WO2007148735A1 - Dispositif d'imagerie ultrasonore, procédé d'imagerie ultrasonore, et programme d'imagerie ultrasonore - Google Patents

Dispositif d'imagerie ultrasonore, procédé d'imagerie ultrasonore, et programme d'imagerie ultrasonore Download PDF

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Publication number
WO2007148735A1
WO2007148735A1 PCT/JP2007/062452 JP2007062452W WO2007148735A1 WO 2007148735 A1 WO2007148735 A1 WO 2007148735A1 JP 2007062452 W JP2007062452 W JP 2007062452W WO 2007148735 A1 WO2007148735 A1 WO 2007148735A1
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Prior art keywords
component
data
ultrasonic
image
created
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PCT/JP2007/062452
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English (en)
Japanese (ja)
Inventor
Tadashi Yamaguchi
Hiroki Suyari
Hiroyuki Hachiya
Hiroshi Shimura
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National University Corporation Chiba University
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Priority to JP2008522501A priority Critical patent/JPWO2007148735A1/ja
Publication of WO2007148735A1 publication Critical patent/WO2007148735A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings

Definitions

  • Ultrasound image creation device ultrasound image creation method, ultrasound image creation program Technical Field
  • the present invention relates to an ultrasound image creation device, an ultrasound image creation method, and an ultrasound image creation program, and in particular, irradiates an organ in a living body with ultrasound and obtains an ultrasound image based on the reflected wave.
  • the present invention relates to an apparatus, a method, and a program used for realizing the apparatus. Background
  • Ultrasound image creation apparatuses that extract lesions in a body organ of a subject are used for diagnosing the lesions of a living body organ at various sites. Diagnosis using such an ultrasonic image creation apparatus (hereinafter referred to as “ultrasonic image diagnosis”) is useful for diagnosis of cirrhosis, for example.
  • “cirrhosis” is a type of liver disease in which liver function is attenuated due to progression of sexual liver disease and the death and replacement of hepatocytes to form fibrous tissue. In the early stage, the fibrosis of the liver progresses without subjective symptoms, and after the compensation period, various symptoms appear due to complications. Therefore, early diagnosis and early detection are important in diagnosing liver cirrhosis and in vivo organ lesions.
  • an ultrasonic diagnostic imaging apparatus equipped with an analysis algorithm capable of observing a minute abnormal lesion
  • an ultrasonic diagnostic imaging apparatus that obtains a tomographic image by irradiating a subject with an ultrasonic pulse.
  • Analytical calculation means for extracting a specific signal using the statistical properties of the intensity or amplitude information of the echo signal generated from the subject site P, and a display means for displaying the result extracted from the analysis calculation means
  • Patent Document 2 is a noninvasive ultrasonic diagnostic imaging method that outputs the pathological conditions of normal liver, chronic hepatitis, and cirrhosis numerically as diagnostic results.
  • the gradation value of each pixel is extracted from the image in the region, the gradation difference between two adjacent pixels is calculated from the liver surface edge side, the absolute value is added in order from the liver surface side, and the cumulative result is a straight line.
  • the slope is approximated and this value is used as the internal evaluation value, which is compared with the slope in the ultrasonic liver image showing the normal liver obtained in advance.
  • the region that has the required number of pixels in the direction along the liver margin of the image and within which the front and back surfaces of the liver are contained is set as the region of interest, and the entire region is subjected to a median filter to expand the histogram. Then, binarization processing and thinning are performed, the contour of the liver margin is extracted, quadratic curve approximation is performed, and the second-order coefficient of approximation is used as the margin evaluation value, and the normal obtained in advance.
  • an ultrasonic diagnostic imaging apparatus that quantitatively diagnoses liver tissue properties in comparison with the secondary coefficient of liver images related to the liver and the like.
  • Patent Document 1 Japanese Patent Laid-Open No. 2001-238884
  • Patent Document 2 Japanese Patent Laid-Open No. 2006-046527
  • Patent Document 3 Japanese Patent Laid-Open No. 2005-319081
  • the present invention provides an ultrasonic image creation device, an ultrasonic image creation method, and an ultrasound image creation program that solve the above-described problems and are capable of more accurate and objective evaluation. Objective.
  • an ultrasonic image creating apparatus as one means of the present invention is based on a probe that receives a reflected wave of an ultrasonic wave radiated to a living body organ, and a reflected wave that is received by the probe.
  • a receiving unit for generating one signal data
  • an image data generating unit for generating first image data based on the first signal data, a first image data, and a first image data different from the first image data.
  • a synthesis unit that synthesizes the second image data to generate composite data; and an analysis unit that performs independent component analysis on the synthesized data and generates a plurality of component data.
  • this means is not limited, but it is also preferable to have a display unit for displaying at least a plurality of component data created by the analysis unit and a displacement force.
  • the analysis unit in this means is not limited, but the first component data including only the positive component and the second component including at least one of the positive component and the negative component. It is also preferable to create data and, if the second component data contains negative components, create third component data consisting of only negative components based on the second component data.
  • the second image data is preferably created based on a reflected wave obtained by irradiating a normal internal organ with ultrasonic waves, although not limited thereto.
  • Masle As used herein, “normal in vivo organ” refers to an organ that does not have a change in tissue structure due to disease or accident.
  • the second image data is created based on a reflected wave obtained by calculation in a computer imitating a normal in vivo organ, although not limited thereto. Is also preferable. Note that even if the images are not collected with actual diagnostic equipment, The surface may be a speckle pattern.
  • the second image data is preferably composed of a component that can be approximated to a Rayleigh distribution, although not limited thereto.
  • the component that can be approximated to the Rayleigh distribution is a component that is obtained when the amplitude probability density distribution of an echo signal obtained by irradiating a sound wave on a medium having a structure in which scatterers are minutely and densely present is calculated. .
  • an ultrasonic image creation apparatus as another means of the present invention includes a probe that receives a reflected wave of an ultrasonic wave radiated to an organ in a living body, and a reflected wave that is received by the probe. And a combining unit that generates first signal data based on the first signal data, a first signal data, and a second signal data different from the first signal data to generate combined data; An analysis unit that performs independent component analysis on the data and creates a plurality of component data.
  • a display unit that displays at least a plurality of component data created by the analysis unit and a displacement force.
  • the analysis unit is not limited, but the analysis unit includes the first component data including only the positive component and the second component including at least one of the positive component and the negative component. It is also preferable to create component data and, if the second component data includes a negative component, create third component data consisting of only the negative component based on the second component data.
  • the second signal data is preferably created based on a reflected wave obtained by irradiating a normal in vivo organ with ultrasonic waves. .
  • the second signal data is created based on a reflected wave obtained by calculation in a computer simulating a normal in vivo organ, although not limited thereto. Is also preferable.
  • the second signal data is preferably composed of a component that can approximate a Rayleigh distribution, although not limited thereto.
  • an ultrasonic image creating method radiates an ultrasonic wave to a living organ, receives a reflected wave thereof, and obtains first signal data based on the received reflected wave. Create first image data based on the first signal data, and the first image data, The second image data different from the first image data is synthesized to create synthesized data, independent component analysis is performed on the synthesized data, a plurality of component data is created, and the created plurality of components Display at least some of the power of the data.
  • the independent component analysis includes, but is not limited to, the first component data including only the positive component and at least one of the positive component and the negative component.
  • the second component data includes a negative component
  • the second image data is preferably created based on a reflected wave obtained by irradiating normal living organs with ultrasonic waves. .
  • the second image data is preferably composed of a component that can be approximated to a Rayleigh distribution, although not limited thereto.
  • an ultrasonic image creation method radiates an ultrasonic wave to an organ in a living body, receives a reflected wave, and obtains first signal data based on the received reflected wave.
  • the first signal data and the second signal data different from the first signal data are synthesized to create synthesized data, and independent component analysis is performed on the synthesized data to obtain a plurality of component data.
  • Create image data from the created component data and display the image data.
  • the independent component analysis includes, but is not limited to, the first component data including only the positive component and at least one of the positive component and the negative component.
  • the second component data includes a negative component
  • the second signal data is preferably created based on a reflected wave obtained by irradiating normal living organs with ultrasonic waves, although not limited thereto. .
  • the second signal data is not limited to Rayleigh. It is also preferable to consist of components that can approximate the distribution.
  • an image processing creation program includes a first image data created based on a reflected wave of an ultrasonic wave radiated to a living organ, and a first image As a synthesis unit that combines the second image data different from the image data to create composite data, and an analysis unit that performs independent component analysis on the composite data and creates multiple component data Make it work.
  • this means function even with a display unit that displays at least one of the component data created by the analysis unit.
  • the analysis unit is not limited, but the analysis unit includes the first component data including only the positive component and the second component including at least one of the positive component and the negative component.
  • the analysis unit includes the first component data including only the positive component and the second component including at least one of the positive component and the negative component.
  • the second image data is preferably created based on a reflected wave obtained by irradiating normal living organs with ultrasonic waves. .
  • the second image data is created based on a reflected wave obtained by calculation in a computer simulating a normal in vivo organ, although not limited thereto. Is also preferable.
  • the second image data is preferably composed of a component that can be approximated to a Rayleigh distribution, although not limited thereto.
  • an ultrasound image creation program includes a first signal data created on the basis of a reflected wave of an ultrasound radiated to a living body organ, A synthesizing unit that synthesizes the second signal data different from the first signal data and generates synthetic data, and an analysis unit that performs independent component analysis on the synthesized data and generates a plurality of component data.
  • the display unit functions as a display unit that displays at least one of the plurality of component data created by the analysis unit.
  • the analysis unit includes a first component data including only a positive component and a second component including at least one of a positive component and a negative component. When component data is created and a negative component is included in the second component data, it is also preferable to have a function of creating third component data consisting of only a negative component based on the second component data.
  • the second signal data is preferably created based on a reflected wave obtained by irradiating a normal living organ with ultrasonic waves, although not limited thereto. .
  • the second signal data is created based on a reflected wave obtained by calculation in a computer simulating a normal in vivo organ, although not limited thereto. Is also preferable.
  • the second signal data is preferably composed of a component that can be approximated to a Rayleigh distribution, although not limited thereto.
  • an ultrasonic image creating apparatus with higher accuracy and capable of more objective evaluation.
  • FIG. 1 is a diagram showing functional blocks of the ultrasonic image creation apparatus according to the present embodiment.
  • the ultrasonic image creation apparatus includes a transmission unit 1, a probe 2, a reception unit 3, an image data creation unit 4, a synthesis unit 5, an analysis unit 6, and a display unit 7. It is configured to have at least.
  • the transmission unit 1, the probe 2, and the reception unit 3 can generate signal data by radiating at least an ultrasonic wave to a living body organ and receiving the reflected wave by combining them.
  • signal data means one-dimensional data in which waveform signal data received by the probe 2 is continuously arranged in time series.
  • the signal data is not limited as long as it is described above, and it is preferable to use force S, RF signal data and signal data obtained by covering the signal S, which can adopt various signal data. it can.
  • “in vivo organs” for which ultrasound images are to be created include, but are not limited to, various organs, and examples include liver, kidney, kidney, heart, breast and the like.
  • the transmitter 1 can output a signal for radiating ultrasonic waves to the organ in the living body to the probe 2.
  • the receiver 3 receives signal data based on the reflected wave received by the probe. Data (hereinafter referred to as “first signal data”) can be created and stored.
  • the probe 2 is a device that can radiate ultrasonic waves to a living organ and receive the reflected waves.
  • each structure of the transmission part 1, the probe 2, and the receiving part 3 can employ
  • the signal data (hereinafter referred to as “second signal data”) of the same kind of in-vivo organ is also created and stored, although to a different extent.
  • the second signal data is not limited, but from the viewpoint of diagnostic accuracy, signal data of a normal in-vivo organ that does not include a lesion part includes only the Rayleigh component. More preferred.
  • the image data creation unit 4 is a unit having a function of creating two-dimensional image data based on the signal data output from the reception unit 3. More specifically, the first signal data output from the receiving unit 3 is converted into image data by this unit (hereinafter referred to as “first image data”).
  • first image data Means one-dimensional signal data subjected to rearrangement processing as two-dimensional data, and further includes processing such as logarithmic compression and luminance modulation applied to the rearrangement processing.
  • image data various image data can be used as much as possible in the analysis unit described later. However, B-mode image data, which is common in ultrasonic image diagnosis, is used for data processing. Preferable from the viewpoint.
  • the image data creation unit 4 creates second image data based on the second signal data.
  • the configuration of the image data creation unit 4 is not limited as long as it performs this function.
  • the image data creation unit 4 executes a program (including a case where it is a part of a program) stored in a recording medium such as a hard disk in a computer. It is feasible.
  • the image data creation unit 4 can also create second image data based on the second signal data measured by the reception unit 3.
  • the synthesizing unit 5 is a unit having a function of synthesizing the first image data and the second image data to create synthesized data, and the configuration is not limited as long as this function is exhibited. However, for example, it can be realized by executing a program (including a case where it is a part of a program) stored in a recording medium such as a hard disk in a computer.
  • a program including a case where it is a part of a program
  • “compositing” means rearranging a data array in a plurality of two-dimensional image data to form one-dimensional data. This rearrangement process can be appropriately adjusted according to the type of independent component analysis by the analysis unit 5 described later, and is not limited.
  • the analysis unit 6 performs independent component analysis on the synthesized data and creates a plurality of component data.
  • Independent Component Analysis is a technique for separating and extracting observation signals, in which signals from multiple independent signal sources are linearly mixed, into original independent signals.
  • first component data component data including only positive components
  • second component data component data including positive components and negative components
  • component data means two-dimensional data obtained as a result of independent component analysis.
  • the analysis unit 6 further extracts only negative components from the obtained second component data and creates component data (hereinafter referred to as "third component data"). .
  • This extraction of the negative component can be easily performed by separating using 0 as a threshold value (data components having 0 components may be included in the second component data, It can be included in the third component data.)
  • the flow in the synthesis unit 5 and the analysis unit 6 is shown in FIG.
  • the analysis unit 6 is not limited in configuration as long as it exhibits the above functions, but for example, executes a program (including a case where it is a part of a program) stored in a recording medium such as a hard disk in a computer. It is feasible.
  • speckle pattern a pattern called speckle (hereinafter referred to as “speckle pattern”) exists in the two-dimensional image data, and the speckle pattern can be approximated to the Rayleigh distribution, and the force of the organ is in vivo.
  • speckle pattern a pattern called speckle
  • the ultrasonic image creation apparatus performs independent component analysis, a component that follows the Rayleigh distribution (hereinafter referred to as “Rayleigh component”), and a component that does not follow the Rayleigh distribution (hereinafter referred to as “non- This was equivalent to the point that the tissue of the affected internal organ could be extracted more quantitatively.
  • the first image data based on the tissue of the in vivo organ having the lesion site to be measured and the tissue of the normal in vivo organ. Since the second image data is synthesized, the Rayleigh component in the first image data and the Rayleigh component force in the second image data are newly reconstructed (hereinafter referred to as “first component data”).
  • second component data including new Rayleigh components and non-Rayleigh components determined to be independent of the first component data.
  • third component data the component data
  • the excluded data (positive component) is supplemented with a predetermined data component (for example, 0), and the negative component is added.
  • a predetermined data component for example, 0
  • the negative component is added.
  • FIG. 3 shows the concept of independent component analysis by the analysis unit 5.
  • Figure 4 shows the concept of imaging the results of this independent component analysis.
  • the upper left figure is an organization chart of an actual in-vivo organ and is not obtained by the ultrasonic image creation device. It can be seen that there is (see the figure below).
  • the display unit 6 accepts and displays input of data obtained as a result of processing by the analysis unit 5 or the like.
  • a display device such as a liquid crystal monitor can be suitably used.
  • an ultrasonic image creating apparatus As described above, according to the ultrasonic image creating apparatus according to the present embodiment, an ultrasonic image creating apparatus, an ultrasonic image creating method, and an ultrasonic image creating program that are more accurate and can be objectively evaluated are provided.
  • this ultrasonic image creation device focuses on the relationship between the anatomy and the algorithm that collects the received signal data, and separates the speckle pattern, which is noise generated so as to cover the entire image, over a wide range. It also has the advantage of not having local blurring of results.
  • the medium model is a simulated biological sample that is created by simulating on a computer or by combining acoustic characteristics with a biological tissue, and by collecting echo signals with parameters such as frequency used at the time of examination, Judgment conditions for organs can be determined.
  • FIG. 5 shows a functional block diagram of the ultrasonic image creating apparatus according to the present embodiment.
  • the synthesized data created by the synthesizing unit 5 is different in that the first signal data and the second signal data referred to in the first embodiment are synthesized. Since the relationship between the tissue of the changed organ in vivo and the Rayleigh distribution is the same, the analysis can be performed in the same manner.
  • the image data creation unit 4 described in the first embodiment may not be present, but it is easy for the person performing the diagnosis to display the third component data on the display unit 7. Therefore, it is possible to create the first image data and display it together with the third component data.
  • the present invention has industrial applicability as an ultrasound image creation device, ultrasound image creation method, and ultrasound image creation program that can be used in ultrasound image diagnosis.
  • FIG. 1 is a diagram showing functional blocks of an ultrasonic image creation apparatus according to Embodiment 1.
  • FIG. 2 is a diagram illustrating a flow of a synthesis unit, an analysis unit, and a display unit of the ultrasonic image creation apparatus according to the first embodiment.
  • FIG. 3 is a diagram illustrating a concept of independent component analysis by an analysis unit 5 of the ultrasonic image creation device according to the first embodiment.
  • FIG. 4 is a diagram showing a concept in the case where the result of independent component analysis by the analysis unit 5 of the ultrasonic image creating apparatus according to Embodiment 1 is imaged.
  • FIG. 5 is a diagram showing functional blocks of an ultrasonic image creation apparatus according to a second embodiment.

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  • Life Sciences & Earth Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
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Abstract

La présente invention concerne un dispositif d'imagerie ultrasonore, un procédé d'imagerie ultrasonore, et un programme d'imagerie ultrasonore pouvant réaliser une évaluation précise et objective. Le dispositif d'imagerie ultrasonore comporte: une sonde pour recevoir une onde réfléchie d'une onde ultrasonore émise vers un organe vivant; une unité de réception pour produire une première donnée de signal selon l'onde réfléchie reçue par la sonde; une unité de création de données d'image pour créer une première donnée d'image selon la première donnée de signal; une unité de synthèse pour créer une image synthétisée par la combinaison de la première donnée d'image et de la seconde donnée d'image différente de la première donnée d'image; une unité d'analyse pour créer une pluralité de données de composantes en effectuant une analyse de composantes indépendantes pour la donnée synthétisée; et une unité d'affichage pour afficher une parmi la pluralité de données de composantes créées par l'unité d'analyse.
PCT/JP2007/062452 2006-06-21 2007-06-20 Dispositif d'imagerie ultrasonore, procédé d'imagerie ultrasonore, et programme d'imagerie ultrasonore WO2007148735A1 (fr)

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Cited By (2)

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WO2020042033A1 (fr) * 2018-08-29 2020-03-05 深圳迈瑞生物医疗电子股份有限公司 Dispositif d'examen du foie à base d'ultrasons, appareil à ultrasons et procédé d'imagerie ultrasonore
WO2021035400A1 (fr) * 2019-08-23 2021-03-04 深圳迈瑞生物医疗电子股份有限公司 Procédé de mesure et dispositif pour un contraste d'écho hépato-rénal, système médical, et support d'informations

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Cited By (4)

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Publication number Priority date Publication date Assignee Title
WO2020042033A1 (fr) * 2018-08-29 2020-03-05 深圳迈瑞生物医疗电子股份有限公司 Dispositif d'examen du foie à base d'ultrasons, appareil à ultrasons et procédé d'imagerie ultrasonore
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WO2021035400A1 (fr) * 2019-08-23 2021-03-04 深圳迈瑞生物医疗电子股份有限公司 Procédé de mesure et dispositif pour un contraste d'écho hépato-rénal, système médical, et support d'informations
CN112788997A (zh) * 2019-08-23 2021-05-11 深圳迈瑞生物医疗电子股份有限公司 肝肾回声对比的测量方法、设备、医用系统和存储介质

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