GR1007722B - Process for the preparation of aripirazole - Google Patents

Process for the preparation of aripirazole

Info

Publication number
GR1007722B
GR1007722B GR20110100478A GR20110100478A GR1007722B GR 1007722 B GR1007722 B GR 1007722B GR 20110100478 A GR20110100478 A GR 20110100478A GR 20110100478 A GR20110100478 A GR 20110100478A GR 1007722 B GR1007722 B GR 1007722B
Authority
GR
Greece
Prior art keywords
preparation
aripirazole
aripiprazole
formula
reaction mixture
Prior art date
Application number
GR20110100478A
Other languages
Greek (el)
Inventor
Θεοχαρης Βασιλειου Κοφτης
Rohit-Ravikant Bapulal Soni
Hitarth Harsendu Acharya
Kandarpkumar Hasmukhabai Patel
Manoj Devidas Ahirrao
Original Assignee
Φαρματεν Αβεε,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Φαρματεν Αβεε, filed Critical Φαρματεν Αβεε,
Priority to GR20110100478A priority Critical patent/GR1007722B/en
Priority to PCT/EP2012/003284 priority patent/WO2013020672A1/en
Publication of GR1007722B publication Critical patent/GR1007722B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of high pure crystalline Aripiprazole of formula (I) having low residue ethanol content. The process comprises slurrying Aripiprazole obtained from the reaction mixture with water.
GR20110100478A 2011-08-05 2011-08-05 Process for the preparation of aripirazole GR1007722B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GR20110100478A GR1007722B (en) 2011-08-05 2011-08-05 Process for the preparation of aripirazole
PCT/EP2012/003284 WO2013020672A1 (en) 2011-08-05 2012-08-02 Process for the preparation of aripiprazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20110100478A GR1007722B (en) 2011-08-05 2011-08-05 Process for the preparation of aripirazole

Publications (1)

Publication Number Publication Date
GR1007722B true GR1007722B (en) 2012-10-18

Family

ID=46724311

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20110100478A GR1007722B (en) 2011-08-05 2011-08-05 Process for the preparation of aripirazole

Country Status (2)

Country Link
GR (1) GR1007722B (en)
WO (1) WO2013020672A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016181406A1 (en) * 2015-05-08 2016-11-17 Davuluri Ramamohan Rao Improved process for the preparation of aripiprazole with reduced particle size
CN105924393A (en) * 2016-07-05 2016-09-07 陕西省食品药品检验所 Aripiprazole new crystal form and preparation method thereof
CN112479999A (en) * 2020-12-13 2021-03-12 谢小芬 Synthetic method of medical intermediate for preparing mental drugs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060079689A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
US20060258869A1 (en) * 2006-04-03 2006-11-16 Alembic Limited Process for the preparation of aripiprazole
WO2007094009A1 (en) * 2006-02-15 2007-08-23 Unichem Laboratories Limited A novel process for preparation of aripiprazole and its intermediates
WO2007118923A1 (en) * 2006-04-13 2007-10-25 Fermion Oy A process for the preparation of aripiprazole and intermediates thereof
WO2007148191A2 (en) * 2006-06-20 2007-12-27 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of aripiprazole

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006528A (en) 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060079689A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
WO2007094009A1 (en) * 2006-02-15 2007-08-23 Unichem Laboratories Limited A novel process for preparation of aripiprazole and its intermediates
US20060258869A1 (en) * 2006-04-03 2006-11-16 Alembic Limited Process for the preparation of aripiprazole
WO2007118923A1 (en) * 2006-04-13 2007-10-25 Fermion Oy A process for the preparation of aripiprazole and intermediates thereof
WO2007148191A2 (en) * 2006-06-20 2007-12-27 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of aripiprazole

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BONACORSI S J JR ET AL: "Synthesis of multilabeled [14C]aripiprazole", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 49, 22 December 2005 (2005-12-22), pages 1 - 9, XP002428678, ISSN: 0362-4803, DOI: 10.1002/JLCR.1017 *

Also Published As

Publication number Publication date
WO2013020672A1 (en) 2013-02-14

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Legal Events

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Effective date: 20121122