c and the construction wire portion 5a are pressed against the inner wall of the blood vessel 100, the foreign substance capturing space 31 is reliably ensured.

[0086] [4] After the foreign matter capturing space 31 is formed (secured), the intravascular foreign matter removing wire 1A is moved in the proximal direction, that is, the intravascular foreign matter removing wire 1A is embolized 200. Pull back to the front. At this time, the embolus 200 starts to enter from the opening 43 (see FIG. 6). When the intravascular foreign matter removing wire 1A is further pulled in the proximal direction, the embolus 200 is scooped into the foreign matter catching space 31 of the catching portion 3 as shown in FIG. Is done.

[5] When the embolus 200 is stored in the capturing part 3, the wire body 2 is pulled in the proximal direction with respect to the catheter 8. As a result, the proximal end portions of the branch wire portions 4a, 4b and 4c are respectively brought into contact with the distal end opening portion 81 (the edge portion thereof) to be drawn into the catheter 8 while narrowing the interval therebetween. Thereby, the embolus 200 is fastened by the branch wire portions 4a, 4b and 4c. [0088] With this tightening force, soft thrombi such as fibrin can be crushed and the occlusion of the blood vessel 100 can be eliminated. The embolus 200 that is not crushed can be more reliably held by the capture unit 3 by this tightening force, and can be reliably recovered while preventing the emboli 200 from dropping (detaching) from the capture unit 3.

[6] The intravascular foreign matter removing wire 1A is removed together with the force tail 8 while maintaining the above-mentioned tightened state. As a result, the embolus 200 is collected (removed) in the parent guiding catheter or sheath introducer (not shown).

[0090] When the embolus 200 is housed in the capturing part 3 without performing the tightening operation in the above operation [5], the intravascular foreign matter removing wire 1A is pulled out together with the catheter 8 as it is, and the embolus is removed. 200 may be removed.

[0091] <Second Embodiment>

[0092] Hereinafter, a second embodiment of the intravascular foreign matter removing wire and the medical instrument of the present invention will be described with reference to this figure. However, the difference from the above-described embodiment will be mainly described and similar matters will be described. Will not be described.

[0093] This embodiment is the same as the first embodiment except that the installation form (installation state) of the erection wire portion is different.

In the intravascular foreign matter removing wire 1 B shown in FIG. 8, the erected wire portion 5 a ′ is disposed so as to be inclined with respect to the shaft 22 of the wire body 2. When the embolus 200 is stored in the foreign matter capturing space 31, the contact area force S between the erected wire portion 5a ′ and the embolus 200, and the contact area S between the erected wire portion 5a and the embolus 200 in the first embodiment are as follows. growing. As a result, the force S can be more securely held in the captured embolus 200. In addition, when the inclined (diagonal) erected wire portion 5a ′ is disposed on the distal end side, the area (surface area) of the foreign substance capturing space 31 that comes into contact with the embolus 200 (thrombus) is first expanded (increased), and the clot recovery rate is There is also an advantage when you go up!

FIG. 9 is a perspective view showing a third embodiment of the intravascular foreign matter removing wire of the present invention. [0096] Hereinafter, the third embodiment of the intravascular foreign matter removing wire and the medical instrument of the present invention will be described with reference to this figure. However, the difference from the above-described embodiment will be mainly described, and similar matters will be described. Will not be described.

This embodiment is the same as the first embodiment except that the intravascular foreign matter removing wire further includes a connecting member.

The intravascular foreign matter removing wire 1C shown in FIG. 9 further has a connecting member 6 having a flat plate shape. The connecting member 6 connects the tips 41 of the branch wire portions 4a to 4c.

Further, the connecting member 6 is installed so that the surface 61 thereof is substantially perpendicular to the axis 22 of the wire body 2. That is, the connecting member 6 is installed so that one surface (surface 61) faces the front end direction. As a result, when the capturing part 3 is placed (protruded) in the blood vessel 100 (for example, in the state shown in FIG. 5), the connecting member 6 is in a posture substantially perpendicular to the blood flow. In this state, the blood flow is suppressed in the vicinity of the capturing unit 3 (the connecting member 6), and therefore, an operation (capturing operation) for capturing the embolus 200 can be easily performed.

[0100] Further, the connecting member 6 has a disk shape. Thereby, the capturing part 3 (the connecting member 6) can move smoothly with respect to the blood vessel 100, and thus the intravascular foreign matter removing wire 1C can be operated easily and smoothly.

[0101] Further, the connecting member 6 is not limited to a flat plate shape, and may be a spherical curved plate shape, for example.

[0102] The constituent material of the connecting member 6 is not particularly limited, and various metal materials, various plastics, and the like can be used alone or in combination.

[0103] <Fourth Embodiment>

[0104] Hereinafter, the fourth embodiment of the intravascular foreign matter removing wire and the medical instrument of the present invention will be described with reference to this figure. The difference from the above-described embodiment will be mainly described, and similar matters will be described. Will not be described.

[0105] This embodiment is the same as the first embodiment except that the number of installation wire portions is different. It is like.

[0106] In the intravascular foreign matter removing wire ID shown in Fig. 10, a plurality (four in this embodiment) of erected wire portions 5a, 5b, 5c and 5d are laid between the branch wire portions 4a and 4b. ing. These erected wire portions 5a to 5d are arranged along the axis 22 direction substantially parallel to each other.

[0107] In the capturing part 3, the erected wire parts 5a to 5d are unevenly distributed on the front end side with respect to the central part 42 of the branch wire part 4a (the same applies to the branch wire part 4b). That is, in the capture part 3, the erection wire part 5a is erected between the central parts 42 of the branch wire parts 4a and 4b, and the erection wire parts 5b to 5d are arranged in order on the tip side of the erection wire part 5a. ing. As a result, the embolus 200 captured by the capturing unit 3 can be prevented from unintentionally leaving the distal end side when the intravascular foreign matter removing wire 1D is pulled in the proximal direction.

[0108] In addition, in the capturing part 3, the arrangement density of the erected wire parts 5a to 5d is gradually sparse toward the distal direction. That is, in the capturing part 3, the interval between the adjacent erected wire parts gradually increases toward the leading end. As a result, the gap between the branch wire portions 4a and 4b, in particular, the distance between the branch wire portions 4a and 4b (at the portion where the erected wire portions 5a to 5d are installed) is not excessively or deficient. Regardless of the magnitude of the external force, the force S can be maintained to be almost constant (uniform).

[0109] The number of installation wire portions is not limited to four, and may be two, three, or five or more, for example.

[0110] The intravascular foreign matter removing wire and medical device of the present invention have been described above with reference to the illustrated embodiment. However, the present invention is not limited to this, and the intravascular foreign matter removing wire and medical device are not limited thereto. Each component of the instrument can be replaced with any component that can perform the same function. Moreover, arbitrary components may be added.

[0111] Further, the intravascular foreign matter removing wire and medical device of the present invention may be a combination of any two or more configurations (features) of the above embodiments! /.

[0112] For example, the installation wire portion of the third embodiment may be slanted like the installation wire portion of the second embodiment.

[0113] The erection wire portion of the third embodiment is similar to the erection wire portion of the fourth embodiment. There are multiple installations!

[0114] Further, the plurality of erection wire portions of the fourth embodiment may be inclined like the erection wire portion of the second embodiment among the erection wire portions.

[0115] Further, in each of the above-described embodiments, the number of branch wire portions installed is not limited to three, but may be four or more, for example.

[0116] Further, in each of the above embodiments, the erection wire portion is installed between a pair of adjacent branch wire portions, and the erection wire portion is provided between the remaining two sets of adjacent branch wire portions. It is not installed. In each of the embodiments described above, the present invention is not limited to this, and an erection wire portion is erected between two sets of adjacent branch wire portions, and erection is performed between the remaining one pair of adjacent branch wire portions. The wire part may not be installed. In this case, the number of installation wire portions between the branch wire portions on which the installation wire portions are installed is not particularly limited, and may be one, for example, or two or more.

[0117] Further, the capturing unit may be provided with a detachment preventing means for preventing the captured embolus from detaching. The separation preventing means is not particularly limited. For example, a material having a relatively high static friction coefficient (elastic material) coated on the capturing part, minute irregularities generated by roughing the capturing part, and capturing foreign matter. There are many minute linear objects protruding into the space.

[0118] Further, one or a plurality of wires constituting the branch wire portion are extended to the distal end side, and a proposal for guiding (guiding) the capturing portion into a blood vessel like a so-called "guide wire". An interior may be formed.

[0119] In use, an opening force between a pair of adjacent branch wire portions not provided with an erection wire portion is surely located close to the embolus! /, Side (proximal side). A radiopaque contrast marker for confirmation under radioscopy such as a line, etc. A part of the capturing part (for example, in the configuration shown in FIG. 2, the branch wire parts 4b, 4c, etc. constituting the opening) or the whole It ’s okay.

[0120] The thing captured by the intravascular foreign matter removing wire is not limited to a thrombus, and may be, for example, a small piece of medical instrument placed in a blood vessel.

Industrial applicability An intravascular foreign matter removing wire according to the present invention includes a flexible long wire body, at least three branch wire portions branched from the distal ends of the wire body, and connected to each other. At least one installation wire section that is installed between the remaining adjacent branch wire sections excluding at least one pair of adjacent branch wire sections and that maintains the distance between the branch wire sections. Have Therefore, even when an external force is applied to these parts by inserting a foreign body removal wire into a blood vessel with a relatively small inner diameter and pushing each branch wire part or erection wire part into the blood vessel inner wall. It is reliably prevented that the interval between the branch wire portions where the erected wire portion is erected by the action is changed, that is, the interval is reliably maintained. As a result, even when an external force is applied, a space for capturing the foreign matter in the blood vessel is reliably ensured, and thus the foreign matter can be reliably captured (stored) in the space. . Therefore, the intravascular foreign matter removing wire of the present invention has industrial applicability.

Claims

The scope of the claims

[1] a flexible long wire body;

Except at least one pair of the adjacent branch wire portions, at least one installation wire portion that is installed between the remaining adjacent branch wire portions and maintains the distance between the branch wire portions. A wire for removing foreign matter in a blood vessel, comprising:

[2] an elongated wire body having flexibility;

At least three branch wire portions branched from the tip of the wire body;

A plate-shaped connecting member that connects the ends of each branch wire portion;

3. The intravascular foreign matter removing wire according to claim 2, wherein the connecting member is installed so that a surface thereof is substantially perpendicular to an axis of the wire body.

4. The intravascular foreign matter removing wire according to claim 2, wherein the connecting member has a disc shape.

[5] The branch wire part according to claim 1 or 3, wherein three branch wire parts are provided, and the installation wire part is provided between a pair of adjacent branch wire parts among them. Wire for removing foreign matter in blood vessel according to item 2.

[6] The intravascular foreign matter removing wire according to [1] or [2], wherein the erected wire portion connects the central portions in the longitudinal direction of the branch wire portion.

[7] The intravascular foreign matter removing wire according to [1] or [2], wherein the erected wire portion is disposed substantially perpendicular to the axis of the wire body.

[8] The intravascular foreign matter removing wire according to [1] or [2], wherein the erected wire portion is disposed to be inclined with respect to an axis of the wire body.

[9] The intravascular foreign matter removing wire according to [1] or [2], wherein the erected wire portion is curved outward.

[10] The intravascular foreign matter removing wire according to claim 1 or 2, wherein a plurality of the erected wire portions are provided between a pair of adjacent branch wire portions.

11. The intravascular foreign matter removing wire according to claim 10, wherein the plurality of erected wire portions are unevenly distributed on the distal end side with respect to the central portion in the longitudinal direction of the branch wire portion.

12. The intravascular foreign matter removing wire according to claim 10, wherein the plurality of erected wire portions are gradually sparser in the arrangement density in the distal direction.

[13] The intravascular foreign matter removing wire according to [1] or [2], wherein the erected wire portion is made of an alloy exhibiting superelasticity in a living body.

[14] The blood vessel according to claim 1 or 2, wherein the branch wire portions are arranged at substantially equal angular intervals around the axis of the wire body when viewed from the distal end side. Wire for removing foreign substances.

15. The intravascular foreign matter removing wire according to claim 1 or 2, wherein each branch wire portion is curved outward.

[16] An opening between a pair of adjacent branch wire portions not provided with the installation wire portion is provided.

3. The intravascular foreign matter removing wire according to claim 1 or 2, which is used as an inlet for foreign matters in blood vessels.

[17] a flexible long wire body;

An intravascular foreign matter removing wire comprising: at least one erected wire portion that is laid between two adjacent branch wire portions and maintains a distance between the branch wire portions.

[18] The intravascular foreign matter removing device according to claim 17, wherein the at least three branch wire portions include at least one branch wire on which the erection wire portion is not erected. Wire.

[19] The intravascular foreign matter removing wire according to any one of claims 1 to 18, and a catheter having a lumen capable of storing the intravascular foreign matter removing wire. Features medical equipment.