WO2008006237A1 - Récipient cupuliforme centrifuge pourvu de multiples chambres de séparation relativement indépendantes - Google Patents

Récipient cupuliforme centrifuge pourvu de multiples chambres de séparation relativement indépendantes Download PDF

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Publication number
WO2008006237A1
WO2008006237A1 PCT/CN2006/001312 CN2006001312W WO2008006237A1 WO 2008006237 A1 WO2008006237 A1 WO 2008006237A1 CN 2006001312 W CN2006001312 W CN 2006001312W WO 2008006237 A1 WO2008006237 A1 WO 2008006237A1
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WO
WIPO (PCT)
Prior art keywords
cup
blood
centrifuge cup
centrifuge
barrier
Prior art date
Application number
PCT/CN2006/001312
Other languages
English (en)
Chinese (zh)
Inventor
Xiaojin Wang
Original Assignee
Xiaojin Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xiaojin Wang filed Critical Xiaojin Wang
Priority to PCT/CN2006/001312 priority Critical patent/WO2008006237A1/fr
Publication of WO2008006237A1 publication Critical patent/WO2008006237A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl

Definitions

  • Centrifugal cup composed of a plurality of relatively independent separation chambers
  • the invention relates to a centrifuge cup.
  • the invention also relates to a method of separating biological substances, such as blood cells and plasma, using a centrifugal principle. Background technique
  • Plasmapheresis is described in U.S. Patent 4,086,924.
  • Whole blood is mixed with an anticoagulant and transferred to a centrifuge cup to separate whole blood into plasma and non-plasma components.
  • the centrifugal cup is a device for separating substances by the principle of centrifugation.
  • the general purpose is to separate the shields to be separated under the action of high-speed centrifugal force, so as to achieve separation.
  • FIG 1 is a schematic illustration of a currently widely used centrifuge cup comprising a cup 1, a blood/washing fluid inlet 2, a conduit 3, a deceleration ring 4, and a wash fluid outlet 5.
  • the working principle is as follows:
  • the cup body 1 drives the high-speed operation of the material under high-speed operation, and the material is layered under the action of centrifugal force.
  • the washing liquid enters the bottom of the centrifugal cup through the stationary conduit 3 from the mouth 2, and the washing liquid is under the action of centrifugal force. Flowing from the outside to the inside and passing through the outer layer material to achieve the purpose of washing, the washing liquid continues to ascend through the stationary deceleration ring 4, and flows out from the washing liquid outlet 5.
  • the arrows indicate the route of blood and washing into the separation zone.
  • Figure 2 is another form of centrifugation.
  • the basic principle is the same as that of Figure 1. Although it can be implemented cheaper in engineering, the washing effect will not be very good.
  • the space between the cup 1 and the inner liner is an effective separation interval.
  • the effect of separation is not ideal, because there is a phase between the cup wall and the blood cell during start and stop. For exercise, this relative motion causes the level between the blood cell and the plasma to be disturbed during deceleration, so that the separation is completely destroyed.
  • the existing centrifuge cup has the highest blood cell pressure (the ratio of blood to liquid in the liquid) when separating blood. Achieve a volume ratio of about 60%, if the separation of a variety of cells or a variety of substances will not achieve the purpose
  • the amount of washing liquid used to reach a certain washing rate is large, generally reaching 1 : 4, because the washing liquid can not effectively wash the blood cells, and the self-forming flow path often affects the washing effect.
  • Another object of the present invention is to provide a method of separating biological materials such as blood cells from plasma. Summary of the invention
  • the present invention provides a centrifuge cup comprising a rotating cup 1 in which the rotating cup 1 is sealingly connected to the cup 1; the cup 1 is composed of an outer wall 10 and a bottom 13 having a bladder in the cup 1
  • the inner wall 12 and the outer wall 11 of the inner liner form a closed cavity 14 such that a separation zone 15 is formed between the outer wall 10 and the outer wall 11 of the inner casing;
  • the stationary cup cover 6 has an inlet 2, a longitudinal conduit 3 communicating with the inlet 2 and thus facing the cup Introducing blood and/or washing liquid to be washed, discharging the washed blood and/or washing liquid out of the passage 16 formed by the deceleration ring 4 of the cup body 1, and the outlet 5 communicating with the passage 16; in the cup body 1
  • a plurality of barrier grids 17 are provided along the radial direction of the cup 1 to divide the separation zone 15 of the cup 1 into a plurality of relatively independent separation chambers 18.
  • the invention also provides a method for separating blood cells and plasma by using a centrifugal cup, wherein the centrifugal cup comprises a cup body 1, a blood/washing liquid inlet 2, a duct 3, a deceleration ring 4, a washing liquid outlet 5, and a substantially longitudinal direction in the cup body 1.
  • a plurality of isolation barriers are provided along the radial direction of the cup 1 to divide the cup 1 into a plurality of relatively independent separation chambers, the method comprising the steps of: Put blood into the cup 1 through the blood/washing liquid inlet 2 and the conduit 3;
  • the cup body 1 drives the blood in the high speed operation at high speed, and the blood is layered into a blood cell layer and a plasma layer under the action of centrifugal force;
  • the washing liquid is introduced into the cup from the blood/washing liquid inlet 2 and the conduit 3, and the washing liquid flows from the outside to the inside through the centrifugal force and passes through the blood cell layer and the plasma layer to perform washing;
  • Figure 1 is a schematic illustration of a prior art centrifuge cup.
  • FIG. 2 is a schematic illustration of another version of a prior art centrifuge cup.
  • Figure 3 is a schematic illustration of one embodiment of a centrifuge cup of the present invention, wherein Figure 3.2 is a cross-sectional view of the centrifuge cup.
  • FIG. 4 is a schematic illustration of another embodiment of a centrifuge cup of the present invention.
  • Figure 5 is a schematic illustration of another embodiment of a centrifuge cup of the present invention.
  • FIG. 6 is a schematic illustration of another embodiment of a centrifuge cup of the present invention. detailed description
  • FIG. 3 A schematic view of the centrifuge cup of the present invention is shown in Figures 3-6.
  • the present invention provides a centrifuge cup comprising a stationary cup cover 6 in which a rotating cup 1 is sealingly connected to a cup 1; a cup 1 consisting of an outer wall 10 and a bottom 13 having an inner portion in the cup 1 a closed cavity 14 formed by the inner wall of the bladder and the outer wall of the inner liner, thereby forming a separation zone 15 between the outer wall 10 and the outer wall 11 of the inner liner;
  • the stationary cup cover 6 has an inlet 2, a longitudinal conduit 3 communicating with the inlet 2 and thus towards the cup 1 Introducing blood and/or washing liquid to be washed, discharging the washed blood and/or washing liquid out of the passage 16 formed by the deceleration ring 4 of the cup body 1, and the outlet 5 communicating with the passage 16;
  • a plurality of isolation barriers 17 are provided along the radial direction of the cup 1 to divide the separation zone 15 of the cup 1 into a plurality of relatively independent separation chambers 18.
  • the cup cover 6 of the centrifuge cup of the present invention comprises a plurality of feed tubes and seals.
  • the specific construction of the feed tubes and seals of the centrifuge cup is detailed in U.S. Patent No. 4,983,158.
  • the cup cover 6 has upper and lower friction plates 21 and 22, a rubber bracket 23, and a cap for protecting the rubber and the friction surface. twenty four.
  • the inlet 2 (also referred to as blood/washing fluid inlet 2) on the cup 6 leads to a longitudinal feed tube 3 (also referred to as conduit 3) through which blood and/or washing liquid enters the cup 1 bottom.
  • Figure 3.2 is a cross-sectional view of the centrifuge cup along the isolation barrier 17.
  • the rotating cup 1 is sealed to the cup 1.
  • the manner of sealing can be the manner commonly used in the prior art for the cup, see US 4300727 and ZL99255623.6.
  • the isolation barrier 17 of the present invention divides the separated region 15 in the centrifugal cup into individual separation sections 18, which fundamentally avoids the blood cell relative to the cup wall and the supernatant liquid phase during the acceleration and deceleration of the centrifuge cup. The relative movement between the blood cells so that the separated blood does not remix.
  • the centrifuge cup of the present invention can be used for separation of substances under high-speed rotation, and separation of various substances, especially blood, such as separation of red blood cells, platelets or other blood components. See US 4,983,158 and US 4,307,017, Chinese utility model patent ZL 99255623.6.
  • the blood to be treated is introduced from the inlet 2 through the conduit 3 into the bottom of the centrifuge cup; a starting power source (not shown) rotates the cup of the centrifuge cup to cause the blood to be treated to enter the separation zone 15 and stratify under the action of centrifugal force;
  • the washing liquid is then passed from the mouth 2 through the stationary conduit 3 into the bottom of the centrifugal cup. Under the action of the centrifugal force, the washing liquid enters the separation chambers 18 of the separation zone 15, and flows from the outside to the inside and passes through the outer layer material to achieve washing. Purpose; With the addition of the washing liquid, the material to be cleaned is collected toward the center of the cup and decelerated through the slit 16 through the outlet 5 when the deceleration ring 4 is encountered.
  • the barrier can regularly divide the centrifuge cup into a plurality of regions or irregularly divide the centrifugal cup into a plurality of regions.
  • the barrier may be perpendicular to the inner or outer wall of the centrifuge cup, but may not be placed 'vertically.
  • the plane of the barrier may be parallel to the axis of rotation of the centrifuge cup, but may not be parallel.
  • the barrier may be spirally raised or may have a wave shape, and the spiral may be raised clockwise, but may also rise counterclockwise.
  • the isolation grid is tilted so that it spirals upwards, which allows the washing liquid to have a sufficiently long exchange process with the blood, thereby improving the washing rate in some cases.
  • some intentionally reserved holes or slits may be added to the barrier, or some holes or slits may be added for engineering purposes.
  • the centrifugal cup of the present invention presets a communication passage at a certain height of the isolation grid, so that the centrifugal cup can be utilized
  • the principle of the connected device achieves an ideal washing effect.
  • the centrifuge cup of the present invention has a bottom isolation barrier at the bottom corresponding to the isolation barrier, which reduces the relative movement of blood relative to the bottom of the centrifuge cup during entry and return.
  • the centrifuge cup of the present invention interconnects relatively independent barriers at the lower edge portion of the cup, thereby ensuring that the liquid and blood cell levels are balanced in each of the relatively separate separation regions during centrifugation.
  • the relatively independent separation chambers at the upper limit position or the slightly upper position of the upper blood cells of the cup body may be inter-connected, thereby ensuring liquid and blood cell level in each relatively independent separation area during centrifugation. maintain balance.
  • the inner tank can be made of a material having a certain elasticity, so that better sealing can be achieved.
  • the isolation grid can be made of a material having a certain elasticity, so that better sealing can be achieved.
  • the inner cup and the outer bladder (outer wall 10) of the centrifugal cup may be non-parallel, such as the inner and outer gallbladder spacing is upper and lower, or vice versa, and the The barrier also corresponds to it.
  • the shape of the centrifuge cup may be bell-shaped, but may also be in the shape of a straight barrel.
  • the centrifuge cup of the present invention is used to separate platelets or other blood components.
  • the centrifugal cup of the present invention can achieve a specific washing effect by changing the centrifugal speed when performing separation.
  • the centrifuge cup of the present invention can utilize the change in the speed of the feed to achieve a particular wash effect during separation, such as the formation of a regular movement of liquid in each of the separation chambers.
  • the isolation grille may be grooved, bifurcated, lapped or the like in a portion in contact with the inner liner or the outer bladder to achieve better sealing.
  • the notch at different heights may be inconsistent when the isolation grid is cut in a plane perpendicular to the rotation axis, that is, the isolation barrier may be placed in a distorted manner between the inner liner and the outer casing.
  • the isolation barrier can be placed intermittently, so that the plasma and the blood cells can be moved for a predetermined purpose.
  • the centrifuge cup of the present invention has a sufficient space at the bottom to allow the blood cells to gather in the space during the stop or slow rotation.
  • the washing liquid can be added, and after adding a certain amount, the centrifugal cup is high speed. Rotate to increase the wash rate.
  • the bottoms thereof are isolated from each other, but they may also be mutually permeable.
  • the centrifuge cup thus designed allows for the washing of substances and is widely used for the separation of blood cells from blood plasma.
  • the centrifuge cup can be used for separation of substances under high-speed rotation, and separation of various substances, especially blood separation, such as separation of red blood cells, platelets or other blood components, but the application of the present invention can obviously have a wider range of applications. .
  • the acceleration and deceleration of the liquid in the centrifugal cup of the present invention no longer depend on the friction force, but directly through the isolation grid, not only the damage to the blood cells caused by the friction and the relative motion but also the deceleration and acceleration are avoided.
  • the interface between the blood cell and the supernatant will not be disturbed. Under a little control, the interface between the supernatant and the blood cell can be kept at the original separation state. When the centrifuge cup is stopped, the recovery will be directly obtained. High blood pressure.
  • the barrier is only present in a partial area, and each of the separate separation zones will be in communication with each other in a partial area, so that under the specific conditions throughout the operation of the centrifuge cup, each will be made according to the principle of the connector
  • the blood interface in the independent separation zone, the interface of the blood cells and the supernatant are consistent, which is necessary for stratified recovery (such as recovery of platelet-rich blood) and recovery of hyperbaric blood.
  • the new centrifugal cup is less likely to damage and disturb the blood layer than the classic centrifugal cup, so that there is a better washing effect.
  • the number of the isolation barriers used in the present invention may be one or more, and the planar surface of the isolation grid coincides with the central axis of the centrifugal cup, that is, the isolation grid always points to the axial center on a plane perpendicular to the axis.
  • Each isolation separation zone is connected at a position of a certain height at its upper end, and each isolation separation zone is also connected at a certain position at the lower end.
  • Figures 3 and 4 show an embodiment with six and twenty isolation barriers, respectively.
  • Figures 5 and 6 show an embodiment in which 20 isolation barriers and 6 isolation barriers are added, respectively.
  • the barrier is placed at a different angle from the wall of the cup to achieve different cleaning purposes and to make engineering easier to implement.
  • the isolation barrier is not completely isolated, that is, the isolation barrier has an appropriate size gap with the inner wall or the outer wall of the centrifugal cup, so that under the proper conditions, the same isolation effect as the complete isolation can be achieved, or partially isolated.
  • the effect can be achieved for special washing purposes. Evaluation of the standard for centrifuge cups In evaluating the washing of blood, the criteria for the centrifuge cup portion are as follows:
  • the minimum amount of blood produced, the volume of the cup is the minimum amount of blood produced in the classical centrifugation method
  • Washing rate the ratio of the total amount of material to be washed and the total amount of the substance before washing after washing with a certain amount of washing liquid
  • the fat removal rate, platelet retention rate, recovery rate, washing rate, and washing blood pressure product should be as high as possible, and the damage to the blood cells should be as small as possible.
  • the minimum blood output is as small as possible. .
  • the invention has at least one of the following benefits:
  • the hematocrit can be increased, and the interface between the blood cell and the supernatant is not disturbed by the action of the barrier, so that the blood of the high pressure product can be obtained;
  • pulsating blood washing can be used, because the effect of the isolation grid can reduce the disturbance to the interface caused by the pulsating blood inlet, so pulsed blood can also be used to achieve special washing purposes;
  • the damage to the blood cells can be reduced, and the existence of the isolation grid greatly reduces the relative motion and friction between the blood cells and the cup wall, so the damage to the blood cells is greatly reduced;
  • platelet-rich blood can be recovered under appropriate conditions
  • the minimum processing amount can be made small, because the interface between the blood cell and the supernatant is retained, so that the minimum processing amount can be greatly reduced, for example, when it is detected that the supernatant becomes a supernatant, the recycling is not performed. This can achieve the goal of reducing the minimum amount of blood processed.
  • the original centrifugal cup needs to have The children's cup is suitable for children with small blood volume, but in the new centrifugal cup mode, a centrifugal cup can be used for various occasions;
  • the last treatment can use blood and normal saline to return blood to the blood bag, so that the water consumption rate of the unit blood volume is reduced, that is, the two pumps can be transferred together, one back to concentrate the blood one time.
  • Normal saline which can further improve the washing rate, even can be washed only by concentration (in theory, 100% of concentrated blood plus physiological saline can be pure);
  • the centrifuge cup can be stopped urgently or with a large acceleration without causing disturbance and damage to the blood due to friction;

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Centrifugal Separators (AREA)

Abstract

L'invention concerne un récipient cupuliforme centrifuge qui comprend un corps (1), une entrée (2) pour du sang/un liquide de lavage, un tube-guide (3), un anneau de décélération (4), et une sortie (5) de liquide de lavage. Le corps (1) du récipient cupuliforme est divisé de manière radiale en multiples chambres de séparation individuelles par plusieurs grilles d'isolation.
PCT/CN2006/001312 2006-06-13 2006-06-13 Récipient cupuliforme centrifuge pourvu de multiples chambres de séparation relativement indépendantes WO2008006237A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2006/001312 WO2008006237A1 (fr) 2006-06-13 2006-06-13 Récipient cupuliforme centrifuge pourvu de multiples chambres de séparation relativement indépendantes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2006/001312 WO2008006237A1 (fr) 2006-06-13 2006-06-13 Récipient cupuliforme centrifuge pourvu de multiples chambres de séparation relativement indépendantes

Publications (1)

Publication Number Publication Date
WO2008006237A1 true WO2008006237A1 (fr) 2008-01-17

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PCT/CN2006/001312 WO2008006237A1 (fr) 2006-06-13 2006-06-13 Récipient cupuliforme centrifuge pourvu de multiples chambres de séparation relativement indépendantes

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WO (1) WO2008006237A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105664537A (zh) * 2014-11-18 2016-06-15 四川南格尔生物科技有限公司 一种血液成份分离杯组装方法
CN109568690A (zh) * 2019-01-31 2019-04-05 中国人民解放军陆军军医大学第附属医院 一次性采集全血分离prp滤白细胞装置
CN112611881A (zh) * 2020-12-11 2021-04-06 杭州微智兆智能科技有限公司 一种检测加样定位机构

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1221630A (en) * 1969-01-22 1971-02-03 Alfa Laval Ab Improvements in or relating to sludge centrifuges
US4300717A (en) * 1979-04-02 1981-11-17 Haemonetics Corporation Rotary centrifuge seal
US4983158A (en) * 1986-07-22 1991-01-08 Haemonetics Corporation Plasmapheresis centrifuge bowl
CN1058551A (zh) * 1990-08-03 1992-02-12 让·吉根 用离心分离法分离全血中血浆的装置
US5514070A (en) * 1994-01-21 1996-05-07 Haemonetics Corporation Plural collector centrifuge bowl for blood processing
US5882289A (en) * 1996-04-03 1999-03-16 Haemonetics Corporation Centrifuge bowl with improved core structure
CN2317867Y (zh) * 1997-05-05 1999-05-12 张明礼 血液分离回收罐
CN2362593Y (zh) * 1999-01-21 2000-02-09 王勤 带环形罩杯的离心罐
CN1527745A (zh) * 2001-01-18 2004-09-08 Ħ��������˾ 血液处理设备的芯体
CN1785530A (zh) * 2004-12-07 2006-06-14 王晓进 一种由多个相对独立分离室构成的离心杯

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1221630A (en) * 1969-01-22 1971-02-03 Alfa Laval Ab Improvements in or relating to sludge centrifuges
US4300717A (en) * 1979-04-02 1981-11-17 Haemonetics Corporation Rotary centrifuge seal
US4983158A (en) * 1986-07-22 1991-01-08 Haemonetics Corporation Plasmapheresis centrifuge bowl
CN1058551A (zh) * 1990-08-03 1992-02-12 让·吉根 用离心分离法分离全血中血浆的装置
US5514070A (en) * 1994-01-21 1996-05-07 Haemonetics Corporation Plural collector centrifuge bowl for blood processing
US5882289A (en) * 1996-04-03 1999-03-16 Haemonetics Corporation Centrifuge bowl with improved core structure
CN2317867Y (zh) * 1997-05-05 1999-05-12 张明礼 血液分离回收罐
CN2362593Y (zh) * 1999-01-21 2000-02-09 王勤 带环形罩杯的离心罐
CN1527745A (zh) * 2001-01-18 2004-09-08 Ħ��������˾ 血液处理设备的芯体
CN1785530A (zh) * 2004-12-07 2006-06-14 王晓进 一种由多个相对独立分离室构成的离心杯

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105664537A (zh) * 2014-11-18 2016-06-15 四川南格尔生物科技有限公司 一种血液成份分离杯组装方法
CN105664537B (zh) * 2014-11-18 2017-08-25 四川南格尔生物科技有限公司 一种血液成份分离杯组装方法
CN109568690A (zh) * 2019-01-31 2019-04-05 中国人民解放军陆军军医大学第附属医院 一次性采集全血分离prp滤白细胞装置
CN109568690B (zh) * 2019-01-31 2021-04-09 中国人民解放军陆军军医大学第一附属医院 一次性采集全血分离prp滤白细胞装置
CN112611881A (zh) * 2020-12-11 2021-04-06 杭州微智兆智能科技有限公司 一种检测加样定位机构
CN112611881B (zh) * 2020-12-11 2023-08-01 杭州微智兆智能科技有限公司 一种检测加样定位机构

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