WO2007144512A3 - Derivés diazeniumdiolates, leur procédé de préparation, leurs compositions pharmaceutiques et leur utilisation dans le domaine de l ' hypertension et des pathologies cardiovasculaires - Google Patents
Derivés diazeniumdiolates, leur procédé de préparation, leurs compositions pharmaceutiques et leur utilisation dans le domaine de l ' hypertension et des pathologies cardiovasculaires Download PDFInfo
- Publication number
- WO2007144512A3 WO2007144512A3 PCT/FR2007/000989 FR2007000989W WO2007144512A3 WO 2007144512 A3 WO2007144512 A3 WO 2007144512A3 FR 2007000989 W FR2007000989 W FR 2007000989W WO 2007144512 A3 WO2007144512 A3 WO 2007144512A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- hypertension
- fields
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
Composés de formule (I) : dans laquelle : R1 représente un groupement alkanoyle, R2 représente un groupement alkyle substitué par un groupement G, ou R1 et R2 forment ensemble avec l'atome d'azote qui les porte un groupement imidazolyle ou benzimidazolyle, substitués par un groupement G, et G représente un groupement -(CH2)n-A-(CH2)m-(CR4R5)P-(CH2)O-R3 dans lequel n, m, p, o, R4, R5 et A sont tels que définis dans la description, et R3 représente un groupement formule (II) ou formule (III). Comme antagonistes des recepteurs de l'angiotensine et comme donneurs de NO, utiles dans le domaine de l'hypertension et des pathologies cardiovasculaires.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0605318A FR2902428B1 (fr) | 2006-06-15 | 2006-06-15 | Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR0605318 | 2006-06-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007144512A2 WO2007144512A2 (fr) | 2007-12-21 |
WO2007144512A3 true WO2007144512A3 (fr) | 2008-03-20 |
Family
ID=37575276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2007/000989 WO2007144512A2 (fr) | 2006-06-15 | 2007-06-14 | Derivés diazeniumdiolates, leur procédé de préparation, leurs compositions pharmaceutiques et leur utilisation dans le domaine de l ' hypertension et des pathologies cardiovasculaires |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR061377A1 (fr) |
FR (1) | FR2902428B1 (fr) |
WO (1) | WO2007144512A2 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102008005484A1 (de) * | 2008-01-22 | 2009-07-23 | Schaper, Wolfgang, Dr. | Induktion und Förderung der Arteriogenese |
EP2244575B1 (fr) * | 2008-01-24 | 2013-07-17 | Merck Sharp & Dohme Corp. | Antagonistes du récepteur de l'angiotensine ii |
EP2250168B1 (fr) | 2008-02-08 | 2014-11-19 | Merck Sharp & Dohme Corp. | Antagonistes des récepteurs de l'angiotensine ii |
WO2011053519A1 (fr) * | 2009-10-29 | 2011-05-05 | Merck Sharp & Dohme Corp. | Diurétiques |
RU2012138955A (ru) * | 2010-02-12 | 2014-03-20 | Мерк Шарп Энд Домэ Корп. | Циклопентилпроизводные диазенийдиолата |
WO2011146371A1 (fr) | 2010-05-21 | 2011-11-24 | Merck Sharp & Dohme Corp. | Dérivés cyclohexyliques de diolate de diazénium |
KR20130143042A (ko) | 2010-10-29 | 2013-12-30 | 머크 샤프 앤드 돔 코포레이션 | 디아제늄디올레이트 헤테로시클릭 유도체 |
KR20140003482A (ko) * | 2011-01-19 | 2014-01-09 | 머크 샤프 앤드 돔 코포레이션 | 디아제늄디올레이트 유도체 |
JO3350B1 (ar) * | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
EP2704568B1 (fr) | 2011-05-02 | 2018-01-24 | Merck Sharp & Dohme Corp. | Dérivés de diazèniumdiolate cyclohexyle |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0324377A2 (fr) * | 1988-01-07 | 1989-07-19 | E.I. Du Pont De Nemours And Company | Imidazoles à activité bloquante de récepteur de l'angiotensine II et leurs combinaisons avec des agents diurétiques et NSaids |
WO2004062568A2 (fr) * | 2003-01-09 | 2004-07-29 | Amersham Health As | Agent de contraste |
-
2006
- 2006-06-15 FR FR0605318A patent/FR2902428B1/fr not_active Expired - Fee Related
-
2007
- 2007-06-14 WO PCT/FR2007/000989 patent/WO2007144512A2/fr active Application Filing
- 2007-06-15 AR ARP070102626A patent/AR061377A1/es unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0324377A2 (fr) * | 1988-01-07 | 1989-07-19 | E.I. Du Pont De Nemours And Company | Imidazoles à activité bloquante de récepteur de l'angiotensine II et leurs combinaisons avec des agents diurétiques et NSaids |
WO2004062568A2 (fr) * | 2003-01-09 | 2004-07-29 | Amersham Health As | Agent de contraste |
Non-Patent Citations (1)
Title |
---|
CARINI, DAVID J. ET AL: "Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives", JOURNAL OF MEDICINAL CHEMISTRY , 34(8), 2525-47 CODEN: JMCMAR; ISSN: 0022-2623, 1991, XP000674205 * |
Also Published As
Publication number | Publication date |
---|---|
FR2902428A1 (fr) | 2007-12-21 |
FR2902428B1 (fr) | 2008-08-15 |
AR061377A1 (es) | 2008-08-20 |
WO2007144512A2 (fr) | 2007-12-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007144512A3 (fr) | Derivés diazeniumdiolates, leur procédé de préparation, leurs compositions pharmaceutiques et leur utilisation dans le domaine de l ' hypertension et des pathologies cardiovasculaires | |
CY1118199T1 (el) | Ενωσεις υποκατεστημενης πυραζολο[1,5] πυριμιδινης ως ενδιαμεσα στη συνθεση αναστολεων κινασης trk | |
MX2009010552A (es) | Antagonistas de receptor de opioide periferico y usos de los mismos. | |
BRPI0913457A2 (pt) | "composto, composição farmacêutica, e, uso do composto" | |
TR201903663T4 (tr) | Ari̇loazol-2-i̇l si̇yanoeti̇lamino bi̇leşi̇kleri̇, bunlarin oluşturulmasi yöntemi̇ ve bunlarin kullanilmasi yöntemi̇. | |
WO2007107828A3 (fr) | Dérivés amine | |
MY151986A (en) | Adamantyl diamide derivatives and uses of same | |
WO2009028543A1 (fr) | Dérivé de pyrazole substitué | |
BRPI0507005A (pt) | compostos, composições farmacêuticas, uso de um composto, e, método de preparo de uma composição farmacêutica | |
WO2007148185A3 (fr) | 3-amino-pyrrolidino-4-lactames substitués | |
SI2091948T1 (sl) | Novi inhibitorji glutaminil ciklaze | |
WO2008022286A3 (fr) | petits inhibiteurs moléculaires de la kynurénine-3-monooxygénase | |
WO2009142732A3 (fr) | Dérivés pyridazinone substitués comme ligands des récepteurs de l'histamine-3 (h<sb>3</sb>) | |
MY148703A (en) | Polycyclic cinnamide derivatives | |
BRPI0715579A2 (pt) | "composto, composição farmacêutica e uso de um composto" | |
BRPI0923728A2 (pt) | "método de preparação de compostos de di-hidroindeno amida, suas composições farmacêuticas contendo esses compostos e uso como inibidor de proteína quinase". | |
ATE440833T1 (de) | Antithrombotische diamide | |
WO2010027236A3 (fr) | Composé hétérocyclique condensé | |
CY1115623T1 (el) | Μεθοδος για την συνθεση 7,8-διμεθοξυ-1,3-διϋδρο-2η-3-βενζαζεπιν-2-ονης και εφαρμογη αυτης στη συνθεση της ιβαμπραδινης καθως επισης αλατων προσθηκης αυτης με ενα φαρμακευτικως αποδεκτο οξυ | |
WO2008156677A3 (fr) | Ligands peptidiques cycliques des récepteurs de la mélanocortine | |
MX336366B (es) | Antagonistas del receptor opioide periferico y usos de los mismos. | |
MY145644A (en) | 5,6-bisaryl-2-pyridine-carboxamide derivatives, preparation and application thereof in therapeutics as urotensin ii receptor antagonists | |
MX2008002805A (es) | Derivados de carboxamida como antagonistas del receptor muscarinico. | |
NO20085317L (no) | Imidazoazepinonforbindelser | |
UA96759C2 (en) | 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
NENP | Non-entry into the national phase |
Ref country code: RU |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07803750 Country of ref document: EP Kind code of ref document: A2 |