WO2007127212A3 - Anti-viral agents that activate rnase l - Google Patents

Anti-viral agents that activate rnase l Download PDF

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Publication number
WO2007127212A3
WO2007127212A3 PCT/US2007/009959 US2007009959W WO2007127212A3 WO 2007127212 A3 WO2007127212 A3 WO 2007127212A3 US 2007009959 W US2007009959 W US 2007009959W WO 2007127212 A3 WO2007127212 A3 WO 2007127212A3
Authority
WO
WIPO (PCT)
Prior art keywords
viral agents
activate rnase
rnase
activate
viral
Prior art date
Application number
PCT/US2007/009959
Other languages
French (fr)
Other versions
WO2007127212A2 (en
Inventor
Robert Silverman
Paul Torrence
Babal Kant Jha
Paula Francom
Original Assignee
Cleveland Clinic Foundation
Northern Arizona University
Robert Silverman
Paul Torrence
Babal Kant Jha
Paula Francom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cleveland Clinic Foundation, Northern Arizona University, Robert Silverman, Paul Torrence, Babal Kant Jha, Paula Francom filed Critical Cleveland Clinic Foundation
Priority to CA002650028A priority Critical patent/CA2650028A1/en
Priority to AU2007243403A priority patent/AU2007243403A1/en
Priority to JP2009507765A priority patent/JP2009536622A/en
Priority to MX2008013668A priority patent/MX2008013668A/en
Priority to EP07755981A priority patent/EP2016062A2/en
Publication of WO2007127212A2 publication Critical patent/WO2007127212A2/en
Publication of WO2007127212A3 publication Critical patent/WO2007127212A3/en
Priority to IL194890A priority patent/IL194890A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

RNase L Activators and methods of using the same are disclosed herein.
PCT/US2007/009959 2006-04-25 2007-04-25 Anti-viral agents that activate rnase l WO2007127212A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002650028A CA2650028A1 (en) 2006-04-25 2007-04-25 Anti-viral agents that activate rnase l
AU2007243403A AU2007243403A1 (en) 2006-04-25 2007-04-25 Anti-viral agents that activate RNase L
JP2009507765A JP2009536622A (en) 2006-04-25 2007-04-25 Antiviral agent that activates RNase L
MX2008013668A MX2008013668A (en) 2006-04-25 2007-04-25 Anti-viral agents that activate rnase l.
EP07755981A EP2016062A2 (en) 2006-04-25 2007-04-25 Anti-viral agents that activate rnase l
IL194890A IL194890A0 (en) 2006-04-25 2008-10-23 ANTI-VIRAL AGENTS THAT ACTIVATE RNase L

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79506906P 2006-04-25 2006-04-25
US60/795,069 2006-04-25

Publications (2)

Publication Number Publication Date
WO2007127212A2 WO2007127212A2 (en) 2007-11-08
WO2007127212A3 true WO2007127212A3 (en) 2008-03-27

Family

ID=38374152

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009959 WO2007127212A2 (en) 2006-04-25 2007-04-25 Anti-viral agents that activate rnase l

Country Status (10)

Country Link
EP (1) EP2016062A2 (en)
JP (1) JP2009536622A (en)
KR (1) KR20090007609A (en)
CN (1) CN101460471A (en)
AU (1) AU2007243403A1 (en)
CA (1) CA2650028A1 (en)
IL (1) IL194890A0 (en)
MX (1) MX2008013668A (en)
RU (1) RU2008146422A (en)
WO (1) WO2007127212A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009123588A1 (en) * 2008-04-01 2009-10-08 The Cleveland Clinic Foundation Amides of 3, 5-substituted-is0xaz0le-4-carb0xylic acids for the treatment of viral infections, cancer and restenosis
ES2660892T3 (en) * 2009-03-23 2018-03-26 Merck Sharp & Dohme Corp. P2X3 receptor antagonists for pain management
EP2739629B1 (en) 2011-08-05 2016-10-05 Biota Scientific Management Pty Ltd Compounds for treating respiratory syncytial virus infections
RU2487708C1 (en) * 2012-03-12 2013-07-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации" (ГБОУ ВПО УГМА Минздравсоцразвития России) Method of treating parvoviral infection b19 in infants
TWI472518B (en) * 2014-01-02 2015-02-11 Univ China Medical Use of derivative of aniline in anti-virus application
AU2017354372A1 (en) * 2016-11-04 2019-06-20 Carna Biosciences, Inc. Furanone derivates and methods of use thereof
CN109745311B (en) * 2019-02-22 2021-12-17 北京大学深圳研究生院 Application of RNase L enzyme inhibitor
CN112107679A (en) * 2020-09-28 2020-12-22 武汉愔紫生物科技有限公司 Application of macromolecular protein in anti-RNA virus disinfectant
CN112088903A (en) * 2020-09-28 2020-12-18 武汉愔紫生物科技有限公司 Application of macromolecular protein in antibacterial and antiviral disinfectant

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004047760A2 (en) * 2002-11-22 2004-06-10 Smithkline Beecham Corporation Novel chemical compounds
US20050038051A1 (en) * 2003-06-09 2005-02-17 Jodi Nunnari Novel molecules for regulating cell death
US20050042213A1 (en) * 2003-08-14 2005-02-24 Insight Biopharmaceuticals Ltd. Methods and pharmaceutical compositions for modulating heparanase activation and uses thereof
WO2005051318A2 (en) * 2003-11-24 2005-06-09 Viropharma Incorporated Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
WO2005082363A1 (en) * 2004-02-20 2005-09-09 Board Of Regents, The University Of Texas System Thiazolone compounds for treatment of cancer
WO2005082901A1 (en) * 2004-02-25 2005-09-09 Smithkline Beecham Corporation Novel chemical compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004047760A2 (en) * 2002-11-22 2004-06-10 Smithkline Beecham Corporation Novel chemical compounds
US20050038051A1 (en) * 2003-06-09 2005-02-17 Jodi Nunnari Novel molecules for regulating cell death
US20050042213A1 (en) * 2003-08-14 2005-02-24 Insight Biopharmaceuticals Ltd. Methods and pharmaceutical compositions for modulating heparanase activation and uses thereof
WO2005051318A2 (en) * 2003-11-24 2005-06-09 Viropharma Incorporated Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
WO2005082363A1 (en) * 2004-02-20 2005-09-09 Board Of Regents, The University Of Texas System Thiazolone compounds for treatment of cancer
WO2005082901A1 (en) * 2004-02-25 2005-09-09 Smithkline Beecham Corporation Novel chemical compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TOLEDO-SHERMAN LETICIA ET AL: "Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening.", JOURNAL OF MEDICINAL CHEMISTRY 5 MAY 2005, vol. 48, no. 9, 5 May 2005 (2005-05-05), pages 3221 - 3230, XP002448944, ISSN: 0022-2623 *
TONGHUI MA ET AL: "High-Affinity Activators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Conductance Identified by High-throughput Screening", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 277, no. 40, 4 October 2002 (2002-10-04), pages 37235 - 37241, XP002327308, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
RU2008146422A (en) 2010-05-27
CA2650028A1 (en) 2007-11-08
CN101460471A (en) 2009-06-17
MX2008013668A (en) 2009-01-27
KR20090007609A (en) 2009-01-19
WO2007127212A2 (en) 2007-11-08
JP2009536622A (en) 2009-10-15
AU2007243403A1 (en) 2007-11-08
EP2016062A2 (en) 2009-01-21
IL194890A0 (en) 2009-08-03

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