WO2007148191A3 - An improved process for the preparation of aripiprazole - Google Patents

An improved process for the preparation of aripiprazole Download PDF

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Publication number
WO2007148191A3
WO2007148191A3 PCT/IB2007/001615 IB2007001615W WO2007148191A3 WO 2007148191 A3 WO2007148191 A3 WO 2007148191A3 IB 2007001615 W IB2007001615 W IB 2007001615W WO 2007148191 A3 WO2007148191 A3 WO 2007148191A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
aripiprazole
formula
dihydrocarbostyril
Prior art date
Application number
PCT/IB2007/001615
Other languages
French (fr)
Other versions
WO2007148191A2 (en
Inventor
Siripragada Mahender Rao
Santhosh Unni
Nagabushanam Nagamani
Manoharan Muthutamizh
Original Assignee
Orchid Chemicals & Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharmaceuticals Limited filed Critical Orchid Chemicals & Pharmaceuticals Limited
Publication of WO2007148191A2 publication Critical patent/WO2007148191A2/en
Publication of WO2007148191A3 publication Critical patent/WO2007148191A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of Aripiprazole of formula (I), which is useful in the treatment of Schizophrenia. More particularly, the present invention relates to an improved process for the preparation of 7-(4-chlorobutoxy)-3,4-dihydrocarbostyril of formula (III) by reacting 7-hydroxy-3,4- dihydrocarbostyril of formula (II) with 1,4-dichlorobutane, in presence of inorganic base and solvent dimethylacetamide.
PCT/IB2007/001615 2006-06-20 2007-06-18 An improved process for the preparation of aripiprazole WO2007148191A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1050/CHE/2006 2006-06-20
IN1050CH2006 2006-06-20

Publications (2)

Publication Number Publication Date
WO2007148191A2 WO2007148191A2 (en) 2007-12-27
WO2007148191A3 true WO2007148191A3 (en) 2009-09-17

Family

ID=38833815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/001615 WO2007148191A2 (en) 2006-06-20 2007-06-18 An improved process for the preparation of aripiprazole

Country Status (1)

Country Link
WO (1) WO2007148191A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7714129B2 (en) 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
GR1007722B (en) * 2011-08-05 2012-10-18 Φαρματεν Αβεε, Process for the preparation of aripirazole
CN103923002A (en) * 2013-01-16 2014-07-16 广东东阳光药业有限公司 Preparation method of aripiprazole intermediate
CN115340494A (en) * 2022-07-27 2022-11-15 安徽修一制药有限公司 Synthesis method of high-purity aripiprazole

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US20060079689A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
US20060258869A1 (en) * 2006-04-03 2006-11-16 Alembic Limited Process for the preparation of aripiprazole

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US20060079689A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
US20060258869A1 (en) * 2006-04-03 2006-11-16 Alembic Limited Process for the preparation of aripiprazole

Also Published As

Publication number Publication date
WO2007148191A2 (en) 2007-12-27

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