WO2007134168A3 - Process for preparing duloxetine - Google Patents
Process for preparing duloxetine Download PDFInfo
- Publication number
- WO2007134168A3 WO2007134168A3 PCT/US2007/068667 US2007068667W WO2007134168A3 WO 2007134168 A3 WO2007134168 A3 WO 2007134168A3 US 2007068667 W US2007068667 W US 2007068667W WO 2007134168 A3 WO2007134168 A3 WO 2007134168A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparing duloxetine
- duloxetine
- preparing
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
A process for preparing duloxetine or a salt thereof.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07762094A EP2016066A4 (en) | 2006-05-10 | 2007-05-10 | Process for preparing duloxetine |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN828/CHE/2006 | 2006-05-10 | ||
IN828CH2006 | 2006-05-10 | ||
US80525406P | 2006-06-20 | 2006-06-20 | |
US60/805,254 | 2006-06-20 | ||
US82063606P | 2006-07-28 | 2006-07-28 | |
US60/820,636 | 2006-07-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007134168A2 WO2007134168A2 (en) | 2007-11-22 |
WO2007134168A3 true WO2007134168A3 (en) | 2008-01-24 |
Family
ID=38694701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/068667 WO2007134168A2 (en) | 2006-05-10 | 2007-05-10 | Process for preparing duloxetine |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2016066A4 (en) |
WO (1) | WO2007134168A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8278463B2 (en) | 2008-04-04 | 2012-10-02 | Ranbaxy Laboratories Limited | Process for the preparation of pure duloxetine hydrochloride |
EP2123626A1 (en) | 2008-05-21 | 2009-11-25 | Laboratorios del Dr. Esteve S.A. | Co-crystals of duloxetine and co-crystal formers for the treatment of pain |
EP2332930A1 (en) * | 2009-11-23 | 2011-06-15 | Laboratorios Del. Dr. Esteve, S.A. | Salts of duloxetine and NSAIDs for the treatment of pain |
WO2011077443A1 (en) * | 2009-12-22 | 2011-06-30 | Biocon Limited | An improved process for the preparation of duloxetine hydrochloride |
CN114778707A (en) * | 2019-05-13 | 2022-07-22 | 南京制药厂有限公司 | Method for determining duloxetine intermediate amide by liquid chromatography |
CN113429380B (en) * | 2021-07-14 | 2022-07-01 | 新发药业有限公司 | Preparation method of duloxetine |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
US5985322A (en) * | 1997-05-29 | 1999-11-16 | Eli Lilly And Company | Method for the treatment of CNS disorders |
US6245802B1 (en) * | 1998-11-13 | 2001-06-12 | Eli Lilly And Company | Method for treating pain |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0410470D0 (en) * | 2004-05-11 | 2004-06-16 | Cipla Ltd | Pharmaceutical compound and polymorphs thereof |
US7550605B2 (en) * | 2004-08-05 | 2009-06-23 | Sun Pharmaceutical Industries Ltd. | Process for preparation of an anitdepressant compound |
CZ297560B6 (en) * | 2004-10-26 | 2007-02-07 | Zentiva, A. S. | Process for preparing (S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (duloxetine) |
US20060194869A1 (en) * | 2004-12-23 | 2006-08-31 | Santiago Ini | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
US20090221668A1 (en) * | 2005-12-12 | 2009-09-03 | Medichem, S.A. | Synthesis and preparations of duloxetine salts |
HU228458B1 (en) * | 2006-03-13 | 2013-03-28 | Egis Gyogyszergyar Nyrt | Duloxetine salts for producing pharmaceutical compositions |
-
2007
- 2007-05-10 WO PCT/US2007/068667 patent/WO2007134168A2/en active Application Filing
- 2007-05-10 EP EP07762094A patent/EP2016066A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
US5985322A (en) * | 1997-05-29 | 1999-11-16 | Eli Lilly And Company | Method for the treatment of CNS disorders |
US6245802B1 (en) * | 1998-11-13 | 2001-06-12 | Eli Lilly And Company | Method for treating pain |
Non-Patent Citations (2)
Title |
---|
See also references of EP2016066A4 * |
WHEELER ET AL.: "An asymmetric synthesis of duloxetine hydrochloride, a mixed uptake inhibitor of serotonin and norepinephrine and its C-14 labeled isotopomers", J. LABELLED COMPD. RADIOPHARM., vol. 36, 1995, pages 213 - 224, XP009019756 * |
Also Published As
Publication number | Publication date |
---|---|
EP2016066A2 (en) | 2009-01-21 |
WO2007134168A2 (en) | 2007-11-22 |
EP2016066A4 (en) | 2010-11-24 |
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