WO2007100387A3 - Process for preparing tadalafil - Google Patents

Process for preparing tadalafil Download PDF

Info

Publication number
WO2007100387A3
WO2007100387A3 PCT/US2006/060514 US2006060514W WO2007100387A3 WO 2007100387 A3 WO2007100387 A3 WO 2007100387A3 US 2006060514 W US2006060514 W US 2006060514W WO 2007100387 A3 WO2007100387 A3 WO 2007100387A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing tadalafil
tadalafil
preparing
Prior art date
Application number
PCT/US2006/060514
Other languages
French (fr)
Other versions
WO2007100387A2 (en
Inventor
Eswaraiah Sajja
Venkata Naga Kali Var Vetukuri
Srinivas Reddy Ningam
Ravindra Vedantham
Rajyalakshmi Bodepudi
Original Assignee
Reddys Lab Ltd Dr
Reddys Lab Inc Dr
Eswaraiah Sajja
Venkata Naga Kali Var Vetukuri
Srinivas Reddy Ningam
Ravindra Vedantham
Rajyalakshmi Bodepudi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Ltd Dr, Reddys Lab Inc Dr, Eswaraiah Sajja, Venkata Naga Kali Var Vetukuri, Srinivas Reddy Ningam, Ravindra Vedantham, Rajyalakshmi Bodepudi filed Critical Reddys Lab Ltd Dr
Publication of WO2007100387A2 publication Critical patent/WO2007100387A2/en
Publication of WO2007100387A3 publication Critical patent/WO2007100387A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

A process for preparing tadalafil.
PCT/US2006/060514 2005-11-03 2006-11-03 Process for preparing tadalafil WO2007100387A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
IN1606/CHE/2005 2005-11-03
IN1606CH2005 2005-11-03
IN91CH2006 2006-01-19
IN91/CHE/2006 2006-01-19
US74608206P 2006-05-01 2006-05-01
US60/746,082 2006-05-01
US80303606P 2006-05-24 2006-05-24
US60/803,036 2006-05-24

Publications (2)

Publication Number Publication Date
WO2007100387A2 WO2007100387A2 (en) 2007-09-07
WO2007100387A3 true WO2007100387A3 (en) 2008-03-06

Family

ID=38459475

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/060514 WO2007100387A2 (en) 2005-11-03 2006-11-03 Process for preparing tadalafil

Country Status (1)

Country Link
WO (1) WO2007100387A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110684025A (en) * 2019-10-29 2020-01-14 株洲千金药业股份有限公司 Preparation method of tadalafil

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20080285A1 (en) * 2008-02-22 2009-08-23 Endura Spa PROCEDURE FOR THE PREPARATION OF TETRAIDRO-1H-BETACARBOLIN-3-CARBOSSYLIC ACID ESTERS
EP2107059A1 (en) 2008-03-31 2009-10-07 LEK Pharmaceuticals D.D. Conversion of tryptophan into ß-carboline derivatives
EP2181997A1 (en) 2008-10-30 2010-05-05 Chemo Ibérica, S.A. A process for the preparation of tadalafil
CN102796098B (en) * 2011-05-27 2014-04-16 首都医科大学 (1S, 3S)-1-1, 3-benzodioxole-1, 2, 3, 4-tetrahydrophthalic anhydride-beta-carboline-3-formyl-amino acid methyl ester, and preparation method and application thereof
CN106279155B (en) * 2016-08-02 2019-03-19 扬子江药业集团四川海蓉药业有限公司 Impurity reference substance of Tadalafei and preparation method thereof
CN109053724A (en) * 2018-08-22 2018-12-21 上海青平药业有限公司 The purification process and purposes of the preparation method and Tadalafei of a kind of impurity prepared during Tadalafei and the impurity
CN109796461B (en) * 2018-12-30 2020-09-25 江苏科本药业有限公司 Preparation process of tadalafil impurity I
CN110790764B (en) * 2019-11-27 2021-04-06 四川省通园制药集团有限公司 Method for preparing tadalafil by one-pot method
CN111116583A (en) * 2019-12-23 2020-05-08 平光制药股份有限公司 Preparation method of tadalafil intermediate
CN111253399A (en) * 2020-03-30 2020-06-09 苏州弘森药业股份有限公司 Production process of tadalafil raw material medicine
CN115184531A (en) * 2021-04-07 2022-10-14 浙江康恩贝制药股份有限公司 Method for simultaneously determining contents of 3 impurities in tadalafil

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025494A (en) * 1994-01-21 2000-02-15 Icos Corporation Tetracyclic derivatives, process of preparation and use
US6046199A (en) * 1998-01-14 2000-04-04 Cell Pathways, Inc. Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives
WO2002010166A1 (en) * 2000-08-02 2002-02-07 Lilly Icos Llc Fused heterocyclic derivatives as phosphodiesterase inhibitors
WO2002036593A1 (en) * 2000-11-06 2002-05-10 Lilly Icos Llc Indole derivatives as pde5-inhibitors
US6451807B1 (en) * 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025494A (en) * 1994-01-21 2000-02-15 Icos Corporation Tetracyclic derivatives, process of preparation and use
US6046199A (en) * 1998-01-14 2000-04-04 Cell Pathways, Inc. Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives
US6451807B1 (en) * 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
WO2002010166A1 (en) * 2000-08-02 2002-02-07 Lilly Icos Llc Fused heterocyclic derivatives as phosphodiesterase inhibitors
WO2002036593A1 (en) * 2000-11-06 2002-05-10 Lilly Icos Llc Indole derivatives as pde5-inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110684025A (en) * 2019-10-29 2020-01-14 株洲千金药业股份有限公司 Preparation method of tadalafil

Also Published As

Publication number Publication date
WO2007100387A2 (en) 2007-09-07

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