WO2007146039A3 - Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide - Google Patents

Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide Download PDF

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Publication number
WO2007146039A3
WO2007146039A3 PCT/US2007/013384 US2007013384W WO2007146039A3 WO 2007146039 A3 WO2007146039 A3 WO 2007146039A3 US 2007013384 W US2007013384 W US 2007013384W WO 2007146039 A3 WO2007146039 A3 WO 2007146039A3
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WO
WIPO (PCT)
Prior art keywords
dimethylethyl
oxazolyl
thiazolyl
thio
crystalline forms
Prior art date
Application number
PCT/US2007/013384
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English (en)
Other versions
WO2007146039A2 (fr
Inventor
Jack Z Gougoutas
Mary F Malley
John D Dimarco
Soojin Kim
Hai-Yun Xiao
Raj Narain Misra
Original Assignee
Bristol Myers Squibb Co
Jack Z Gougoutas
Mary F Malley
John D Dimarco
Soojin Kim
Hai-Yun Xiao
Raj Narain Misra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Jack Z Gougoutas, Mary F Malley, John D Dimarco, Soojin Kim, Hai-Yun Xiao, Raj Narain Misra filed Critical Bristol Myers Squibb Co
Priority to EP07795829A priority Critical patent/EP2044066A2/fr
Priority to JP2009514368A priority patent/JP2009539846A/ja
Publication of WO2007146039A2 publication Critical patent/WO2007146039A2/fr
Publication of WO2007146039A3 publication Critical patent/WO2007146039A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P35/00—Antineoplastic agents
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Abstract

L'invention concerne des formes cristallines du N-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide. L'invention concerne également une composition pharmaceutique comprenant une ou plusieurs formes cristallines du N-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide, ainsi qu'un procédé d'utilisation desdites formes cristallines pour traiter les cancers et autres maladies prolifératives.
PCT/US2007/013384 2006-06-06 2007-06-06 Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide WO2007146039A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07795829A EP2044066A2 (fr) 2006-06-06 2007-06-06 Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl] thio]-2-thiazolyl]-4-pipéridinecarboxamide
JP2009514368A JP2009539846A (ja) 2006-06-06 2007-06-06 Ｎ−［５−［［［５−（１，１−ジメチルエチル）−２−オキサゾリル］メチル］チオ］−２−チアゾリル］−４−ピペリジンカルボキサミドの結晶形

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81148206P 2006-06-06 2006-06-06
US60/811,482 2006-06-06

Publications (2)

Publication Number Publication Date
WO2007146039A2 WO2007146039A2 (fr) 2007-12-21
WO2007146039A3 true WO2007146039A3 (fr) 2008-07-17

Family

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PCT/US2007/013384 WO2007146039A2 (fr) 2006-06-06 2007-06-06 Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide

Country Status (3)

Country Link
EP (1) EP2044066A2 (fr)
JP (1) JP2009539846A (fr)
WO (1) WO2007146039A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008036954A1 (fr) * 2006-09-21 2008-03-27 Sunesis Pharmaceuticals, Inc. Procédés et compositions pour le traitement du cancer
KR101643280B1 (ko) * 2014-09-02 2016-07-28 한국원자력의학원 항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피페리딘카복사마이드 유도체 및 이의 의학적 용도

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001080813A2 (fr) * 2000-04-27 2001-11-01 Bristol-Myers Squibb Company Methodes de prevention et de traitement de l'alopecie provoquee par la chimiotherapie ou la radiotherapie
WO2002010162A1 (fr) * 2000-07-26 2002-02-07 Bristol-Myers Squibb Company Inhibiteurs n-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide de la kinase dependantes des cyclines
US6515004B1 (en) * 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6521759B2 (en) * 1999-12-15 2003-02-18 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6639074B2 (en) * 1999-12-15 2003-10-28 Bristol Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles

Family Cites Families (4)

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BR9808126A (pt) * 1997-02-27 2000-03-08 Pfizer Quinoxalinodionas
GB9711127D0 (en) * 1997-05-29 1997-07-23 Leo Pharm Prod Ltd Novel cyanoguanidines
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
JP2003506433A (ja) * 1999-08-10 2003-02-18 ロンザ ア−ゲ− ジシアネートカルコンおよびその製造方法

Patent Citations (5)

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US6515004B1 (en) * 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6521759B2 (en) * 1999-12-15 2003-02-18 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6639074B2 (en) * 1999-12-15 2003-10-28 Bristol Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles
WO2001080813A2 (fr) * 2000-04-27 2001-11-01 Bristol-Myers Squibb Company Methodes de prevention et de traitement de l'alopecie provoquee par la chimiotherapie ou la radiotherapie
WO2002010162A1 (fr) * 2000-07-26 2002-02-07 Bristol-Myers Squibb Company Inhibiteurs n-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide de la kinase dependantes des cyclines

Non-Patent Citations (7)

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Title
BRITAIN ET AL: "Polymorphism in Pharmaceutical Solids passage", POLYMORPHISM IN PHARMACEUTICAL SOLIDS, 1999, pages 235 - 238, XP002278123 *
GOULD P L: "SALT SELECTION FOR BASIC DRUGS", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 33, no. 1/3, 1986, pages 201 - 217, XP002074725, ISSN: 0378-5173 *
HALEBLIAN J ET AL: "PHARMACEUTICAL APPLICATIONS OF POLYMORPHISM", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 58, no. 8, August 1969 (1969-08-01), pages 911 - 929, XP002020518, ISSN: 0022-3549 *
MISRA RAJ N ET AL: "N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thi azolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 47, no. 7, 25 March 2004 (2004-03-25), pages 1719 - 1728, XP002302339, ISSN: 0022-2623 *
MORISSETTE SHERRY L ET AL: "HIGH-THROUGHPUT CRYSTALLIZATION: POLYMORPHS, SALTS, CO-CRYSTALS AND SOLCATES OF PHARMACEUTICAL SOLIDS", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 56, no. 3, 2004, pages 275 - 300, XP009072233, ISSN: 0169-409X *
TONG W-Q ET AL: "IN SITU SALT SCREENING-A USEFUL TECHNIQUE FOR DISCOVERY SUPPORT AND PREFORMULATION STUDIES", PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, NEW YORK, NY, US, vol. 3, no. 2, May 1998 (1998-05-01), pages 215 - 223, XP001203865, ISSN: 1083-7450 *
YU L ET AL: "PHYSICAL CHARACTERIZATION OF POLYMORPHIC DRUGS: AN INTEGRATED CHARACTERIZATION STRATEGY", PHARMACEUTICAL SCIENCE AND TECHNOLOGY TODAY, ELSEVIER TRENDS JOURNALS, CAMBRIDGE,, GB, vol. 1, no. 3, June 1998 (1998-06-01), pages 118 - 127, XP000949322, ISSN: 1461-5347 *

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EP2044066A2 (fr) 2009-04-08
WO2007146039A2 (fr) 2007-12-21

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